| Person: |
|
Characters |
Episodes |
| • Troy Evans | played | Officer Martin / Frank Martin / Frank | 128 Episodes |
| • Ellen Crawford | played | Nurse Lydia Wright / Lydia | 113 Episodes |
| • Conni Marie Brazelton | played | Nurse Connie Oligario / Conni | 110 Episodes |
| • Brian Lester | played | EMT Dumar / Dumar | 89 Episodes |
| • Laura Cerón | played | Nurse Chuny Marquez / Chuny | 78 Episodes |
| • Yvette Freeman | played | Haleh / Nurse Haleh Adams / Haleh Adams | 77 Episodes |
| • John Aylward | played | Dr. Donald Anspaugh | 73 Episodes |
| • Kristin Minter | played | Randi Fronczak | 69 Episodes |
| • Abraham Benrubi | played | Jerry | 69 Episodes |
| • Dinah Lenney | played | Nurse Shirley / OR Nurse Shirley / Shirley | 66 Episodes |
| • Leland Orser | played | Dr. Lucien Dubenko / Dr. Dubenko | 61 Episodes |
| • Deezer D. | played | Malik / Nurse Malik McGrath | 56 Episodes |
| • Gedde Watanabe | played | Nurse Yosh Takata | 54 Episodes |
| • Demetrius Navarro | played | Morales / EMT Morales | 52 Episodes |
| • Michelle Bonilla | played | EMT Harms / EMT Harms (as Michelle C. Bonilla) / Harms | 44 Episodes |
| • Lynn A. Henderson | played | Olbes / Pamela Olbes / EMT Olbes | 43 Episodes |
| • Emily Wagner | played | Pickman / Doris Pickman | 43 Episodes |
| • Lily Mariye | played | Nurse Lily Jarvik / Lily | 36 Episodes |
| • Monté Russell | played | Zadro / Dwight Zadro | 34 Episodes |
| • William H. Macy | played | Dr. David Morgenstern | 34 Episodes |
| • Jorja Fox | played | Dr. Maggie Doyle (as Jorjan Fox) | 33 Episodes |
| • Louie Liberti | played | Paramedic Bardelli | 33 Episodes |
| • Angel Laketa Moore | played | Nurse Dawn Archer / Dawn | 33 Episodes |
| • Khandi Alexander | played | Jackie Robbins / Jackie | 31 Episodes |
| • Vanessa Marquez | played | Nurse Wendy Goldman / Wendy | 31 Episodes |
| • Lisa Nicole Carson | played | Carla Reese / Carla Simmons | 29 Episodes |
| • CCH Pounder | played | Dr. Angela Hicks | 27 Episodes |
| • Amy Aquino | played | Dr. Janet Coburn | 26 Episodes |
| • Bellina Logan | played | Nurse Kit | 25 Episodes |
| • Gil McKinney | played | Dr. Paul Grady | 25 Episodes |
| • Kathleen Wilhoite | played | Chloe Lewis | 24 Episodes |
| • J. P. Manoux | played | Mime / Dr. Crenshaw / Dr. Dustin Crenshaw | 24 Episodes |
| • Matthew Watkins | played | Reese Benton | 24 Episodes |
| • Dominic Janes | played | Alex Taggart | 24 Episodes |
| • Chloe Greenfield | played | Sarah / Sarah Riley | 24 Episodes |
| • Yvonne Zima | played | Rachel Greene | 23 Episodes |
| • Sam Anderson | played | Dr. Jack Kayson | 22 Episodes |
| • Oliver Davis (1) | played | Alex Taggart | 22 Episodes |
| • Christine Harnos | played | Jennifer Greene / Jennifer Simon / Jenn Greene | 22 Episodes |
| • Kyle Richards | played | Nurse Dori | 21 Episodes |
| • Erica Gimpel (1) | played | Adele Newman / Adele Neuman DCFS | 20 Episodes |
| • Christine Elise | played | Dr. Harper Tracy | 20 Episodes |
| • David Brisbin | played | Dr. Alexander Babcock | 19 Episodes |
| • Michael Beach | played | Al Boulet | 19 Episodes |
| • Perry Anzilotti | played | Ed / Anesthesiologist / Perry, Anesthesiologist / Perry | 18 Episodes |
| • Frances Sternhagen (1) | played | Millicent Carter | 18 Episodes |
| • Ron Eldard | played | Ray 'Shep' Shepard | 17 Episodes |
| • Glenn Plummer | played | Timmy Rawlins / Timmy | 17 Episodes |
| • Pamela Sinha | played | Amira | 16 Episodes |
| • Samuel L. Jones (1) | played | Charlie 'Chaz' Pratt Jr. / Chaz Pratt | 16 Episodes |
| • Suzanne Carney | played | Scrub Nurse #1 / OR Nurse / Nurse Janet / OR Nurse Janet / Scrub Nurse | 16 Episodes |
| • Hallee Hirsh | played | Rachel Greene | 16 Episodes |
| • Nadia Shazana | played | Jacy | 16 Episodes |
| • Matthew Glave | played | Dale Edson / Dr. Dale Edson | 15 Episodes |
| • Laura Innes | played | Dr. Kerry Weaver | 15 Episodes |
| • Rick Rossovich | played | Dr. John 'Tag' Taglieri / Dr. John Taglieri | 15 Episodes |
| • Sara Gilbert | played | Jane Figler | 15 Episodes |
| • J. P. Hubbell (1) | played | EMT Lars Audia | 14 Episodes |
| • Cress Williams | played | Officer Reggie Moore | 14 Episodes |
| • Andrea Parker | played | Linda Farrell | 14 Episodes |
| • John Cullum | played | David Greene | 14 Episodes |
| • Chad McKnight | played | Officer Wilson | 14 Episodes |
| • Busy Philipps | played | Hope Bobeck / Dr. Hope Bobeck / Dr. Hope Bobek | 13 Episodes |
| • Mariska Hargitay | played | Cynthia Hooper | 13 Episodes |
| • Elizabeth Mitchell (1) | played | Dr. Kim Legaspi | 13 Episodes |
| • Sally Field (1) | played | Maggie Wyczenski | 12 Episodes |
| • Michael B. Silver | played | Dr. Paul Myers (as Michael Buchman Silver) / Dr. Paul Myers / Dr. Myers | 12 Episodes |
| • Scott Jaeck | played | Dr. Steven Flint / Dr. Steve Flint | 12 Episodes |
| • Gina Ravera | played | Betina DeJesus / Bettina DeJesus / Dr. Bettina DeJesus | 12 Episodes |
| • Charles Noland | played | E. Ray Bozeman / E-Ray | 12 Episodes |
| • Lucy Rodriguez | played | Nurse Bjerke | 12 Episodes |
| • Lisa Vidal | played | CFD Lt. Sandy Lopez / Sandy Lopez | 12 Episodes |
| • Malaya Riviera Drew | played | Katey Evans / Katey Alvaro | 12 Episodes |
| • John Leguizamo | played | Dr. Victor Clemente | 12 Episodes |
| • Thandie Newton | played | Makemba 'Kem' Likasu | 12 Episodes |
| • Emily Rose | played | Dr. Tracy Martin | 12 Episodes |
| • Beah Richards | played | Mae Benton / Mrs. Benton | 11 Episodes |
| • Mike Genovese (1) | played | Officer Al Grabarsky / Off. Al Grabarsky | 11 Episodes |
| • Shiri Appleby | played | Ms. Murphy / Dr. Daria Wade | 11 Episodes |
| • Stanley Tucci | played | Dr. Morretti / Dr. Kevin Moretti | 11 Episodes |
| • Justina Machado | played | Unknown / officer Claudia Diaz | 11 Episodes |
| • Donal Logue | played | Chuck Martin | 11 Episodes |
| • Steven Christopher Parker | played | Gus (as Steven C. Parker) / Harold Zelinski / Harold Zellinsky / Harold Zelinksi / Harold Zelinsky | 11 Episodes |
| • Stuart McLean (1) | played | Radiology Tech / Mike Devore / X-Ray Tech / Tech | 10 Episodes |
| • Eion Bailey | played | Jake Scanlon | 10 Episodes |
| • Madchen Amick | played | Wendall Meade | 10 Episodes |
| • John Doman | played | Dr. Carl Deraad | 10 Episodes |
| • Lisa Zane | played | Diane Leeds | 10 Episodes |
| • Omar Epps | played | Dr. Dennis Gant | 10 Episodes |
| • Ving Rhames | played | Walt Robbins / Walt | 10 Episodes |
| • Sumalee Montano | played | Duvata Mahal | 10 Episodes |
| • Rick Marzan | played | Camacho | 10 Episodes |
| • Paul Moncrief | played | E.R. Tech / E.R. Terch | 10 Episodes |
| • Rossif Sutherland | played | Lester Kertzenstein / Dr. Lester Kertzenstein | 10 Episodes |
