Bethany Horowitz asks Alan Shore to help her out with a case against a large tobacco company. But when it turns out that the defense attorney is Phoebe Prentice, an old flame of Alan's, he finds himself distracted and fears that he won't be able to perform in court. Meanwhile, Denny is distraught over his own personal lack of performance in the bedroom.
After Denny Crane almost dies from toxic shock due to his unintended misuse of an arsenal of prescription drugs, Alan Shore takes on a pharmaceutical company for employing deceptive advertising to scare people into using their products. Meanwhile, Shirley Schmidt asks Carl Sack to defend her cheeky 17-year-old granddaughter who's been arrested for voting in the primary with falsified records, and Jerry Espenson and Katie Lloyd sue a private detention facility after a 15-year-old girl is raped by a guard.
"Dances with Wolves" Denny Crane is arrested yet again for carrying a concealed firearm after he shoots a man in self defense who's attempting to mug him and Jerry Espenson. Meanwhile, Alan Shore fights for a sex surrogate's right to joint custody of her daughter -- while grappling with the fact that he was a former client of hers
Alan Shore is called upon by ex-flame Phoebe Prentice to prove her husband's innocence in the murder of a nurse. But deep down, Alan's unrequited love for Phoebe makes him hope that her husband is guilty so that they can rekindle their relationship.
Alan Shore and Shirley Schmidt take on the armed forces when a man's brother dies in a local military hospital due to malpractice. But a friendly wager Denny Crane makes with Alan regarding the outcome of the case could cost Alan his job.
Meanwhile, Jerry Espenson's sister, Joy - whose son was conceived through an anonymous donor - - asks him to get a ruling which would allow her to find out who the father is to determine if her son and his girlfriend are related
Alan Shore and Denny Crane take a breather from the office and saddle up at a Dude Ranch in Utah. But the two city slickers soon find themselves at odds with their fellow horse enthusiasts and may need to call on the always irritating attorney Melvin Palmer - who also happens to be at the ranch. Meanwhile, Shirley Schmidt defends the murderous Catherine Piper (Betty White) when she unintentionally blows up her doctor after setting his office on fire for prescribing medication that almost killed her.
Alan Shore and Denny Crane sue the government when cattle rancher Carol Hober who, Crane believes, is the spitting image of actress Valerie Bertinelli -- accuses the USDA of not allowing her to test all of her cows for Mad Cow Disease, an affliction that's close to Denny's heart. But Denny continually irritates Carol when he tries to make her confess that she really is Valerie Bertinelli. Meanwhile, Jerry Espenson is up for partner at the firm, but his quirky social inadequacies could lead to his downfall with the firm's panel, which includes Paul Lewiston.
Jerry Espenson assaulted a bully after a run-in with him and wants to defend himself in court much to the dismay of the fellow partners.
Meanwhile, an underage pregnant girl wants an abortion and Shirley and Alan try to obtain a judicial by-pass for the girl.
Songs: Keb' Mo' -- The Times They Are A-Changin'
When a planned state execution goes awry for a death row inmate, the corrections officer took matters into his own hands by shooting the prisoner. Carl and Denny go to Virginia to defend the officer.
Meanwhile, Shirley and Alan are working on a case where this woman Martha Headly was fired for voting for John McCain for President and while they worked long hours Alan tries to heat things up with Shirley.
This Thanksgiving Shirley just wanted to spend the day with her partner Carl, but after she invites the gang over for dinner; Alan, Denny, Jerry and Katie and the ever emotional and unstable Ed Poole who in turns brings along his foster son who tried to mug Shirley to join them in the feast.
Alan pleads before the Massachusetts Supreme Court to allow his best friend Denny (who learns some disturbing news about the progression of his Alzheimer disease) have access to an experimental drug which could slow the progression of his Alzheimer's disease is available but not FDA approved.
Meanwhile, Jerry and Katie take on a case of a woman who used a brain-enhancing drug while taking her SATs and was disqualified from Harvard. The murderous Catherine Piper returns.
The law firm is in financial needs and is looking for a buyer; Shirley and Carl make arrangements for a wedding; and Denny argues before the Supreme Court to let Denny have access to a non approve FDA drug that will help him with his "mad cow". Denny poses an important question to Alan on the series 5 year finale.
In tonights final episode after 5 long years the law firm is in need of financial help and is looking for a buyer to help out. Alan argues before the Supreme Court to let Denny have access to a non approve drug to help with his Alzheimer's. Meanwhile, Shirley and Carl Sack make plans for a wedding; and Denny poses an important question to Alan in the series 5 year finale.