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« Season 3   Settings    Season 4 (Printable Guide) Season 5 »
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Season 4
Come Rain or Shine - From Grey's Anatomy to Private Practice (Sep/19/2007)
"Come Rain or Shine: From Grey's Anatomy to Private Practice" goes into the life of Dr. Addison Montgomery as she transitions from Seattle Grace to Oceanside in the new spin-off Private Practice. The episode also includes the premiere of the Grey's Anatomy music video featuring "Breath In Breath Out," a song by Mat Kearney. The video features clips from the previous three seasons and the episode will feature a glimpse at the new season of Grey's Anatomy.
 
62 :04x01 - A Change Is Gonna Come (Sep/27/2007)

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Meredith and Cristina return from Cristina's honeymoon to find that Burke is long gone. Izzie, Alex, Meredith and Cristina start their first day as residents, each with their own set of interns. Among the interns are George, who is repeating his internship after failing the exam, and Lexie, Meredith's half-sister. Meanwhile, Derek begins to look elsewhere after his relationship with Meredith hits an emotional impasse; Bailey grapples with the fact that her former interns now report to Callie, the new Chief Resident; and Richard returns to his position as Chief of Surgery.
Guest Stars: Tymberlee Chanel as Claire, Joseph Williamson as Intern Pierce, Winston Story as Intern Leo, Joy Osmanski as Intern Lucy, Molly Kidder as Intern Megan, Amrapali Ambegaokar as Intern Dani, Candice Afia as Intern Laura, Steven M. Porter as Joey, Stephanie Childers as Nancy, Sandra Thigpen as Clara, Mark Pellegrino as Chris, Richard Keith as Mitch Greenberg, Gloria Garayua as Graciella
Director: Rob Corn
Writer: Shonda Rhimes
Songs: Blonde Redhead -- 23, Lily Allen -- Knock 'Em Out, I'm From Barcelona -- Oversleeping, Meiko -- Reasons To Love You, Cinematic Orchestra -- To Build A Home
 
63 :04x02 - Love/Addiction (Oct/04/2007)

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The interns and residents treat victims of an apartment complex explosion as Alex looks into the cause of the devastating accident. Mama Burke arrives at Seattle Grace to pick up the rest of Burke's personal things while Cristina trades wedding gifts for surgeries. Meanwhile, Lexie tries to talk to Meredith, who is less than willing to do so; Callie deals with the stress of being Chief Resident; and Bailey tries to figure out what to do with her excess leadership skills.
Guest Stars: Nicholas Gonzalez as Clark, Brendan Elliott as Dave, Ben Vereen as Archie, Diahann Carroll as Jane Burke, | Co-Guest Stars: Joseph Williamson as Intern Pierce, Mark Saul as Intern Steve, Amrapali Ambegaokar as Intern Dani, Candice Afia as Intern Laura, Ray Ford as Ray the Paramedic, Brooke Blanchard as Jill the Paramedic, Moe Irvin as Nurse Tyler, Tanya Linette Smith as Jennifer, Amy Landers as Marla Krestler
Director: James Frawley
Writer: Debora Cahn (1)
Songs: Amy Obenski -- Carousel, Chris Garneau -- Castle Time, Laura Izibor -- From My Heart To Yours, The Rentals -- Little Bit of You in Everything, Gomez -- Moon and Sun, Trolle Siebenhaar -- The Yard
 
64 :04x03 - Let the Truth Sting (Oct/11/2007)