| • Penny Johnson Jerald | played | Nurse Practitioner Lynette Evans | 9 Episodes |
| • Mary Mara | played | Loretta Sweet | 9 Episodes |
| • Ron Rifkin | played | Dr. Carl Vucelich | 9 Episodes |
| • Courtney B. Vance | played | Russell Banfield | 9 Episodes |
| • Vondie Curtis-Hall | played | Henry Colton / Roger McGrath | 9 Episodes |
| • Glenne Headly | played | Dr. Abby Keaton | 9 Episodes |
| • Lee Sellars | played | EMT / Scott / Chopper EMT | 9 Episodes |
| • Malgoscha Gebel | played | Dr. Bogdanilivestsky 'Bob' Romansky / Bob | 9 Episodes |
| • Bresha Webb | played | Laverne St. John / Dr. Laverne St. John | 9 Episodes |
| • Reiko Aylesworth | played | Julia / Julia Dupree | 8 Episodes |
| • Sam Vlahos | played | Pablo | 8 Episodes |
| • Julie Bowen | played | Roxanne Please | 8 Episodes |
| • John Terry | played | Dr. David 'Div' Cvetic / Dr. Div Cvetic | 8 Episodes |
| • Tara Karsian | played | Social Worker Liz Dade / Liz Dade | 8 Episodes |
| • Michael Ironside | played | Dr. William 'Wild Willy' Swift / Dr. William Swift | 8 Episodes |
| • Ming-Na | played | Deb Chen (as Ming-Na Wen) / Deb Chen | 8 Episodes |
| • Scott Grimes | played | Dr. Archie Morris | 8 Episodes |
| • Liza Del Mundo | played | Severa | 8 Episodes |
| • Tom Everett Scott | played | Eric Wyczenski | 8 Episodes |
| • Tyra Ferrell | played | Dr. Sarah Langworthy | 8 Episodes |
| • Leslie Bibb | played | Erin Harkins | 8 Episodes |
| • Marcello Thedford | played | Leon | 8 Episodes |
| • Paula Malcomson | played | Meg | 8 Episodes |
| • Kim Strauss | played | Ari / Anesthesiologist | 7 Episodes |
| • Kristen Johnston | played | Eve Peyton / Nurse Manager Eve Peyton | 7 Episodes |
| • Zachary Browne | played | Jake Leeds | 7 Episodes |
| • Gloria Reuben | played | Jeanie Boulet | 7 Episodes |
| • Clancy Brown | played | Dr. Ellis West | 7 Episodes |
| • Ed Lauter | played | Fire Captain Dannaker / Fire Captain Dannaker - Haz Mat | 7 Episodes |
| • Scott Michael Campbell (1) | played | EMT Riley Brown / Reilly Brown | 7 Episodes |
| • Deborah May | played | Mary Cain | 7 Episodes |
| • Paul McCrane | played | Dr. Robert Romano | 7 Episodes |
| • Dahlia Salem | played | Dr. Jessica Albright | 7 Episodes |
| • Jonathan Scarfe | played | Chase Carter | 7 Episodes |
| • Megan Cole | played | Pathologist / Dr. Upton | 7 Episodes |
| • Rose Gregorio | played | Helen Hathaway | 7 Episodes |
| • Judy Parfitt | played | Isabelle Corday | 7 Episodes |
| • Jordan Calloway | played | K.J. | 7 Episodes |
| • China Jesusita Shavers | played | Olivia Evans | 7 Episodes |
| • April L. Hernandez | played | Nurse Inez / Nurse Inez (as April Lee Hernandez) | 7 Episodes |
| • Charlayne Woodard | played | Angela Gillian / Angela Gilliam | 7 Episodes |
| • Julie Delpy | played | Nicole | 7 Episodes |
| • Julian Morris | played | Dr. Andrew Wade | 7 Episodes |
| • Aidan Gonzales | played | Baby Joe Kovac | 7 Episodes |
| • Andrew Gonzales | played | Baby Joe Kovac | 7 Episodes |
| • Carlos Gomez | played | Paramedic Raul Melendez / Raul | 6 Episodes |
| • Kip Pardue | played | Ben Parker | 6 Episodes |
| • Eric Payne | played | Off. Billy Wilder (as Eric A. Payne) / Police Officer (as Eric A. Payne) / Cop / Officer Beechum (as Eric A. Payne) | 6 Episodes |
| • Michelle Hurd | played | Courtney Brown | 6 Episodes |
| • Djimon Hounsou | played | Mobalage Ikabo | 6 Episodes |
| • Harry J. Lennix | played | Dr. Greg Fischer | 6 Episodes |
| • Michael Gross (1) | played | John 'Jack' Carter Jr. | 6 Episodes |
| • Jami Gertz | played | Dr. Nina Pomerantz | 6 Episodes |
| • Pierre Epstein | played | Dr. Bradley | 6 Episodes |
| • Sharif Atkins | played | Dr. Michael Gallant | 6 Episodes |
| • Meg Thalken | played | McManus / Paramedic / Chopper EMT Dee McManus / Flight Nurse | 6 Episodes |
| • Glenn Howerton | played | Dr. Nick Cooper | 6 Episodes |
| • Victor Rasuk | played | Dr. Ryan Sanchez | 6 Episodes |
| • Michele Morgan (1) | played | Allison Beaumont | 6 Episodes |
| • Forest Whitaker | played | Curtis Ames | 6 Episodes |
| • Kirsten Dunst | played | Charlene 'Charlie' Chiemingo | 6 Episodes |
| • Linda Shing | played | ICU Nurse Corazon | 6 Episodes |
| • Mark Dakota Robinson | played | Steven / Steven Robbins / Steven Robbins (as Marc Dakota Robinson) | 6 Episodes |
| • Andres Delgado | played | Zeke | 6 Episodes |
| • Christopher Amitrano | played | Officer Hollis | 6 Episodes |
| • Marc Jablon | played | Dr. Larry Weston / Larry Weston | 6 Episodes |
| • Brendan Patrick Connor | played | Reidy / Paramedic | 6 Episodes |
| • Garret Dillahunt | played | Steve Curtis | 5 Episodes |
| • Christopher Michael | played | Security Officer / Security Guard | 5 Episodes |
| • Akosua Busia | played | Kobe Ikabo | 5 Episodes |
| • Kevin Michael Richardson (2) | played | Patrick | 5 Episodes |
| • John LaMotta | played | Ivan Gregor | 5 Episodes |
| • Julie Ann Emery | played | Paramedic Niki | 5 Episodes |
| • Richard Minchenberg | played | Dr. P.K. Simon, Vucelich's Assistant | 5 Episodes |
| • Valeri Ross | played | McGillis | 5 Episodes |
| • Michael Patrick McGill | played | Security #1 / Security Guard #2 / Owens / Detective Ed Bernstein | 5 Episodes |
| • Mary McDonnell (1) | played | Eleanor Carter | 5 Episodes |
| • Kari Matchett | played | Dr. Skye Wexler | 5 Episodes |
| • Red Buttons | played | Jules 'Ruby' Rubadoux / Mr. Rubadoux | 5 Episodes |
| • Maury Sterling | played | Dr. Nelson | 5 Episodes |
| • Mark Valley | played | Richard Lockhart | 5 Episodes |
| • Julia Ling | played | Mae Lee Park / Michelle | 5 Episodes |
| • Ted Rooney | played | Neonatologist Dr. Tabash | 5 Episodes |
| • Marg Helgenberger | played | Karen Hines | 5 Episodes |
| • Kat Dennings | played | Zoe Butler | 5 Episodes |
| • Trevor Morgan | played | Scott Anspaugh | 5 Episodes |
| • Christopher Richardson | played | Jesse | 5 Episodes |
| • Kamar de los Reyes | played | Paramedic / Hernandez | 5 Episodes |
| • Lourdes Benedicto | played | Rena Trujillo | 5 Episodes |
| • Alan Alda | played | Dr. Gabriel Lawrence | 5 Episodes |
| • Paul Blackthorne | played | Dr. Jeremy Lawson | 5 Episodes |
| • Keith David | played | Pastor Watkins | 5 Episodes |
| • Rebecca De Mornay | played | Elaine Nichols | 5 Episodes |
| • Mary McCormack | played | Debbie | 5 Episodes |
| • Jillian Bach | played | Penny Nicholson | 5 Episodes |
| • Larry Michelson | played | Sunburned Man / Frequent Flyer / Roger / Mr. Arrigo | 5 Episodes |
| • Bruno Campos | played | Dr. Eddie Dorset | 5 Episodes |
| • Hassan Johnson | played | Darnell | 5 Episodes |
| • Rolando Molina | played | Rolando | 5 Episodes |
| • Simone-Elise Girard (1) | played | Gillian | 5 Episodes |
| • Ariel Winter | played | Lucy Moore | 5 Episodes |
