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Calleigh and Ryan are called to a house to investigate a man’s death, and they find his body in the attic. But when someone enters the house and locks them up in the attic, the lives of the CSI’s are in jeopardy as a fire breaks out inside the house. They barely make it out of the house, however, the danger isn’t over yet as Calleigh has a late reaction to all the smoke she inhaled. She is immediately driven to the hospital, where Alexx and her team tries to help her.
Title Reference: "Smoke Gets in Your CSI's"
Though we are unsure what the origin of the expression is, "Smoke Gets in Your Eyes" is a fairly common expression for someone in immediate danger of dying from fire, or from the smoke created by the fire. In the beginning, Ryan and Calleigh are trapped in the attic of a house, and then someone sets the house on fire. This is what the title means, as these two CSI's are in immediate danger from fire.