Guest Stars: William Daniels as Dr. Craig Thomas (Minnesota Hospital Staff: Cardiology) | Ursula Burton as E.R. Nurse (Caught Staring at Callie) | Brian Houtz as Resident (Minnesota Hospital Staff, Annoyed by Cristina) | Arriane Alexander as Gate Attendant (Seattle Airport) | Tina Majorino as Dr. Heather Brooks (Intern) | Dan Gordon (4) as Flight Attendant (Flight 531: Seattle to Rochester, Minnesota) | Tessa Ferrer as Dr. Leah Murphy (Intern) | Jerrika Hinton as Dr. Stephanie Edwards (Intern) | Camilla Luddington as Dr. Jo Wilson (Intern) | Philip Casnoff as Dr. Mel Barnett (Pediatrics) | Gaius Charles as Dr. Shane Ross (Intern) | Steven Culp as Dr. Parker (Minnesota Hospital Staff) | Jason Winston George as Dr. Ben Warren (Fiancé of Dr. Miranda Bailey)

Songs: Mynabirds -- Body of Work, Mikky Ekko -- Feels Like the End, Ingrid Michaelson -- Into You, Miss Li -- My Heart Goes Boom, Tristan Prettyman -- My Oh My, Rilo Kiley -- Portions for Foxes, One-Two -- Without You

Guest Stars: Craig Susser as Dr. Hurst | Holley Fain as Dr. Julia Canner (Ex-Girlfriend of Dr. Mark Sloan) | Elizabeth Tobias as Boise Chief | Jim Turner (2) as Dr. Schacter | Tina Majorino as Dr. Heather Brooks (Intern) | Gaius Charles as Dr. Shane Ross (Intern) | Adina Porter as Dr. Ramsey

Songs: Kodaline -- All I Want

Guest Stars: Rebecca Lowman as Mrs. James (Mother of Emery James: Leg Injury Patient) | Meeghan Holaway as Representative for the Doctors | Matthew Downs as Frank (Fiancé of Roxie Meyers: Skin Removal Patient) | Tony Mirrcandani as Pop-Pop (Patient: Enlarged Heart) | Boo Arnold as Mr. James (Father of Emery James: Leg Injury Patient) | Christopher Michael as Ray (Man Who Shows Derek the Wreckage) | Skyler Day as Emery James (Patient: Leg Injury from Boating Accident) | Ned Vaughn as Representative for the Airline | William Daniels as Dr. Thomas (Minnesota Hospital Staff) | Steven Culp as Dr. Parker (Minnesota Hospital Staff) | Camilla Luddington as Dr. Jo Wilson (Intern) | Gaius Charles as Dr. Shane Ross (Intern) | Jerrika Hinton as Dr. Stephanie Edwards (Intern) | Stefanie Black as Roxie Meyers (Patient: Excess Skin Removal and Hernia Repair)

Songs: Icky Blossoms -- Heat Lightning, Julia Stone -- It’s All Okay, Dolorean -- What Could You Do?, The Heavy -- What Makes a Good Man?, Benjamin Francis Leftwich -- Won’t Back Down

Guest Stars: Gaius Charles as Dr. Shane Ross (Intern) | Camilla Luddington as Dr. Jo Wilson (Intern) | Tina Majorino as Dr. Heather Brooks (Intern) | Jerrika Hinton as Dr. Stephanie Edwards (Intern) | Tessa Ferrer as Dr. Leah Murphy (Intern) | Marcuis Harris as Rob Mays (Patient: Bodyguard with Rare Retroperitoneal Tumor) | Trever O'Brian as Bryan Greenberg (Patient: Scrotal Lymphedema) | Ethan Embry as Dr. David Moore (Arizona's Prosthetist) | William Charlton as Jeff (Husband of Janet: PDA and Blocked Arteries Patient) | Julia Silverman as Janet (Patient: PDA and Blocked Arteries) | Julie Mann (1) as Paula (Friend of Bryan Greenberg: Patient) | William Daniels as Dr. Craig Thomas (Minnesota Hospital Staff) | Debbie Allen as Catherine Avery (Mother of Dr. Jackson Avery) | Steven Culp as Dr. Parker (Minnesota Hospital Staff)

Songs: Miss Li -- Forever Drunk, Daughter -- Home, Birdy -- I’ll Never Forget You, Calahan -- Moving On

