Grissom and his team are sent to an APAPSP convention, "Association to Promote Acceptance of Plus-Sized People", to search for a killer. The evidence the collect shows that the victim died from asphyxia due to a large object stuck in his chest. Meanwhile, Catherine and her team are thrust into the world of high-stakes gambling when a man is found dead in the Vegas outskirts with a large amount of money and betting slips on him.