Kevin Smith's wife is mentioned during the letter opening sequence. Her name is Jen Schwalbach and is the fan asking about why no women appear on the show.
Patrick Swayze agent's decided that it wouldn't be appropriate for Mr. Swayze to voice himself as a character that works in a pet shop. They felt it might say that his career has taken a step down.
The entire title of this episode is: Leonardo Is Caught In The Grip Of An Outbreak Of Randal's Imagination And Patrick Swayze Either Does Or Doesn't Work In The New Pet Store.
Reporter: Could the virus kill the Grimace?
Police Chief: NOTHING can kill the Grimace.
Dante: There never was a Motaba virus. It was just a hoax played by an idiot with too much time on his hands.
Bomber Pilot Quentin Tarantino?
Dante: Yes, I'm gay.
Despite the fact the Desomnd's burger joint is based off the show, and that the show focused on the Civil War in the North, the guy at the drive-thru is wearing a South uniform.
When Dante answers the phone, there's a shelf behind his head. In the next shot it's gone, and then it reappears again in the next shot.
The first time Randal waters the Chia-Pet, he takes the watering can in with him. The second time he waters it, the can is back behind the box, and he takes it back in with him again.