This is the 2nd appearance of Francis Griffin if you don't count him being seen in the crowd in "Perfect Castaway".
Stewie tells the viewers to switch to "Desperate Housewives" just to prove that they are not missing much. Desperate Housewives was really playing at the same time, and was showing the actress Stewie was talking about.
The Broadcast of this episode was moved ahead 20 minutes because of a Presidential Adress.
Peter: Oh that Fonzie is a work of magic. I love how he hits that jukebox to make it work.
Francis: ...real religion! what i saw today wasn't real religion, it was just a bunch of sheep, singing songs and listening to ridiculous tall tales.
Brian: Actually, that is religion.
Quagmire: Reverend Peter, I gotta talk to you... last night I had sex with a teenage blonde, and her mother.
Peter: Well that's quite a story, Quagmire, but my church doesn't have confession. So why are you telling me?
Quagmire: Are you kidding? I'm telling everybody! Giggity-goo-ga.
Stewie: I'm just saying 70's boobs were different...
Peter: Tell us about World War One and how America defeated Kaiser Permanente.
Peter: Could there be anyone stupider than me?
Peter: Oh yeah, she's pretty stupid. That's something we can all agree on. Right?
Brian: Absolutely. Francis?
Francis: Oh major idiot. Major idiot.
Lindsey Lohan: (naked, walking like a crab) This is how a crab walks!
Peter: It sure is!
"Jesus was a miracle worker, who went from place to place, trying to set right what once went wrong, and hoping each time, that his next leap, would be the leap home"
A reference to the hit show Quantom Leap, which features a time traveler who temporarily takes over people's bodies in order to change their lives for the better.
Stewie: You would not believe the morning I've had
When Stewie is getting shot around on the Pin Ball Machine; it is very similar to an old counting lesson from the kids show Sesame Street.
Bill Lumbergh from the movie Office Space asks Lois to sit at the kids table. Fans of the movie know Bill as the bearer of bad news in a brief way.