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1 :01x01 - Lost For Words
Writer: Peter Ocko
Director: Davis Guggenheim
Guest star: Michael O'Neill (James Wills), Steve Braun (Otis Wills), Gloria Garayua (Lucy Canet), Addison Timlin (Charlotte Hanson), Julia Campbell (Roberta Mack), Zabryna Guevara (Melania Ortiz), Jennifer Ferrin (Penny Marx), Griffin Dunne (Dr. Jerry Cole), Madeline Zima (Cassie Mack), Nick Offerman (Dr. Coffey), Tamara Taylor (Della), Deena Dill (Beth Cole), Molly Bryant (Nurse Joanne), Petrea Burchard (O.R. Nurse), Liz Burnette (Anesthesiologist), Eleanor Seigler (Nurse Melissa), Maximino Arciniega, Jr. (Jose)
Two top New York neurosurgeons, Dr. Hanson and his protégé, Dr. Jonathan Seger, explore the mysteries of the brain as they perform life-saving brain surgeries. A tumor is discovered in the brain of a young teen -- Dr. Hanson wants to operate right away, but the girl's mother is hesitant to allow him to do so.
2 :01x02 - Of Two Minds
Writer: Davey Holmes
Director: Arlene Sanford
Guest star: Erin Dilly (Kate), Adam Stein (Dennis), Toks Olagundoye (Mary), Zabryna Guevara (Melania Ortiz), Leslie Kritzer (Donna), John Behlmann (James Parks), Don Stephenson (Dr. Lex Nylan), Rayme Cornell (Circulating Nurse), Starla Benford (Ultrasound Nurse), Ron Nakahara (Dr. Ryan Kim), Malachi Weir (Eddie)
Dr. Hanson takes a blunt approach to telling his patient, Kate Larson, that performing radiation on her brain tumor will most likely kill her unborn child. Upon hearing this, Kate refuses to undergo radiation, but agrees to a complex brain surgery.
3 :01x03 - Heart-Stopping
Writer: Scott Kaufer
Director: John David Coles
Guest star: Ned Eisenberg (Brad Ellis), Jessica Hecht (Rebecca Ellis), Zabryna Guevara (Melania Ortiz), Ben Walker (Nick Ross (as Benjamin Walker)), Jenn Miller Cribbs (Nurse), Wrenn Schmidt (Female Student), Linda Maurel Sithole (Kathleen), Jerzy Gwiazdowski (Male Student), Anna George (Dr. Helen Clark), Cyrus Farmer (Isaiah), Jack Gilpin (Dr. Wardell)
A woman Hanson operated on three years ago returns after suffering from double vision. Tests show that she has had another aneurysm and only has a 20% chance of survival. Despite the odds, the woman agrees to be operated on, but her brother does all he can to stop it.
4 :01x04 - Disarming
Writer: Peter Ocko
Director: Nicole Kassell
Guest star: Celia Weston (Tilly Bates), Cynthia Nixon (Dr. Corinne Dubinsky), Zabryna Guevara (Melania Ortiz), Griffin Dunne (Dr. Jeffrey Coles), Jennifer Ferrin (Penny Marx), Keira Naughton (Sarah Bates), Joaquin Perez Campbell (Clay Conlin), Erin Fritch (Cindy Hargrove), Cyrus Farmer (Isaiah), Jessica Stone (Vicky), Louis Ozawa Changchien (ICU Nurse), Ashlie Atkinson (Nurse Rhonda), Jordan Carlos (Intern), January LaVoy (Eileen), Amy Hohn (Dr. Pamela Bellflower), Linda Maurel Sithole (Nurse Kathleen), Joel Veach (McFadden)
While celebrating his return from Iraq with his fiancé, Clay Harper suffers a stroke. Hanson and Seger debate how to treat Harper: Hanson focuses on the medical facs while Seger argues that his recovery will depend on support from Cindy. Meanwhile, the doctors treat Tilly Bates, an older woman with a brain tumor that has affected her personality.
5 :01x05 - The God Spot
Writer: Jessica Ball
Director: John Fortenberry
Guest star: Addison Timlin (Charlotte Hanson), Maggie Siff (Lisa Ketchum), Zabryna Guevara (Melania Ortiz), Karl Bury (Matt Ketchum), Kate Jennings Grant (Kristen Lund), James McCaffrey (Eric Lund), Juliette Goglia (Erica Lund), Sidné Anderson (Lois), Cyrus Farmer (Isaiah), Ashlie Atkinson (Rhonda), Marivaldo dos Santos (Street Drummer #1), Bob Colletti (Creepy Guy), Carlos Thomas (Street Drummer #2), Malachi Weir (Eddie), David Brown (EMT #1), Mark Hammer (Old Man)
When Erica Lund's seizures escalate in severity, Hanson tells her he needs to operate, but she refuses because she claims she sees God in the moments before the seizure strikes. Meanwhile, another patient being treated for a severe head wound that causes him to blurt out his deepest, most intimate thoughts.
6 :01x06 - Bad Boys
Writer: Peter Ocko
Director: Sanford Bookstaver
Guest star: Cynthia Nixon (Dr. Corinne Dubinsky), Isabel Keating (Rosemary Donovan), Malachi Weir (Eddie), Cristin Milioti (Megan Rafferty), Addison Timlin (Charlotte Hanson), Zabryna Guevara (Melania Ortiz), Holley Fain (Rachel), Linda Maurel Sithole (Nurse Kathleen), January LaVoy (MRI Tech), Adam Huskey (Jared Donovan), Andrew Jade Williams (Boyfriend), Mark Kenneth Smaltz (Dr. Philip Walker), Jeremy Redleaf (Gary), Harry Zittel (Jimmy)
After a teenager crashes on his motorcycle, he starts an emotional war between his severe mother and Goth girlfriend that trickles over to the hospital staff; hospital assistant Eddie fears the worst after an MRI scan.
7 :01x07 - The Cutting Edge
Writer: Matt McGuinness
Director: Ken Girotti
Guest star: Frances De La Tour (Dr. Rosalind Halliday), Claire Lautier (Donna Callahan), Zabryna Guevara (Melania Ortiz), Jonathan Walker (Rick Callahan), Adam Wasserman (Market Employee), Justin Bruening (Paul Wyler), Ron Nakahara (Dr. Ryan Kim), Linda Maurel Sithole (Nurse Kathleen), Cyrus Farmer (Isaiah), Sarah Stockton (Amy)
Hanson's former mentor, Dr. Rosalind Halliday, asks him to perform a groundbreaking gene therapy procedure on one of her patients, but it soon becomes clear she isn't giving him the full picture.
8 :01x08 - Plugged In
Writer: Davey Holmes
Director: Ken Girotti
Guest star: Cynthia Nixon (Dr. Corinne Dubinsky), Sharon Washington (Lilly Thompson), Marc John Jefferies (Adam Thompson), Jeremy Davidson (Dr. Tom Beasley), Audra Blaser (Deborah Rivers), Charles Cooper (Clark Thompson), Melisa Hart (Meredith), Harvey S. Feuerstein (Charles), Samantha MacIvor (Waitress), Me'lisa Sellers (EMT (as Me'lissa Sellers)), Ron Nakahara (Dr. Ryan Kim), Justin Clynes (Young Guy), Sergia Louise Anderson (Young Girl)
Hanson and Seger try a radical surgical procedure to cure a man with depression. Holland works with a private physician on a patient who sees music as colors.