Dr. Doug Hanson is a brilliant, sharp-witted neurosurgeon who looks at the brain as wires in a box. His protégé, Dr. Jonathan Seger, takes a more personal approach to the brain by getting to know the patient before operating. Despite their opposing points of view on how to handle their patients, their secret mutual respect for each other's talents and skills, as well as a healthy dose of humor, helps them to be the best surgeon in their field.