Guest Stars: Elly Jaresko as Melissa (Patient: Hit by Car While Riding Her Bike, Trapped) | Kelly Keaton as Neighbor (Greets Cristina as They Pass in the Hallway) | Gatsby Coram as Truck Driver (Encourages Everyone to Help Lift Car Off Melissa) | Leanna Tallmeister as Woman at Accident (Helps Lift Car Off Melissa) | J. Rene Pena as Female Driver (Accidently Hit Melissa with Her Car) | Lizzy Davis as Barista (Initially Refuses to Help Move Car Off Melissa) | Jerrika Hinton as Dr. Stephanie Edwards (Intern) | Tina Majorino as Dr. Heather Brooks (Intern) | Steven Culp as Dr. Parker (Minnesota Hospital Staff) | William Daniels as Dr. Craig Thomas (Minnesota Hospital Staff) | Matthew Carey (1) as Will (Doomsday Prepper Husband of Katy: Heart Patient) | Zoe Perry as Katy (Doomsday Prepper Patient: Congenital Heart Defect) | Camilla Luddington as Dr. Jo Wilson (Intern)

Songs: Conner Youngblood -- Australia, O+S -- Flowers Turn to Fire, On An On -- Ghosts, Wake Owl -- Gold, Daniel Ellsworth & The Great Lakes -- Passenger

Guest Stars: Andrew Leeds as Andy, Representative for the Doctors | Corey Craig as Brian Danzinger | Annie LaRussa as Dorie Danzinger | Matthew Iott as Ken Danzinger | Teresa Huang as Nurse | Meeghan Holaway as Representative for the Doctors | Tim De Zarn as Santa Claus (Patient: Homeless Man) | Tina Majorino as Dr. Heather Brooks (Intern) | Dominic Hoffman as Dr. Jeff Russell | Tessa Ferrer as Dr. Leah Murphy (Intern) | Camilla Luddington as Dr. Jo Wilson (Intern) | Gaius Charles as Dr. Shane Ross (Intern) | Jerrika Hinton as Dr. Stephanie Edwards (Intern)

Songs: Aron Wright -- And Still, The Darkness Comes, Caught A Ghost -- Connected, Iko -- Dazed and Confused, Damien Jurado -- Museum of Flight, Miss Li -- You Could Have it So Much Better Without Me

Guest Stars: Camilla Luddington as Dr. Jo Wilson (Intern) | Jessy Hodges as Donna | Jerrika Hinton as Dr. Stephanie Edwards (Intern) | Tina Majorino as Dr. Heather Brooks (Intern) | Joe Nieves as Michael Baker | Gaius Charles as Dr. Shane Ross (Intern) | Ivar Brogger (1) as Graham | Roma Maffia as Roberta | Miguel Sandoval as Hank

Songs: Milo Greene -- 1957, Katie Herzig -- Let You Go, The Soft Pack -- Mexico, Matt Hires -- Signal in the Sky

Guest Stars: Alyssa Preston as Kimmy's Mama | Sean Donnellan as Mr. Crossley | Julie Wittner as Mrs. Crossley | Laila Ayad as Laura | Graham Sibley as Noah | Tessa Ferrer as Leah | Jerrika Hinton as Stephanie | Tina Majorino as Heather | Gaius Charles as Shane | Camilla Luddington as Jo | Neve Campbell as Liz Sheperd

Songs: Tiësto -- Knock You Out (Owen Westlake Remix), Broadheds -- Nothing That I Care About, Beirut -- Santa Fe, Broadheds -- Something All Our Own

Guest Stars: Tessa Ferrer as Dr. Leah Murphy | Tina Majorino as Dr. Heather Brooks | Camilla Luddington as Dr. Jo Wilson | Neve Campbell as Liz Sheperd | Loretta Devine as Adele Webber

Songs: Luke Sital-Singh -- Fail for You, Sugar + The Hi-lows -- Jingle Bells, Sky Ferreira -- Lost in My Bedroom, Tal & Acacia -- Silver Bells, Gabe Simon -- Sweetest Sound

Guest Stars: Gaius Charles as Dr. Shane Ross | Richard Kahan as Stuart | Wren T. Brown as Michael | Jaye Razor as Rage | Tessa Ferrer as Dr. Leah Murphy | Jerrika Hinton as Dr. Stephanie Edwards | Tina Majorino as Dr. Heather Brooks | Camilla Luddington as Dr. Jo Wilson | Frankie Faison as William Bailey | Dale Dickey as Emily "Gasoline" Bennett | Jason Winston George as Dr. Ben Warren | Loretta Devine as Adele Webber

