The CSI's offices have relocated to a Manhattan high rise which includes new labs, a staff break room and new office equipment with state-of-the-art technology. Also, after expressing his interest in moving out of the coroner's office, Dr. Hawkes joins the team in the field and his first case has him working with Mac on the death of a skyscraper climber. Although hundreds of witnesses were on hand to see the climber fall, the team suspects foul play and believes someone may have caused his death. Meanwhile, Stella and Danny investigate the murder of a New York fashion designer killed while wearing an eight million dollar diamond bar from his own collection.
While investigating the murder of a plastic surgeon, Mac and Hawkes discover that suspects abound since the doctor had pending lawsuits with patients who sued him for millions. Meanwhile, Stella and Danny delve into the world of cuddle parties while tracking the killer of a blind woman found on a Manhattan rooftop. Stella enlists the help of a sculptor to aid her with a facial reconstruction project that will help nab the suspect. Also, Aiden grows frustrated when she's unable to find evidence to finally send a repeat rapist to jail. And, the CSIs lose a member of the team.
When a man is torn to pieces by a tiger at the New York animal conservatory, Mac, Lindsay and Danny must discover who was responsible for getting him there.
While investigating a vicious tiger mauling at a New York zoo, the CSIs question the workers at the meatpacking plant the victim owned. Meanwhile, Stella and Dr. Hawkes must solve the murder of a debutante found dead on a Central Park carousel. Also, a new CSI (Anna Belknap) joins the team.
When a man collapses and dies in the middle of the annual San Gennaro festival in Little Italy, the team must investigate how the victim ended up with a wood sliver in his heart.
The San Gennaro festival draws over one million revelers annually, making the site a tough crime scene to process. When Stella and Danny are called to investigate a murder at this site, the clues lead them to a pool hall destroyed in a brawl. Meanwhile, Mac and Lindsay investigate the murder of a CFO found decapitated on a bench in Central Park. The investigation leads them to a financial office where the executives practice martial arts competitively. Also, Dr. Hawkes and Det. Flack investigate a suspicious apartment fire that kills a 10-year-old chess champion.
After a wealthy middle-aged man is murdered in the elevator of his Park Avenue apartment building, the team must track the only witness to the crime who fled the scene.
After a wealthy man is shot at close range in an elevator just outside of his penthouse apartment, Mac and Det. Flack realize that a companion may have witnessed the murder. Their investigation leads Danny and Lindsay into the world of underage high school girls who disguise their age and revel in the Manhattan social scene in order to meet wealthy men. Meanwhile, Stella and Dr. Hawkes investigate the death of a seemingly well-off young man found in a Central Park lake who seems to have two identities.
A crossover episode that began on "CSI Miami" concludes with escaped serial killer Henry Darius murdering a group of teens in a luxury apartment where he tries to steal millions of dollars from a high-tech security vault. While working the case in Manhattan, Horatio is served with a subpoena that names him as a suspect in an unsolved murder more than 20 years ago in Queens.
After a player is caught cheating and is kicked out of a high stakes poker game, the results are deadly when the host is murdered with a shotgun.
A friendly poker game turns deadly when the players realize one of their own is cheating, beat him mercilessly and kick him out of their apartment. When a knock on the door is followed by a shotgun blast that kills the host, Mac and Stella follow their only lead, the ejected player. Meanwhile, Danny and Dr. Hawkes investigate the murder of a local news station's weather girl and their search uncovers a tape she was desperately trying to hide.
After a pile-up during a heated match between two of New York's all-female roller derby teams turns deadly, Mac, Stella and Lindsay investigate the skater's death, whose beauty and multiple endorsements may have caused her murder.
When a game between rival teams, the Manhattan Minx and Brooklyn Clobbers, ends in the murder of the premier skater in the league, the CSIs must discover if her murder was an act of jealousy from one of her teammates or if she was killed by an opposing skater because of her competitive edge. Meanwhile, Danny and Sheldon investigate the death of a gifted writer who is found with the final chapter of his latest novel written on his entire body, leading them to believe that their suspect likely suffers from hypergraphia.
Mia Sara ("Ferris Bueller's Day Off") guest stars as Cala Winger, victim Griffin Holden's book editor, who reports him missing and seems more concerned with the missing chapter from his manuscript than with his death.
Lady Sovereign -- Random, Coldplay
Mac, Det. Flack and Dr. Hawkes investigate the death of a model and an injured 20-something billionaire who were both speared by an arrow while hooking up at his party. Stella, who was attending the event as a guest, joins the investigation as the team works to discover who was the intended target--the playboy who is notorious for his conquests, or the model he had just met.
Meanwhile, Danny and Lindsay question a multitude of suspects when a music promoter is found dead, coated with glue and covered in the billboard posters of the band he was trying to break out.