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The new interns are in awe of fellow intern George's skill level, and Lexie tries to keep his "repeater" status secret. Meredith comes to Lexie's aide when Lexie is faced with her first emergency situation. The Chief and Sloan have to use a radical surgery to save a woman's vocal ability. Meanwhile, George debates telling Callie about his affair with Izzie.
Guest Stars: Jack Axelrod (1) as Really Old Guy (Charlie), Debra Christofferson as Elaine, Amy Hill as Joanne, Eve Gordon as Mary, Caroline Aaron as Connie, Edward Herrmann as Norman, | Co-Guest Stars: Molly Kidder as Intern Megan, Joy Osmanski as Intern Lucy, Mark Saul as Intern Steve, Joseph Williamson as Intern Pierce, Winston Story as Intern Leo, Alison Crowley as Clinic Nurse, Peter Smith (5) as Clinic Nurse, Richard Keith as Intern Mitch, Gloria Garayua as Intern Graciella, Martin Spanjers as Hunter Chapman, Moe Irvin as Nurse Tyler, Ray Ford as Ray the Paramedic, Linda Eve Miller (1) as ER Nurse, Candice Afia as Intern Laura, Amrapali Ambegaokar as Intern Dani, Tymberlee Chanel as Intern Claire
Director: Dan Minahan (1)
Writer: Mark Wilding
Songs: The Perishers -- Best Friends, Feist -- My Moon My Man, The Bravery -- The Ocean
 
65 :04x04 - The Heart Of The Matter (Oct/18/2007)

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Izzie reveals her true feelings for George to one of her and George's friends, and the reaction she receives is not what she expected. Meanwhile, Adele Webber rushes her niece to Seattle Grace; Derek gives Cristina pointers on how to be a better teaching resident; and Norman, the world's oldest intern, misdiagnoses Meredith's patient.
Guest Stars: Loretta Devine as Adele Webber, Ron Melendez as Will, Camille Winbush as Camille, Miriam Flynn as Ms. Bitzer, Maggie Siff as Ruthie, Matt Lanter as Adam, Michael McGrady as Stanley, Edward Herrmann as Norman, | Co-Guest Stars: Joy Osmanski as Intern Lucy, Mark Saul as Intern Steve, Winston Story as Intern Leo, Cassandra Braden as Housekeeping Staffer, Nicole Cummins-Rubio as Paramedic, Molly Kidder as Intern Megan, Richard Keith as Intern Mitch, Gloria Garayua as Intern Graciella, Tymberlee Chanel as Intern Claire, Maile Flanagan as Lab Tech, Jeremy Rabb as ER Doctor, Shelley Robertson as Arlene
Director: Randall Zisk
Writer: Allan Heinberg
Songs: Northern State -- Better Already, Meiko -- Hawaii, Prince Fatty -- Milk And Honey, Yeah Yeah Yeahs -- Rockers To Swallow, John Legend -- Sun Comes Up, Kim Richey -- The Absence Of Your Company
 
66 :04x05 - Haunt You Every Day (Oct/25/2007)

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It's Halloween at Seattle Grace and the day is chock-full of surprises for the doctors. Alex has a surprise visit from a former patient; Meredith thinks her mother's ashes are haunting her; Cristina is snubbed by a top surgeon; and everyone is shocked when Callie reveals George and Izzie's relationship to the public.
Guest Stars: Anjul Nigam as Raj, Sarah Utterback as Nurse Olivia, Dylan Minnette as Ryan, David Clennon as Jack, Kali Rocha as Sydney Heron, Rocky Carroll as James, Elizabeth Reaser as Ava, Edward Herrmann as Norman, | Co-Guest Stars: Suzanne Quinn as Clinic Nurse, Linda Eve Miller (1) as ER Nurse, Ray Ford as Ray the Paramedic, Jeremiah Hu as Fingerless Guy, Crystal Kwon as Nurse Jolene, Bhama Roget as Erin
Director: Bethany Rooney
Writer: Krista Vernoff
Songs: The Perishers -- Come Out Of The Shade, Katie Herzig -- Fools Gold, The Perishers -- Get Well, Kendall Payne -- I Will Show You Love, The Gossip -- Listen Up!, The Bird & The Bee -- Polite Dance Song
 
67 :04x06 - Kung Fu Fighting (Nov/01/2007)

