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To help pay off his incredible debt, Peter participates in medical experiments to make some extra cash.
First, he is injected with the "Seth Rogen" gene (guest voice Rogen) that "gives you the appearance of being funny even though you haven't actually done anything funny."
Then he is injected with a gene that leads him to a new mate, leaving a broken-hearted Lois behind.
Although the family is crushed, they quickly realize the most important thing is that Peter is happy
This episode drew 7,090,000 viewers & was FOX's #7 show for the week
On FOX, this episode was rated TV-14 for suggestive dialogue, (D), offensive language (L), and sexual situations (S). On Cartoon Network, this episode is rated TV-MA (with no sub-rating) for its heavy references to homosexuality.
This episode along with “I Dream of Jesus”
& “Road to Germany”
were the ones submitted to the Emmy committee that earned Family Guy
a “Best Comedy”
nomination for the 61st Primetime Emmy Awards, which no big shocker, they lost to “30 Rock”
When Peter returns home to Scott they are both standing a few steps inside the front door but when Scott calls the guys for the 11 way they are suddenly across the room a few steps outside the bedroom door.
'Til Death (2006-2010)
was included in the canceled shows but, at the time of the episode's airing, March 08th 2009, it had actually been renewed for a fourth season.
However, it was finally cancelled on March 23, 2010.
Peter: “Lois, I'm a guy you can trust with a task. I'm the one who almost conquered the Dragon's Lair”
“Dragon's Lair” was a laserdisc video game published by Cinematronics in 1983.
It was a revolutionary game since it featured (although limited) fully animated game play instead of the standard bitmap display.
Stewie: “Brian, is Paul Sorvino standing behind me?”
Brooklyn born, American actor Paul Sorvino
is mentioned by Stewie in this episode.
Lois: “Is there a reason all those horses are named after cancelled FOX shows?”
The announcer mentions...
“Kitchen Confidential” (2005: Cancelled after 4 episodes)
“Wedding Bells” (2007: Cancelled after 4 episodes)
“Happy Hour” (2006: Cancelled after 4 episodes)
“The War At Home” (2005-2007: Cancelled after 2 seasons)
“Drive” (2007: Cancelled after 5 episodes)
“The Winner” (2007: Cancelled after 1 season (6 episodes))
“Life On A Stick” (2005: Cancelled after 5 episodes)
“The Loop” (2006-2007: Cancelled after 2 seasons)
“Head Cases” (2005: Cancelled after 2 episodes)
“Stand Off” (2006-2007: Cancelled after 1 season)
“Vanished” (2006: Cancelled 9 episodes)
“Free Ride” (2006: Cancelled after 1 season (6 episodes))
“Method & Red” (2004: Cancelled after 9 episodes)
“Tru Calling” (2003-2005: Cancelled after 2 seasons (Finale never aired))
“Quintuplets” (2004: Cancelled after 1 season)
“Stacked” (2005: Cancelled after 14 episodes)
“Justice” (2006: Cancelled after 1 season (Finale never aired))
“North Shore” (2004: Cancelled after 1 season (Finale never aired))
“Back To You” (2007-2008: Cancelled after 14 episodes)
& “'Til Death” ('Til Death actually returned for its fourth and final season)
American actor Matt Damon (1970-)
is featured in this episode as employing Peter to be his neck
Peter: “Awwww I wish I was Beyoncé”
American singer and actress Beyoncé Knowles (1981-)
is mentioned in this episode
Peter: “Tony Randall was married, Rock Hudson was married, Ronald Reagan was married”
American actor Tony Randall (1920-2004)
wasn't gay despite the rumors.
American actor Rock Hudson (1925-1985)
was indeed married from 1955-1958 and hid his homosexuality all his life from the public and it was only revealed after his death in 1985 of AIDS that he was in fact gay.
Former President Ronald Reagan (1911-2004)
of course wasn't gay, the insinuation is strictly for the cutaway joke.
The leader of the former USSR, Mikhail Gorbachev (1931-)
is featured in the Reagan cutaway.
Lois: “Well how long will that take?”
Doctor: “A week, a month, a year, five hundred twenty five thousand six hundred minutes?”
Peter: “Ooh RENT, Rent, Rent”
“RENT” is a rock opera, with music and lyrics by Jonathan Larson based on Giacomo Puccini's opera “La Bohème”. It tells the story of a group of impoverished young artists and musicians struggling to survive and create in New York's Lower East Side in the thriving days of Bohemian Alphabet City, under the shadow of AIDS.
The show opened on January 25, 1996 & became the 7th longest running Broadway music w/ 5,124 performances and after grossing $280 million dollars & a 12 year Broadway run closed September 7, 2008 but still continues to tour with the road company.
The 525,600 minutes reference is an allusion to one of the songs from “RENT” called “Seasons of Love”
Peter is seen reading the 1979 novel by V. C. Andrews “Flowers in the Attic”.
While he's reading you can hear the song “Sixteen Going on Seventeen” performed by Charmian Carr & Daniel Truhitte from the 1965 movie “The Sound of Music”
Brian: “Who knows by now, Peter could be completely heterosexual by now”
The musical number following Brian's line is a reference to the same number performed in the 1974 comedy “Blazing Saddles”