| • David Lyons | played | Dr. Simon Brenner | 5 Episodes |
| • Jake Lloyd | played | Jimmy Sweet | 4 Episodes |
| • Harrison Page | played | Stan | 4 Episodes |
| • Steven Culp | played | Dr. Charles Cameron, Rush Memorial / Dave | 4 Episodes |
| • Lawrence Monoson | played | Dean Rollins | 4 Episodes |
| • Diane Delano | played | Delores / Stella Willis | 4 Episodes |
| • George Cheung | played | Mr. Fong / Mr. Chen (as George Kee Cheung) / Mr. Chen / Mr. Chan | 4 Episodes |
| • Skip Stellrecht | played | Chaplain / Chaplain Miller | 4 Episodes |
| • Martha Plimpton | played | Meg Corwin | 4 Episodes |
| • David Spielberg | played | Dr. Neil Bernstein / Dr. Neil Bernstein, Chief of Pediatrics | 4 Episodes |
| • Paul Dooley | played | Henry Lewis | 4 Episodes |
| • Edward Asner | played | Dr. James McNulty | 4 Episodes |
| • Iqbal Theba | played | Dr. Zogoiby / Dr. Zagerby | 4 Episodes |
| • Burt Bulos | played | Lovejoy | 4 Episodes |
| • James Cromwell | played | Bishop Stewart | 4 Episodes |
| • Bob Minor | played | Officer Jenkins / Buck / Security Guard | 4 Episodes |
| • Daniel Dae Kim | played | Ken Sung | 4 Episodes |
| • Caitlin Dulany | played | Heather Morgan | 4 Episodes |
| • Valerie Mahaffey | played | Joi Abbott | 4 Episodes |
| • Christina Hendricks | played | Joyce | 4 Episodes |
| • Bruce Weitz | played | Alderman John Bright | 4 Episodes |
| • Mirron E. Willis | played | Cop / Detective Watkins | 4 Episodes |
| • Charlotte Rae | played | Herself / Mrs. Gaines | 4 Episodes |
| • Liz Vassey | played | Liz | 4 Episodes |
| • Hedy Burress | played | Joanie Moore | 4 Episodes |
| • Jesse Borrego | played | HIV-Positive Patient / Javier | 4 Episodes |
| • Julie Fulton | played | Swanson | 4 Episodes |
| • Pamela Gordon | played | Regina | 4 Episodes |
| • Channing Chase | played | Claire / Claire, Vucelich's Secretary | 4 Episodes |
| • Chad Lowe | played | George Henry / Med Student George Henry / Dr. George Henry | 4 Episodes |
| • Alan Dale (1) | played | Al Patterson | 4 Episodes |
| • Matthew Settle | played | Brian Westlake / Brian Westlake (voice) | 4 Episodes |
| • Shi Ne Nielson | played | Sheila - Medical Student | 4 Episodes |
| • Charles Esten | played | Dr. Grossman / Dr. Barry Grossman | 4 Episodes |
| • Christian Coleman | played | Mookie James / Mookie / Mookie 'Slice' James | 4 Episodes |
| • James Farentino | played | Ray Ross | 4 Episodes |
| • Joe Torry | played | Chris Law | 4 Episodes |
| • Dan Hedaya | played | Herb Spivak | 4 Episodes |
| • Dennis Boutsikaris | played | Dr. David Kotlowitz | 4 Episodes |
| • Victor Williams | played | Roger / Roger McGrath | 4 Episodes |
| • Jeff Cahill | played | Tony Fig / Transport Dispatcher Tony Fig | 4 Episodes |
| • Mare Winningham | played | Dr. Amanda Lee | 4 Episodes |
| • Noah Wyle | played | Dr. John Carter | 4 Episodes |
| • David Green (1) | played | Alan McConagha / Detective Greider | 4 Episodes |
| • Lois Smith | played | Gracie | 4 Episodes |
| • Callie Thorne | played | Jodie Kenyon | 4 Episodes |
| • Armand Assante | played | Richard Elliot | 4 Episodes |
| • Sasha Mitchell (1) | played | Bartender / Patrick | 4 Episodes |
| • Andy Powers | played | Dr. Howard Ritzke | 4 Episodes |
| • Don Cheadle | played | Paul Nathan | 4 Episodes |
| • Natacha Roi | played | Serena Lipnicki | 4 Episodes |
| • Debbie Podowski | played | Brenda, Romano's Receptionist (as Deb Podowski) | 4 Episodes |
| • Christopher Grove | played | Dr. Marty Kline | 4 Episodes |
| • Spider Madison | played | Carl Twomey (as Gabriel Mick) / Mr. Whipple / Lenny / Douglas | 4 Episodes |
| • Claudine Claudio | played | Paramedic Silva | 4 Episodes |
| • Danny Glover | played | Charlie Pratt Sr. / Charlie Pratt | 4 Episodes |
| • Miles Heizer | played | Joshua Lipnicki | 4 Episodes |
| • Joe Manganiello | played | Officer Litchman | 4 Episodes |
| • Nasim Pedrad | played | Suzi | 4 Episodes |
| • Dorian Christian Baucum | played | Max | 4 Episodes |
| • Castulo Guerra | played | Unknown / Judge Alter | 3 Episodes |
| • Freda Foh Shen (1) | played | Hearing Specialist | 3 Episodes |
| • Sonya Eddy | played | Student Affairs Secretary / Harriet | 3 Episodes |
| • Veena Bidasha | played | Belly Dancer #1 / Genetics Nurse Asha | 3 Episodes |
| • Christine Healy (2) | played | Administrator / Hospital Administrator Harriet Spooner | 3 Episodes |
| • Dwier Brown | played | Dr. David Herlihy | 3 Episodes |
| • Michael Pena | played | Officer Mitch Palnick / Bjerke / (as Michael Peña) | 3 Episodes |
| • Page Leong | played | Gloria / Erin | 3 Episodes |
| • Louise Fletcher | played | Roberta 'Birdie' Chadwick | 3 Episodes |
| • Jimmie F. Skaggs | played | Joe Chattarowski | 3 Episodes |
| • Zoran Radanovich | played | Niko | 3 Episodes |
| • David Selburg | played | Dr. Dyer / Brian Westlake | 3 Episodes |
| • Eileen Brennan | played | Betty | 3 Episodes |
| • Lucy Liu | played | Mei-Sun | 3 Episodes |
| • Katie Mitchell (1) | played | Incident Commander / Shelley | 3 Episodes |
| • Vyto Ruginis | played | (Unknown) / Wright | 3 Episodes |
| • Ken Lerner | played | Harry Stopak / Stan Seidel | 3 Episodes |
| • Gregory Wagrowski | played | Herm Bullard / Walton | 3 Episodes |
| • Keith Robinson | played | William White | 3 Episodes |
| • Paul Benjamin | played | Mr. Ervin / Al Ervin | 3 Episodes |
| • Roger Robinson | played | Mr. Wass / Carl Ferris | 3 Episodes |
| • Danny Mora | played | Guillermo | 3 Episodes |
| • David Joyner (1) | played | Dialysis Tech / Tech | 3 Episodes |
| • Andrew Bowen | played | Andrew | 3 Episodes |
| • Tom Gallop | played | Dr. Roger Julian | 3 Episodes |
| • Tod Thawley | played | Smith | 3 Episodes |
| • Joanna Gleason | played | Iris | 3 Episodes |
| • Helen Geller | played | Jean / Mrs. Reynolds | 3 Episodes |
| • Billye Ree Wallace (1) | played | Helen / Silvie Rubadoux | 3 Episodes |
| • Ingo Neuhaus | played | McNally / Cop | 3 Episodes |
| • Bob Newhart | played | Ben Hollander | 3 Episodes |
| • Toy Connor | played | Kynesha | 3 Episodes |
| • Daniel Farber | played | Griffin | 3 Episodes |
| • Shane West | played | Dr. Ray Barnett | 3 Episodes |
| • Brent Jennings (1) | played | Nat | 3 Episodes |
| • Barbara Eve Harris | played | Mrs. Kendrick / Chance's Mother | 3 Episodes |
| • Misha Collins | played | Ray's Bandmate / Bret | 3 Episodes |
| • Marcelo Tubert | played | Father Joe Galloway | 3 Episodes |
| • Jim Jenkins | played | Alger, Gamma's Chauffeur | 3 Episodes |
| • Chris Sarandon | played | Dr. Burke | 3 Episodes |
| • Julie Ariola | played | Frank Martin / Anna / Emily | 3 Episodes |
| • Randy Lowell | played | Dr. Dan Shine, Hematologist / Dr. Shire / Dr. Shine | 3 Episodes |
