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Grey's Anatomy
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« Season 1   Settings    All Season (Printable Guide) Season 5 »
S-1 | S-2 | S-3 | S-4 | S-5 | All

Season 1
1 :01x01 - A Hard Day's Night (Mar/27/2005)
On the morning of her first day as a surgical intern at Seattle Grace Hospital, Meredith Grey is running late as she recovers from a one-night stand and prepares for her first day. Meredith quickly befriends George O'Malley, who's quirky, yet lovable, Cristina Yang, a highly competitive woman, and Izzie Stevens, a model turned surgical intern. Each of the new interns get assigned to Dr. Miranda Bailey, who past interns have dubbed "the Nazi".

Meredith's first patient, a young beauty pageant contestant, recently began having severe, life-threatening seizures and Meredith uncovers that she'll need brain surgery to save her life. However, things take a turn when the neurosurgeon, Dr. Derek Shepard, happens to be Meredith's one-night stand. He wants their brief relationship to progress into something more, but Meredith is firm on her stance - their relationship should remain strictly professional.
Guest Stars: Randall Arney as Mr. Bryce, Martin Ighani as Rectal Exam Patient, Skyler Shaye as Katie Bryce, | Co-Guest Stars: Robbie Troy as Ms. Bryce, David Vegh as Tony Savitch, Laura Carson as Gloria Savitch, Moe Irvin as Tyler Christian, Sendhil Ramamurthy as Intern #2, Lynne Marie Stewart as Nurse, Sean Palmer as Intern #3, Richard Gilbert-Hill (2) as Small Town Doc, Grinnell Morris as Intern #4, Kathleen M. Darcy as Anesthesiologist, Brad Pennington as Radiologist, Noelle McCutchen as Nurse #2, Josh Bywater as Intern #1, Gregory Erff as Mr. Jones, Billy Wood as Senior Resident
Director: Peter Horton
Writer: Shonda Rhimes
 
2 :01x02 - The First Cut Is the Deepest (Apr/03/2005)
The surgical staff tries to stay positive when a young woman, despite brain surgery, is clinging to life after a brutal attempted rape. Meanwhile, Meredith risks her spot in the intern program when she crosses the line in order to save a newborn suffering from a undiagnosed heart condition. The other interns learn that in order to be a good surgeon and doctor, much more than medial knowledge is needed.
Guest Stars: Kate Burton as Ellis Grey, | Co-Guest Stars: Alice Lo as Qing Lu, Robin Pearson Rose as Patricia, Kristy Munden as Trauma Nurse, Scott Michael Morgan (1) as Patient #2, Sonia Jackson as Patient #1, Kerri Higuchi as Pediatrics Intern, Walter Wong as Tech, Scarlett Lam as Ahn, Kerry Carney as Intern #1, Dennis Gubbins as Paul, Stacey Hinnen as Mr. Johnson, Elise Robertson as Ms. Johnson, Alex Thayer as Allison, Jeff Marlow as Drunk Man, Kylie Dragna as Ellen Parkins, Shannon Burwell as Crying Patient, Gary Kraus (1) as Louis Cardon, Stephen Blackehart as Vic, Cindy Drummond as Louis' Wife, Helen McCardle (1) as ER Doc (as Helene McCardle), Chip Keyes as Big Man, Andre Panossian as Code Team Leader, Patricia Harris-Smith as Patient's Wife, Debra Holt as Big Man's Wife, Nate Reese as Father of Patient #1, Joan McCrea as Louis' Wife's Mother, Linda Nile as Louis' Wife's Sister
Director: Peter Horton
Writer: Shonda Rhimes
 
3 :01x03 - Winning a Battle, Losing the War (Apr/10/2005)
On the day of a bike race, injured individuals flood into the hospital, including a pedestrian who is left brain dead. Seeing that he has no chance of ever waking up, Cristina and Izzie wish to use his organs for organ donation, but find that the process is an emotional one. George gets assigned to Mack, a good friend of Chief Webber, and constantly flirts with George. Meanwhile, Meredith continues to try to distance herself from Derek and is forced to deal with Alex's big ego, but through the day, Meredith begins to realize the key to winning the battle.
Guest Stars: Callum Blue as Viper, Keith David as Lloyd Mackie, | Co-Guest Stars: Kristy Munden as Trauma Nurse (Kristy L. Munden), Kathleen M. Darcy as Anesthesiologist, Dinah Lee as Grungy Chick, Kelsy Kemper as Shelley's Daughter, Rudolph McCollum as Vipor's Male Friend, Claire Lautier as Shelly, Steven W. Bailey (1) as Jeremy, Zina Zaflow as Nurse
Director: Tony Goldwyn
Writer: Shonda Rhimes
 
