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Andy thinks that Ephram is beginning to doubt getting into Julliard when he applies to a Colorado college as a back-up plan. Harold is also worried about Amy's college career when she tells him that she's not going to the college that Harold had set his hopes on: Princeton. Meanwhile, Andy researches new therapies for Amanda's husband; and Edna and Irv's relationship hits a rough patch.
Stephanie Niznik (Nina Feeny) and Sarah Drew (Hannah) do not appear in this episode.
Edna: (to Jake) By the way, next time you're at the dentist, ease off on the bleaching. Hurts my eyes.
Even though Ephram's studio is sound-proof, he could hear Dr. Abbott knock and Dr. Abbott could hear Ephram's reply without the door being open.
Episode Title: Shoot the Moon
"Shoot the Moon" is the title of a song by Norah Jones.