Songs: Ed Sheeran -- Kiss Me, Iko -- Lightning Bolts, Angela McCluskey -- My Funny Valentine, Diego Garcia (musician) -- Nothing to Hide, Metric -- Speed the Collapse, Atlas Genius -- Trojans, Erin McCarley -- What I Needed

Guest Stars: Bob Bancroft as Leonard Olsen | Roma Maffia as Roberta Thompson | Aubrey Peeples as "Hot" Girlfriend | Ben Stillwell as James Leggett | Mandy Levin as Dana Leggett | Doug Simpson as Phil Leggett | Tara Shayne as Taylor Lanz | Julie Warner as Mrs. Lanz | Tessa Ferrer as Dr. Leah Murphy (Intern) | Tina Majorino as Dr. Heather Brooks (Intern) | Gaius Charles as Dr. Shane Ross (Intern) | Camilla Luddington as Dr. Jo Wilson (Intern) | Debbie Allen as Dr. Catherine Avery (Mother of Dr. Jackson Avery) | Beth Grant as Sheila Olsen | Jerrika Hinton as Dr. Stephanie Edwards (Intern)

Songs: Mynabirds -- Disaster, Left Hand Smoke -- Shine on Everything, Serena Ryder -- Stompa, Engineers -- What It’s Worth

Guest Stars: Leah Morgan as Nyah (Patient: Young Girl from Africa) | Vito Viscuso as Pilot (Organ Transplant Flight) | Michael Albala as Harvest Surgeon (Warns Intern Not to Make the Same Mistake as Shane) | Ameenah Kaplan as Makena (African Pediatrics Program) | Navi Rawat as Heidi (Partner of Brie: Pregnant Patient in Liver Failure) | Elizabeth Anweis as Brie (Patient: Pregnant Woman in Liver Faiure) | Laura Heisler as Carla (Sister of Jimmy: Acoustic Neuroma Patient) | Wes Ramsey as Jimmy (Patient: Acoustic Neuroma) | Jerrika Hinton as Dr. Stephanie Edwards (Intern) | Gaius Charles as Dr. Shane Ross (Intern) | Camilla Luddington as Dr. Jo Wilson (Intern) | Justin Bruening as Paramedic Matthew Taylor | Constance Zimmer as Dr. Alana Cahill (Physician Advisor/Efficiency Consultant)

Songs: Matt Hires -- Forever, Future of Forestry -- Someone, Lord Huron -- Time to Run

Guest Stars: Andy Milder as Dr. Darryl Nessbaum (Teaches Class on Standard Hernia Repair Technique) | Tessa Ferrer as Dr. Leah Murphy (Intern) | Molly Schreiber as Flight Nurse (Escorts Logger Patient onto Elevator) | Lexi DiBenedetto as Simmi Johnson (Patient: Double Hip Replacement) | Dominic Hoffman as Dr. Jeff Russell (Head of Cardiology) | Jerrika Hinton as Dr. Stephanie Edwards (Intern) | Gaius Charles as Dr. Shane Ross (Intern) | Constance Zimmer as Dr. Alana Cahill (Physician Advisor/Efficiency Consultant) | Helen Eigenberg as Lillian Campion (Mother of Rich Campion: Jehovah's Witness Patient) | Michael-james Olsen as Brock (Friend of Rich Campion: Jehovah's Witness Patient) | David Goryl as Ron Campion (Father of Rich Campion: Jehovah's Witness Patient) | Kovar McClure as Dr. Tim Redmond (Head of Dermatology) | Camilla Luddington as Dr. Jo Wilson (Intern)

Songs: Sara Jackson-Holman -- Come By Fire, Josh Ritter -- In Your Arms Again, Wild Belle -- Shine, Stealing Sheep -- Shut Eye, NO -- Town on Fire (Michael Guy Chislett Remix)

