Ichigo and Rukia just finish up battling a hollow, when a bunch of white things invade town. And Kon see a mysterious man, well Ichigo and Rukia seen a mysterious Shinigami who beats all the blanks by releasing zanpakuto.
Rukia goes back to the Soul Society and Ichigo tries to chase after Senna, but is stopped by Matsumoto and Hitsugaya. Who go to Urahara's shop to explain the current situation. Because in the Soul Society was a mirror image of the real world.
Urahara explains about the blanks and a Memory Rosary and a valley between the Soul Society and Real World called the "Valley of Screams." And explains that the bad guy named Ganryu is trying to destroy the Soul Society and Real World, by the blanks.
Ichigo and Senna help a boy find his father, when some of the Soul Society comes for Senna, but is ambushed by Ganryu's and the Dark One's. Taking Senna to the Valley of Screams.
The Dark One's and Mayuri explain the about the blanks and why they can cause the destruction of the universe. Ichigo and Rukia go looking for the Valley of Screams entrance. They find it only because Ichigo remember what Senna said earlier.
Ichigo goes in well Rukia goes back to Urahara and Soul Society, cutting in the captains meeting asking for help. Yamamoto doesn't feeling comfortable with the time limit and turns her down. Rukia takes Renji to the real world to help Ichigo. Who is battling to save Senna.
As show as Rukia and Renji arrive Hitsugaya and Matsumoto are there to help. They enter and help battle the Dark One's. With the help of Kenpachi Zaraki, with Yachiru Kusajishi hanging from his back. Aside from Zaraki, Soi Fong, Izuru Kira, Byakuya Kuchiki, Tetsuzaemon Iba, Sh?hei Hisagi, Ikkaku Madarame, and Yumichika Ayasegawa. Ichigo is able to focus on saving Senna and the universe.
Meanwhile, Yamamoto sick of waiting for the crew that was sent out to report they stopped the blanks form destroying the dimension. Fires the kido cannon into the Valley of Screams hoping to destroy the dimension. Ichigo battles it out with Ganryu, and almost stops the destruction of the dimension, but it was a little late.
Senna knows what she must do to save the dimension and Ichigo. Rukia tells something important about the blanks and Senna. But Ichigo's reply with a good ending words.