While on a surveying expedition, Cheyenne and pal Smitty run afoul of a band of robbers but then must fight alongside them when the stagecoach the gang planned to rob gets attacked by marauding Shoshones.
Cheyenne and Smitty tangle with a band of desperadoes after they're hired to guide a lost wagon train.
Cheyenne throws in with two gold prospectors and the trio hits paydirt. Then greed sets in and one of them plans to deal Cheyenne and the other out and take all the gold for himself.
At a town along the Mexican border, Cheyenne allies himself with a priest to prevent a vicious gang from taking over the town.
Cheyenne gets caught up in a blackmail scheme due to his previous friendship with a woman.
Temporary deputy marshal Cheyenne has his troubles keeping a prisoner charge with murder alive. It seems as though the townspeople want to lynch the man.
A cowardly Army major decides to avoid a Native American war party by traveling through the burning desert.
Cheyenne tries to unite small ranchers against a hot shot named Storm. A mother and her stepdaughter both want Cheyenne's attention.
Cheyenne discovers that the man who saved his life is a killer.
Cheyenne tries to rescue two girls being held captive by Native Americans.
While working as a guide, Cheyenne faces showdowns with both a Comanche chief and an outlaw known as the Utah Kid.
In Mexico, Cheyenne gets caught up in the attempts of a group of Mexican nationals to repel invading French troops.
Cheyenne tries to prevent a small-town sheriff from being conned by a conniving female.
Cheyenne's Mexican friend and a ranchers daughter fall in love. Her father objects strenuously to this turn of events.
In order to avoid a trumped up murder charge, Cheyenne joins a wagon train bound for California.
Cheyenne's dealings with con woman Samantha Crawford get him involved in a murder.
After signing on as a cowhand, Cheyenne tires to prevent one of his co-workers from harassing a woman who resides nearby.
A woman and poker bring major troubles for Cheyenne and pal Hoot Hollister when they take a riverboat trip to St. Louis.
Cheyenne helps a marshal capture a wanted man unaware that the lawman prefers not to bring his prisoners back alive.
Cheyenne tries to help ranchers capture a group of cattle rustlers.
A herd of wild mustangs is up for grabs to whoever can capture them but hostile Native Americans control the range where they roam.
When a cattle owner dies, Cheyenne is left in charge to guide the herd into Dodge City and must deal with the resentment of the other cowboys.
Arriving in the town of Stage City, Cheyenne is taken prisoner and forced to work at slave labor in a nearby mine.
A gang of youths robs a train on which Cheyenne is a passenger.
When he's mistaken for a killer, Cheyenne is forced to join an outlaw band to bring the right man to justice.
Cheyenne clashes with an Army captain while tracking cattle rustlers.
Cheyenne gets involved in a dispute between a gold prospector and a band of renegades. As if that wasn't bad enough, the Sioux decide to go on the warpath.
Cheyenne's efforts to help a crusading newspaperman clean up a corrupt town are complicated by two women.
Cheyenne plays detective to uncover what's behind the deaths of travelers in a mysterious basin and uncovers a terrifying secret.
When Cheyenne takes a job as a small-town sheriff he becomes involved with a girl from an unusual family. Her father was once a lawman and her brother is a killer.
Cheyenne tries to set a teenager on the straight and narrow path so he won't follow in his older brother's footsteps to the gallows.
Cheyenne arrives in the town of Gaslight to collect a debt owed him by the owner of a livery stable. The man gives him the deed to the stable as payment. Soon afterwards, our hero receives a visit from a man demanding a monthly fee for "protection" of his business.
Cheyenne tries to protect the land claim of an heir from a murderous land grabber.
Cheyenne's sense of duty wavers when the wanted man he captured saves him from the jaws of a bear trap.
A female newspaper reporter tries to wrangle an interview with Sioux chief Sitting Bull and ends up inciting a Native American uprising.
Cheyenne steps in when a school is besieged by outlaws seeking revenge against the schoolmaster.
Cheyenne poses as an actor to expose a ring of subversives.
Cheyenne gets involved with an attractive female sheep rancher.
During the French occupation of Mexico in the 1860's, Cheyenne meets and falls in love with a beautiful Hapsburg princess who's engaged to marry a French Army officef---whom she's never met.
Cheyenne guides a nasty bunch of fortune hunters on a search for buried diamonds.
Cheyenne tries to prove a friend not guilty of murder only to have an entire town turn against him as well.
A rancher mistakes Cheyenne for a hired gun who's out to kill him.
Cheyenne refuses job offers from a pair of feuding ranchers but one of them won't take no for an answer.
Cheyenne tries to save a renegade white man caught selling guns and liquor to the Comanches from a lynch mob.
Cheyenne takes over a saloon for a woman whose daughter is returning home after spending years at a finishing school back east.
Cheyenne has been captured by Comanches and while in captivity tries to think of a plan to avert further bloodshed between the tribe and the cavalry.
A man tries to aid the widow of a man he accidentally killed only to discover that her son is seeking vengeance.
Cheyenne, traveling west with a wagon train, becomes suspicious of the wagonmaster whom he suspects is deliberately leading the party into a Native American ambush so he can return later and loot their possessions.
Cheyenne is mistaken for a member of a holdup gang and the posse is closing in fast.
A disguised Cheyenne acts as a trail boss for a woman whose husband he was forced to kill in self-defense.
Cheyenne takes part in the search for a missing 10 year old boy and is aided by a Sioux youth.
