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Brandy Harrington is a member of the Florida Harringtons, a prestigious family who knows only the finer things in life. However, while on her way to a five-star spa to be spoiled and pampered, Brandy encountered an erroneous fate by the hands of Mr. Whiskers, who caused the two to plummet straight into the middle of the Amazon Rainforest. While she still longs for a way back home, Brandy has decided to make the most out of her situation and she thrives on trying to become the Amazon’s most popular individual, though she constantly keeps a keen eye out for any potential boyfriends that she may be able to acquire. Despite the fact that she blames Mr. Whiskers for the her being in the Amazon, she has accepted her role as his big sister and she lives with him in their tree house, where Brandy spends her time hoping to find a way back home.

Mr. Whiskers is a rabbit who doesn’t have very many friends, mostly due to his poor personality and body odor, though his life has also prevented him from settling down in one spot. While on his way to a zoo in Paraguay, he encountered Brandy Harrington of the Florida Harringtons, though he inadvertently opened the plane’s cargo door and the two of them plummeted into the middle of the Amazon Rainforest. Mr. Whiskers managed to become Brandy’s friend and the two of them built a tree house together, though despite their shared living quarters, Mr. Whiskers often gets on Brandy’s nerves. Mr. Whiskers’ best friend, aside from Brandy is Ed the Otter, who is one of the few people in the Amazon who are capable of enduring Mr. Whiskers’ antics. Unlike Brandy, Mr. Whiskers enjoys his time in the Amazon Rainforest and he doesn’t spend his time trying to get rescued.