Jeff finds himself in a dangerous situation involving Samantha's husband as Charlie returns to work.
Rita is not happy after a patient turns out to be dishonest. Cal attempts to help a schoolgirl deal with her HIV,. Max convinces a rock legend to be honest.
Connie’s former boss Andrea shows up and risks a young boy’s life to hide her secret.Dixie is concerned about Tamzin and Jeff’s relationship.
Robyn and Lofty aren't happy at work. Noel sets Max up on a date. Connie asks Tess about Charlie's retirement.
A day out for several doctors ends in disaster as Jeff has plans to marry Tamzin.
A couple of former faces return to the hospital as the team comes together to say farewell to their friend Ash feels guilty about his colleague's death whilst Dixie throws herself into work and Cal is concerned after Ethan disappears from his hospital bed to attend the funeral.
Connie finds herself worried if she missed something as Cal and Ethan work together when they find a rare virus.
Zoe returns to the ED, bringing a surprise with her. Lofty treats a boy who is fed up of been stopped and searched. Dixie causes ripples through the department when shes rages about Jeff's death, clashing with Ash. Connie has a complaint made against her.
Briony is injured at the local derby game, it soon becomes apparent to Cal that she is having relationship issues with her fiancê Matthew. Raucous football fans find themselves in the ED after a fight gets out of hand. Ash struggles under the pressure. Dixie can't get over Jeff.
Ethan finds himself in charge of the ED one night where strange things start to occur.
Mac starts his new job back at the ED as a health care assistant as emotions cause Ash to struggle.
The lifestyle choice of a patient annoys Ash as a heroic old lady gets treatment.
Ash and Dylan are unable to agree about how to treat a suspected overdose. Cal helps a patient with a large abscess whilst Zoe becomes annoyed after Cal flirts with her patient.
The team have to deal with an incident at a local cathedral and Lofty attempts to help a patient who believes that he’s Jesus. Zoe catches Max watching her and Dylan at the houseboat and is forced to confront him about their relationship.
New Year approaches with New Years resolutions being made but Connie's personal life causes problems.
A demanding patient is forcing Connie to spend less time with Grace as Zoe starts to realise life can be short.
Connie finds herself in a showdown with Hailey Blake as Robyn decides to set up a hospital food bank.
Rita has a blast from her past when Mark turns up but concern grows when Grace goes missing.
Now that Grace has left, Connie throws herself into work as Big Mac tries to help a man after he gambled his brother's money.
The ED is facing an inspection but Connie is unaware to problems that lay ahead as a soldier training day suffers an explosion.
Connie suggests that Dylan applies for the vacancy of Consultant as the team's professionalism is tested by a criminal.
A teenager struggles to accept that she is in need of help as Dylan and Lofty help a patient who has a big secret.
A father is giving up on himself but Dixie tries to help as Connie finds a friend in a patient.
Lily is able to convince a wife to be honest with her husband about not wanting a baby anymore and not continuing with IVF. Rita tries to help a man change his stubborn attitude after he refuses to tell people he is suffering with a neurological disease.
Driving home from work, Lily ends up hitting a schoolgirl as the argument between Connie and Rita continues causing a work-to-rule.
Two major incidents put the ED under pressure and cause trouble for Zoe but the return of Maggie provides an alternative offer.
With Alfred's condition getting worse, Connie tries to give him special treatment as Ethan isn't happy to learn Cal stole his money.
When a young girl ends up giving birth in Dixie's ambulance, a teacher claims to be adopting the baby as the victim of bullying takes revenge on his bully.
There is an accident on the Emergency Department doorstep which results in the hospital having to operate on a generator. A distressed Taylor calls Carl who finds her in a park toilet with a knife in her leg. Lofty attempts to put Robyn off him and turns to Max for help.
Arrested on suspicion of helping Alfred to die, Connie fights to prove her innocence as two-star-crossed lovers receive help from Robyn.
It's the day of Connie's trial and if Rita comes clean and Charlie takes the tranquilizers to the police, her name might be cleared. Dixie goes to a care home where she tries to help a girl who has cut her wrists.
Charlie and Connie travel to Bucharest in Romania to try and save Charlie's son. After Charlie shows up at the hospital in Bucharest he finds out that Louis is a heroin addict and has become involved in some bad business. Louis leaves hospital in a car driven by a drug dealer called Cristian. Charlie discovers that his son is planning to sell his kidney to pay off his debts.
More worried than ever about Louis' safety and wellbeing, Charlie is very agitated as a talented skater falls in with a bad group of lads.
Cal and Ethan make plans to travel to Finland to help a patient take part in a clinical trial that could save her life. They end up though trying to helping her adopted son’s biological brother, comes to terms with his mother’s illness. Zoe tries to help Riley, who has been in a car accident and is unable to speak and soon finds out that his mother died in a road traffic accident.
Connie has returned and is testing a new leadership technique but if she is to win her team's respect she needs to be herself. Dylan is suffering with a lack of confidence and after a patient dies in his care in the ED, following a team building exercise which goes wrong, things get much worse for him.
Dixie tries to help a mother called Suzy, who is grieving for her baby. She soon believes though that Suzy has abducted a baby to replace her own. Cal and a leukaemia patient work together to try and raise money for charity.
Charlie attempts help Louis deal with his heroin withdrawal but he finds a way of running away. Cal is able to get a pushy mum to be honest with her daughter, after they fail to reach a beauty pageant. Dylan has to deal with another bad day but after he absent-mindedly pockets a ‘lucky’ talisman things begin to improve for him.
A mother on the run discovers that her daughter is pregnant and sacrifices her life for her. Dylan finds out about the power of belief through a patient who has a holistic therapist. Louis is found by Charlie in a crack den and he threatens to inject himself if Louis does, causing him to accept his help.
The night shift for the department finds Ethan involved in a murder case as the presence of Hanseen puts Ethan under pressure.
An unlikely hero sees the a crucial diagnosis whilst Rita helps a man realise that he needs help.
It is Jacob's first day in the department and he finds himself using his powers of persuasion when a lie nearly kills a young girl as Honey returns to Holby.
After a cowardly father is faced with an ultimatum, Charlie tries to help him do the right thing for his daughter. A son causes his father's much younger fiancée to end up in the Emergency Department after his bid to break off their recent engagement does not go to plan.