U.S. Marshal Annie Frost and her partner Jimmy Godfrey are put on a case involving a serial killer that robs safes and kills the families who own them. He thwarts the Marshalls time and time again until one person makes him slip up. A new recruit, Luke, joins the team and together they hunt down to capture one of the Most Wanted criminals.
A mother (Jennifer Morrison) goes on the run with her young daughter after a grisly murder. The team must reassess their strategy for capturing her, however, when doubts arise about the woman's mental state.
On the hunt for fugitive Carson Puckett who is using explosives to get revenge, Anniegets injured and is forced to rely on bounty hunter Ben Crowley. In Annie's absence, under Jimmy's leadership, the team must use Daisy's tactical expertise to stop Puckett, and Luke is forced to step up to the plate.
When a U.S. Marshal impersonator, Bob McGraw, starts killing people in a misguided attempt to capture fugitives, he becomes one himself. The case becomes personal when McGraw turns the tables on U.S. Marshal Annie Frost. Meanwhile, Luke gets a surprise visitor who threatens his relationship with the U.S. Marshal team.
A serial killer escapes prison and U.S. Marshal Annie Frost must rely on jailed fugitive Mason Boyle for answers. The case takes a twist when the U.S. Marshal team discovers that the fugitive's ultimate victim is not who she appears to be.
U.S. Marshals Annie Frost and Daisy Ogbaa team up to catch small-town fugitives Karen Nelson and Ivy Collins, a duo who use their feminine wiles to lure innocent victims into participating in bank heists. Annie and Daisy become closer while working to break the fugitives' twisted , co-dependent bond before they continue down a self-destructive road.
U.S. Marshals Annie Frost and Luke Watson pursue fugitive Chris Novack, who takes the city of Houston hostage after escaping from the county courthouse, in violent pursuit of his best friend and girlfriend who have betrayed him. Meanwhile, the day's events allow Luke to understand his place in the force and Jimmy Godfrey looks at girlfriend, Natalie, in a new light.
When Pablo Cordova is arrested on suspicion of drug distribution and the lead witness in the case winds up dead, the U.S. Marshals discover the killer is his wife, Isabella. Isabella will stop at nothing to keep Pablo from going to jail and ensure that her family stays together, which ultimately puts Annie in serious danger. In a case that hits close to home, Marco is forced to recall his dark days with the narcotics division, while Jimmy must decide the fate of his relationship with Natalie.
The U.S. Marshal team enlists the help of bounty hunter Ben Crowley to apprehend a dangerous criminal who has evaded arrest due to the protection of his loyal friends and family. Meanwhile, Annie experiences sleepless nights filled with strange dreams that include Ben, Jimmy and a dark premonition from her father.