4 :01x04 - No Man's Land (Apr/17/2005)
While George begins to feel that he's loosing his masculinity due to Izzie and Meredith treating him like a sister, Izzie's newest patient may loose his masculinity to prostate cancer. Cristina assigns herself to a sick woman, who she believes will need surgery, but ends up learning more from the woman then standing in on a surgery would ever give her. Meredith faces the reality of her mother's Alzheimer's when Derek treats a patient with nails in his brain. Meanwhile, Alex tapes up pictures of Izzie's racy spread all over the locker room.
Guest Stars: Anna Maria Horsford as Nurse Liz Fallon, F. J. Rio as Jorge Cruz, Valerie Cruz as Zona Cruz, Kate Burton as Ellis Grey, Taylor Nichols as Rick Humphrey, | Co-Guest Stars: Tom Choi as Flouroscope Tech, Chris Hendrie as Dr. Harry Victor, Helen McCardle (1) as ER Doc, Jack Merrill as Radiology Tech #2, John O'Brien (1) as Radiology Tech #1, Moe Irvin as Tyler, | Uncredited: Linda Klein as Medical Technician
Director: Adam Davidson
Writer: James D. Parriott
 
5 :01x05 - Shake Your Groove Thing (Apr/24/2005)
Meredith realizes the responsibility of adulthood when her mother has to sign all of her assets over to her. Izzie decides to throw a party for her boyfriend, Hank, and the scale of the party, which Meredith is unaware of, increases throughout the day. After popping a glove during a heart surgery, Meredith fears that she damaged the patient's heart and has to face a meeting with the chief and lawyers who will determine her future as a doctor. Meanwhile, sparks start to fly between Cristina and Burke, and Meredith and Derek's relationship is exposed when Bailey catches them together at the party.
Guest Stars: Brent Sexton as Jerry Frost, Kathryn Joosten as Mrs. Drake, Barry Shabaka Henley as Mr. Patterson, Kate Burton as Ellis Grey, Jonathan Scarfe as Hank, | Co-Guest Stars: Moe Irvin as Tyler, Kate Forster as Jane Richie, Vladimir Rajcic as Resident Doctor, Jeff Doucette as Warren Sterman, Steven W. Bailey (1) as Anesthesiologist Jeremy, Jane Morris as Ms. Goff, Andre Panossian as Perfusionist
Director: John David Coles
Writer: Ann Lewis Hamilton (3)
 
6 :01x06 - If Tomorrow Never Comes (May/01/2005)
The interns are speechless when a woman comes in with a large, record-breaking tumor, but unfortunately for the woman, her outlook isn't good. Derek and Meredith's jobs are at risk now that Bailey knows about their relationship, and Dr. Bailey makes it clear that Derek better not give Meredith special treatment. Meanwhile, Izzie urges George to ask Meredith out, and Cristina and Burke's relationship continues to progress.
Guest Stars: Bruce Weitz as Mr. Levangie, Jane Galloway Heitz (1) as Annie's Mother, Alex Alexander (1) as Annie Connors (as Alex S. Alexander), Lara Phillips as Mary Levangie, | Co-Guest Stars: Linda Klein as Nurse, Brad Pennington as Radiologist, Moe Irvin as Tyler Christian, Steven W. Bailey (1) as Anesthesiologist, Sean Palmer as Intern, Patricia Bethune as Older Nurse, Yvonne Farrow as Heart Patient's Wife, John O'Brien (1) as CT Tech, Yolanda Snowball as Physical Therapist, Walter Wong as Echo Tech, Noelle McCutchen as Cardiac Nurse, Sharmila Devar as Female Intern
Director: Scott Brazil
Writer: Krista Vernoff
 
7 :01x07 - The Self Destruct Button (May/08/2005)
Derek and Meredith try to spend a night together at Meredith's, but their appearance the next morning does more harm than they expected and leads Bailey to tell Meredith to end it. Alex treats a self-mutilation patient, while Izzie's patient literally won't let go of his girlfriend. Meanwhile, George is suspicious that an anesthesiologist is drinking on the job and Cristina fills ill with flu-like symptoms.
Guest Stars: Russell Hornsby as Digby Owens, Ever Carradine (1) as Athena, Kim Morgan Greene as Mrs. Rice, Amanda MacDonald as Claire Rice, | Co-Guest Stars: Shenita Moore (1) as Surgical Nurse, Sarah Utterback as Nurse Olivia, Rebecca Rogers as Jamie Hayes, Vanessa Rogers as Jamie Hayes, Joseph Kell as Mr. Rice, Regan Forman as Gwen Hayes, Bill Birch as J.P., Larry Cahn as Dr. Taylor, Doug Sinclair as Brett Hayes, Steve Monroe (1) as Orderly
Director: Darnell Martin (1)
Writer: Kip Koenig
 
8 :01x08 - Save Me (May/15/2005)
The interns treat a patient who, after a series of seizures, thinks he's gained psychic abilities. Meredith becomes dissatisfied with her relationship with Derek when she realizes that she knows nothing about his personal life. Alex treats a patient whose religion interferes with her recovery; Izzie debates whether or not to reconnect with her mother; and Cristina's patient disagrees with her medical advice.
Guest Stars: Joan McMurtrey as Zoey Glass, Kevin Rahm as Mr. Duff - Psychic Guy, Sarah Hagan as Devo Friedman, Josh Stamberg as Tommy Walker, | Co-Guest Stars: Steven W. Bailey (1) as Anesthesiologist Jeremy, Anjul Nigam as Psych Intern, Sarah Utterback as Nurse Olivia, Ping Wu as Seymour Glass, Charles Walker as Dr. Chesney, Chad Einbinder as Sam Friedman, Lisa Kaminir as Doris Friedman, Kathleen Bailey (1) as Reproductive Counselor, Darlene Kegan as Ruby Walker
Director: Sarah Pia Anderson (1)
Writer: Mimi Schmir
 
