Chyna Parks joins the A.N.T. (Advanced Natural Talent) program at High School because she is a musical prodigy. Chyna and her ANT friends Fletcher Quimby and Olive Doyle find out about a school party being hosted by Lexi Reed, a popular "big kid" who's starred in every school play. They sneak out of the house to attend the party after Fletcher makes wax copies of them. Chyna, Fletcher, and Olive accidentally ruin Lexi's party by crashing into the sound system, causing everyone to turn on Chyna, including Olive and Fletcher. However, she makes things better by singing "Dynamite". When Chyna's father catches them at the party, after spotting their melted wax figures, he almost pulls Chyna out of the A.N.T. program, but he levels it down to three months of grounding.
Chyna and Olive make an effort to be more involved with their school's extracurricular activities and try out for the cheeerleading squad, run by Lexi and Paisley. Only Chyna gets accepted into the squad, but she gets more than she bargained for, when Lexi puts her cheerleading skills to the test. She weakens her enough to make her lose her voice, right before the school musical auditions. Meanwhile, Cameron creates his own club called "The End Hunger Today Club" as an excuse to eat hot wings all for himself, but when Fletcher catches him in the act and threatens to tell the teachers about his fake club, Cameron is forced to let Fletcher join. When Cameron has to earn money to keep the "The End Hunger Today Club" alive, Fletcher makes flyers stating that Oprah supports their cause. When Principal Skidmore discovers the "The End Hunger Today Club" is an excuse to get wings, instead of punishing Cameron and Fletcher, she joins them with the scheme. Meanwhile, after being encouraged by Olive, Chyna decides to try out wholeheartedly for the musical, and gets the lead because the casting director thinks that she's acting the part of a bruised, damaged girl who's lost her voice.
Cameron is annoyed by Olive so asks Lexi if he can borrow instructions for how to create a wild goose chase. When Lexi sends Cameron on one herself (involving the water heater), Cameron becomes covered in dust and realizes that Olive is easily frightened. Cameron tricks Olive into thinking that her locker was set above an ancient burial ground and is haunted - a very small ancient burial ground. Olive then moves into Chyna's locker in order to avoid the ghost, but ends up annoying Chyna (by rearranging her lunches and making up stuff like meat-rollups, putting balls in her locker, and revealing her crush on a boy to the boy) to the point where she devises a scheme to make Olive face her fears. That night, Olive and Chyna try to spend the night in Olive's locker, but while Cameron is "haunting" them, he also wrecks the prank and Olive and Chyna discover Cameron's plan. Meanwhile, Fletcher is having problems with making Principal Skidmore look beautiful in a painting. He also believes that Chyna, Lexi and Angus keep calling him "stupid".
Chyna wants to stay up to watch High Heels High, and Darryl gives her special permission if she studies after a couple of episodes. However, she stays up all night, and when she aces her science exam, she thinks that the teachers are giving her and the ANTs special treatment so they can compete and win trophies for Webster High. When Chyna is paired up with Olive for the science fair, she tries to do the worst possible project, thinking she'll get an A. However, Chyna crashes her project into Fletcher's and Chyna gets an F. It turns out that day, the teacher was just tired and gave everyone A-pluses. Meanwhile, Lexi and Cameron find Principal Skidmore's phone and make all their teachers do what they say. But when Lexi finds out Darryl is a cop, she and Cameron plan a scheme to show that they just found it. In the end, Darryl calls Skidmore's phone and Cameron answers it, and they both get in huge trouble.
After Chyna is denied entrance to a school dance, Olive tricks Chyna into running for student council. As she is campaigning, Angus tells her that to run for A.N.T rep you have to participate in every school activity and Olive was the runner up. So Chyna tricks Olive into running too. Meanwhile, Fletcher feels like Chyna doesn't even notice him. Angus tells him in order to get a girl to like you, you first need to relate with their dad. Fletcher then befriends Chyna's dad to see if he has a possibility with Chyna but Cameron gets jealous. At the end, Cameron beats Chyna and Olive for student council and Darryl starts hanging out with Cameron again.