| • Debra Mooney | played | Leila Morgan, Seth's Foster Mother / Barbara Feingold | 3 Episodes |
| • Oscar Jordan | played | Cullen | 3 Episodes |
| • Cynthia Ettinger | played | Mrs. Powell / Linda Pryor | 3 Episodes |
| • Bradley Whitford | played | Sean O'Brien | 3 Episodes |
| • Theodore Borders | played | Joey Paige / Keyshawn | 3 Episodes |
| • Marion Yue | played | Dr. Sandra Li | 3 Episodes |
| • Valerie Perrine | played | Cookie Lewis | 3 Episodes |
| • Tamala Jones | played | Joanie / Joanie Robbins | 3 Episodes |
| • David Richards | played | Priest / Henderson | 3 Episodes |
| • Ann Shea | played | Day Care Worker / Valerie | 3 Episodes |
| • Ashlee Lauren | played | Annie / Annie Sweet | 3 Episodes |
| • Chris Edwards (1) | played | William Litman | 3 Episodes |
| • Roberto Alvarez (2) | played | Ernesto Ruiz | 3 Episodes |
| • James LeGros | played | Dr. Max Rosher | 3 Episodes |
| • Vince Vieluf | played | Bernard Gamely | 3 Episodes |
| • Kwame Amoaku | played | Neighbor / Trumpet Player / Cabbie | 3 Episodes |
| • Ray Porter | played | Sam Broder | 3 Episodes |
| • Kyle Chambers | played | Ricky Abbott | 3 Episodes |
| • Sheila Kelley (1) | played | Coco / Coco Robbins | 3 Episodes |
| • Elizabeth Rodriguez | played | Nurse Sandra | 3 Episodes |
| • Imani Hakim (1) | played | Anastasia Johnson | 3 Episodes |
| • Rosemary Clooney | played | Mary Cavanaugh / 'Madame X' | 3 Episodes |
| • Elizabeth Barondes | played | Heather | 3 Episodes |
| • Bobby Nish | played | Police Officer / Officer Danny Yau / Officer Yau | 3 Episodes |
| • David Roberson | played | Officer Durcy | 3 Episodes |
| • Matt Craven | played | Hospital Counsel Gordon Price | 3 Episodes |
| • Liza Weil | played | Samantha Sobriki | 3 Episodes |
| • Rise Stefani | played | Nurse #1 / Scrub Nurse / CT Nurse | 3 Episodes |
| • Stacy Keach (1) | played | Mike Gates | 3 Episodes |
| • David Krumholtz | played | Paul Sobriki | 3 Episodes |
| • Pat Carroll (1) | played | Rebecca Chadwick | 3 Episodes |
| • RonReaco Lee | played | Davis | 3 Episodes |
| • Viola Kates Stimpson (1) | played | Ethyl / Estelle Webb | 3 Episodes |
| • Gerry Black | played | Mr. Fletcher | 3 Episodes |
| • Kris Murphy (1) | played | Flight Nurse | 3 Episodes |
| • Eamonn Walker | played | Dr. Dakarai | 3 Episodes |
| • Russell Edge | played | CT Tech | 3 Episodes |
| • Demetrius Grosse | played | Newkirk | 3 Episodes |
| • Nicole Nagel | played | Hulda | 3 Episodes |
| • Joy Bryant | played | Valerie Gallant | 3 Episodes |
| • James Chisem | played | Weisel | 3 Episodes |
| • Matthew Robert Gottlieb (1) | played | Ashley | 3 Episodes |
| • Cecil Hoffman (1) | played | Gail Herlihy (as Cecil Hoffmann) | 3 Episodes |
| • Mark Finney | played | Paramedic / Rolli / Rescue Team | 3 Episodes |
| • Johnny Ray McGhee | played | Custodian / Housekeeping Guy / Bailiff | 3 Episodes |
| • Daniel Spink | played | Tyler Pollard | 3 Episodes |
| • Mary Heiss | played | Nurse Mary / Mary | 3 Episodes |
| • Patrick Fugit | played | Sean / Shawn Simmons | 3 Episodes |
| • Jarreth J. Merz | played | Charles (as Jarreth Merz) | 3 Episodes |
| • Kali Majors | played | Sydney | 3 Episodes |
| • Cole Hauser | played | Steve Curtis | 3 Episodes |
| • Giovannie Pico | played | Ludlow | 3 Episodes |
| • Michael Spellman | played | Dr. Jim Babinski | 3 Episodes |
| • Michelle Wong | played | Tiffany | 3 Episodes |
| • Fred Ward | played | Eddie | 3 Episodes |
| • Moe Daniels | played | Sheila Johnson | 3 Episodes |
| • Petra Porras | played | Perez | 3 Episodes |
| • Quanita Adams | played | Zahra | 3 Episodes |
| • Juanita Jennings (1) | played | Mrs. Davis / ICU Doctor | 2 Episodes |
| • Mark Hutter | played | Mark's Doctor | 2 Episodes |
| • John Mariano | played | Leonard Apfenbach | 2 Episodes |
| • John Doolittle | played | Alan / Unknown | 2 Episodes |
| • Anthony Starke | played | Dr. Craig | 2 Episodes |
| • Tom Wright (1) | played | Wharton | 2 Episodes |
| • Michael Bowen | played | Nurse Connie Oligario / Murray's Father | 2 Episodes |
| • Alaina Reed Hall | played | Betty Dixon | 2 Episodes |
| • Connie Sawyer | played | Kathy Brennan | 2 Episodes |
| • Sam Scarber | played | Unknown / Willy Archibald | 2 Episodes |
| • Tyrone Granderson Jones (1) | played | Hector "Cue Ball" Rodriguez | 2 Episodes |
| • Jeris Lee Poindexter | played | Nate (as Jeris Lee Poindexter) / Rafe (as Jeris Lee Poindexter) | 2 Episodes |
| • Santos Morales | played | Mr. Zevallo | 2 Episodes |
| • Leeza Vinnichenko | played | Ella / Yetna | 2 Episodes |
| • Norma Maldonado | played | Corrine Munoz | 2 Episodes |
| • Jesse D. Goins (1) | played | Mr. Paige | 2 Episodes |
| • Billy Mayo | played | Sheriff / Det. Brannigan | 2 Episodes |
| • Esther K. Chae | played | Reporter Justin / Reporter Justine | 2 Episodes |
| • Maurice G. Smith | played | Stanley / Lester Kertzenstein | 2 Episodes |
| • Bryan Rasmussen | played | Robert Martin | 2 Episodes |
| • Marty Ryan | played | Brant | 2 Episodes |
| • Shaun Duke | played | Detective / (as Duke Moosekian) | 2 Episodes |
| • Bruce Nozick | played | Craig Simon | 2 Episodes |
| • Ted Marcoux | played | Derek Fossen | 2 Episodes |
| • Jenette Goldstein | played | Judy Stiles / Helicopter Medic | 2 Episodes |
| • Brigid Brannagh | played | Jamie Hendricks (as Brigid Walsh) / Jamie Hendricks | 2 Episodes |
| • Myndy Crist | played | Valerie Page | 2 Episodes |
| • Taneka Johnson | played | Kris | 2 Episodes |
| • Tim Griffin | played | Capt. John Evans | 2 Episodes |
| • François Chao | played | Neuro Resident / Neurosurgeon | 2 Episodes |
| • Dee Freeman | played | Dr. Lutz | 2 Episodes |
| • Robert Knott (2) | played | Donny / Donny Costanza | 2 Episodes |
| • Lance E. Nichols | played | Detective Barnes | 2 Episodes |
| • Michael Adler | played | Marty / Nick | 2 Episodes |
| • Brenda Strong | played | Sally Niemeyer | 2 Episodes |
| • Peggy Mannix | played | Mrs. Styman / Mrs. Breeland | 2 Episodes |
| • Emile Hirsch | played | Chad Kottmeier | 2 Episodes |
| • Patrick Kerr (1) | played | George Deakins | 2 Episodes |
| • Sean Moran | played | Mr. Blinker | 2 Episodes |
| • Suanne Spoke | played | OB Receptionist / Mrs. Davies | 2 Episodes |
| • Lawrence Mandley | played | Maintenance Man / Jackson | 2 Episodes |
| • Donna Ponterotto | played | Pearl | 2 Episodes |
| • Bruce Wright | played | Unknown / Janet Wade | 2 Episodes |
| • Wayne Duvall | played | Umpire | 2 Episodes |
| • Gina Philips | played | ER Nurse Kathy | 2 Episodes |
| • Marco Rodriguez (1) | played | Ben / Unknown | 2 Episodes |
| • Raphael Sbarge | played | Mr. Kirkendall | 2 Episodes |
| • Michael Monks | played | Mr. Vennerbeck | 2 Episodes |
| • David Purdham | played | Dr. Kallis | 2 Episodes |
| • Robin Pearson Rose | played | Lois | 2 Episodes |