9 :01x09 - Who's Zoomin' Who? (May/22/2005)
When an STD breaks out, affecting several members of the staff, Webber calls a staff meeting. Later, the chief confides in Derek about his own medical concerns. Izzie and Cristina become stressed when a patient's wife and daughter can't decide on his care. Burke treats an old college friend, Bill, but his diagnosis creates questions about his wife. As Meredith and Derek continue to get closer, their relationship crashes down around them when a person from Derek's past shows up in his life.
Guest Stars: Wendy Davis as Holly Adams, Lauren Bowles as Alice Franklin, Kate Walsh as Addison Montgomery-Shepherd, Wayne Wilderson as Bill Adams, | Co-Guest Stars: Patricia McCormack (1) as Rebecca Franklin (as Patty McCormack), Catherine Dao as Dr. Knox, Sarah Utterback as Nurse Olivia, Joyce Guy as Ms. Henry, Jack Merrill as Lab Tech, Robin Pearson Rose as Patricia, Jack Shearer as Jordan Franklin
Director: Wendey Stanzler
Writer: Gabrielle Stanton, Harry Werksman
 

Season 2
Recap Special: Straight to the Heart (Jan/08/2006)
See how it all began ...

Straight to the Heart re-examines the lives of the five interns and their past relationships, both personal and professional.
Guest Stars: Steven W. Bailey (1) as Narrator
 
10 :02x01 - Raindrops Keep Falling On My Head (Sep/25/2005)
While off from work, Meredith and Cristina discuss their mutual man problems and are interrupted when Joe, the bartender, collapses. While Webber recovers from his surgery, he appoints one of the surgeons as interim chief, but has George report to him all the happenings at the hospital. While Meredith learns more about Derek and Addison's past relationship, Cristina tries to decide what to do in her relationship with Burke.
Special Guest Stars: Kate Walsh as Addison Montgomery-Shepherd, | Guest Stars: Steven W. Bailey (1) as Joe, Wendy Gazelle as Julie Phillips, | Co-Guest Stars: Jeremy Rabb as Resident, Linda Klein as Scrub Nurse, Noelle McCutchen as Nurse Vivian, Robin Pearson Rose as Patricia, | Uncredited: Tracey Evans (1) as Donor Woman
Director: Peter Horton
Writer: Stacy McKee
 
11 :02x02 - Enough Is Enough (No More Tears) (Oct/02/2005)

View Trailer
A family arrives at Seattle Grace after a car accident. While treating the members of the family, Alex discovers that their problems are deeper than their injuries. Meanwhile, Mrs. Webber admits her marital worries to Richard as he recovers.
Special Guest Stars: Kate Walsh as Addison Montgomery-Shepherd, | Guest Stars: Sarah Utterback as Nurse Olivia, Loretta Devine as Mrs. Webber, Scott Michael Campbell (1) as Mr. Hubble, Lukas Behnken as Scott Seibert, Romy Rosemont as Lea Seibert, | Co-Guest Stars: Linda Klein as Nurse, Jeremy Rabb as ER Resident, Seth Adams as Radiologist, Jim Gleason (3) as Dr. Domner, Yvette Cruise as Scrub Nurse, Johanna McKay as Grieving Widow, Robin Pearson Rose as Patricia, John Cappon as Paramedic #1, David Haley as Paramedic #2, Peter Birkenhead as Dr. Orsen
Director: Peter Horton
Writer: James D. Parriott
 
12 :02x03 - Make Me Lose Control (Oct/09/2005)

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Meredith's secrets about the state of her mother, Ellis Grey, are revealed to the staff when Ellis is brought in for surgery. Meanwhile, secrets about Cristina's health are also revealed.
Special Guest Stars: Kate Walsh as Addison Montgomery-Shepherd, | Guest Stars: Kate Burton as Ellis Grey, Angela Goethals as Kelly, | Co-Guest Stars: Jeremy Rabb as Resident #1, Linda Klein as Scrub Nurse, Noelle McCutchen as Nurse Vivian, Stephen Breithaupt as Mr. Geston, John O'Brien (1) as Lab Technician
Director: Adam Davidson
Writer: Krista Vernoff
 
13 :02x04 - Deny, Deny, Deny (Oct/16/2005)
While trying to recover, Cristina proves to be a difficult patient, and matters are made worse when her mother visits. Ellis Grey, Meredith's mother also proves to be a difficult patient when she has the staff running in circles to please her. Derek and Meredith's relationship remains in limbo when Addison's departure is postponed when she becomes involved with the treatment of a cystic fibrosis patient.
Special Guest Stars: Kate Walsh as Addison Montgomery-Shepherd, | Guest Stars: Kate Burton as Ellis Grey, Steven W. Bailey (1) as Joe, Tsai Chin as Helen, Lee Garlington as Farah Linden, Don McManus as Samuel Linden, Katherine La Nasa as Kalpana Vera, Thomas Ian Nicholas as Jeremiah Tate, | Co-Guest Stars: Kathleen M. Darcy as Anesthesiologist, Moe Irvin as Nurse Tyler, Don Wilson (1) as Radiology Tech, Linda Eve Miller (1) as ER Nurse, Noelle McCutchen as Nurse Vivian
Director: Wendey Stanzler
Writer: Zoanne Clack
 
