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Catherine testifies in a murder trial in which a man is accused of murdering his own mother three years ago, but the suspect is found not guilty. Catherine, however, believes he did commit the crime and that he may also have killed two other people, so she sets out to find the other victims. Catherine's probe leads to a small Nevada town where an elderly woman and her daughter were fatally stabbed and shot three years earlier. Back at the lab, Grissom prepares to leave on a four-week sabbatical.
Title: Leaving Las Vegas
The term "Leaving Las Vegas" has a recent history as a cultural meme due to an Academy Award film and the novel by the same name it was adopted from. At its basis, however, it refers, simply, to what it says, "leaving Las Vegas", which is what Grissim is readying to do while going on sabbatical.