| • Annie Abbott | played | Mrs. Torledsky | 2 Episodes |
| • Adrian Ricard | played | Mrs. Howard | 2 Episodes |
| • Don Perry | played | Dr. Stan Breedlove / Dr. Sam Breedlove | 2 Episodes |
| • Robert Gossett | played | Dr. Everett Daniels | 2 Episodes |
| • Ali Glazer | played | Kaitlin Sandburg | 2 Episodes |
| • Marcus Toji | played | Binkey | 2 Episodes |
| • Jonathon Patterson | played | Zach #2 / Zach Herlihy | 2 Episodes |
| • Amzie Strickland | played | Jean Connelly | 2 Episodes |
| • Shashawnee Hall (1) | played | Det. Ford | 2 Episodes |
| • William Utay | played | Dr. Lassally / Dr. Seymour Lassally (as Will Utay) | 2 Episodes |
| • Davenia McFadden | played | Mrs. Bevins / April Robinson | 2 Episodes |
| • Patricia Healy | played | Priscilla | 2 Episodes |
| • Tom Dahlgren | played | Unknown / Dr. Sarah Langworthy | 2 Episodes |
| • Julius Tennon | played | Uniform Cop | 2 Episodes |
| • Omar McClinton | played | Wanderer / Construction Worker#2 | 2 Episodes |
| • Ernest Borgnine | played | Paul Manning | 2 Episodes |
| • Commodore James | played | Visitor / Paramedic | 2 Episodes |
| • Kathleen Lloyd (1) | played | Dr. Mack | 2 Episodes |
| • Stacey Travis | played | Det. Weller | 2 Episodes |
| • Miranda Kwok | played | Kristen Shoop | 2 Episodes |
| • Andi Chapman | played | Jodi | 2 Episodes |
| • Kimberly Scott (2) | played | Sandy's Mother | 2 Episodes |
| • Carol Kiernan | played | Desk Clerk / Doris | 2 Episodes |
| • Todd Merrill | played | Dr. Jagman | 2 Episodes |
| • Steve Vinovich | played | Wayne Lentloff | 2 Episodes |
| • Peggy Pope | played | Unknown / Mrs. Gainsley | 2 Episodes |
| • Fred Applegate | played | Gus's Father | 2 Episodes |
| • Vernee Watson-Johnson | played | April Wilson | 2 Episodes |
| • Luisa Leschin | played | Leila | 2 Episodes |
| • Jason Winston George | played | Ethan Mackiner | 2 Episodes |
| • Justin Doran | played | Student #2 / Jay | 2 Episodes |
| • Keith Diamond | played | Det. Stetler | 2 Episodes |
| • John Davis Chandler (1) | played | Thornberg | 2 Episodes |
| • Steve Franken | played | Hank Travis | 2 Episodes |
| • Patrick Cranshaw | played | Unknown / Mr. Gilman | 2 Episodes |
| • Geoffrey Rivas | played | Haven | 2 Episodes |
| • Darwyn Carson | played | Grieving Woman / Katherine Dunlap | 2 Episodes |
| • Bob Bancroft | played | Albert | 2 Episodes |
| • John Prosky | played | Mr. Brooks | 2 Episodes |
| • Sid Conrad | played | Dosier / Lou | 2 Episodes |
| • Julie Carmen | played | Mrs. Lafferty | 2 Episodes |
| • Tom Milan | played | Randy Niemeyer | 2 Episodes |
| • David Gautreaux | played | Scruffy | 2 Episodes |
| • Bruce Gray | played | Dr. Munch | 2 Episodes |
| • Adrienne Hampton | played | Mrs. Vennerbeck | 2 Episodes |
| • Kenneth Tigar | played | Dr. Keinholz | 2 Episodes |
| • Henry G. Sanders (1) | played | Phillip | 2 Episodes |
| • Michael Fox (1) | played | Mr. Bozinsky | 2 Episodes |
| • Don Keefer | played | Louie | 2 Episodes |
| • Jack Carter (1) | played | Mickey Goldstein | 2 Episodes |
| • Jeanne Mori | played | Mrs. Bradley / Mrs. Bimley | 2 Episodes |
| • Robert Carradine | played | John Koch | 2 Episodes |
| • Barry Pearl | played | Dr. Noble | 2 Episodes |
| • Steve Eastin | played | Lorenzo | 2 Episodes |
| • Virginia Capers | played | Mrs. Wilson | 2 Episodes |
| • Danny Dayton | played | Art | 2 Episodes |
| • Carl Lumbly | played | Dr. Graham Baker | 2 Episodes |
| • Mark Rolston | played | Off. Thomas / Officer Thomas | 2 Episodes |
| • Elaine Kagan | played | Mrs. Shearer | 2 Episodes |
| • David St. James | played | Kaplan | 2 Episodes |
| • Lisa Dinkins | played | Dr. Musgrave / Dr. Hennessy | 2 Episodes |
| • Janet MacLachlan | played | Unknown / Mother | 2 Episodes |
| • K. T. Thangavelu | played | Dr. Subramanian | 2 Episodes |
| • Nelson Mashita | played | Kazuo / Kazou | 2 Episodes |
| • Brad Greenquist | played | Mr. Butler | 2 Episodes |
| • Bill Bolender | played | Hank Riley | 2 Episodes |
| • Stana Katic | played | Blaire Collins | 2 Episodes |
| • Jose Zuniga | played | Eduardo Lopez (as Jose Zuniga) | 2 Episodes |
| • Yvette Cason | played | Oncology Nurse | 2 Episodes |
| • Graham Jarvis | played | Francis | 2 Episodes |
| • Charley Lang (2) | played | Jason Warren / Jason | 2 Episodes |
| • Maggie Egan | played | Kathleen Horne | 2 Episodes |
| • J. Grant Albrecht (1) | played | Ronny Faneca / ICU Attending | 2 Episodes |
| • Liz Torres | played | Sarah Wilson | 2 Episodes |
| • Ashley Johnson | played | Dana Ellis | 2 Episodes |
| • James Mathers (2) | played | Security Guard / Roth | 2 Episodes |
| • Rusty Schwimmer | played | Grollman | 2 Episodes |
| • Keene Curtis | played | Gilbert McCabe | 2 Episodes |
| • Kim Delgado | played | Taxi Driver / Mr. Grumpy | 2 Episodes |
| • Natasha Gregson Wagner | played | Mary | 2 Episodes |
| • Christopher John Fields | played | Dr. Phil Tobiason, Radiologist / Dr. Phil Tobiason | 2 Episodes |
| • Paul Perri | played | Unknown / McGillis | 2 Episodes |
| • Brad Blaisdell | played | Detective | 2 Episodes |
| • Ron Taylor (1) | played | Bob | 2 Episodes |
| • Luck Hari | played | OB Nurse / Lakshmi | 2 Episodes |
| • Wallace Shawn | played | Teddy Lempo | 2 Episodes |
| • Linda Kerns | played | Mrs. Bohlmeyer | 2 Episodes |
| • Warren Sweeney | played | Mr. Tierney | 2 Episodes |
| • Eileen Seeley | played | Mrs. Maryanski | 2 Episodes |
| • Walter Addison | played | Mr. Kane | 2 Episodes |
| • Susan Beaubian | played | Dr. Weiss / Dr. Weiss, Oncologist | 2 Episodes |
| • Priscilla Pointer | played | Mrs. Abernathy | 2 Episodes |
| • Leo Rossi | played | Det. Cruson | 2 Episodes |
| • Paul Eiding | played | Kaminski / Kadalski | 2 Episodes |
| • Kathy Griffin (1) | played | Dolores Minky | 2 Episodes |
| • Megan Gallagher (1) | played | Kathy Snyder / Kathy Snyder, Hospital Counsel | 2 Episodes |
| • Linara Washington | played | Young Woman on Train / Rena | 2 Episodes |
| • Jonathan Slavin | played | Ron | 2 Episodes |
| • Jimmy Shubert | played | Security Guard | 2 Episodes |
| • Juan A. Riojas | played | Vasquez | 2 Episodes |
| • Joe Basile | played | Officer Tom Bennini | 2 Episodes |
| • Tommy Hinkley | played | Mr. Ellis | 2 Episodes |
| • Sal Rendino | played | Mohan | 2 Episodes |
| • Cory Hardrict | played | Lil' 'Toine / Curtis | 2 Episodes |
| • Darris Love | played | Hudson / Pratt's Cellmate | 2 Episodes |
| • Michael Chinyamurindi | played | Mlungisi / Angelique | 2 Episodes |
| • Helen Brown | played | Mrs. Fadem | 2 Episodes |
| • Tom McGowan | played | Joe Bernero | 2 Episodes |
| • James Gallery | played | Seedy Man | 2 Episodes |
| • Tony Hale | played | Norman Chapman | 2 Episodes |
| • Curtis Blanck | played | Murray | 2 Episodes |