14 :02x05 - Bring The Pain (Oct/23/2005)

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Meredith and Derek have to use more than their medical knowledge when a woman's strictly religious father forbids her from having an operation that would save her life. Meanwhile, George and Alex are forced to perform a surgery in scarce conditions, and Derek is forced to decide between Addison and Meredith.
Special Guest Stars: Kate Walsh as Addison Montgomery-Shepherd, | Guest Stars: Steven W. Bailey (1) as Joe, Mimi Kennedy as Verna Bradley, François Chao as Mr. Chue, Brent Briscoe as Henry Lamott, Michelle Krusiec as Anna Chue, Daniel Bess as Pete Willoughby, Kate Burton as Ellis Grey, | Co-Guest Stars: Jeremy Rabb as ER Resident, Bashir Salahuddin as Bailey's Husband, Sally Ann Brooks as Marie Lamott, Sean Moran as Lou Bradley
Director: Mark Tinker
Writer: Shonda Rhimes
 
15 :02x06 - Into You Like A Train (Oct/30/2005)

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Meredith temporarily forgets her worries about Derek's decision when a train crash results in dozens of injuries. Later, Addison sees potential in Izzie, but Izzie is forced to choose between her friendship with Meredith or her career.
Special Guest Stars: Kate Walsh as Addison Montgomery-Shepherd, | Guest Stars: Steven W. Bailey (1) as Joe, Cynthia Ettinger as Jana, Juliette Jeffers as Mary, Michelle Arthur as Brooke, Monica Keena as Bonnie, Bruce A. Young (1) as Tom, Kim Whitley as Yvonne (as Kym Whitley), | Co-Guest Stars: Linda Klein as Nurse, Chad Fisk as Med Tech #2, Brooke Blanchard as Jill the Paramedic, Michael Barreta as Danny, Derick Alexander as Lab Tech, Rigo Sanchez as Stan the Paramedic, Marty Lodge as Anesthesiologist, Ariel Felix as Intern #1, Ray Ford as Paramedic, Karen Lew (1) as Dr. Hoffman, Yvette Cruise as Scrub Nurse, Kerry Carney as Intern #2, Patricia Bethune as Nurse Ginger, Moe Irvin as Nurse Tyler, Robin Pearson Rose as Patricia
Director: Jeff Melman
Writer: Krista Vernoff
 
16 :02x07 - Something to Talk About (Nov/06/2005)

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The entire staff is in awe when a patient, Shane, comes in with a hysterical pregnancy while Cristina, Izzie and Meredith aggressively work on his unique case. Meanwhile, Alex is encouraged to show his feelings for Izzie after treating a young, sheltered young patient.
Guest Stars: Steven W. Bailey (1) as Joe, Francis Guinan as Mr. Verma, Elaine Kagan as Mrs. Griswold, Tyrees Allen as Dr. Saltzman, Patti Yasutake as Mrs. Verma, Michelle Ongkingco as Nicole Verma, Joe Sikora as Shane, Reni Santoni as Mr. Griswold, | Co-Guest Stars: Gianin Loffler as Psych Patient #2, Keeshan Giles as Intern #3, Peyton Hinson as Intern #2, Larry Weissman as Psych Patient #1, Maile Flanagan as Tech, Kerry Carney as Intern #1, Cathy Lind Hayes (3) as Debbie, Moe Irvin as Nurse Tyler, Alison Ward as Tina Herman
Director: Adam Davidson
Writer: Stacy McKee
 
17 :02x08 - Let It Be (Nov/13/2005)

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Friends of Derek and Addison come to Seattle Grace for preemptive surgery to avoid breast and ovarian cancer. But the arrival of their friends tests Derek and Addison's professional relationship. Meanwhile, George treats a patient who fell five stories and is dissatisfied with his outcome and Cristina and Burke attempt a "normal" date.
Guest Stars: Arija Bareikis as Savannah, Janet Rotblatt as Esme, Joseph Lyle Taylor as Weiss, Geoffrey Rivas as Stu, Brittany Ishibashi as Talia, Shelley Berman as Jed, | Co-Guest Stars: Linda Klein as Nurse, Kate Blumberg as Daisy, Brian Reid as Waiter, Ray Ford as Paramedic, Kathleen M. Darcy as Anesthesiologist, Kai Lennox as Speed
Director: Lesli Linka Glatter
Writer: Mimi Schmir
 
18 :02x09 - Thanks for the Memories (Nov/20/2005)

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Thanksgiving proves to be a difficult holiday for both the interns and residents. Izzie plans a big dinner, but it doesn't look like all the invited guests will show up. Meanwhile, George participates in the O'Malley turkey hunting tradition, which abruptly ends after a shooting accident and Meredith treats a comatose patient whose condition might be better than it appears.
Special Guest Stars: Brian Kerwin as Holden McKee, | Guest Stars: Greg Pitts (1) as Jerry O'Malley, Tim Griffin as Ronny O'Malley, Sarah Utterback as Nurse Olivia, Steven W. Bailey (1) as Joe, | Co-Guest Stars: Michael Matthys (1) as Dr. Kent, Gregor Manns (1) as Levi Johnson, Mike Faiola as Guy, Andrew James Allen as Coby McKee, Dee Nelson as Cheryl Leonard, Peter Howard (1) as Hal Leonard, Jack Yang (1) as Walter, | Uncredited: George Dzundza as Harold O'Malley
Director: Michael Dinner
Writer: Shonda Rhimes
 
