A couple who have been having an affair are attacked by masked robbers, and in their effort to escape crash their car. Dixie attempts to help an elderly woman who is in a lot of pain after being knocked over by a cyclist.
Songs: One Direction -- ONE WAY OR ANOTHER
ED nurse Rita Freeman joins the team and is forced to help a patient even before she has started work after a neighbour whose hoarding has got out of control is hurt. Jamie bonds with an asylum seeker too worried to tell the authorities that he is gay.
Songs: Taylor Swift -- I KNEW YOU WERE TROUBLE
After Zoe returns she discovers the ED in chaos, with a crane blocking the entrance. Fletch is locked outside her office with Jamie inside barricaded with asylum seeker Ramin.
Ash and Jeff attempt to save a teenager who has got into trouble in the sea. Fletch and Rita attempt to help a boy who is claiming to be the reincarnation of an elderly woman's brother.
Lily is given an emotional case to deal with involving a teenage cancer patient in order to learn some empathy. Charlie looks at an act of heroism as a bus crash unravels a web of lies.
Iain attempts to help a teenager caught up in the middle of a fatal car crash deal with the truth. Fletch decides to take the blame for Tess's mistake.
Tess needs to deal with her own problems after a pregnant woman is involved in a road accident. Robyn and Jamie see the effects of a batch of bad pills has on the nightlife in the local area.
Rita spends a day working with the paramedics but ends up allowing her personal feelings cloud her judgement after they are called out to the scene of a suspected drug overdose.
Iain ends up being deeply affected by a couple of police officers who manage to stir up memories of his life in the Army. Charlie attempts to help a couple keep hold of their little girl.
The mother of George shows up at the hospital, only to learn that her son has been released into the care of Tommy, a man in his 30s posing as the brother of the patient's homeless friend Skelly.
Fletch attempts to rescue a child from danger after a couple of brothers are involved in an accident. Sam realises the truth about her own relationship after she manages to re-start the heart of a patient.
A young couple find themselves being forced to take refuge at a farm for the birth of their baby. After a man is electrocuted by a Christmas tree, Sam and Tom's wedding plans are disrupted. Fletch is arrested.
Lily and Ethan diagnose Alice with a rare disease. Zoe and Tess attempt to save the life of Dixie's girlfriend.
Songs: Jamie Cullum -- ALL AT SEA
A new locum doctor called Cal shows up for work and his skills are soon tested after a girl with kidney trouble is trapped in a crashed car hanging precariously off a bridge. Ethan discovers the truth about an art student whose sight has been endangered by some flying glass.
A mountain-bike race between a man and his stepson does not go to plan after both riders lose control. Jamie decides to follow Ramin to Australia, but Robyn and Jeff attempt to change his mind.
Iain goes against orders after he runs into a burning building to save a man who is inside looking for his new fiancee. Lily becomes a magician's assistant after pensioner Yvonne is hurt.
An intruder breaks into Robyn's home leading her to impale her foot as Ash decides to teach Lily a lesson.
Former director of surgery Connie Beauchamp returns to the hospital and manages to make a good impression on her first day as she saves a man from prison. Ash decides to finally take his daughter Ella in hand.
Jeff, Rita and Lily attempt to help a really obese man get the help that he requires. Dixie finds herself bonding with an angry motorcyclist.
Cal tries to help a man out who is convinced he has a brain tumour. Whilst Fletch builds bridges with a father and son who are estranged through drug use.
Dixie informs an injured motorbike rider that his mother is in a hospice and that if he doesn't go see her soon, it could be too late. Zoe attempts to find out more about Ginny, a woman who collapsed at her birthday party. Fletch really needs to gt his hands on some money forcing him to ask for extra shifts at work.
An adult reading lesson does not go to plan after a woman becomes jealous of her tutor's girlfriend and causes her to end up in hospital after she suffers with an asthma attack. An elderly woman and her couple of grandchildren make plans to have the best day ever but things don't go to plan.
Ash works out the truth about his daughter after a patient’s experience with drugs goes bad. Fletch fights to repair a broken family on a couple’s wedding day.
Songs: Ellie Goulding -- ANYTHING COULD HAPPEN, Calvin Harris -- UNDER CONTROL
Tess is in a awkward position when a pregnant teenager has issues with her father. Cal has to help out a family in which two siblings are feuding after a horrible accident at a Italian restaurant.
Ben collapses on a run and is brought into the ED, he's left in Connie's care and she soon realises the pressure he's under at home with a father who can't handle his sons sexuality. Cal tries to help a patient out who keeps getting stressed.
A fire breaks out in an elderly care home, leaving Rita in a difficult situation regarding one of the patients, Peter and the care he's getting. Lily helps a man realise the cause of his toothache.
Connie looks after a man who is suffering from dementia. However with the department under strain, she isn't sure if she can get him the care he needs.
Songs: DJ Fresh -- DIBBY DIBBY SOUND, Rudimental -- FEEL THE LOVE, Alton Ellis -- I'M STILL IN LOVE WITH YOU, Route 94 -- MY LOVE, David Guetta -- SHOT ME DOWN
Zoe, Big Mac and Jeff lead the rescue operation, when Jess' surprise helicopter birthday trip goes wrong. Zoe has to try and protect the departments reputation when the press turn up.
Songs: Tom Odell -- Grow Old with Me, UNKLE -- Restless
A train derails in Holby leading to many casualties as Tess finds herself trapped in the wreckage.
Connie attempts to help a sick man tell his wife the truth, and a leukaemia survivor realises that she isn’t ready to start a family yet.
Rita receives a blast from the past which jeopardises her future plans. Lofty and Cal reunite a family using some creative thinking.