Zoe's first day as the ED's clinical lead is a hectic one after the team has to deal with the aftermath of a tunnel collapse at a music festival.
After baby Lucy is left home alone, Tamzin and Jeff are called out to rescue her. With no one to look after her and in her new role of boss, Zoe puts Dylan in charge of the baby's care until social services show up. After Lucy's condition suddenly deteriorates it is left to Tom to revive her. Tamzin and Jeff are asked to help a lap dancer who has collapsed at work. Sam treats a mystery man called Alan, who has lost his memory after being struck by car.
Tom and Sam start to grow closer after they attempt to deal with a female cage fighter who insists on competing, despite their advice. Some really devastating news puts a wedding in doubt.
Dylan and Tess offer advise to a vulnerable pregnant woman whose husband is pressurising her to have a C-section. Fletch offers support to a young swimmer.
A freak storm manages to rock the hospital. A family’s argument reaches boiling point. An ED favourite is involved in a fight for their life.
A short moment of recklessness ends up coming back to haunt a young driver. Fletch attempts to try and lighten up Lloyd.
Linda is upset after Denise announces her plans to leave Holby with the children. A disaster in a warehouse brings a family much closer together. As Linda finds it hard to come to terms with Denise's decision, she throws herself into treating Henry and Jules, a father and son injured in an accident at the warehouse. When things go missing the finger of accusation is pointed at Denise.
Zoe finds it hard to come to terms with her new job as clinical lead. Big Mac returns to work following his heart attack. Dylan is forced to say sorry.
Zoe and the team struggle to find a cure when a possiblly life-threatening form of E-Coli is introduced to the ED by a class of sick children.
The team struggles to cope following Zoe’s decision to go public with the E. coli outbreak. Tom and Sam begin to grow closer at the staff Halloween party.
Amanda makes a return to the ED after a teenager finds it hard to kick a bad habit. A mother-to-be suffers a scare.
Tamzin refuses to treat a drunk and abusive patient and there are serious repercussions. Tom, Sam and Dylan need to find a way to work together to treat a family with a rare genetic disorder.
An intruder sees a teenager’s birthday coming to an abrupt end, sending a patient from Tess's past back to the ED. A woman ends up collapsing in shock after learning that she’s the heir to her estranged aunt’s fortune.
Dylan's suspicions about Amanda increase. Tom finds himself being confronted by an unwelcome face from his past, as Zoe and Fletch treat a mother with Down's Syndrome in distress.
Tom and new locum Dominic fall out over the correct course of treatment for a patient. Tamzin receives some news that could finish her career.
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All the nurses from Holby ED head out to the Christmas Eve party. Fletch dreads all the stress that the big day brings, so he busies himself by trying to sort out everybody else's problems.
Tensions increase between Tom and Dominic as they argue over the treatment of a baby suffering with severe hypothermia. Dylan finally admits that he has not moved on from his break up with Sam.
Four new student nurses called Ally, Aoife, Jamie and Robyn face a difficult first day in the ED, as they find it hard to cope with the devastating effects of a shocking coach crash.
Zoe is worried that Jordan might not be facing up to the severity of Yvonne's condition after she is rushed to the hospital. Tom and Sam have to work together to uncover the secrets between three students. Robyn finds out that Aoife's boyfriend is not as perfect as he looks.
Jordan fights to keep Yvonne’s life support machine turned on but after a young woman arrives in the ED he’s forced to think about his motives.
It is Yvonne's funeral and Jordan finds it hard to say to goodbye. A face from the past turns his world upside down after showing up.
Jordan's return to the hospital comes to a dramatic climax after he is called upon to save the life of the individual to blame for his girlfriend's death.
A familiar face shows up at the hospital after Charlie's former nursing deputy Ash who is now qualified as a doctor rejoins the team. He is forced to hit the ground running though as he treats a patient with suspected rabies. Aoife is forced to take control of her private life after ex-boyfriend Craig shows up.
