Melinda gives birth to a baby boy who has inherited her gift of seeing spirits. However, the baby has one important difference in gift which will have extreme consequences.
Melinda looks into a chain email that appears to be preying on the citizens of Grandview.
Eli's father has a heart attack, leading to a reunion with Eli's mother who has been dead for ten years but unable to cross over.
A haunting at a hospital morgue is investigated by Melinda, and the case involves the death of a surgeon.
Eli's patient believes he is being followed by the ghost of his sister, which leads Melinda to help him. Meanwhile, Melinda and Jim begin to worry about Aiden when she talks about the patient's friends, who aren't ghosts, rather something darker.
The Headless Horseman from the ''Legend of Sleepy Hollow,'' is haunting Melinda. But after the book appears at Aiden's school, she fears Aiden's safety is at stake.
When a medical student goes missing, Jim is led to believe that he is somehow involved, especially after his fellow professors aren't alarmed by a paranormal occurrence. Meanwhile, Aiden continues to mention being afraid of "the shadows."
Melinda gets herself involved in a murder mystery when a ghost leads her to a real estate agent's body.
Aiden becomes friends with the ghost of a little girl who passed away from leukemia, but when the ghost threatens Melinda, she begins to worry about her son.
Melinda believes that the death of a high school student wasn't the accident that the police made it out to be.
When a Grandview radio station airs secrets about a man, the man later dies and his ghost sets out for revenge.
A new family in town threatens to tear apart Melinda's family, which sets her out on a mission to uncover the truth about her new neighbors.
Melinda uncovers a family secret as a ghost haunts the local hospital as well as the town.
When a Ouija board is used in order to solve a mystery where Ned's Occult Anthropology professor is stalked by a secret admirer's ghost, the board instead creates a new one that results in a life being threatened.
A ghost who knows of a hidden munitions dump with unexploded bombs confides in Melinda that one of those bombs is missing and in the wrong hands, warning that someone will lose their life.
A routine estate sale lands Melinda in the center of dark forces battling for the soul of a little girl ("Cassidy") who's been trapped in a violently haunted house for years.
When comic book artist Damon Weaver begins drawing his own run-ins with ghosts before they happen, it is up to Melinda and Avery (Margaret Cho) to discover the secrets behind his art
When the ghost of a private investigator starts haunting Melinda's house, she and Eli look for answers in the investigator's final case.
Aiden is in danger; Melinda investigates the life of an angry murder victim.
When a fun night out turns dangerous for three teens, Melinda investigates an unsolved kidnapping that may put her in more danger than she anticipated
When the ghost Melinda is trying to help suddenly turns up alive, she finds herself in the middle of a dangerous revenge plot and battling enemies she was unaware she had
Melinda's investigation of a poltergeist in the hospital leads to a showdown with supernatural forces terrorizing her and her son, on GHOST WHISPERER, Friday, May 21 (8:00-9:00 PM, ET/PT) on the CBS Television Network.