When one of Clint's patients wakes up, he is upset to learn that his daughter doesn't know if she should hug him. Meanwhile, one of Dr. Crane's old girlfriends wants to work at the clinic in order to get some grants approved.
Marcia, with the help of Clint and Westbury, tries to teach African doctors how to properly operate on African children over the Internet. Meanwhile, Dr. Crane is starring in a play while Tippy is the understudy for the leading lady. But when the leading lady gets sick, and Tippy must fill in, things start to get a little complicated.
When Nate and Major Doss start a family history business, everyone gets to learn a little something about where they came from.
When Nancy feels like her life is stuck in a rut, she rides with Clint on a trip with the New York Emergency Medical Services Team.
Things are changing for everyone in this series finale episode. Nancy is moving to a third-world country to help out with the crises there, but Clint struggles with the decision to ask Nancy to marry him or move back to Montana to help out his friends with a new clinic. Raul gets heart-breaking news that he has diabetes, and Tippy is overjoyed to find out that she is pregnant and promises to name the baby Clint if it's a boy, and Nancy if it's a girl.