This episode drew 8,198,000 viewers & was FOX's #5 show for the week

The flashback of the convention featuring William Shatner and Peter's line “In that episode where you drown your wife. Why are you so fat?” was a deleted scene from the 2006 episode “Deep Throats”

Also, the cutaway did not appear on the [adult swim] airing, it only aired on FOX.

Stewie: Brian look, I purchased authentic blueprints to build a Star Trek transporter.
Brian: Well that's great Stewie. You should get William Shatner to sign them for you.
Stewie: No way, I'm getting Patrick Stewart to sign it. Picard has it all over Kirk. He's poised & measured & doesn't wear a cheap rug.
Rather he accepts even baldness w/ a quiet cool that says I am in command, you are safe with me, I will cradle you in my arms through any crisis in any galaxy.
Brian: Are you queer?
Stewie: Probably

The three books Meg is holding for the book burning are all facing the same way (w/ the pages toward the camera) when she she says the line “What are you talking about, I thought you had seen the light” but when she says “You are not going to turn me from my faith”, the middle book has its spine facing the camera.

Also...

After she says the line “You are not going to turn me from my faith”, she throws the only brown covered book into the fire but after Brian's question & she says “I'm made in his image”, the brown covered book is once again on the stack.

The title for this episode is a take off of the title of the 1989 Don Bluth animated film, “All Dogs Go To Heaven”

The subplot of this episodes revolves around the cast of the TV show “Star Trek: The Next Generation”.
Patrick Stewart, Jonathan Frakes, LeVar Burton, Michael Dorn, Gates McFadden, Marina Sirtis, Brent Spiner, Denise Crosby & Wil Wheaton all appear and provided their own voices.

Peter: “Yeah like that old gypsy did to Britney Spears in that Stephen King book”
Gypsy: {touching Britney's cheek} “Thicker”

Peter is referring to King's novel “Thinner”.
The 1984 novel is about a fat lawyer that accidentally kills a gypsy woman and as punishment her father puts a curse on the lawyer by rubbing his cheek and saying “thinner” causing him to loose weight at an alarming rate.

Peter: “Well it was 1992 & I couldn't be bothered with anything that didn't involve Dan Cortese”

Dan Cortese began his entertainment career on Mtv hosting a extreme sports show called “Mtv Sports” (1992-1996).
He later had acting roles on “Veronica's Closet” (1997-2000) & “Melrose Place” (1995) and other guest spots.

Stewie: “I gotta forward this to my buds”

Stewie's bud is none other then “Calvin” from the long running comic strip “Calvin & Hobbes” (1985-1995) written and illustrated by Bill Watterson

Stewie: “...Jackass number 2”

Stewie is referring to the Johnny Knoxville movie “Jackass Number Two” where Johnny and his friends perform dangerous and gross stunts.

Announcer: “Up next, Kirk Cameron to talk about God”

Allusion to the fact that Kirk Cameron, the former child star of “Growing Pains” (1985-1992) became a born again Christian after his sitcom ended and now spends his time doing Christian tv and movies telling everyone they're going to hell.

Peter: “Dear Lord, please give me the cheat codes for Mike Tyson's Punch Out...”

“Mike Tyson's Punch Out” is a boxing video game for the Nintendo Entertainment System (NES) developed and published by Nintendo in 1987

Denise: “But you're a baby”
Stewie: “Yes that's right Denise Crosby”

Denise getting killed seconds after her arrival in Stewie's transporter is an allusion to the fact her character of Lt. Tasha Yar is killed off three quarters into the first season of “Star Trek: Next Generation” in the episode “Skin of Evil”.

Stewie: “Hey, did you hook up w/ Whoopi Goldberg on the show?”
Patrick: “All the time”

Whoopi Goldberg played the character “Guinan” on “Star Trek: The Next Generation”.
The joke may also be an allusion to the fact the characters Picard and Guinan seemed to have a relationship that went beyond friendship at times.

Brian: “Look at the Hubble Telescope, it's discovered untold wonders of a vast unexplored universe but not one picture of a guy w/ a beard sitting around on a cloud. I mean what's he doing up there?”

The scene after Brian's line is a reference to the 1980 movie “Flash Gordon” w/ God dressed as Flash, complete w/ the title song “Flash” performed by Queen

Peter: “You keep talking like that God's going to get you Brian. Oh God's gonna get you with the Kodak Disc”

Peter sings the commercial jingle for the Kodak Disc camera. The camera was popular from 1982 to 1999. The film was unique consisting of a small disc of film instead of a roll.

Patrick: {smacking Wil's face into the window} “You'll get nothing and like it!”

The same quote is said by the character “Judge Smails” (played by Ted Knight) from the 1980 movie “Caddyshack”

After Brian retrieves the cross that Meg through, she tries to take it from him, but he growls at her. The scene continues until Meg has Brian growl the 1988 song "You Got It (The Right Stuff)" by New Kids on the Block.

Meg: “...so I got his younger brother from Growing Pains”

Jeremy Miller played “Ben Seaver”, Kirk's younger brother from “Growing Pains”.
He retired from acting after “Growing Pains” & despite the joke there's no evidence he was ever involved in drug use of any kind.

Also, the character of “Jason Seaver” (played by Alan Thicke), the father of characters Mike & Ben makes an appearance.

Peter: “You know who doesn't have all these problems? Marmaduke.”

Peter is referring to the comic strip “Marmaduke”. “Marmaduke” was created by Brad Anderson in 1954 and still continues today.
The strip revolves around the Winslow family and their Great Dane, Marmaduke.

Peter: “...or Howard Huge. Let's get Howard Huge”

“Howard Huge” is a comic strip produced by Bunny Hoest (creator of “The Lockhorns”), which appears in “Parade Magazine”

The bottle of Jägermeister in Brian's hallucination, with a German accent, says, "Get to the chopper." The line is a reference to Arnold Schwarzenegger's line from the 1987 movie “Predator”

Michael: “For mine put Dirk Diggler”

Michael Dorn wants to use the name of Mark Wahlberg's porn star character from 1997's “Boogie Nights”

During the book burning Meg throws in the titles, “Origin of the Species” by Charles Darwin, “A Brief History of Time” by Stephen Hawkings & the fictitious title “Logic for First Graders”

Stewie says Wil Weaton's name with a misplaced 'H' sound (Whil Wheaton).
Patrick & Stewie have the same discussion on Stewie's pronunciation of Wil's name as Stewie and Brian & Brian and Meg did in “Barely Legal” and Stewie and New Brian did in “The Man w/ Two Brians”