A dead woman found swallowed up inside a snake leads the CSI to a drug smuggling operation. It is believed the snakes are used to smuggle the drugs inside of them, avoiding detection by customs. Horatio discovers his nemesis, Clavo Cruz is behind the drug smuggling racket and is determined to prove it. Meanwhile, Wolfe leads an investigation of a pair of women, both claiming that each other is part of an identity theft scandal against them.