When a virus from E. Coli strikes in Miami, it kills a young woman and her boyfriend, prompting Eric Delko and Alexx Woods to return to help their team. The CSIs split up to track down the source for the virus, leading Calleigh to a restaurant where the couple ate and Jesse Cardoza and Ryan to a farm where the virus grows on plants. Meanwhile, Eric tries to save a man who died from being brain dead, but when the rescue doesn’t go successfully, the death influences Eric so much that he decides to quit his job.