Gary Cole voices Mike Brady, which is who he played in the two Brady Bunch movies.

This is the first episode where Stewie says Peter.

Smurf 1: Hey, you have a good time last night?
Smurf 2: Smurf-tacular.
Smurf 1: Yeah I saw you leave with Smurfette.
Smurf 2: Oh man. As soon as we got out of the bar, she started smurfin' me.
Smurf 1: Shut the smurf up!
Smurf 2: Yeah!
Smurf 1: Right in the smurfin' parking lot?
Smurf 2: Smurf yeah!
Smurf 1: Ah, that is freakin smurf.
Smurf 2: You smurfed it.
Smurf 1: That is freakin smurf.
Smurf 2: Yeah.

(At a drive through with Lois' pregnant sister.)
Peter: I'll have 3 cheeseburgers...
Lois: For god sakes Peter, she's having a baby!
Peter: Oh that's right, and a kid's meal.

Lois: You know, I'm not wearing any panties.
Peter: Don't worry. We can always throw that chair out.

Stewie: All this work keeping people from having sex! Now i know how the Catholic church feels. BA-ZING!

Brian: Insert Rod A into Rod Support B.
Peter: That's what she--
Brian: If you say 'that's what she said' one more time I'm gonna pop you.

Stewie: Let's see, soda, purple stuff...Sunny D, alright!

Stewie: Another baby? But, but I'm the baby. Why the deuce would they want to replace me? My, my cheeks are pinchable, my bottom is smooth, my laugh is heartwarming. Aha ha ha ha ho ho ho! What's that? I certainly am not overreacting! What the devil do you think happened to Bobby when they added cousin Oliver to the Brady bunch?
(Cut to the Brady family sitting around the table)
Mom: Oliver, did you break this vase?
Oliver: No the floor did (the family all laughs)
Boy: He's so cute.
(Bobby emerges from a door)
Bobby: Hey everybody I...
Dad: Bobby, you get back in the garage! (Thrusts end of broom into Bobby.)
Bobby: Ow, ow!

Lois: Nurse this woman is in labor!
Mayor Adam West: Excuse me, I was here first... My leg is asleep!!!

Stewie: Hey, you know what today is? A bad day to be a sperm!

Quagmire: If I could change the alphabet I would put 'U' and 'I' together.

After Stewie shoots Peter's duodenum with his phasers, Peter runs to the bathroom to go #2. But, when he exits the bathroom it has moved to the left of the frame (from it's original right).

Carol's baby seems to have been born without an umbibical cord.

We see Glen's bedroom has mirrored ceilings, but the two paintings on the walls aren't reflected in the mirrors.

When Stewie walks in and says “ahh baby books”, there's a green, orange and blue book on the floor w/ the blue book's cover reading “Stewie's Baby Book”, but when the scene chances to him looking up at Lois the cover of the blue book is blank and switches back to “Stewie's Baby Book” when Peter says, “you're gonna have a baby brother buddy”

Stewies Helmet

When Stewie is inside Peter, the part where Stewie is shooting down the sperm is a joke on "Star Wars". You can tell because the helmets they are wearing are the helmets that space fighter pilots wore in "Star Wars".

Stewie: Let's see, we've got soda, purple stuff, oh Sunny D, all right!

Sunny Delight is a famous brand of orange drink. The line "Sunny D, alright!" was used on many of the commercials.

Quagmire: Well, in accordance with Megan's Law I am required to inform you that, uhh... you know what, that's fine, I'll take the kids.

Megan's Law states that known sex offenders must inform their neighbors of their past upon moving into the neighborhood.

Emission Impossible

An obvious reference to the famous "Mission Impossible" movie.

This is the first time we are introduced to Lois' sister, Carol, and the last time we see her aside from a childhood Christmas photo in “Fat Guy Strangler”. She doesn't appear again until “Brothers & Sisters”, although she is mentioned in the episode, “Boys Do Cry”