| Name (Sort) | Character (Sort) | |
| •Blake Lively | played | Serena van der Woodsen (95Eps.) |
| •Leighton Meester | played | Blair Waldorf (95Eps.) |
| •Penn Badgley | played | Daniel 'Dan' Humphrey (95Eps.) |
| •Chace Crawford | played | Nathaniel 'Nate' Archibald (91Eps.) |
| •Taylor Momsen | played | Jenny Humphrey (S01-S04) (79Eps.) |
| •Ed Westwick | played | Charles 'Chuck' Bass (91Eps.) |
| •Jessica Szohr | played | Vanessa Abrams (episode 14-87, recurring previously) (59Eps.) |
| •Kaylee Defer | played | Ivy Dickens (S05+; recurring previously) (3Eps.) |
| •Kelly Rutherford | played | Lillian 'Lily' Humphrey (83Eps.) |
| •Matthew Settle | played | Rufus Humphrey (91Eps.) |
| •Kristen Bell | voiced | Gossip Girl (uncredited) (95Eps.) |