The team are plagued by the continuing flu outbreak, and with Zoe off sick, Ash and the rest of team are pushed to the brink as they find it hard to deal with the crisis. A man's efforts to track down his ex-wife result in a car crash, but once in the ED he reveals how she might be able to save their son, the boy she abandoned as a baby 10 years ago.
Zoe returns to work from sick leave and finds herself walking straight into a confrontation with Ash. Jeff needs to persuade a man to act in his son's best interest. Fletch is determined to help an elderly gentleman.
Big Mac believes that he could have finally found the woman of his dreams, and after she mistakes him for a doctor he doesn't set the record straight. Ash clashes with Zoe when he carries out a risky procedure without her knowledge.
Ash and Zoe find it hard to get a teenage boy to accept the seriousness of his father's condition. Linda attempts to help a pregnant woman deal with her no-good boyfriend.
Jeff finds himself in the middle a marital dispute. Robyn breaks a patient confidentiality. Linda attempts to give a woman with a learning disabled son a little bit of respite.
A day out at the fair ends up not being much fun after Robyn skives off work to spend the day with old school friend Fran, who seems to spend most of her time putting Robyn down. Following an accident on the ghost train Robyn ends up having more to worry about than playing truant from work as she attempts to save her friend's life. Tom finds himself in trouble with both Sam and Zoe.
Tom attempts to try and help a young man who he suspects may be the victim of a sexual assault.
Jamie is concerned that the stepfather of a young boy knows more that he is letting on about the boy's head injury.
Zoe and Ash are forced to work together to reunite two schoolgirls who are hurt during a science exam. Tom attempts to help a frightened mother and son.
Zoe attempts to help and protect a young girl suffering with a delicate problem. Fletch tries to help a man whose lifestyle is damaging his health.
Jeff is worried after his father and sister are involved in a car accident. Jamie finally manages to stand up to his overbearing father. Linda attempts to help a woman suffering with post-natal depression.
Some hoodies break into an off-licence, but it ends up being more than just a random attack. A confused and disoriented man brings his dog into the ED, which forces the team to work together in an effort to uncover the truth behind his condition.
Ash's daughter is admitted to the ED after she is hit by a drunken police motorist. Tom's finds his judgement being called into question after he discharges a baby, only for the child to almost die.
Tom attempts to help a group of relatives who are in denial about their problems. Linda takes sides after she believes that a patient is being harassed by a gang of youths.
Tom wants to prove that a previous misdiagnosis is not affecting his current confidence. Tess attempts to help a young woman face her future.
After Tess sees a stabbing taking place, she becomes personally involved with the victim and the attacker. Charlie attempts to help a couple whose relationship is feeling the strain of the wife's long-term illness.
Lloyd becomes determined to learn the truth about a cannabis factory as he starts his final day as a nurse. Tess and Fletch attempt to counsel a young couple.
Tom has to deal with a dilemma involving truth and confidentiality regarding the paternity of a baby. Sam attempts to help a man deal with his anger and offers him a chance to save his marriage as well.
Fletch goes with Dixie and Jeff as they are called out to help a diabetic woman in the city's highest tower block. After the nurse is involved in a run-in with a group of unruly teenagers threatening a man in one of the lower flats, he ends up having to perform an emergency operation.
Songs: Ellie Goulding -- Anything Could Happen, Magnetic Man feat P Money -- Athemic, Two Fingers -- Fools Rhythm, Professor Green feat Ed Drewett -- I Need You Tonight, Magnetic Man -- Karma Crazy, Netsky -- Love Has Gone, Noisa -- Red Heat, Noisia feat Foreign -- Shellshock 32, Two Fingers -- Stripe Rhythm, Rihanna -- We Found Love
Tom and Sam end up clashing over the best course of action for a mother who is not able to cope any longer. Ash receives another visit from his daughter Ella.