"Chelsea Lately" is an irreverent look at hot topics covering news to celebrity gossip. Chelsea Lately opens cold and Handler performs a short stand-up monologue, focused on pop coluture or current events and may include a video clip or other visual aid. Over the opening credits, the announcer presents the topics of discussion and the show's guest. After the open, a 3-guest panel is introduced, usually a combination of comedians, actors or staff members, and her assistant Chuy. Afterwards, for roughly 6-minutes a guest is interviewed.