19 :02x10 - Much Too Much (Nov/27/2005)

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Meredith is horrified when her one-night stand needs treatment after suffering from priapism. Meanwhile, Alex begins to frustrate Izzie and a pregnant woman carrying quintuplets stresses over her high-risk pregnancy.
Guest Stars: Sunkrish Bala as Steve Murphy, Curtis Armstrong as Mr. Martin, Margaret Welsh as Dorie Russell, Sarah Utterback as Nurse Olivia, Robin Pearson Rose as Patricia, Pat Healy as Tom Russell, | Co-Guest Stars: Jon Hershfield as Doyle
Director: Wendy Stanzler
Writer: Gabrielle Stanton, Harry Werksman
 
20 :02x11 - Owner of a Lonely Heart (Dec/04/2005)

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Cristina finds little sympathy for an inmate who purposely endangers her health to get out of serving her term in solitary confinement. Meanwhile, the interns are put in charge of watching the newborn quintuplets, each with varying health concerns; Izzie's frustrations with Alex's shortcomings hit their end; and Derek teaches Izzie an important, yet painful lesson.
Guest Stars: Rosanna Arquette as Constance Ferguson, Timothy Bottoms as Mr. Murphy, Curtis Armstrong as Mr. Martin, Pat Healy as Tom Russell, Margaret Welsh as Dorie Russell, Sarah Utterback as Nurse Olivia, | Co-Guest Stars: Patricia Bethune as Nurse Ginger, Monica Garcia as Peds Nurse, Elaine Kao as NICU Nurse, Brooke Blanchard as Jill the Paramedic, Amie Donegan as NICU Nurse #2
Director: Dan Minahan (1)
Writer: Mark Wilding
 
21 :02x12 - Grandma Got Run Over By a Reindeer (Dec/11/2005)

View Trailer
Burke and Cristina's differences are shown when a young boy needs a transplant but he refuses to get it. Meanwhile, the interns help Alex prepare for his exams when it's revealed that he failed them. Meredith has to re-instill the Christmas spirit in Izzie and Derek refuses to feel festive.
Guest Stars: Rik Deskin as Pedestrian #1, Helen Slater as Mrs. Shelton, Richard Jenik as Jimmy Shelton, Steven W. Bailey (1) as Joe, Robin Pearson Rose as Patricia, Kathe E. Mazur (1) as Mrs. Hasting (as Kathe Mazur), Jenny O'Hara as Mrs. Shelton's Mother, Michael Hyatt (1) as Mariann, Andrew Bilgore as Tim Hasting, C. J. Sanders as Justin, | Co-Guest Stars: Sarah McDermott as Leah, Troy Curvey, Jr. as Priest, Alan Fudge as Ernie, Kathleen M. Darcy as Anesthesiologist, Alex Stamm as Josh, Linda Klein as Scrub Nurse, Savannah McDermott as Jesse, John Cappon as John the Paramedic, Sean McDermott as Jake
Director: Peter Horton
Writer: Krista Vernoff
 
22 :02x13 - Begin the Begin (Jan/15/2006)

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As the new year unfolds, Izzie vows to let Alex's affair go, and it comes easier when she hits it off with Denny Duquette, a heart transplant patient. George treats Bex, a teen hermaphrodite, with a tumor and Alex treats a man who ate his novel after not being pleased with the results. Meanwhile, Derek talks with Meredith's mom, Addison expresses her disgust with Derek's living arrangements, and the residents, especially Cristina, have a hard time dealing with the new work limit.
Guest Stars: Jeffrey Dean Morgan as Denny Duquette, Becca Gardner as Bex, Kate Burton as Ellis Grey, Stephen Spinella as Author, Lauren Tom as Wife, John Prosky as Bex's Father, Shannon Cochran as Bex's Mother, | Co-Guest Stars: Joyce Guy as Administrator, Rob Narita as Anesthesiologist, Linda Klein as Nurse Linda
Director: Jessica Yu (1)
Writer: Kip Koenig
 
23 :02x14 - Tell Me Sweet Little Lies (Jan/22/2006)

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Cristina and Meredith hide the truth about their relationships from each other. George is assigned to discharge an elderly patient who refuses to leave; and Alex learns the fate of his career when the results from his medical exams come in.
Guest Stars: Carole Cook as Mrs. Sophie Larson, Donovan Leitch as Rick Freeark, Nancy Linari as Sophie's Daughter, Robin Pearson Rose as Patricia, | Co-Guest Stars: Cathy Lind Hayes (3) as Nurse Debbie, Jill Holden (1) as Naomi Cline, Christopher Boyer (2) as Tom Cline, John O'Brien (1) as Jeffrey, Ricardo Molina (1) as ID Resident Amir, Rigo Sanchez as Paramedic, Natalie N. Okamoto as Yumi, Kate Anthony as GI Nurse, Yutaka Takeuchi as Kamaji, Tyshawn Bryant as Friend #1
Director: Adam Davidson
Writer: Joan Rater, Tony Phelan
 
