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Horatio takes confession with a New York City Cardinal who is one of only a few people who know of the deadly crime he committed in his past. Meanwhile, Miami's fiercest gang seeks revenge on a rival gang member and opens fire at his mother's funeral. When the gang discovers that Horatio plans to find them and destroy their illegal smuggling operation, they put out a hit on Horatio. Also, Natalia Boa Vista (La Rue), a new CSI lab technician, creates conflict with a different government agenda from that of the team.