Grissom and Catherine look into the case of a comic who died while doing an act on stage, apparently a result of poisoning. The evidence appears to suggest that he died due to a tainted bottle of water. The investigation becomes more complicated when a teenaged boy dies after drinking the same brand of water. Has someone tampered with them? Meanwhile, Detective Brass reopens a case of a woman’s death that was deemed accidental, after Brass sees the woman’s husband with a trophy date in an expensive new car.