Gibson is depressed about his grandma moving out, so Chyna and Fletcher try to cheer him up. When he keeps following him, ruining Fletcher's chances of getting closer to Chyna, they try to find Gibson a girlfriend. Chyna and Fletcher find out that Sofie, Gibson's ex-girlfriend from his childhood, is in jail for a robbery. So they take Gibson to the jail to show him that Sofie is a criminal, so he can get over her and hopefully stop spending all his time with Chyna and Fletcher. But Gibson thinks it is a big house and Sofie has a 25-year time out, and Chyna figures out that he will hang out with her and not them. Meanwhile, Lexi tries to get on the front page of the news, but must show Olive that she's done something newsworthy, But it's tricky to do because of Abigail Timmons who rescues an old man from a burning building, and helps Paisley when she choked on a meatball. In the end, Lexi gets her picture taken but it is because she got accidentally sprayed by fire extinguisher foam, which Olive takes a picture of and embarrasses Lexi.
After Darryl gets Chyna a bag from the evidence locker at the police station, she pretends to appreciate the thought of the gift. But when Fletcher tells Chyna and Olive about "Pudding Points" she tries to eat as much to buy a new designer bag. Darryl finds the new bag inside the bag he gave her and he accuses her of shoplifting and sends a police officer, Officer 3-9, undercover. When Chyna, Fletcher, and Olive find out that "Charlie Brown" is a cop and that he is spying on them, they pretend that they are robbing a house.
Chyna goes on a date with a new student from England, but a jealous Fletcher tries to sabotage the date. Meanwhile, Darryl challenges Olive and Cameron at an arcade to see who can get the highest score on a game.
Chyna convinces Cameron that he is psychic in order to help him discover his true talent. Meanwhile, Fletcher battles Principal Skidmore over the cafeteria's nuggets.
Cameron pretends to be Chyna's manager when they meet a top hip-hop producer. Meanwhile, Olive and Fletcher compete against each other in a home-economics challenge.
Chyna, Olive and Fletcher host a fund-raiser to save Gibson's job after he is let go due to budget cuts. Meanwhile, Lexi unfairly wins a beauty pageant.
A con artist passes off one of Fletcher's paintings as his own at a gallery. Meanwhile, Lexi and Paisley audition to be a princess at a kid's birthday party.
Olive becomes the new history teacher and sends rivals Lexi and Chyna to detention, where they team up to get rid of Olive as their teacher.
Chyna discovers that monsters are attending school with normal high-school students. China Anne McClain performs "Calling All the Monsters."
Chyna loses a pop singer's phone number during a field trip to a fortune-cookie factory.
hyna gets selected to give a speech at the ANT recruitment event. However, Cameron accidentally breaks Chyna's ANTpad while trying to play a boxing game. The ANTpad was the only place the speech was saved, but they realize Olive has seen it and must have it memorized! The problem is that Olive ends up losing her memory after hearing a loud noise and is kicked out of the A.N.T. Program by Principal Skidmore. In the process of doing so she loses some of her friends. Meanwhile, Cameron enters a dog show against Lexi to try and pay for the ANTpad.
Chyna hosts a slumber party after she isn't invited to Lexi's sleepover. Meanwhile, Cameron gets Fletcher to help him draw a comic book.
Chyna and Lexi audition for a talent show and are invited to Hollywood for the next round. When they arrive, the show's producer wants them to share a hotel room so viewers will think they are best friends. Meanwhile, Olive and Paisley enter a game-show competition.
Chyna, Olive and Fletcher make toys for kids at an orphanage, but then learn that Principal Skidmore is actually selling the toys for profit. Meanwhile, Lexi and Paisley are hired by a mall gift-wrapping department.
Chyna lands the lead in the school musical, but jealous Lexi tries to sabotage the show. Meanwhile, Cameron learns that a teacher is living at school and offers to rent his family's living room to the man.
Chyna tries to persuade her mom to let her go to a concert with the older kids.
Chyna and Fletcher go on a double date together. Meanwhile, Gibson takes over as cheerleading coach.
Olive and Fletcher exclude Chyna from their product idea. Meanwhile, Paisley gets attention from her injuries and Lexi get jealous.
A new girl at school isn't afraid of the older kids, including Lexi, who orders Chyna to keep the girl far away from her. Meanwhile, Cameron and Lexi take a drivers-education class.
Olive is shocked to discover that her pet robot is no longer functioning and has suspicious screwdriver scratches on the marks on its back. When a screwdriver is found in Chyna's locker, Chyna suspects she has been framed and vows to find the real culprit.
