The duration of this episode, in the American Dad! world, is 1 year.

We find out that Francine used to be on the show Scarecrow and Mrs. King with Kate Jackson, Bruce Boxleitner, and George Clooney.

Stan's has a "Cheney/Quayle '08" on his SUV's bumper sticker.

According to the commentary, the character of Franz is based on Steve Hely, Staff Writer & Story Editor for American Dad

Stan: Time for cake.
Klaus: I get the piece with the rose on it. I called it. You heard me.
Steve: Mom, cut me and end piece.
Hayley: How can you even think about eating that cake? Do you realize how many innocent cows were raped, or as you say, "milked," to make that cake?!
Stan: Shut up, Hayley.

(In Stan's car)
Francine: I have a new dream now. You want to know what it is? You really want to know?
Stan: Eh.
Francine: My dream is to destroy George Clooney. That arrogant, overrated, limo-riding bastard! He's not even an actor! He just does the same cheesy move every time. Looks down, then looks back up, squinting underneath his eyebrows. And everybody's buying it! God, if I just had the chance I know exactly how I'd bring him down. You see, Clooney's never fallen in love. It's always a fling here, a fling there. Well, I'd make him fall in love with me, and then I'd break his heart... and watch him cry until his eyeballs bleed!
Stan: Francine, I'm sorry, but that's the craziest, most unsettling thing I've never heard in my entire life...
(Scene changes; Stan and Francine are now on an airplane)
Stan: ...and we're totally gonna make it happen!

Stan: (About George Clooney) According to my intel, he starts production tomorrow on a new movie called Dr. Love. He plays a brilliant heart surgeon.
Francine: Let me guess. The only heart he can't heal is his own.
Stan: Look at that, word for word.
Francine: That knuckle-dragging son of a bitch!

Airplane Pilot: We are now beginning our descent into Prague.
Stan: And now George Clooney begins his descent into hell.
Airplane Pilot: Please put your seat-backs and tables in the upright position.
Stan: Please put George Clooney's heart in the... in the... in the sad-right... position. Should've ended with that whole descent into hell thing.

Francine: Stan, what's going on?
Stan: Francine, we're here to break George Clooney's heart. This is war. And no war is won without a crack squad of murderers and thieves.
Franz: Ahem.
Stan: And rapists. Sorry, Franz.
Franz: Thank you.

Petkov: (To Francine) The final key to Clooney is resisting his charm. Men and women alike find it irresistible and kiss his ass until they are sucked inside. But if you stay out of his ass, he will pursue you until he is all the way up yours.

George Clooney: Here, I got you a pipe.
Stan: Thanks, but I don't smoke pipes.
George Clooney: No one does. I'm bringing them back.

Roger: That's right, foster children: hard work builds character!
Kid: Water break, boss?
Roger: Oh, honey, don't call me "boss." That makes me feel like some kind of monster. Call me "Dad".
Kid: Water break, Dad?
Roger: No.

Francine punches a window; when she removes it it is bloody and glass is sticking out. Then a man comes over and bandages it, without taking the glass out!

In this episode, Hayley prays to God to cure her cancer, but in "Deacon Stan, Jesus Man", it's implied that Hayley is an atheist.

Hayley protests against cows being milked, failing to realize that if a cow isn't milked, it will end up dead from a burst udder (much like how a person dies if he holds his urine in his bladder for too long) or an infection.

This episode title “Tears of a Clooney” is of course a take off of the phrase “Tears of a Clown”.

This episode also revolves entirely around Oscar© winner and 2 time Oscar© nominee, American actor George Clooney (1961-)

(voicing themselves) Bruce Boxleitner & Kate Jackson reprise their “Scarecrow and Mrs. King” (1983-1987) characters, Lee "Scarecrow" Stetson & Amanda King for this episode.

Paparazzi: “Is it true you're dating Usher?”

Musician and singer Usher (1978-) is mentioned in this episode.

Francine: “What do the Coen brothers see in him?”

Francine is referring to Ethan Coen (1957-) & Joel Coen (1954-).
They directed George Clooney in the 2000 movie “O Brother, Where Art Thou?” and 2003's “Intolerable Cruelty”.
They received an Academy Awards nomination for “O Brother, Where Art Thou?” in 2001.

The character “Sergei Petkov” was inspired by the serial killer profiler from the 1995 TV movie “Citizen X”

When Roger is having the kids work in the vineyard; he is dressed as the head guard from the 1967 movie “Cool Hand Luke” starring Paul Newman (1925-2008) & George Kennedy (1925-)

George Clooney's co-star in 2001's “Ocean's Eleven”, 2004's “Ocean's Twelve” & 2002's “Confessions of a Dangerous Mind”, Oscar© winning & 2 time nominated actress Julia Roberts (1967-) is mentioned in this episode.

During the Clooney/Francine montage, Seth MacFarlane sings “I've Got You Under My Skin” written by Cole Porter in 1965 and made famous performed by the legendary Frank Sinatra (1915-1998)

Visual: “Night vision w/ Stan”

This scene is a reference to the 1991 horror/thriller “The Silence of the Lambs” starring Jodie Foster (1962-).

In the scene, Stan replaces Foster's character, “Agent Clarice Starling” and Francine, who's wearing the night vision goggles replaces the character “Buffalo Bill” played by Ted Levine (1957-)

Roger: “Why that's absurd. These children are merely playing 'Happy Fun Vineyard' from Milton Bradley”

The Milton Bradley Company is an American game company established by Milton Bradley in Springfield, Massachusetts, in 1860

Steve: “I let you kiss each other while I watched and this is how you repay me?”

When Steve says this line the 2 girls are strangling him with chains in the same manner the character “Princess Leia” strangled “Jabba the Hut” in 1983's “Return of the Jedi”.
The slave outfits the girls are wearing are also modeled afte the outfit worn by Leia.

Oscar© winning actress Susan Sarandon (1946-) is mentioned in this episode.

Oscar© winning actress Catherine Zeta Jones (1969-) is mentioned in this episode.