Are You There, Chelsea is based on the book and comedian/talk show host Chelsea Handler. This show follows the adventures of Chelsea (Laura Prepon), a twenty-something woman who doesn't let anything stand in her way of succeeding in her life. With her friends, who know that it is Chelsea's way or else, Mark (Jo Koy) and Shoniqua (Angel Laketa Moore) are there to add support for their friend. However, Todd (Mark Povinelli) doesn't take Chelsea's attitude and keeps her mannerisms to a minimum.
Chelsea Handler, herself, makes a reoccurring appearance as Chelsea's sister, Sloan, a woman who is married and has a new baby. She and Chelsea share a commonality together, that is vodka. Are You There, Chelsea follows the life of a wonderful woman with a story to tell. Created by Chelsea, this show dives into the famous woman's life and takes the viewers on a journey of who she is and how she has lived her life.