| • John C. McDonnell (4) | played | Rick | 2 Episodes |
| • Sandy Martin | played | Mrs. Zarian / Sister Helen | 2 Episodes |
| • Brian Cousins (1) | played | Allman | 2 Episodes |
| • Christopher Darga | played | Wilson | 2 Episodes |
| • Donna Hardy | played | Harriet | 2 Episodes |
| • Geoff Meed | played | Bart / Gary Parnell | 2 Episodes |
| • Ebony Monique Solomon | played | Shandra Freeman | 2 Episodes |
| • Dex Elliot Sanders | played | Deon | 2 Episodes |
| • David Kaufman | played | Nick Dunn | 2 Episodes |
| • Joan Pringle | played | Hyams / Matronly Woman | 2 Episodes |
| • Barry Shabaka Henley | played | Unknown / Detective | 2 Episodes |
| • Sheryl Lee Ralph | played | Gloria Gallant | 2 Episodes |
| • Richard Narita | played | Frank Mikami / Ortho #1 | 2 Episodes |
| • Jonelle Allen (1) | played | Debbie Marlin / Lincoln Gerald | 2 Episodes |
| • Bonnie Bartlett | played | Ruth Greene | 2 Episodes |
| • Phyllis Frelich | played | Dr. Lisa Parks | 2 Episodes |
| • Kimmy Robertson | played | Unknown / Arlena | 2 Episodes |
| • Sal Lopez | played | Hispanic Man / Abuelo | 2 Episodes |
| • Ernie Hudson | played | James Gallant | 2 Episodes |
| • Derek Stephen Prince | played | Fireman #2 | 2 Episodes |
| • Dino Anello | played | Orderly / Picketer | 2 Episodes |
| • Bo Eason | played | Charlie | 2 Episodes |
| • Chad Power | played | First Baseman | 2 Episodes |
| • Natanya Ross | played | Mandy Horn | 2 Episodes |
| • Steven Anderson (1) | played | Surgical Resident / Dr. Davitch | 2 Episodes |
| • Abraham Verduzco | played | Palmer | 2 Episodes |
| • Jeanette Miller (1) | played | Flora | 2 Episodes |
| • M. Darnell Suttles | played | Lemoyne | 2 Episodes |
| • Aldis Hodge | played | Brad / Young Man | 2 Episodes |
| • Heidi Swedberg | played | Robin Turner | 2 Episodes |
| • Derick Alexander | played | Hospital Officer | 2 Episodes |
| • Tina Lifford | played | Evelyn Pratt | 2 Episodes |
| • Betty Carvalho | played | Mrs. Zevallo / Vilma Zevallo | 2 Episodes |
| • Thomas Wilson Brown (1) | played | Paramedic / TV Producer | 2 Episodes |
| • Radmar Agana Jao | played | OB Nurse / Nathan Prior | 2 Episodes |
| • John Walcutt | played | Cancer Specialist | 2 Episodes |
| • Benjamin Brown | played | Lab Tech / Cop | 2 Episodes |
| • Angelo Tiffe | played | Unknown / Tom Putnam | 2 Episodes |
| • Robert Rigamonti | played | Mr. Adler | 2 Episodes |
| • Louisa Abernathy | played | Mrs. Law | 2 Episodes |
| • Keiko Agena | played | Mrs. Shimahara / Mrs. Vasquez | 2 Episodes |
| • Silas Weir Mitchell | played | Luis / Marcus Haynie | 2 Episodes |
| • Autumn Winters | played | Blair | 2 Episodes |
| • Andrew McFarlane (2) | played | Jesse Robbins | 2 Episodes |
| • Pragna Desai | played | Angelique | 2 Episodes |
| • Piper Laurie | played | Sarah Ross | 2 Episodes |
| • Tom Poston | played | Earl | 2 Episodes |
| • David Hayward | played | Unknown / Mother | 2 Episodes |
| • Michael Bryan French (1) | played | MacGruder / Dr. MacGruder | 2 Episodes |
| • Tom Bosley | played | Walter Nikolaides | 2 Episodes |
| • Victor Campos | played | Unknown / Patient | 2 Episodes |
| • Lake Bell | played | Jody | 2 Episodes |
| • Jack Impellizzeri | played | Man / Bartender | 2 Episodes |
| • Ruth Silveira | played | Chemo Tech Marni | 2 Episodes |
| • Sam Sarpong | played | Gangster #1 / Antwan | 2 Episodes |
| • Jeremy Ray Valdez | played | Roberto Rosales | 2 Episodes |
| • Michael Manasseri | played | Michael Kenny | 2 Episodes |
| • Cathy Lind Hayes (3) | played | Elaine Gasner | 2 Episodes |
| • Rhyon Nicole Brown | played | Wendy / Erika Crawford | 2 Episodes |
| • Jesse Head | played | Tommy Stevens | 2 Episodes |
| • Jonathan Roger Neal | played | Jeffrey (as Jonathan Neal) / Jeffrey | 2 Episodes |
| • Rafael J. Noble | played | Smitty | 2 Episodes |
| • Stephanie Dunnam (1) | played | Dr. McLucas, OB / GYN | 2 Episodes |
| • Adam Scott | played | David Kerstetter | 2 Episodes |
| • Danielle Harris | played | Laura Quentin | 2 Episodes |
| • George Wyner | played | Rabbi | 2 Episodes |
| • E. J. de la Pena | played | Kirby | 2 Episodes |
| • Ntare Mwine | played | Asst. D.A. / Coach Paul Traylor | 2 Episodes |
| • Amy Ryan | played | Sister Elizabeth / Sister | 2 Episodes |
| • Chad Lindberg | played | Jad Houston | 2 Episodes |
| • Clea DuVall | played | Katie Reed | 2 Episodes |
| • Richard Herd | played | Dr. Murphy | 2 Episodes |
| • Rachael Bella | played | Sarah Gasner | 2 Episodes |
| • Morris Chestnut | played | ICU Nurse Frank 'Rambo' Bacon | 2 Episodes |
| • Patrick Cassidy | played | Dr. Ramsey | 2 Episodes |
| • Wesley Thompson | played | Fritz | 2 Episodes |
| • Catherine Paolone | played | Adoption Caseworker | 2 Episodes |
| • Catherine MacNeal (1) | played | Anne | 2 Episodes |
| • Roma Maffia | played | Ms. Prager, Peter's Attorney | 2 Episodes |
| • Alan Rosenberg (2) | played | Samuel Gasner / Sam Gasner | 2 Episodes |
| • Sally Livingstone | played | Dr. David Morganstern / Allison | 2 Episodes |
| • Pat Millicano | played | Mr. Hahn | 2 Episodes |
| • Robert Maffia | played | Perfusionist | 2 Episodes |
| • Roxanne Hart | played | Mrs. Kottmeier | 2 Episodes |
| • David Allen Brooks (1) | played | Gunn / Dr. Gunn | 2 Episodes |
| • George Eads | played | EMT Greg Powell / Paramedic Greg Powell | 2 Episodes |
| • Jesse Littlejohn | played | Noah | 2 Episodes |
| • Archie Kao | played | Yuri | 2 Episodes |
| • John F. O'Donohue | played | Mr. Goodwin | 2 Episodes |
| • Jon Sklaroff | played | Eddie Hainey / Apocalypse Believer | 2 Episodes |
| • Colton James | played | Mickey | 2 Episodes |
| • Jennifer Gatti | played | Melanie Graff | 2 Episodes |
| • Alexis Cruz | played | Terry | 2 Episodes |
| • Ned Bellamy | played | Police officer / Detective | 2 Episodes |
| • Paul Hipp | played | Craig Turner | 2 Episodes |
| • Tracy Vilar | played | Doris | 2 Episodes |
| • Ann Ryerson | played | Oncology Doctor / City of Mercy Administrator | 2 Episodes |
| • Veronica Cartwright | played | Mrs. Houston | 2 Episodes |
| • Mati Moralejo | played | Flight Nurse | 2 Episodes |
| • Jeff Phillips | played | Wayne / Unknown | 2 Episodes |
| • Julianna Margulies | played | Carol Hathaway / Head Nurse Carol Hathaway | 2 Episodes |
| • Julianna McCarthy (1) | played | Mrs. Raskin | 2 Episodes |
| • Coleen Maloney (1) | played | Mrs. Tierney | 2 Episodes |
| • Remy Auberjonois | played | Elliot | 2 Episodes |
| • Lizzie Maxwell | played | Seedy Woman | 2 Episodes |
| • Karla Green | played | Kanesha Freeman | 2 Episodes |
| • Kathryn Graf | played | Mrs. Adler | 2 Episodes |
| • Benjamin Mouton | played | Mr. Randall / Walt Robbins | 2 Episodes |
| • Brenda Hayes | played | Dolly McCabe | 2 Episodes |
