Drake and Josh must adjust to their new lives as brothers when their parents get married and move in together. Also, once Drake finds out that Josh is Miss. Nancy, an advice columnist for the school paper, he uses this to his advantage.
When Drake breaks the rules and goes out for a ride in the new dune buggy, he severely injures himself and winds up in the hospital. To avoid getting in trouble, he keeps this accident a secret and tries to play off his injuries.
Drake's new girlfriend, Susan, creates some tension between him and Josh when she fabricates lies about Josh coming on to her.
Drake and Josh learn that baby-sitting is a lot harder than it looks while caring for the child of Walter's boss. Things get even worse for Josh when Drake ditches him for a band gig.
Josh, trying to impress his crush, Kathy, lies and says he plays the guitar. When she asks him to play at her upcoming birthday party, Josh goes to Drake for help.
Josh's grandmother and Drake butt heads when she stays over to watch the boys after Audrey and Walt leave town.
Drake and Josh bet each other to see who can last the longest without their obessions, junk food and video games, respectively. The bet escalates when Megan, Walt, and Audrey get in on the action as well.
When Josh accidentally destroys Drake's new guitar, he frantically tries to replace it before Drake finds out.
When Drake and Josh get jobs at a local movie theater, Josh is working hard, while Drake is hardly working. Yet somehow, to Josh's disgust, Drake is made his superior.
Drake, trying to make his brother cooler, advises Josh to go out for the school football team.
When Drake finds out what a great pool player his brother is, he takes advantage of Josh's billiard skills and starts hustling people out of their money.
Drake, infatuated with an intelligent girl, accidentally offers to join her in an academic tournament.
When famous child star Ashley Blake is in town for her movie premiere, Helen gives Drake and Josh the task of looking after her. Things, of course, go terribly wrong when she gets hit on the head and is given a sleeping pill by the doctor that conveniently lives across the street.
When Drake's song is stolen by another band at the talent show, Josh must conquer his fear of performing in public and help his brother win the competition.
After Drake fails his driving test, he gets the newly-licensed Josh to chauffeur him around.
Drake has to deal with one of Megan's friends, a girl who seems far too obessed with him and his music. Meanwhile, Josh is the new leader of a camping club. However, the kids don't appreciate his teaching of wilderness skills.
Drake's teacher threatens him with summer school if he breaks up with her irritating daughter. To avoid losing out on his summer vacation, he tries to find a way to make her be the one to break up with him.
Drake and Josh get more than they bargained for when they go into the "Gary Grill" selling business.
When Josh finds a new friend, Drew, who seems to be exactly like Drake, Drake gets jealous and starts hanging out with a new friend Jerry, who is exactly like Josh.
When Drake is falsely accused of parking a teacher's car in the middle of her classroom, Josh sets out to prove his brother's innocence. Unfortunately, Josh's rival, Mindy, represents Drake's rival, Mrs. Hafer, in the case.
When their parents leave them home alone, Drake and Josh turn their home into a hotel of sorts.
In an attempt to win a plasma-screen TV, Drake and Josh enter a salsa-making contest. Things get intense when Megan goes up against them and enters the contest as well.
Josh's Yudonian e-pal, Yooka, decides to pay him a visit. However, he is plagued by jealousy when Yooka seems more interested in Drake. Conversely, Drake and Josh misinterpret a conversation Yooka has with her parents and think she's homesick. So, in an attempt to make her feel more welcome, Josh arranges what he thinks is a friendship ceremony for her. Little does he know that it is really a marriage ceremony.
With Mindy out of the picture, Josh finally believes he stands a chance at this year's science fair. Josh is stunned by her surprise return and of course her better science project. He's even more surprised, however, when he realizes that he has feelings for Mindy and that she has feelings for him.
After Drake and Josh notice that Walt has been spending a lot of time with another woman, they assume he is having an affair and try to catch him in the act.
When Tori, who has been going out with Drake for a while, refers to him as her boyfriend, Drake panics and breaks up with her. Meanwhile, Josh has grown a mustache, much to the dismay of... everybody.
When Helen undergoes eye surgery, she asks that Drake and Josh help her around for a while. They of course end up taking advantage of this, once they see the inside of her home.
After Josh is injured and hospitalized, Drake is mistaken for an actual doctor at the hospital.
Drake and Josh realize that they have met once before, when they got in a fight at a San Diego Padres game as children. They then argue about who was to blame for the fight.
Josh, in an attempt to impress Mindy's parents, invites them over for dinner. Meanwhile, Drake and his girlfriend battle to prove which one of them is stronger.
