The cast rehearsed this episode by videotaping each other's performances as the characters and then recreating the relevant mannerisms.
The unsung star of the episode was ADR (Additional Dialog Recording) Engineer Angus Robertson who spent hours witch each actor ensuring that the performances matched.
When they attended their first ComicCon after the filming of Season 1, David Kemper asked Claudia Black what she thought Crichton would do if he were in Aeryn's body.
Ian Watson didn't consider the Halosians to be a deliberate tribute to the Skeksis in Jim Henson's 1982 movie The Dark Crystal, although he agrees that every episode of Farscape pays homage to some film.
The original intention was for everyone to be overdubbed with the voice of the actor who normally played the character, but Ian Watson overruled that, because he felt that the swapping would be more effective if the actors themselves were heard.
Jonathan Hardy joked that Ben Browder's version of Rygel was like the famous English actor, Sir John Gielgud.
Writer Michael Cassutt had worked with both Rockne S. O'Bannon and David Kemper on TV's The Twilight Zone in 1985.
The photos fixed to everyone's fronts were an addition to the script by director Ian Watson and provided yet another use for the versatile DRDs.
"Out of Their Minds" is also the title of a novel by science fiction author Clifford Simak and one of writer Michael Cassutt's favorite books.
In response to numerous comments about the title, Cassutt agrees that it should be "Out of Their Bodies", but the original title stuck.