24 :02x15 - Break on Through (Jan/29/2006)

View Trailer
When the nurses at Seattle Grace go on strike, the doctors are forced to work without them. While most of the doctors cross the picket line, George refuses to cross due to his union roots. With Bailey on maternity leave, the interns meet their temporary resident, Dr. Sydney Heron, who is the exact opposite of Dr. Bailey, which Cristina has a hard time adjusting to. Meanwhile, secrets from Izzie's past are revealed as she treats a young, pregnant teen; and Meredith makes a mistake in treating an elderly patient.
Guest Stars: Leisha Hailey as Claire Solomon, Kenneth Mitchell as Wade Solomon, Sarah Utterback as Nurse Olivia, Betty Garrett as Eleanor, Rae Allen (1) as Ruth, Monica Calhoun (1) as Shyan's Mother, June Lockhart as Agnes, Kali Rocha as Sydney Heron, Steven W. Bailey (1) as Joe, Regine Nehy as Shyan, Robin Pearson Rose as Patricia, Kate Burton as Ellis Grey, | Co-Guest Stars: Cathy Lind Hayes (3) as Nurse Debbie, Jeremy Rabb as ER Resident, Zibby Allen as Temp Nurse, Kate Anthony as GI Nurse, Donna Hardy as Grace Bickham, Moe Irvin as Nurse Tyler, Amy Cale Peterson (2) as Nurse Home Staffer, Pamela Roylance as Alice Bickham, Teddi Siddall as Anne
Director: David Paymer
Writer: Zoanne Clack
 
25 :02x16 - It's the End of the World (1) (Feb/05/2006)

View Trailer
All morning, Meredith felt like she was in for a bad day. Her fears are realized when a medical case threatens the lives of everyone at Seattle Grace, causing officials to put the hospital on a "code black".
Special Guest Stars: Christina Ricci as Hannah Davies, | Guest Stars: Kyle Chandler as Dylan Young, Sarah Utterback as Nurse Olivia, Larry Clarke (1) as Paul, Jillian Armenante as Mrs. Carlson, Cress Williams as Tucker, | Co-Guest Stars: Marty Lodge as Dr. Milton, Moe Irvin as Nurse Tyler, Cathy Lind Hayes (3) as Nurse Debbie, Kathleen M. Darcy as Anesthesiologist, John Bishop (1) as James Carlson, O. Austen Rey as Bomb Squad #1, Jamal Thomas as Larry the Paramedic
Director: Peter Horton
Writer: Shonda Rhimes
 
26 :02x17 - (As We Know It) (2) (Feb/12/2006)

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Despite the staff doing all they can, the potentially disastrous situation continues to escalate. Meredith begins to panic about her situation, as does Derek when he's told about her circumstances. Meanwhile, while the hospital is in chaos, Bailey and Webber have to deal with their own health issues.
Special Guest Stars: Christina Ricci as Hannah Davies, | Guest Stars: Kyle Chandler as Dylan Young, Loretta Devine as Adele Webber, Jillian Armenante as Mrs. Carlson, Cress Williams as Tucker, | Co-Guest Stars: Cathy Lind Hayes (3) as Nurse Debbie, Kathleen M. Darcy as Anesthesiologist, John Bishop (1) as James Carlson, Scott Lusby as Med Tech
Director: Peter Horton
Writer: Shonda Rhimes
 
27 :02x18 - Yesterday (Feb/19/2006)

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When a person from Derek and Addison's past arrives at Seattle Grace, their now stable relationship is shaken up. Meanwhile, after visiting with her mother, Burke is told Cristina's secret; and after a visit with her mother, Meredith digs to find the family's secrets.
Guest Stars: Kate Burton as Ellis Grey, Eric Dane as Dr. Mark Sloan, Jeff Perry as Thatcher Grey, Steven W. Bailey (1) as Joe, Julio Oscar Mechoso as Chucky Eaton, Arlene Tur as Pamela, Jesse Plemons as Jake Burton, | Co-Guest Stars: Carlos Cervantes as Mr. Calva, Deborah Geffner as Mrs. Burton, David Grant Wright (1) as Mr. Burton, Brooke Blanchard as Jill the Paramedic, Ariel Felix as CT Tech, Chad Fisk as The Anesthesiologist
Director: Rob Corn
Writer: Krista Vernoff, Mimi Schmir
 
28 :02x19 - What Have I Done To Deserve This? (Feb/26/2006)

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Meredith and George fight over who gets to treat a patient. Bailey, despite being on maternity leave, treats Addison for a specific feminine problem. Izzie starts spending time with Denny, and Alex becomes jealous. Meanwhile, Burke treats a man who had a heart attack, and the man's fiancée leaves him when she learns about the risky surgery he's decided to have.
Guest Stars: Jeffrey Dean Morgan as Denny Duquette, Sarah Utterback as Nurse Olivia, Cress Williams as Tucker, Sara Ramirez as Dr. Callie Torres, Mark Harelik as Keith Polus, Ann Cusack as Amy, Jonathan Slavin as Rick, Matt Roth as Michael, Noah Gray-Cabey as Shawn Beglighter, | Co-Guest Stars: Cathy Lind Hayes (3) as Nurse Debbie, Jeremy Rabb as ER Resident, Ray Ford as Ray the Paramedic
Director: Wendey Stanzler
Writer: Stacy McKee
 