It's Cheyenne to the rescue when an outlaw threatens to destroy a village in order to avenge the deaths of two of his compadres.
A crooked attorney hinders Cheyenne's hunt for a killer.
An innocent man finds himself in a tough position. If he doesn't hang for murder his wife will be killed.
A woman rushes to Cheyenne's aid when he gets wounded while tracking down a killer.
Cheyenne attempts to re-united a family that was bitterly divided by the Civil War.
Cheyenne poses as a dead bank robber in order to find the crook's missing loot.
Delivering printing equipment, Cheyenne gets mixed up in a murder plot.
Cheyenne uses an old stage trick to nab a killer.
After cattleman Sam Magruder is killed, another man assumes his identity and takes over his business. A suspicious Cheyenne gets a job as a cowboy on the Magruder ranch in order to look into things.
Replacing a popular foreman on a ranch, Cheyenne faces hostility both from the countryside and fellow ranch employees.
This two-part episode deals with Cheyenne's role in the infamous Battle of the Little Big Horn. In the opener, he discovers gold on Sioux land which could ignite a war.
Cheyenne, who'd earlier signed on as a scout for Custer, is court-martialed for desertion at Little Big Horn.
Trying to stop a lynch mob, Cheyenne is forced to shoot the son of a prominent citizen.
Cheyenne tries to help a white man raised by Apaches keep his marriage together.
Cheyenne is disgusted by the corruption he finds in the town of Cripple Creek and thus resigns his position as town marshal. But his successor may need his help in keeping the peace.
When a bridegroom disappears it leads to Cheyenne being jailed on a trumped-up murder charge.
Cheyenne intervenes when the enemies of a dead hero try to prevent his honorable burial.
Cheyenne returns to his hometown and re-opens an old feud with an old enemy.
Cheyenne goes after a band of robbers who stole a gold shipment he was guarding.
Delivering mining equipment, Cheyenne gets involved in feud between rival mine owners.
Cheyenne rescues an Apache woman who was to be killed for marrying a white man.
On a buffalo hunt, Cheyenne accuses a sheriff of cheating at cards. A war of nerves ensues.
At a pal's wedding, Cheyenne discover a plot to wipe out the entire family of the bride.
Gunrunner Pike Hanson must be a nasty one. He's got Cheyenne, Bronco Layne, and Tom "Sugarfoot" Brewster on his trail
A vengeful man gets together a lynching party for Cheyenne.
Cheyenne brings in a robber only to have a marshal release the man.
When outlaws takeover a town, only newcomer Cheyenne is willing to help the marshal.
Cheyenne, working as an Army scout, has a stubborn cavalry captain ignore his advice and lead his men into an almost certain massacre.
The stagecoach on which Cheyenne is escorting a prisoner to justice is attacked by marauding Native Americans.
Cheyenne gets an unlikely assist from famed outlaw Billy the Kid in foiling land-grabbers.
Cheyenne gets involved with a fiery cattlewoman and her struggles.
Cheyenne tangles with a corrupt deputy who's been selling chain gang labor.
Cheyenne searches for a runaway groom who decided to bolt on his wedding day.
When young Gilby Collins shoots another man in defense of his girlfriend, Cheyenne rides with the posse in pursuit of Gilby to make sure he gets justice.
In pursuit of a sheriff's murderer, Cheyenne's quest is interrrupted by a town's pleas for help against a gang of bandits.
Townspeople oppose Cheyenne as he tries to apprehend Robin Hood bandits who stole from an unpopular tycoon.
Cheyenne agrees to help a young lad find his missing parents but then the boy also pulls a vanishing act.
Cheyenne learns that his father might still be alive.
Cheyenne's efforts to aid a sick child are complicated by a Brahma bull.
In Mexico, Cheyenne runs afoul of a ruthless bandit who has become a virtual dictator of a province in Mexico.
Three brothers are determined to kill a notorious gunslinger but they mistake Cheyenne for him.
Cheyenne captures notorious outlaw Cole Younger but it's a long way to the nearest jail and there are numerous complications afoot.
Is a pretty young lass the author of anonymous death threat letters? Cheyenne tries to find out.
Dakota Territorial Marshal Frank Ragan tangles with a cattle baron when he rides into a town searching for an old friend.
The old maid sister of a group of bullying brothers falls for Cheyenne.
Cheyenne's in pursuit of a killer and Native Americans inform him that his quarry is a monster called Satonka.
Cheyenne becomes suspicious of a town hero because he thinks his heroics were staged.
Cheyenne tries to help an injured amnesiac discover his true identity and piece together details of his life.
Cheyenne tries to help a disgraced lawman restore his reputation.
Once again, Cheyenne is caught in the middle when the discovery of gold on Sioux lands threatens to ignite a war.
A blind singer is coerced by a crooked gambler to back up a murder accusation against Cheyenne.
Knowing it will cause a Native American uprising, Cheyenne tries to prevent a railroad from running its line through sacred burial grounds.
When he's appointed to fill an empty seat in the state senate, conservationist Cheyenne begins a campaign to save the American bison.
Appointed temporary sheriff in yet another town, Cheyenne tries to quell his friend's taste for vengeance.
A Native American scout is accused of treason when the Army unit he's guiding rides into an ambush. Cheyenne tries to prove otherwise.
Cheyenne somehow winds up being charged with his own murder.
In the series finale, Cheyenne take on yet another ruthless cattle baron.