When a murder takes place in the crown of the Statue of Liberty, the CSI’s also find a trace of blood down Lady Liberty’s face. But Danny uncovers that there is too much blood there to be from the victim, so something else must’ve happened as well. But while walking around on Liberty Island, the team spots what looks like a man on the other side of the river just sitting and looking at them, but on closer inspection, the man is dead and has the words “2 more will die” on his shirt.
In a boat “fight” between New Jersey and New York, the dead body of a man who went diving is found lying in the water. But when Hawkes uncovers that the victim apparently lost oxygen and drowned with a full tank and a back-up, Sid finds out that a starfish was in the victim’s body, eating on the internal organs. Meanwhile, Danny and Hawkes go underwater to find evidence where the victim died, but when Hawkes gets stuck and Danny has problems freeing him, Hawkes’ life is put in jeopardy.
When Flack and his girlfriend are disrupted by a break-in, Flack chases the man through a building and the Manhattan streets stopping at nothing to arrest the guy. But when the guy’s car turns out to have some James Bond-equipment and manages to block the street by causing a fire, he escapes out of Flack’s control. But while investigating the case, even more odd and suspicious evidence shows up that involves 007.
When a “crazy” man runs through the streets naked and with a whole bunch of gears and equipment attached to his head, he runs right into the CSI headquarters, confessing to a murder. But what he tells Mac in private right before he dies is that he is from the future and is going to kill a man named Kevin the next day. While the CSIs believe the murder won’t happen when the man who confessed is dead, they believe they are handling their most complicated case yet when a man, named Kevin, falls to his death the next day at the exact time and with the same head gears.
A janitor finds a young woman dead among mannequins, but while doing the autopsy, Sid uncovers that the woman is in no way normal. Investigating further, the team uncovers that almost everything about their victim is exactly similar to a character in the virtual game Second Life, and Mac creates his own character to try and get in contact with the killer online.
The CSIs look in to a mass murder at the Amityville Horror house and come across several eerie events along the way.
Mac and the CSIs investigate the murder of a man who was found in Madison Square Park as well as a woman who was shot at the Metropolitan Museum of Art. While looking into the deaths, they find that the man and the woman share a similar criminal past.
A supermodel is found dead on top of a Times Square billboard, crammed into a giant martini glass.
Mac is called in when a man is killed on the day of his wedding. He is found stuffed in a box and wrapped like a wedding present, and Stella finds a box of bloody-covered puzzle pieces in her car, which leads Mac to Chicago in order to solve the biggest mystery of his career.
Mac believes he is closer to finding his "333" stalker and learns the meaning of the numbers. Meanwhile, a CSI team member is held as a hostage.
The CSIs' investigation of a murder leads them to "laughing Larry", an infamous seller or killer pranks. And Danny works on a case involving a boy from his neighbourhood.
The CSIs are called when a woman is crushed under an ice castle sculpture with her red glittery shoes sticking out from underneath the ice. The victim, known as "Wicked Witch of the Upper East Side", had several enemies, all of which the CSIs must investigate in order to find the killer. Meanwhile, a teenager's body is discovered, leading the CSIs into the world of New York City's prep school parties.
Two separate murders occur in the same area, leading the CSIs to investigate whether or not the deaths are connected.
What seems to be like a freak accident involving a drowning victim in a self-cleaning restroom turns into foul play.
An anonymous tip has the CSIs searching an emptied warehouse in a hunt for one of the cities most wanted criminals.
After a fire breaks out in Stella's apartment, the CSIs must determine if it was arson.
The team is sent to investigate when a salesman is found dead next to several dead sharks on Rockaway Beach, which leads them down a twisted trail of evidence as they search for the killer.
The CSIs are called when a guidance counselor is killed under mysterious circumastances. Meanwhile, the serial killer dubbed the "Taxi Cab Killer" continues to make his mark on the city.
The hunt for the "Taxi Cab Killer" continues as the CSIs race against the clock follow a new trail of evidence before the now notorious killer takes another life.
When the man thought to the be "Cabbie Killer" is found dead himself, Mac and the CSIs must determine whether or not the man is really the serial killer and whether or not the city of New York can rest easy.
When a bank heist goes wrong and the bank's manager winds up dead, the gunman takes the entire bank hostage. His only demand is that the CSI team prove he didn't kill the bank manager.