In the beginning of the episode, we see a robber jumping off a rooftop before the theme song. This scene was filmed at 1100 Wilshire in Downtown Los Angeles, California.
Title Reference: "Wolfe in Sheep's Clothing"
This title, as well as many parts of the episode, have references to one of the fables of Aesop, called "The Wolf in Sheep's Clothing". The fable centers around a wolf finding a sheep's fleece, putting it on and walking around other sheeps while secretly stealing lamb for supper. The situation Ryan Wolfe is in is a clear reference to this fable, in which Ryan acts like a CSI while stealing evidence in the case in order to save the life of a little boy.