Together, they wish for their lives to change. An unknown power within each of them is suddenly unlocked, bringing them together and changing each of their lives. And that's when the mysterious and wealthy Darryl Van Horne arrives in town. He helps them discover their unique powers in ways they never could have imagined. But by igniting their hearts' desires, he might just be opening Pandora's Box.
As Eastwick prepares for its annual fall HarvestFest, Joanna, Kat and Roxie's lives continue to take a turn for the strange. Distracted by distressing psychic visions of her new neighbor, Jamie, Roxie struggles to protect Mia from harassment by her ex-boyfriend, Gus. As Kat gains the courage to end her own toxic relationship - her marriage to Raymond -- he's back in their home to recuperate from being struck by lightning. And while Joanna worries that Will's romantic attentions are only due to her hypnotic power, she and Penny embark on a perilous mission to uncover Darryl Van Horne's true identity. Joanna finds Milton Philmont, a retired Gazette reporter who years ago wrote about the death of a man named Sebastian Hart - a man who looks uncannily like a young Darryl Van Horne. Armed with an old photo of Hart with three beautiful women, she and Penny seek answers from the eccentric and reclusive Eleanor Rougement.
Haunted by the ghost of her daughter's ex-boyfriend, Roxie questions her sanity and turns to a local psychic for help. Declining Darryl's offer of a high-powered - and high-priced - divorce attorney, Kat decides to give Raymond another chance, but is she only delaying the inevitable? Joanna's quest to find the truth about Darryl leads her to a new and different scandal, and then she realizes her discovery was no accident. Meanwhile, Roxie's daughter, Mia, reluctantly attends her boyfriend's memorial, and though Bun has lost her memory, her mind is consumed with a mysterious symbol.
With a little urging from Darryl, Roxie decides to learn more about her mysterious new neighbor, Jamie (Jack Huston) - and she ends up making a magical discovery. Terrified by Raymond's threat to take their children, Kat decides to go on the offensive and finally accepts the help of Darryl's divorce lawyer. And just as Joanna's long-awaited date with Will approaches, Morgan, her ex-fiance, arrives in town, tempting her to find out what went wrong between them
Kat fulfills a fantasy; Mia and Roxie find themselves in an embarrassing predicament; Joanna's rush to print a story gets her into trouble.
Eastwick celebrates Halloween, Roxie tries to prevent her current vision from coming true, Kat undertakes the task of bringing Joanna and Will together, and Joanna discovers that things can get worse.
Roxie wants to fulfill the last wish of Chad, but must figure out what it is. Joanna deals with her lingering questions about the kidnapping ordeal. Kat discovers that the answer she needs may be answered by Bun's old friend.
Roxie forgets that his motives might be less than pure when Darryl arranges an art show for her work at his mansion... and invites New York art maven Greta Noa to come, while Joanna uncovers the fact that every action she takes with her power to get her life back on track have consequences. Meanwhile, Kat is still wondering how to move on from Ray, and shies away from a budding romance with Will.
Roxie's mother, Edie, visits her and Roxie uncovers a newfound power, while Jamie's unsuccesful attempt to poison Darryl places Greta Noa in the hospital seconds from dying. Meanwhile, Kat is told to use her healing powers in order to save one of Darryl's friends, and Joanna attempts to rescue her failed writing career, but a rivalry between her and cocky reporter Max gives her problems. And finally, Jamie needs to team up with Bun and Eleanor to finish the job on Darryl.
Jamie tells Roxie that Darryl is his father and afterwards, she arranges a dinner party where father and son can bond, but Jamie has a secret plan for the evening. Meanwhile, Kat decides to use her newfound power to heal every patient she comes in contact with, but her compassion results in drastic physical consequences. Also, Max requests Joanna to help him solve an unsolved murder, but Joanna is quite reluctant and their snooping gets them into a perilous situation with Eleanor.
Making a pact in which they will never reveal what they did to Jamie, the ladies realize they must choose their separate paths and abandon their powers, while a guilty Joanna attempts to help Penny find closure. Meanwhile, the friendship between Kat and her hot new neighbor comes to a halt when the fact that he came to Eastwick with his young son and a dark secret, is exposed. Also, Darryl returns to Eastwick with the truth behind his mysterious past, which complicates things for Roxie, Kat and Joanna.
Roxie's nightmares come true as she struggles to escape from Jamie, and Joanna and Max fight for their lives.
Roxie's deceased husband returns, Kat suspects something is not right about Colin's son, and Joanna tries to deflect Penny's suspicion that Jamie was murdered.