The second season begins with a teen movie star shadowing Chyna to research a film role, but chaos ensues when the actress tries to assume Chyna's identity.
Chyna and Olive raise money for a school dance by selling Fletcher's paintings. Meanwhile, Cameron asks a new girl at school to be his date for the dance.
Chyna helps Cameron impress a model he has a crush on. Meanwhile, Lexi gets a job at Hippo's new restaurant.
The school's Internet access is shut down, but the ANTs use their advanced skills to help students find information they would normally get online.
Olive sues Fletcher after he creates an animated story about his life and portrays her in an unflattering way.
Fletcher gets lost in the Outback when he attends an A.N.T. convention in Australia, and Chyna, Olive and Angus try to find him.
Chyna and Cameron go to a county fair and spend all their money on carnival games. Meanwhile, Olive and Lexi enter their dolls in a beauty pageant; and Fletcher tries to break his streak of embarrassing roller-coaster photographs.
Both Chyna and Lexi are determined to take home the $1,000 cash prize at a local carnival's Salute to Friendship contest.
Chyna, Fletcher and Olive fear funding cuts will affect the art and music programs. Meanwhile, Lexi takes over morning announcement duties from Cameron.
Tensions rise when Chyna scores higher than Olive on an intelligence test.
Chyna finally agrees to go on a date with Fletcher, but when their relationship becomes too serious too fast, she enlists Lexi's help in finding a way to break up with him. Meanwhile, Olive and Paisley team up for a psychology experiment and make Cameron their main subject
Mutant Chyna develops a forbidden crush on a boy who is human. Mutant Olive creates a duplicate of herself.
Chyna creates a fake crime scene at school to drum up business for her dad's new private-investigation business.
With half the school out sick, Principal Skidmore sends the A.N.T.s on an educational scavenger hunt around San Francisco, where Chyna and Lexi lead two teams onto Skywalker Ranch to get George Lucas' autograph. Chaos ensues and the gang winds up meeting R2D2 and C3PO.
Chyna is asked to join her favorite girl singing group, Trifecta, but is sad to have to leave her friends and family behind. With Chyna gone on a year-long tour, Olive and Fletcher try to proceed as usual sans Chyna, and Lexi decides to put on another school musical where she'll finally get to be the star.
Chyna and the ANTs are tasked with creating a special project for Black History Month. As Chyna struggles to write a song for her presentation, she decides to lock herself in a recording booth until she comes up with a great song. After accidentally falling asleep, Chyna takes a dream journey back in time where she becomes famous African American music icons from the past, Ella Fitzgerald, Aretha Franklin and Janet Jackson. Using her dream as inspiration, Chyna writes a new version of the "A.N.T. Farm" theme song, "Exceptional," with lyrics that pay tribute to the great women who came before her.
Chyna discovers that Skidmore has been extracting all the ANTs personalities with a fro-yo machine, and tries to save them- but they accidentally switch bodies. Meanwhile, Lexi keeps dreaming she is in love with Camreon and is almost about to kiss him.
A talented young chef named Graham starts working at IHOW and Olive is immediately smitten. The ANT's are thrilled when he joins the A.N.T. program until they discover that Graham is bit conceited. Meanwhile, when Lexi learns that some major pop stars got their start as singing waitresses, she asks Hippo if the wait staff can sing at IHOW.
When Teen Zoltan arrives in a time machine and falls in love with Chyna, he refuses to go back to the 80′s without his true love, so Chyna decides to accompany him back as his prom date. Meanwhile, Lexi hopes to travel back in time to correct a horrible event from the past, an ugly 5th grade picture in a newspaper.
Chyna promises Zoltan that she will keep an eye on the unpredictable Madam Goo Goo to make sure she doesn't disappear before she performs a song at his charity function. Meanwhile, Lexi learns her beauty score from a famous mathematician.
The mutants are back for Halloween and this time they arrive at what they think is a new boarding school for monsters, only to discover it's actually a prison run by Winter. When they try to escape, they accidently open a portal to the A.N.T. boarding school and meet the human versions of themselves.
When Cameron visits Chyna and tells her about his dream to attend film school, she agrees to ask Zoltan if he can shoot a movie at Z-tech. After Zoltan says no, Chyna helps Cameron make his movie in secret. Meanwhile, Fletcher can't sleep because Angus keeps waking up with bad dreams.