29 :02x20 - Band Aid Covers the Bullet Hole (Mar/12/2006)

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Cristina has a hard day on the job when Bailey has her take care of her baby after she gets involved in a case, despite being on maternity leave. Meredith continues to deal with the fact that she slept with George, who begins to bond with Burke much to Cristina's disgust. Addison and Derek have a deep talk about their relationship and Denny continues to get in the way of Alex being closer to Izzie. Meanwhile, the interns must deal with a hockey player who wants an unnecessary amputation and a woman with a fork stuck in her neck.
Guest Stars: Jeffrey Dean Morgan as Denny Duquette, Teddy Dunn as Heath, Stephen Lee (2) as Mr. Gibson, Sara Ramirez as Dr. Callie Torres, Tim Edward Rhoze as Kyle Booker, Natalie Cole as Sylvia Booker, | Co-Guest Stars: Kelley Hazen as Mrs. Mercer, Anne Moore as Penny Gibson, Ray Ford as Ray the Paramedic, Helen McCardle (1) as ER Doctor (as Helene McCardle)
Director: Julie Ann Robinson
Writer: Harry Werksman, Gabrielle Stanton
 
30 :02x21 - Superstition (Mar/19/2006)

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The doctors' superstitious sides are brought out after several deaths and strange events take place at Seattle Grace. Derek and Addison talk about a more permanent living situation, Izzie worries about Denny's surgery, and Richard gets reacquainted with an old friend.
Guest Stars: Mary Kay Place as Ollie, Michaela Watkins as Nikki, Anjul Nigam as Raj, Jeffrey Dean Morgan as Denny Duquette, Sara Ramirez as Dr. Callie Torres, Omar Metwally as Jesse, the OCD Patient, | Co-Guest Stars: Annie Morgan as Gretchen, Linda Klein as Scrub Nurse, Chad Fisk as Richard's Anesthesiologist, Pamela Zane as AA Member #1, Alex Downs as AA Member #2, Domingo Vara as AA Member #3, Tola Thompson as AA Member #4, Kathleen M. Darcy as Derek's Anesthesiologist, Brooke Blanchard as Jill the Paramedic, Wayne Lopez as Paramedic #2, Keeshan Giles as Intern #2, Kerry Carney as Intern #1, Rob Narita as Burke's Anesthesiologist, Kate Anthony as Nurse Kate, Shenita Moore (1) as ER Nurse
Director: Tricia Brock
Writer: James D. Parriott
 
31 :02x22 - Name of the Game (Apr/02/2006)

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Derek performs brain surgery on Andrew, a young spelling bee champion who suffered a serious head injury. George, who begins to overstay is welcome at Burke's, has trouble not speaking up when one of his patients constantly lies about her health to her daughter. Bailey begins to worry that the interns will no longer see her as "the Nazi" now that she has a child. Meanwhile, Addison treats a patient with pregnancy issues; Alex gets a lesson in manners; and secrets are revealed about Meredith's father.
Special Guest Stars: Chris O'Donnell as Finn Dandridge, | Guest Stars: Mare Winningham as Susan Grey, Laurie Metcalf as Beatrice, Jeffrey Dean Morgan as Denny Duquette, Sara Ramirez as Dr. Callie Torres, Jeff Perry as Thatcher Grey, Mandy Siegfried as Molly Thompson, Steven W. Bailey (1) as Joe, Jusak Yang Bernhard as Seminar Teacher, Harrison Knight as Andrew, Emilee Wallace as Amelia Carver, | Co-Guest Stars: Obie Sims as Neuro Fellow, Soledad St. Hilaire as Lola
Director: Seith Mann
Writer: Blythe Robe
 
32 :02x23 - Blues for Sister Someone (Apr/30/2006)

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A strict Catholic mother of seven children comes to the hospital to ask Addison for medical help because her equally religious husband refuses to use condoms. Addison is able to come up with a solution to her problem, but Alex's interference causes problems for both Addison and the mother. Derek rethinks his marriage after treating a divorce attorney for seizures. Izzie hounds George for information about his private life and pressures him to move back into the house. Meanwhile, Meredith agrees to go out with Doc's vet and Burke is faced with considerable pressure when he has to operate on his musical hero.
Special Guest Stars: Chris O'Donnell as Finn Dandridge, | Guest Stars: Sara Ramirez as Dr. Callie Torres, Jeffrey Dean Morgan as Denny Duquette, Albert Hall as Eugene Foote, Jayne Brook as Gwen Graber, Jean Louisa Kelly (1) as Rose Ward, Andrew Borba as Mr. Ward, | Co-Guest Stars: Noelle McCutchen as Nurse, Bryce Robinson as Timothy Ward, Kathleen M. Darcy as Burke's Anesthesiologist
Director: Jeff Melman
Writer: Elizabeth Klaviter
 
33 :02x24 - Damage Case (May/07/2006)

