| •Kiefer Sutherland | played | Jack Bauer |
| •Annie Wersching | played | Renee Walker (S07-??) |
| •Cherry Jones | played | President Allison Taylor (S07-??) |
| •Janeane Garofalo | played | Janis Gold (S07-??) |
| •Jeffrey R. Nordling | played | Larry Moss (S07-??) |
| •Mary Lynn Rajskub | played | Chloe O'Brian (S05-??, recurring previously) |
| •D. B. Woodside | played | President Wayne Palmer (S06-??, recurring previously) |
| •James Morrison (1) | played | Bill Buchanan (S05-??, recurring previously) |
| •Peter MacNicol (1) | played | Tom Lennox (S06-??) |
| •Jayne Atkinson (1) | played | Karen Hayes (S06-??, recurring previously) |
| •Carlo Rota | played | Morris O'Brian (S06-??, recurring previously) |
| •Marisol Nichols | played | Nadia Yassir (S06-??) |
| •Regina King | played | Sandra Palmer (S06-??) |
| •William Devane | played | Secretary of Defense James Heller (S04, recurring otherwise) |
| •Kim Raver | played | Audrey Raines (S04-05, recurring otherwise) |
| •Eric Balfour | played | Milo Pressman (S06, recurring previously) |
| •Gregory Itzin | played | President Charles Logan (S05, recurring otherwise) |
| •Jean Smart | played | First Lady Martha Logan (S05) |
| •Roger R. Cross | played | Curtis Manning (S04-05, recurring otherwise) |
| •Elisha Cuthbert | played | Kimberly Bauer (S01-03, recurring otherwise) |
| •Carlos Bernard (2) | played | Tony Almeida (S02-03, S05, recurring otherwise) |
| •Louis Lombardi | played | Edgar Stiles (S05, recurring previously) |
| •Reiko Aylesworth | played | Michelle Dessler (S02-03, recurring otherwise) |
| •Dennis Haysbert | played | President David Palmer (S01-03, recurring otherwise) |
| •Alberta Watson | played | Erin Driscoll (S04) |
| •Lana Parrilla | played | Sarah Gavin (S04) |
| •Penny Johnson Jerald | played | Sherry Palmer (S02, recurring otherwise) |
| •Sarah Clarke (1) | played | Nina Myers (S01-03) |
| •James Badge Dale (1) | played | Chase Edmunds (S03) |
| •Sarah Wynter (1) | played | Kate Warner (S02) |
| •Xander Berkeley | played | George Mason (S02, recurring previously) |
| •Leslie Hope | played | Teri Bauer (S01) |
