“100 A.D.” was seen by 6.05 million viewers

This episode's title is in honor of American Dad reaching its 100th episode.

The opening of this episode announced 100 characters would die.
Some of the named characters that died in a bus crash were,

• Brett Morris (Dope and Faith)
• Dr. Meg Penner (Wife Insurance)
• Mr. Kerkhoff (Delorean Story-An)
• Beauregard LaFontaine (Star Trek & Irregarding Steve)
• Belmonpan (Meter Made)
• Paco (American Dream Factory)
• Coco (One Little Word)
• Alejandro Roja (Wife Insurance)
• Clifford (Of Ice & Men)
• Bobby the Bullet (Stannie Get Your Gun)
• Gertie (Roger Codger)
• Ted Feedler (Threat Levels)
• Pillow Hands McGraw (Threat Levels)
• Bjorn (I Can't Stan You)
• Katie (Not Particularly Desperate Housewives)
• Ray (42-Year-Old Virgin)
• Matty Moyer (Stanny Slickers 2: The Legend of Ollie's Gold)
• Duper (Roger Codger) (Although his clone lives on)