| • Najee Bright | played | Ben McCabe | 2 Episodes |
| • Louie Leonardo | played | Ortez | 2 Episodes |
| • Caroline Lagerfelt | played | Andrea | 2 Episodes |
| • Courtney Gains (2) | played | Ronnie | 2 Episodes |
| • Jared Rushton | played | Andy Bohlmeyer | 2 Episodes |
| • Donnice Wilson | played | Sally | 2 Episodes |
| • Kylie Tyndall | played | Ashley | 2 Episodes |
| • Keaton Tyndall | played | Ashley | 2 Episodes |
| • Robert Winley | played | Ace | 2 Episodes |
| • Jason Edwards | played | Santa | 2 Episodes |
| • Erin LeShawn Wiley | played | Shelly | 2 Episodes |
| • Susan Bugg | played | Sally | 2 Episodes |
| • Irvin Mosley, Jr. | played | Harry | 2 Episodes |
| • Kristin Davis (1) | played | Leslie | 2 Episodes |
| • Louis Ortiz | played | Jorge | 2 Episodes |
| • Eda Reiss Merin | played | Unknown / Michael Clifford | 2 Episodes |
| • Stephen Rowe | played | Unknown / Pamela | 2 Episodes |
| • Nancy Youngblut | played | Unknown / Sarah Howe | 2 Episodes |
| • Arnie Moore | played | Drunken Slob | 2 Episodes |
| • Joe Minjares | played | Phil | 2 Episodes |
| • Colleen Flynn | played | Jodi O'Brien | 2 Episodes |
| • Shelley Malil | played | Dr. Urami | 2 Episodes |
| • Monty Ash | played | Old Man With Dentures | 2 Episodes |
| • Bradford Drazen | played | Dr. Ralph Drake | 2 Episodes |
| • Wolfgang Bodison | played | Al Boulet | 2 Episodes |
| • Vincent Hammond | played | Gurney Man | 2 Episodes |
| • Michael Strickland | played | Seth | 2 Episodes |
| • Bari K. Willerford | played | Mr. McDowall | 2 Episodes |
| • Kathleen Dennehy | played | Mrs. Ryan | 2 Episodes |
| • Maria Cellario | played | Mrs. Baba | 2 Episodes |
| • Jane Cecil | played | Shirley | 2 Episodes |
| • June C. Ellis | played | Sari | 2 Episodes |
| • Rebeccah Bush (1) | played | Allison Wood | 2 Episodes |
| • Brianne Prather | played | Katie Nemeth | 2 Episodes |
| • Catherine Lloyd Burns (1) | played | Amy | 2 Episodes |
| • Patrick Collins (1) | played | Dr. Netzley / Dr. Netzley, pediatric surgeon | 2 Episodes |
| • Elizabeth Norment (1) | played | Mrs. Sandburg | 2 Episodes |
| • Brenda Hillhouse | played | Mrs. Schaffer | 2 Episodes |
| • Herman Sinitzyn | played | Uncle Michel | 2 Episodes |
| • Giorgi Tarlian | played | Helen Hathaway | 2 Episodes |
| • Sylvia Short | played | Marjorie / Marjorie Ellison | 2 Episodes |
| • Carole Goldman | played | Bartender / Doc | 2 Episodes |
| • Ernest Perry, Jr. | played | Server / Gus | 2 Episodes |
| • George Lugg | played | Bellman / Wrigley Field Hot Dog Guy | 2 Episodes |
| • Joe Sachs | played | EMT | 2 Episodes |
| • Gabrielle Boni | played | TC Lucas | 2 Episodes |
| • Melissa Chan | played | Leung / Dr. Leung Joo Hua | 2 Episodes |
| • Jenny O'Hara | played | Nurse Rhonda Sterling | 2 Episodes |
| • Fran Bennett (1) | played | Phyllis? / Michelle | 2 Episodes |
| • Clarinda Ross | played | Mrs. Martinez / Mrs. Foster | 2 Episodes |
| • Jackie Millines | played | Thomas Anders / Stab Wound | 2 Episodes |
| • Michael Jace | played | Billy Nelson / Bill Nelson | 2 Episodes |
| • Alex Skuby | played | Medivac / Renato | 2 Episodes |
| • Tara Chocol | played | Vicki McNeal | 2 Episodes |
| • Alice Amter | played | Dr. Miriam Nagerwala / Dr. Miriam Nagarvala | 2 Episodes |
| • Janni Brenn | played | Nurse Kass | 2 Episodes |
| • Mike Bacarella | played | Cabbie / Cabby | 2 Episodes |
| • Devyn La Bella | played | Celia | 2 Episodes |
| • Gina Hecht | played | Unknown | 2 Episodes |
| • Julia Pearlstein | played | Day Care Worker | 2 Episodes |
| • Vincent Berry | played | Seth Williams | 2 Episodes |
| • Corey Parker Robinson | played | Antoine Bell | 2 Episodes |
| • Ernie Lee Banks | played | Old Man / Man in Crowd | 2 Episodes |
| • Marilyn Sue Perry | played | Nurse Rogers / Prison Ward OB Nurse Judy Rogers | 2 Episodes |
| • Maura Tierney | played | Abby Lockhart / Dr. Abby Lockhart | 2 Episodes |
| • Joey Naber | played | Santa Juan / Henderson | 2 Episodes |
| • Paul Adelstein | played | Unknown / Mrs. Carlson | 2 Episodes |
| • Hal Holbrook | played | Walter Perkins | 2 Episodes |
| • Ben Weber | played | Lou | 2 Episodes |
| • Elizabeth Morehead | played | Mrs. Simmons | 2 Episodes |
| • Amy Madigan | played | Mrs. Taggart / Mary Taggart | 2 Episodes |
| • Jessica Hecht | played | Stephanie Lowenstein | 2 Episodes |
| • John Stamos | played | Paramedic Tony Gates / Tony Gates | 2 Episodes |
| • Eddie Shin | played | Med Student Stanley Mao | 2 Episodes |
| • Gary Riotto | played | Cousins | 2 Episodes |
| • Jennifer Jostyn | played | Prosthetic Doc / Prosthetist | 2 Episodes |
| • Amy Stewart (1) | played | Linsey Cordova | 2 Episodes |
| • L. Scott Caldwell (1) | played | Dr. Rabb | 2 Episodes |
| • Michele Shay | played | Mrs. Royston / Court Reporter | 2 Episodes |
| • Kevin Berntson | played | Student #1 / Willie Goldman | 2 Episodes |
| • Terry Maratos | played | Garvey | 2 Episodes |
| • Kelsey Oldershaw | played | Nurse Tess | 2 Episodes |
| • Michael C. Mahon | played | Joe, Chloe's Boyfriend | 2 Episodes |
| • Richard Brooks | played | Mr. Freeman | 2 Episodes |
| • Joe Lisi | played | Mr. Gunther / NYPD Lt. Swersky | 2 Episodes |
| • Molly Price | played | NYPD Off. Faith Yokas / Mrs. O'Fallon | 2 Episodes |
| • Annabella Sciorra | played | Diane Moore / Diana Moore | 2 Episodes |
| • Anne O'Sullivan | played | Mrs. Davies | 2 Episodes |
| • Kevin Sussman | played | Colin | 2 Episodes |
| • Meredith Zinner | played | Chasity Lee | 2 Episodes |
| • Liza Lapira | played | Christine | 2 Episodes |
| • Marceline Hugot | played | Bonnie Curtis / Bonnie | 2 Episodes |
| • Michael Ealy | played | Rick Kendrick / Ryan Kendrick | 2 Episodes |
| • Shannon Marie Woodward | played | Kelly Taggart | 2 Episodes |
| • Jennifer Echols | played | Estelle | 2 Episodes |
| • Chris Freeman | played | DeShazo / Oliver | 2 Episodes |
| • Wells Rosales | played | Cory / Cory Carson | 2 Episodes |
| • Garrett Morris (1) | played | Edgar Luck | 2 Episodes |
| • Julianne Nicholson | played | Jordan Dunn | 2 Episodes |
| • Petrea Burchard | played | Judge Amoroso | 2 Episodes |
| • Frances Conroy | played | Becky Riley | 2 Episodes |
| • Joel de la Fuente | played | Med Student Ivan Fu | 2 Episodes |
| • David Eigenberg (1) | played | Det. Trent Mallory | 2 Episodes |
| • Shelly Desai | played | Cabbie | 2 Episodes |
| • Jeffrey Alan Chandler (1) | played | Mr. Skapinski (as Jefrey Alan Chandler) | 2 Episodes |
| • Annabella Price | played | Mrs. Sheff / Mrs. Schap | 2 Episodes |
| • Ren Hanami | played | NICU Nurse | 2 Episodes |
| • Taraji Henson | played | Patrice Robbins (as Taraji Henson) / Elan (as Taraji Henson) | 2 Episodes |
| • Louis Gossett, Jr. | played | Leo Malcolm | 2 Episodes |