Guest Stars: Brett Rickaby as Mr. Weston (Father of Brian: Double Mastectomy Patient) | Paull Walia as Dr. Kan Mattoo (Portland General Hospital Staff: E.R. Doctor) | Nazanin Boniadi as Amrita (Public Relations Photographer Shadowing Alex) | Stephanie Maura Sanchez as Admitting Nurse (Portland General Hospital Staff) | Renee Pezzotta as E.R. Nurse (Portland General Hospital Staff) | Yvette Saunders as Dr. Collier (Portland General Hospital Staff) | Jeremy Cohenour as Dr. Boyd (Portland General Hospital Staff) | Brandon Ford Green as Dr. Allen (Portland General Hospital Staff) | John Duerler as Grant (Pegasus Representative) | Gerald Downey as Dr. Kenton Giles (Portland General Hospital Staff: Orthopedics) | Rob Brownstein (2) as Larry (Public Relations Photographer Shadowing Avery) | Maggie Henry as Olivia Noel (Mother of Maya Noel: Infant with Gastroschisis) | Tina Majorino as Dr. Heather Brooks (Intern) | Jerrika Hinton as Dr. Stephanie Edwards (Intern) | Gaius Charles as Dr. Shane Ross (Intern) | Camilla Luddington as Dr. Jo Wilson (Intern) | Constance Zimmer as Dr. Alana Cahill (Physician Advisor/Efficiency Consultant) | Rachel Brosnahan as Brian (Transgender Teen Patient: Double Mastectomy) | Matt Pascua as Jess (Girlfriend of Brian: Double Mastectomy Patient) | Justin Bruening as Paramedic Matthew Taylor | Nicole Cummins as Paramedic Nicole

Songs: Grizzly Bear -- Gun-Shy, Phosphorescent -- Song for Zula, Leagues -- Spotlight, Lucius (band) -- Turn it Around

Guest Stars: Danielle Bisutti as Liz Langer (Businesswoman, Mother of Newborn in N.I.C.U.) | Charles Michael Davis as "Chest Peckwell" (Jo's Date) | Liisa Cohen as Neonatologist (Gives Alex Information on Newborn in N.I.C.U.) | Noah Harpster as Ike Morris (Father of A.J.: Young Patient with Cancer) | Teresa Huang as Nurse (Speaks for the Nursing Staff During the Meeting) | John Duerler as Grant (Pegasus Representative) | Michael Reilly Burke as Mr. Finch (Businessman, Father of Newborn in N.I.C.U.) | Jerrika Hinton as Dr. Stephanie Edwards (Intern) | Tina Majorino as Dr. Heather Brooks (Intern) | Constance Zimmer as Dr. Alana Cahill (Physician Advisor/Efficiency Consultant) | Gaius Charles as Dr. Shane Ross (Intern) | Eddie Jemison as Stan Grossberg (Financial Advisor to Dr. Derek Shepherd) | Roma Maffia as Roberta Thompson | Justin Bruening as Paramedic Matthew Taylor | Camilla Luddington as Dr. Jo Wilson (Intern)

Songs: Ellie Goulding -- Dead in the Water, Rihanna -- Stay (featuring Mikky Ekko), Metric -- Synthetica

Guest Stars: Erica Giles as Receptionist (Crest Capital) | Roma Maffia as Roberta Thompson | Hart Bochner as Julian Crest (Crest Capital) | Eddie Jemison as Stan Grossberg (Financial Advisor to Dr. Derek Shepherd) | Jerrika Hinton as Dr. Stephanie Edwards (Intern) | Tina Majorino as Dr. Heather Brooks (Intern) | Gaius Charles as Dr. Shane Ross (Intern) | Tessa Ferrer as Dr. Leah Murphy (Intern) | Constance Zimmer as Dr. Alana Cahill (Physician Advisor/Efficiency Consultant) | Camilla Luddington as Dr. Jo Wilson (Intern) | Debbie Allen as Catherine Avery (Mother of Dr. Jackson Avery)