When Megan purchases a pregnant sheep over the internet, Drake and Josh strike a deal with her: they won't tell their parents if she promises not to play pranks on them for another three months.
When Josh gets a student teaching job in Megan’s classroom, he goes a little overboard and the entire class turns against him. In addition, Drake finds a whole new drummer for his band who is also in Josh's class. In order for him to be able to play in the show next week, he will have to skip school-Which Josh isn't happy about. So, Megan and Drake team up to humiliate, drench and burn Josh to get him fired, and when it works, he's extremely upset-And Megan feels sorry so she allows him to join her and her friends at a party to make up for it.
When Drake is assigned to mentor a young boy, Sammy, he is shocked to find out he prefers Josh over him.
When Josh gets a job playing a criminal for a television reenactment, it gets him some unwanted attention.
Waiting in line for a turn on the new roller coaster at Mystic Mountain, proves far more thrilling for Drake, Megan and Josh than the ride itself.
The boys concoct an alien-invasion hoax to get back at Megan for pulling one too many pranks on them, but they soon realize how out of hand their little prank has gotten.
In this season finale, a bickering Drake and Josh appear on a talk show, The Dr. Phyllis Show, and reminisce about past events.
When Drake and Josh accidentally put their sister, Megan, on a plane to Los Angeles instead of Colorado, they grab the next flight out to Hollywood to find her. However, they soon find out their lives are in danger, when they manage to get themselves involved with criminals.
Spin City Records wants to use Drakes song for a commercial. Josh signed the contract for Spin City Records without reading it because of really big shrimp and that gets Drake really mad because Spin City Records messed Drakes song up.
Drake and Josh make Christmas promises they can't keep to kids.
Drake surprises Josh with a birthday present of tickets to "The Ophrah Winfrey Show".
Josh offers to watch Mrs.Hafers house while she goes on vacation for the weekend but when they get there they see her dog Tiberius things get bad
Josh doesn't know what to think when Mindy declares her love for him.
Drake and Josh are on their way to their Aunt Catherine's wedding with the cake for the reception when their car breaks down in the middle of nowhere.
Drake claims that Josh can't get girls. So they make a bet to see who can get the most dates in one week.
Drake and Josh meets "The Great Doheny" and finds that his career is in a slump. They find themselves in a tough situation trying to help him get his career back.
Drake and Josh enter a contest, but with unexpected results, get robbed. They then pay back their debts buy working at a sushi factory, but their stuff gets found later.
Drake's band is going to play, and Josh invites all of their friends to go on the bus. Walter declares that it will be very sunny outside, but all of a sudden it starts thundering. Walter's boss makes Walter do a weather report in the pouring, thurndering rain. Meanwhile, Drake needs to get his ex-girlfriends away from his current girlfriends. Everyone is stuck in the house because the concert was cancled because of the rain. They watch the weather report from a TV that Craig and Eric crank with a crank. Everyone is bored so Helen (Josh's Boss) comes up with an idea. Will everyone survive in the house? What is Helen's idea? Find out in this episode.
Drake and Josh want to purchase a car, but Drake takes the money that they planned on spending for the car, and buys a monkey. They then find out that the guy they sold it to, eats monkies, so they attempt at rescuing it back.
Drake and Josh launch a rocket at a neighbor's tree. The treehouse get's destroyed, so Drake, Josh, and Megan spend their weekend trying to rebuild the it. After they are done completing the treehouse project, the treehouse falls done again, and they get stuck their for the rest of the night.
Josh has had enough of Drake getting him into trouble, and decides that he is done with Drake.
Drake is punched by nerdy Eric, who ends up gaining popularity after the accidental hit. Meanwhile, Josh suspects Mindy may have a new boyfriend.
When Drake and Josh accidentally kill Megan's rare hamster, they become hysterical thinking that she's plotting revenge.
As punishment for using fake IDs, the boys must enter a "Steered Straight" program, but things take a turn for the worse when they become friends with a real criminal.
When Megan starts acting suspicious, Drake and Josh start investigating. When they follow Megain to schol, they over hear her talking to her friend about meeting someone at the movies and how he's going to bring the "stuff." Instead of going to this party they were going to attend, they follow Megan to the movie theater and find out she has a boyfriend.
Drake and Josh get invited to their friend's sweet 16 that is going to be aired on TV, but when Drake kisses their friend's girlfriend, their friend un-invites them.
Drake gets a free ride on a helicopter with a free skydiving lesson and he takes Josh with him, but their pilot becomes unconscious and they don't know how to fly it themselves.
The brothers enter a local dance contest, but Josh ends up solo when Drake steals his dance partner.