When Harry (Rob Estes) and Debbie Wilson (Lori Loughlin) relocate their family to Beverly Hills from Kansas, it doesn't take long for Annie Wilson (Shenae Grimes) and her brother Dixon (Tristan Wilds) to realize Beverly Hills is a world very different than their life in Kansas as they begin school at West Beverly Hills High School. The close-knit relationship between Annie and Dixon allows them to cope with new classmates, including Naomi (AnnaLynne McCord), a spoiled rich girl; Ethan (Dustin Milligan), a popular jock who instantly views Dixon as a rival; Navid (Michael Steger), a reporter for the school's newscast; and Erin "Silver"(Jessica Stroup), a girl who rebels from "normal" Beverly Hills behavior. Even the faculty has a different nature than that of their Kansas school, including teacher Ryan Matthews (Ryan Eggold) and guidance counselor Kelly Taylor (Jennie Garth).

90210 is an edgy, contemporary spin-off of the iconic drama Beverly Hills, 90210.