| • Aida Turturro | played | Sheryl Hawkins | 2 Episodes |
| • Warner Saunders | played | News Anchor / TV Reporter | 2 Episodes |
| • Jacob Urrutia | played | Jose Rodriguez | 2 Episodes |
| • Renee Victor | played | Florina Lopez | 2 Episodes |
| • Kenneth Alan Williams | played | Dr. Thomas Gabriel | 2 Episodes |
| • Louis Iacoviello | played | Officer Rovner / Rovner | 2 Episodes |
| • Julie Pop | played | Mary Gitlitz / Hannah | 2 Episodes |
| • Masam Holden | played | Teller | 2 Episodes |
| • Skyler Gisondo | played | Timmy | 2 Episodes |
| • Andrew J. Ferchland | played | Ozzie Sheff / Ozzie Schap | 2 Episodes |
| • Terry Savage | played | Radiologist / Radiologist Nurse | 2 Episodes |
| • José Ramón Rosario | played | Driver (as Jose Rosario) / Driver | 2 Episodes |
| • Brian Chenoweth | played | Radiology Tech | 2 Episodes |
| • Flora Burke | played | Old Woman / Mrs. Tanzi | 2 Episodes |
| • George Plimpton | played | John Truman Carter, Sr. | 2 Episodes |
| • Mark Leahy | played | Orderly | 2 Episodes |
| • Amanda Rogers | played | Mrs. Bower | 2 Episodes |
| • Wesley Hayashi | played | Stewey | 2 Episodes |
| • Kelly Schmidt | played | Tarita | 2 Episodes |
| • Kristina Coggins | played | Sally Eiger | 2 Episodes |
| • John DiSanti | played | Uncle Ted | 2 Episodes |
| • Darryl Fong | played | Mr. Chang | 2 Episodes |
| • Trenton Knight | played | Celia / Unknown | 2 Episodes |
| • John McMahon | played | Tom | 2 Episodes |
| • Byron Thames | played | Willy | 2 Episodes |
| • Alanna Ubach | played | Unknown / Terry's Friend | 2 Episodes |
| • Vicki Wauchope | played | Nancy | 2 Episodes |
| • Lili Flanders | played | Ms. Brown | 2 Episodes |
| • Ilia Volokh | played | Kovalev | 2 Episodes |
| • Angel Aviles | played | Ramos | 2 Episodes |
| • Kelly Coleman | played | Nina | 2 Episodes |
| • Aymara De Llano | played | Joanie Lafferty | 2 Episodes |
| • Angela Jones | played | Michelle | 2 Episodes |
| • Seidy Lopez | played | Rosaria 'Puppet' Gutierrez / Rosaria Guitterez | 2 Episodes |
| • Tim De Zarn | played | Mr. Krawczyk | 2 Episodes |
| • Kurt Naebig | played | Paramedic | 2 Episodes |
| • Joanie Fox (1) | played | Waitress #1 / Waitress | 2 Episodes |
| • Oren Williams | played | Pirate Boy / Derrick Royston | 2 Episodes |
| • Vanessa Martinez | played | Tiffany / Tiffany James | 2 Episodes |
| • James T. Callahan (1) | played | Oliver / Mr. Bristol (as James Callahan) | 2 Episodes |
| • Justin Henry | played | Med Student James Sasser | 2 Episodes |
| • Tricia Dong | played | Nurse Joyce | 2 Episodes |
| • Jesse Garcia | played | Daniel Rodriguez (as Jesse Matthew Garcia) / Carlos Vega | 2 Episodes |
| • Tiger Mendez | played | Police Officer / Jaguar Chauffer | 2 Episodes |
| • Jessica Gaona | played | Patient / Holly Evans | 2 Episodes |
| • Chris Wells (1) | played | Mr. Morris / 'Cupid' | 2 Episodes |
| • Jim Carrane | played | Manny, used-car dealer / News Vendor | 2 Episodes |
| • Ken Davitian | played | Mr. Papazian / Zakar | 2 Episodes |
| • Roberta Valderrama | played | Stephanie | 2 Episodes |
| • Candice Cook | played | Paramedic / SICU Nurse | 2 Episodes |
| • Paul Freeman (1) | played | Dr. Charles Corday | 2 Episodes |
| • Leontine Guilliard | played | Winona / Santa | 2 Episodes |
| • Liane Alexandra Curtis (1) | played | Mrs. Shayotovich, Fossen's Neighbor (as Liane Curtis) | 2 Episodes |
| • Max Kasch | played | Andrew, Rachel's Boyfriend | 2 Episodes |
| • Salli Saffioti | played | Carmen Turino | 2 Episodes |
| • Eleanor Comegys | played | Sister Monica | 2 Episodes |
| • John Siciliano | played | Tobias / Toby | 2 Episodes |
| • Cynthia Cervini | played | Woman / Nurse Anna Waldron | 2 Episodes |
| • Claire Jacobs | played | Mrs. Daniels | 2 Episodes |
| • Jeff Corbett | played | Paramedic Niki / Mike Dodds | 2 Episodes |
| • Heather DeLoach | played | Helen | 2 Episodes |
| • Carly Reichert | played | ER Nurse / SICU Nurse | 2 Episodes |
| • Shawn Smith | played | Turner | 2 Episodes |
| • Abdul Ayoola | played | Patrique | 2 Episodes |
| • Mareo-Ahmir Lawson | played | Intimidating African Soldier | 2 Episodes |
| • Nick D'Agosto | played | Andy | 2 Episodes |
| • Carla Jimenez | played | Eloise | 2 Episodes |
| • Frank McRae | played | Freddie | 2 Episodes |
| • Karla Zamudio | played | Latina Mom / Alma Benitez | 2 Episodes |
| • Luis Chávez | played | Roger | 2 Episodes |
| • Don Oscar Smith | played | Bob | 2 Episodes |
| • James Earl | played | Elgin / Elgin Gibbs | 2 Episodes |
| • Michael Raymond-James | played | Mr. Tunny (as Michael Raymond James) / Stuart Moore | 2 Episodes |
| • Eduardo Ortiz | played | Jackson | 2 Episodes |
| • Henry O | played | Mr. Chen | 2 Episodes |
| • Jasmine D'Angelo | played | Jamila | 2 Episodes |
| • Narmar Hanna | played | Hayat | 2 Episodes |
| • Anthony Giangrande | played | Dr. Jeremy Munson | 2 Episodes |
| • Damali Scott | played | Clemons | 2 Episodes |
| • Britain Spellings | played | Sackowitz | 2 Episodes |
| • Jeremy Overstreet | played | Quinn | 2 Episodes |
| • Patricia Lentz | played | Nursing Supervisor | 2 Episodes |
| • Michael Weston | played | Rafe Hendricks | 2 Episodes |
| • Tito Ernesto Ortiz | played | Carlos Lopez | 2 Episodes |
| • Shea Whigham | played | Bobby | 2 Episodes |
| • Carissa Koutantzis | played | Kendra / Jill Connelly | 2 Episodes |
| • Dane Farwell | played | Hospital Police Officer | 2 Episodes |
| • Sergey Brusilovsky (1) | played | Adrian (as Sergey Brusilovsky) / Boris Nadinovitz | 2 Episodes |
| • Julia Jones (1) | played | Kaya Montoya / Dr. Kaya Montoya | 2 Episodes |
| • Rebecca Hazlewood | played | Jaspreet | 2 Episodes |
| • Raymond Alexander Cham Jr. | played | Max | 2 Episodes |
| • Eli Goodman | played | NICU Resident | 2 Episodes |
| • Eddie B. Smith | played | Officer Jones / Detective Jones | 2 Episodes |
| • Michael Rady | played | Brian Moretti | 2 Episodes |
| • Kathleen Garrett | played | Dr. Steinman / Unknown | 2 Episodes |
| • Keith L. Lewis | played | Bystander | 2 Episodes |
| • Randy Shabalala | played | Asha | 2 Episodes |
| • Tshemano Sebe | played | Sadig's Deputy | 2 Episodes |
| • Dumisane Siswe Mbebe | played | Officer Sadig | 2 Episodes |
| • Ezra Mabengeza | played | Janjaweed Soldier / Janjaweed #1 | 2 Episodes |
| • Chris Gxalalaba | played | Ibrahim | 2 Episodes |
| • Wandile Molebatsi | played | Harun | 2 Episodes |
| • Thomas Kariuki | played | Ishaak | 2 Episodes |
| • Mary E. Kennedy | played | Trudy Lange | 2 Episodes |
| • Paul H. Kim | played | Tech | 2 Episodes |
| • Cecily Lewis | played | Jocelyn Pratt | 2 Episodes |
| • Rooney Mara | played | Woman With Baby / Megan | 2 Episodes |
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