A man is brutally murdered while trying to learn how to pick up women at a hip Miami nightclub. The victim was taking lessons from seasoned pros on how to score women in the competitive Miami nightlife, and was nearly successful before he was killed. The CSI’s, left only with a club full of likely suspects and a murder weapon wiped clean, must find the killer amongst the treacherous backdrop of Miami's sexual nightlife. Meanwhile, Eric's sister, Marisol, is arrested for buying a large amount of marijuana, and Horatio, learning that she bought the drugs to help her and her fellow cancer sufferers, must find a way to help her avoid jail time.