'Stewie Kills Lois' was leaked to the internet 2 weeks before the November 4th air date
'Stewie Kills Lois' was originally slated to be the 5th season's finale cliffhanger episode
This episode jumps one year in to the future.
When Stewie shoots Lois on the boat, bullet holes are shown on her back, but when she is sinking down into the ocean, the bullet holes on her back are gone.
Lionel Richie's - Can't Slow Down
Peter gives Lois Can't Slow Down for her birthday
Star Trek: The Next Generation
The "To Be Continued" font for the ending credits and theme music are from the Star Trek: The Next Generation two-parter "The Best of Both Worlds".
Paul McCartney is shown humoring Ringo Starr about his song writing skills
The Lake House
Stewie explains the plot of the 2006 Keanu Reeves/Sandra Bullock movie to Rupert
The Muppet Show
Stewie imagines the intro to Pigs in Space, a regular sketch from the 1976-1981 show
Glen mentions his bit about Getz when he tried stand up comedy.
In December, 1984, Bernie Getz shot four black teenagers on a New York subway. He spent a year in jail on a gun charge.
Herbert holds an old phonograph machine over his head recreating the scene from the John Cusack movie where his character Lloyd Dobler holds a boom box over his head for Diane Court