The lives of two CSI’s, Ryan and Natalia, are in critical danger when they arrive at a house that’s actually a meth lab on the inside. When they enter, the meth explodes and there may be dire consequences for both of them. Meanwhile, the rest of the team looks into the death of a man whose body was found in the trunk of a car, which was chased by two police cars and crashed. The driver tells Horatio he was forced to do what he did, but evidence suggests otherwise.