In the 10th-season opener, mudslide victims arrive in the ER. Meanwhile, Meredith faces a tough choice; Callie deals with Arizona's unfaithfulness; and Richard's life is in jeopardy.
Songs: The Belle Game -- Tradition
The staff continue to assist mudslide victims. Meanwhile, Callie comes to a decision about her relationship; and tragic news brings the doctors together.
Songs: Banks -- Before I Ever Met You, Laura Welsh -- Cold Front, Elliphant -- Down on Life, Katie Herzig -- Lie Or Lie Awake, Rudimental feat. Emeli Sandé -- More Than Anything, B.o.B. -- So Good
Meredith and Derek feel torn about work as they stay home with their newborn son. Elsewhere, Arizona attempts to repair her marriage; Alex and Jo adjust to being a couple; Owen and Jackson disagree about finances; and April awaits crucial test results.
Songs: Garrison Starr & AG -- All Fall Down, C2C -- Because of You (feat. Pigeon John), Kendrick Lamar -- Swimming Pool's (Drank), Max Frost -- White Lies, John Legend -- You & I (Nobody In the World)
The hospital holds a fund-raising event, which takes on a competitive twist thanks to Jackson. Meanwhile, Bailey treats some demanding patients; Shane and Stephanie attempt to manage a chaotic ER on their own; and Alex exposes his vulnerable side to Jo.
Meredith struggles to balance her work with motherhood. Elsewhere, Stephanie strives to impress Jackson's mother; Jo gets too attached to a patient; and Callie and Owen get wrapped up in an emotional dilemma concerning a patient.
Guest Stars: Taja V. Simpson
as Samantha Calder (Patient: Heart and Liver Transplant) | Debbie Allen
as Dr. Catherine Avery (Dr. Jackson Avery's Mother, Webber's Girlfriend) | Rick Gifford
as Davis Calder (Husband of Patient Samantha Calder) | Treva Tegtmeier
as Doris Samuels (Wife of Patient Mr. Samuels) | Jason Antoon
as Mr. Samuels (Patient: Put His Penis in Hornets Nest) | James Remar
as James Evans (Patient: Dr. Alex Karev's Father) |
Derek and Callie team up for a brain-mapping project while Meredith contemplates continuing her mom's research. Elsewhere, Richard proposes that his physical condition be used as a learning tool; and feelings of guilt about Heather's death plague Shane.
Guest Stars: Marguerite Moreau
as Dr. Emma Marling (Maternal Fetal Medicine Surgeon from Seattle Pres.) | Jere Burns
as Ben Bosco (Patient: Heart Tumour) | Annie Potts
as Joyce Bosco (Wife of Patient Ben Bosco) | James Remar
as James Evans (Dr. Alex Karev's Father) |
It's Halloween and the doctors of Grey Sloan Memorial are hit with a barrage of spooky patients, which affects their own plans and puts one doctor’s well-being in jeopardy. Meanwhile, Derek collaborates with Ben on a new surgical technique, and Richard angers Bailey when he asks a second year resident to perform his next surgery.
A betrayal intensifies the issues between Cristina and Meredith; Matthew and April make a decision about their relationship; Bailey faces difficulties with Ben's return.
Guest Stars: Marty Ryan
as Zach Mischer (Husband of Patient Duncan) | Marguerite Moreau
as Dr. Emma Marling (Owen's Girlfriend, Maternal Fetal Medicine Surgeon) | Martinez
as Don Glazier (Father of Infant Heart Patient Nathan) | Lainie Kazan
as CJ (Patient: In The Room Next To Dr. Webber) | Evan Crooks
as Will Swanson (Patient: Liver Sarcoma) | Lou Carbonneau (1)
as Harvey (Patient: Hemifacial Spasm) | Sean Abbott
as Reverend Drew (Gives April and Matthew's Compatibility Test) | Justin Bruening
as Matthew Taylor (Dr. April Kepner's Fiance) | Jason Winston George
as Dr. Ben Warren (Dr. Bailey's Husband, Anesthesiologist) |
The issues between Meredith and Cristina hit a boiling point when one of them ultimately betrays the other at the hospital. Derek tells Jackson that he needs to let go and allow the second year doctors to work on his patients, and April and Matthew make a bold decision about their relationship. Meanwhile, Bailey has difficulties with Ben’s return.
Ben regrets a conversation he had with Derek, fearing it may lead to problems for Bailey. Elsewhere, Cristina finds a friend in Shane; April's wedding plans cause awkwardness for others; and Meredith decides to host Thanksgiving dinner.
April’s sisters arrive to help celebrate April’s upcoming nuptials and quickly get on her nerves. Matthew and Jackson are forced to work together when they witness a terrible accident. Callie and Arizona work hard to reestablish their relationship and Cristina is pressured to live stream an upcoming surgery. Meanwhile, a familiar face returns to the hospital.
Guest Stars: Emily Happe
as Libby Kepner (Dr. April Kepner's Sister) | Grace Bannon
as Alice Kepner (Dr. April Kepner's Sister) | Elizabeth Bond
as Kimmie Kepner (Dr. April Kepner's Sister) | Jeremiah Birkett
as John McMurdo (Husband of Patient Becca McMurdo) | Justin Bruening
as Matthew Taylor (Dr. April Kepner's Fiance) | Tracy Vilar
as Becca McMurdo (Patient: In Derek and Callie's Brain Mapping Trial) | Illeana Douglas
as Dr. Alma (Dr. Miranda Bailey's Psychiatric Doctor) | James Remar
as James Evans (Patient: Dr. Alex Karev's Father) |
On the day of April's wedding, the Grey Sloan Memorial doctors are all preoccupied with their own drama. Meredith and Cristina continue to argue about their research and careers, Bailey comes clean to Ben about her feelings regarding him moving back to Seattle, and Shane puts himself in a risky situation.
Meanwhile, Derek gets a phone call that will change his life.