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The interns attend to Marshall, an intern from another hospital with short-term memory loss. Marshall was also the cause of a bad accident involving a family, which leads Derek to let his emotions get in the way of his work. Meanwhile, a woman from the past comes to visit one of the female interns, and Burke and Izzie have an idea relating to Denny's condition.
Special Guest Stars: Chris O'Donnell as Finn Dandridge, | Guest Stars: Sara Ramirez as Dr. Callie Torres, Jeffrey Dean Morgan as Denny Duquette, Frances Fisher as Betty Johnson, John Cho as Marshall, Gabriel Tigerman as Noah Reynolds, Sarah Lafleur as Melanie Reynolds, Graham Beckel as Jim Johnson (as Graham S. Beckel), | Co-Guest Stars: Maile Flanagan as CT Tech #1, Ray Ford as Ray the Paramedic, Wayne Lopez as Paramedic #2, Maria Elena Maglaris as Nurse, P. D. Mani (1) as Anesthesiologist, John O'Brien (1) as CT Tech #2, | Uncredited: Sean Lake as X-Ray Tech
Director: Tony Goldwyn
Writer: Mimi Schmir
 
34 :02x25 - 17 Seconds (May/14/2006)

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Finn continues to work with Doc and is able to give his owners, Meredith and Derek, and update on his condition. George is assigned to work with Derek, while Meredith is assigned to work with Callie. Denny still is without a heart donor, leaving Izzie and Burke to continue the hunt for a potential donor. Meanwhile, a 12-week pregnant woman dies in the O.R., and her parents' decision to try to keep the baby alive creates a rift between Addison and Derek.
Special Guest Stars: Chris O'Donnell as Finn Dandridge, | Guest Stars: Sara Ramirez as Dr. Callie Torres, Jeffrey Dean Morgan as Denny Duquette, Ken Marino as Brad, Jesse Head as Will, Sydney Tamiia Poitier as Deborah, Michael Arden as Neal, Michael Milhoan as Doug Thomas, Brooke Smith (1) as Dr. Erica Hahn, Steven W. Bailey (1) as Joe, Robin Pearson Rose as Patricia, | Co-Guest Stars: Kathleen M. Darcy as Derek's Anesthesiologist, Toby Meuli as Chaz, Kate Mines as Burke's Nurse, Carmen Mormino as Monnie, David Paluck as Surgeon #2, Jeremy Rabb as ER Resident, Keith Sellon-Wright as Surgeon #1, Patti Tippo as Cindy Thomas, | Uncredited: Jennifer Nyholm as Kendra
Director: Dan Minahan (1)
Writer: Mark Wilding
 
35 :02x26 - Deterioration of the Fight or Flight Response (May/15/2006)

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George and Izzie race to find Denny a heart as his heart gets weaker and weaker by the minute. Derek is faced with the pressure of performing surgery on one of his friends, while Cristina is faced with the pressure of running the O.R. after she is left in charge. Meanwhile, the interns are supervised by Erica, a new attending, who tries her hardest to act like Bailey, but has a tough time doing so.
Special Guest Stars: Chris O'Donnell as Finn Dandridge, | Guest Stars: Sara Ramirez as Dr. Callie Torres, Jeffrey Dean Morgan as Denny Duquette, Loretta Devine as Adele Webber, Hallee Hirsh as Claire, Tessa Thompson as Camille, Tiffany Hines as Natalie, Brooke Smith (1) as Dr. Erica Hahn, Sarah Utterback as Nurse Olivia, | Co-Guest Stars: Charles Duckworth as Brian, Ariel Felix as Anesthesiologist, Linda Klein as Nurse Linda, David Paluck as Surgeon #2, Jeremy Rabb as ER Resident, Keith Sellon-Wright as Surgeon #1
Director: Rob Corn
Writer: Joan Rater, Tony Phelan
 
36 :02x27 - Losing My Religion (May/15/2006)
After Richard learns who Derek is operating on, he tries to pump Addison for information. Callie and George have a talk about their relationship and George's true feelings. Meanwhile, Meredith and Derek get together to talk about Doc, and later realize that their feelings for each other may not entirely be gone despite Finn being in Meredith's life and Addison being in Derek's.
Guest Stars: Chris O'Donnell as Finn Dandridge, Sara Ramirez as Dr. Callie Torres, Jeffrey Dean Morgan as Denny Duquette, Loretta Devine as Adele Webber, Hallee Hirsh as Claire, Tessa Thompson as Camille, Tiffany Hines as Natalie, Brooke Smith (1) as Dr. Erica Hahn, Charles Duckworth as Brian, Sarah Utterback as Nurse Olivia, | Co-Guest Stars: Linda Klein as Nurse Linda, Ariel Felix as Anesthesiologist
Director: Mark Tinker
Writer: Shonda Rhimes
 
Under Pressure (Apr/23/2006)
A one-hour special recaping the lives of the interns at Seattle Grace Hospital. Starting with their first day, the intern's lives, both personal and professional, are recapped, along with the struggles of their first year of being surgical interns.
Guest Stars: Steven W. Bailey (1) as Narrator
 

Season 3
Complications of the Heart (Sep/21/2006)
In a clip-show, "Complications of the Heart" recaps the highlights of the previous season from the arrival of Addison to Meredith's cliff-hanging season finale scene. The episode will also feature the music video for The Fray’s single, “How to Save a Life" which features clips from season 2 as well as clips from the season 3 premiere.
Guest Stars: Steven W. Bailey (1) as Narrator