Mac, Stella and Det. Flack uncover the latest fantasy game sweeping New Yorkers of every class and status -- an assassination game called "water gun wars," where each player receives a pack of photos from an unknown source, and then must track and shoot their targets with a water gun or balloon before another player kills them first.
Meanwhile, when a woman is found dead in her Manhattan apartment, Danny, Sheldon and Det. Maka trace her steps to an exotic cuisine event where the main course includes live centipedes, Brazilian cockroaches, live octopus and fried tarantulas, among other delicacies.
When blood begins pouring from the faucets of a building, Mac, Det. Flack and Lindsay investigate and find a female doorman dead in the building's water tank.
After learning that the building in which their victim was found had six suspicious deaths over a 10 year period, Lindsay begins to question the science and wonders if the building is cursed. Mounting evidence seems to point to only one suspect, a doctor who swears he had no interaction with the victim, even though their lives seem intertwined.
Meanwhile, when a trend spotter is killed in Washington Heights after photographing a stylish teen, Stella, Sheldon and Danny question the marketing executive whose business was affected most by the victim's foray into the neighborhood.
Mac, Stella, Sheldon and Lindsay investigate the death of a museum curator murdered in the wing her wealthy family donated and the crime's only witness refuses to talk.
Mac becomes particularly protective of the only witness in his murder investigation, a young boy found in shock at the exhibit, which after seeing the grizzly crime confuses the events at the museum with a comic book he was reading at the time. The team works to discover if the motive was money, given the curator's wealth, or if the witness has something to do with it when the CSIs find he has ties to the victim.
Meanwhile, Danny and Det. Flack are called to a construction site where a man is found dead with a mouth full of foam sealant, which leads them to an extreme golf association with members who play in the streets of the city's five boroughs.
When a helicopter containing a liver from an organ donor is hijacked from the roof of a Manhattan hospital, and a medical intern is killed in the process, the CSIs must find the perpetrators and the liver before the transplant patient dies.
Mac, Sheldon, Danny and Det. Flack's only witness is an unconscious helicopter pilot, but their initial clues lead the CSIs to suspect that the helicopter hijacking may have been an inside job. Meanwhile, the rape and murder of a restaurant hostess found in an alley shocks Stella and Lindsay when they discover that she anonymously engaged in phone sex with her patrons, leaving a suspect list a mile long.
The murder of a would-be super hero leads the team to uncover the illegal sale of prescription drugs to junkies and they suspect the victim's killer is behind it all. Meanwhile, when a college football superstar is killed in his hotel room shortly after being chosen as a first draft pick for the league, Danny and Lindsay question a long list of suspects who came into contact with him after his sudden fame.
An anonymous caller reveals to Mac that a young man is buried at a football stadium and, after uncovering the body, the evidence leads the CSIs once again to the Tanglewood gang.
After being unable to jail the leader of the Tanglewood Boys a year before, Mac makes it his mission to succeed this time, but he's shocked when the evidence puts Danny at the crime scene instead. Meanwhile, when a banker is found dead in a hotel room, the team questions the man who runs a high-priced escort service claiming to offer their clientele the ultimate date experience at a very steep cost. Also, as Stella and Frankie's relationship progresses, she is surprised to receive a special sculpture from him.
A concert goer attempting to sneak in to a Kid Rock show gets the shock of her life when she discovers a dead man in a limo outside of the concert hall. Mac and Lindsay are forced to question concert goers, groupies and uncooperative handlers when the star becomes their prime suspect. Meanwhile, a routine call heard over the police scanners floors the team when they realize the emergency may affect one of their own team members.
Mac and Stella are shocked when, while at a crime scene, two grief-stricken women approach them claiming to be married to the victim. The women explain they were both knowingly in a committed threesome relationship with the deceased. Meanwhile, when a young woman dressed as a mermaid is found tangled in the kelp off a ferry dock, Danny and Lindsay investigate her murder and discover that her last known whereabouts were at a child's birthday party. The case affects Lindsay the most when she realizes the victim is from her home state.
Songs: Bird York -- In The Deep
The CSIs face their toughest challenge yet when a bomber uses random cell phone pages to detonate C-4 bombs across the city, and a member of the team fights for life when seriously injured during one of the explosions.
In a race against the clock, the team works with local agencies and government authorities to locate the bomber and narrow down the next trigger among the city's six million cell phones before he strikes again. Meanwhile, as Mac investigates a routine crime scene, he stumbles upon a bag containing C-4 explosives and is unable to evacuate the building quickly enough to get his team out of harms' way. While a CSI is rushed to surgery, Mac struggles with the memories of the last person he was unable to save, a fellow Marine killed during the 1983 Beirut barracks bombing.