Peter: (writing letter) Dear MacGuyver, Enclosed is a rubber band, a paper clip, and a drinking straw. Please save my dog.

Meg: Chris, you're hogging up all the fans.
Chris: Well, you're hogging up all the... ugly!

Stewie: Rupert, did you call that engineer at Lockheed yet? Well of course you didn't you worthless little... (Hits Rupert the Toy Bear). There, see what you made me do? Do you think I enjoy hitting you? Well actually I do. I enjoy it so much I'm going to do it AGAIN!!! (Hits Rupert the Toy Bear)

Peter: If Liza is wrong, then I don't want to know what right is.

When Peter brings in the Dog Show bulletin, the fans have vanished.

At the dog show there's a close up of Stewie in his stroller demanding Meg push him in the nearest lake. We see there's no one sitting on the bottom row of the stands behind him.
When we switch to the wider shot of Meg saying she'll find him a juice box, the whole bottom row in filled w/ spectators including Meg & Chris.
The row is once again completely empty when Stewie says “Get the lead out pudgy”.

Lois pokes The Pillsbury Doughboy and starts to roll him onto an empty cutting board.
It's the same one she's seen already using when she says they're “fresh from the tube”.

Brian says he'll be on the veranda since Peter's on the cross as he gets out of his chair.
After the black and white cartoon and the flashback of the first meeting of Brian and Peter the chair has vanished.

Brian criticizes Peter suggesting he can't afford to buy his family an air conditioner but earlier in the episode, Meg is seen standing in front of a window mounted a.c. unit

When Stewie does his half-bow to Brian at the end of the episode, he's not standing on the area rug but right before he runs upstairs, he's clearly standing in the center of the rug

The title of this episode, “Brian: Portrait of a Dog”, is a reference to the 1986 movie “Henry: Portrait of a Serial Killer”

Peter: “Come on everyone, that Eight is Enough reunion show is about to start”

The characters from “Eight Is Enough” (1977-1981), Tom Bradford, Mary Bradford & ?Nancy Bradford? return for an updated reunion special.
The characters Abby Bradford & Nicholas Bradford are mentioned but not seen.
Dick Van Patton reprises his role as Tom Bradford for this episode.

Peter: “Believe me I've been trying, that's why I went on that game show”

Peter appeared on the long running game show “Jeopardy”

Brian: “Showtime!”

A reference to the 1979 movie, “All That Jazz”

Lois: “Are you offering Brian drugs?”
Peter: “Not drugs just those little blue things celebrities take to help them perform”
Lois: “Well those celebrities are wrong”
Peter: “LOIS! If Liza is wrong then I don't want to know what right is”

American actress/singer Liza Minnelli is seen needing a little blue pill, which turns out to be the classic candy “M&M's”

Liza: “...it's time to make life a Cabaret”

Liza Minnelli is referring to her 1972 movie “Cabaret”, as well a lyric from the main theme of the same name.

Lois: “Who wants to sing show tunes?”

Lois tries to distract from Peter & Brian's fight by singing “Anything Goes” from the 1934 musical of the same name

Lois makes cinnamon buns out of “The Pillsbury Doughboy” aka “Poppin' Fresh”, the long time advertising icon and mascot of The Pillsbury Company

Lois: “Peter, Brian, Stop this. Can't you two go back to the way you used to be?”

The cartoon cutaway it a allusion to the original black and white “Mickey Mouse” cartoons of the late 1920's & 1930's.
Brian is even wearing pants similar to what Mickey wore in his first 1928 cartoon “Steamboat Willie”

The mother & daughter commercial regarding “freshness” is a parody of a real Massengill Douche commercial from the 80s

Brian: “Oh No! Don't do that that's what they expect you to do!”

Brian is outraged by the sight of the 2 dogs eating in the alley.
This is a direct reference to the 1955 Disney movie “The Lady and the Tramp” in which the characters “Lady” and the “Tramp” share the same spaghetti dinner.

The police foot chase is an allusion to the 1984 Harrison Ford Kate Capshaw movie “Indiana Jones & the Temple of Doom”

Brian: “Joyce DeWitt?! So that's where you've been”

Joyce DeWitt was one of the 3 stars of the sitcom “Three's Company” (1977-1984).
After “Three's Company” she choose to stay off of Hollywood's radar. Although, she is slowly started to work in the entertainment industry again.

{Peter's letter}: “Dear MacGyver, Enclosed is a rubber band, a paper clip, and a drinking straw. Please save my dog”

“MacGyver” (1985-1992) starred Richard Dean Anderson.
MacGyver had the ability to take simple things and solve complex problems.

When the family is visiting Brian in the slammer, Lois tells Peter to stop staring at a female dog pressing herself against the glass for Brian's cellmate.
This is a reference to a similar scene from the 1978 movie “Midnight Express”

Brian's copy of “Barely Legal Bitches” is a take off of the real life porn magazine “Barely Legal”

Peter: “He's mental for those Snausages”

Snausages are a type of dog treat comprised of small pieces that resemble miniature "pigs in blankets"

Peter: “Quiet, Murder She Wrote”

“Murder, She Wrote” (1984-1996) was a CBS drama that starred Angela Lansbury