Songs: Esthero -- Never Gonna Let You Go

Guest Stars: David Naughton as Nick Parker (Father of Brad Parker: End-Stage ALS Patient) | Logan Fahey as Brad Parker (Patient: End-Stage ALS) | Tiffany Boone as Jaelyn Donovan (Patient: Kidney Dialysis, Girlfriend of Theo) | Dave Florek as Herman Crum (Patient: Heart Failure, Enemy of Shultz) | Matt Ferrucci as Closing Surgeon | Barbara Kerford as Transplant Surgeon | Tessa Ferrer as Dr. Leah Murphy | Teresa Huang as Nurse (Helps Owen Fill in the O.R. Scheduling Board) | Jordan Wright as Theo (Patient: Kidney Dialysis, Boyfriend of Jaelyn) | Suzanne Ford as Hazel Parker (Mother of Brad Parker: End-Stage ALS Patient) | Camilla Luddington as Dr. Jo Wilson (Intern) | Tom Bower (1) as Mr. Schultz (Patient: Heart and Lung Recipient, Enemy of Crum) | Jerrika Hinton as Dr. Stephanie Edwards (Intern) | Charles Michael Davis as Dr. Jason Myers / "Chest Peckwell" (Boyfriend of Dr. Jo Wilson) | Tina Majorino as Dr. Heather Brooks (Intern) | Debbie Allen as Dr. Catherine Avery (Mother of Dr. Jackson Avery)

Guest Stars: Annette O'Toole as Unknown | Todd Stashwick as Unknown | Tina Majorino as Dr. Heather Brooks (Intern) | Gaius Charles as Dr. Shane Ross (Intern) | Tessa Ferrer as Dr. Leah Murphy (Intern) | Camilla Luddington as Dr. Jo Wilson (Intern)

Guest Stars: Kate Rene Gleason (1) as Elyse Cruse | Tessa Ferrer as Dr. Leah Murphy (Intern) | Enid Graham as Rachel Dawson (Patient: Car Accident, Wife of Paul Dawson) | Mark Chadwick as Cam Miller (Patient: Car Accident, Sneaks Out for a Cigarette) | Misha Gonz-Cirkl as Social Worker | Patrick Cavanaugh as Vince Cruse | Hunter Reid as Parker Hedges | Tina Majorino as Dr. Heather Brooks | Michael Buie as Paul Dawson (Patient: Car Accident, Husband of Rachel Dawson) | Kyle Silverstein as Ethan Dawson (Son of Paul and Rachel Dawson) | Justin Bruening as Paramedic Matthew Taylor (Boyfriend of Dr. April Kepner) | Kaine Reid as Parker Hedges | Raedin Reid as Parker Hedges | Jerrika Hinton as Dr. Stephanie Edwards (Intern) | Camilla Luddington as Dr. Jo Wilson (Intern) | Charles Michael Davis as Dr. Jason Myers (Boyfriend of Dr. Jo Wilson) | Sarah Chalke as Casey Hedges (Mother of Parker Hedges: Young Patient) | Gaius Charles as Dr. Shane Ross (Intern)

Guest Stars: Lou Richards as Steven (Husband of Joyce) | Misha Gonz-Cirkl as Social Worker | Sarah Lilly as Joyce Basche | Kyle Silverstein as Ethan Dawson (Son of Paul and Rachel Dawson) | Enid Graham as Rachel Dawson (Patient: Car Accident, Wife of Paul Dawson) | Justin Bruening as Paramedic Matthew Taylor | Tina Majorino as Dr. Heather Brooks (Intern) | Gaius Charles as Dr. Shane Ross (Intern) | Jerrika Hinton as Dr. Stephanie Edwards (Intern) | Tessa Ferrer as Dr. Leah Murphy (Intern) | Michael Buie as Paul Dawson (Patient: Car Accident, Husband of Rachel Dawson)

Guest Stars: Sam Fuller as Cash Keller | Andy Manning as Tony Keller | Anton Narinskiy as Gunnar (Friend of Tony Keller) | Michael Buie as Paul Dawson (Patient: Coma, Husband of Rachel Dawson) | Charles Michael Davis as Dr. Jason Myers (Boyfriend of Dr. Jo Wilson) | Idara Victor as Amelie Ward (Patient: Pregnant) | Abbie Cobb as Francis "Frankie" Keller | Robin DeMarco as Jane Keller | Katy Kurtzman as Deedee Keller | Michael G. Hagerty as Al Keller | Tessa Ferrer as Dr. Leah Murphy (Intern) | Enid Graham as Rachel Dawson (Patient: Car Accident, Wife of Paul Dawson) | Kyle Silverstein as Ethan Dawson (Son of Paul and Rachel Dawson) | Camilla Luddington as Dr. Jo Wilson (Intern) | Sarah Lilly as Joyce Basche | Anthony Montgomery as Chris Ward (Husband of Amelie Ward: Pregnant Patient)