Reformed thief Cade Foster discovers that aliens are among us in the form of genetic clones, intent on enslaving the population. To assess the human potential to fight back, they gather data from 117 test subjects. When Foster remembers the tests conducted on him, the aliens frame him for his wife's murder. Pursued by police, aliens, and mysterious government agents, Foster discovers the lost quatrains of Nostradamus. The quatrains tell of three waves which will destroy the planet, unless a "twice blessed man" can stop them. Aided by quirky cyber-journalist - Crazy Eddie, Foster investigates strange occurrences which have ties to Nostradamus' quatrains, hoping to find what he needs to forestall the aliens' plans.
Mabus attempts to control the minds of Foster, Eddie, Jordan and Joshua in order to fulfill the requirements necessary to initiate the Second Wave. Meanwhile, the four allies must try and escape from the asylum they have been assigned to