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With his marriage once again falling apart, Chief Webber invites the male surgeons out on a "gentleman's evening." Meanwhile, Cristina and Izzie compete for the same surgeries, mainly to impress the doctor performing them; Meredith treats the survivor of a skydiving accident; and two finalists competing in a promotional competition are treated by the doctors.
Guest Stars: Chryssie Whitehead as Helena, Steve Sandvoss as Jason, Amanda Loncar as Jackie, Tommy Dewey as Mike, Marina Black as Sally, Cullen Douglas (2) as Mr. Arnold, David Denman as Rick
Director: Tom Verica
Writer: Stacy McKee
Songs: New Buffalo -- Cheer Me Up Thank You, Miss Li -- Don't Try To Fool Me, Magic Numbers -- Let Somebody In, Kate Nash -- Merry Happy, Imani Coppola -- Raindrops From The Sun, Buddy -- Say A Lot
 
68 :04x07 - Physical Attraction... Chemical Reaction (Nov/08/2007)

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George and Izzie's relationship is tested, as is Derek and Meredith's when Derek wants more than a physical relationship with her. Meanwhile, Mark falls for a surgeon and Callie's position as Chief Resident is put on the line when she gives too many duties to Bailey.
Guest Stars: Enuka Okuma as Teresa, Kurt Fuller as Jerry, David Burke (1) as Don, Vicki Lewis (1) as Harriet, Stephanie March as Jane, Rockmond Dunbar as Sean, Jeff Perry as Thatcher Grey
Director: Jeff Melman
Writer: Joan Rater, Tony Phelan
Songs: Northern State -- iluvitwhenya, Derek Webb -- Name, Calahan -- Pouring On The Gasoline, Priscilla Ahn -- Rain, Joe Purdy -- San Jose
 
69 :04x08 - Forever Young (Nov/15/2007)

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The ER is thrown into a state of chaos following a school bus accident. Meanwhile, Bailey treats her high school crush; Derek goes on a date; and Thatcher comes to Seattle Grace in search of Meredith.
Guest Stars: Andrea Vercetti as Marissa, Stephen Sowan as Danny, Brooke Nevin as Tricia, Madeline Zima as Marissa, Lauren Stamile as Rose, D. B. Woodside as Marcus, Kali Rocha as Sydney Heron, Jeff Perry as Thatcher Grey
Director: Rob Corn
Writer: Mark Wilding
Songs: Chris Garneau -- Black & Blue, Rilo Kiley -- Breakin' Up, Tegan & Sara -- Call It Off, John Ralston -- Second Hand Lovers, Cary Brothers -- The Last One, Ben Lee (1) -- What Would Jay-Z Do?
 
70 :04x09 - Crash Into Me (Part 1) (Nov/22/2007)

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Meredith and the Chief rush to the scene of a devastating ambulance crash in which the lives of the paramedics are at stake. Bailey treats a difficult patient and Ava returns to find Alex with a new girlfriend.
Guest Stars: Alison La Placa as Jacob's Wife, Kimberly Huie as Mary Daltren, Theo Rossi as Stan, John Billingsley as Jacob, Gale Harold as Shane, Cress Williams as Tucker, Lauren Stamile as Rose, Elizabeth Reaser as Ava, Seth Green as Nick, | Co-Guest Stars: Nick Hoffa as Firefighter #2, Emma Prescott as Lucy, Suzi Holrichter as Sandra, Parker Goris as Garrett, Linda Klein as O.R. Nurse, Roger Bridges as Firefighter, Crystal Kwon as Nurse Jolene, Joy Osmanski as Intern Lucy, Candice Afia as Intern Laura, Joseph Williamson as Intern Pierce, Mark Saul as Intern Steve, Shanelle Gray as Sara, Ray Ford as Ray the Paramedic
Director: Michael Grossman
Writer: Krista Vernoff, Shonda Rhimes
Songs: Correatown -- All The World (I Tell Myself), Ben's Brother -- Let Me Out, Roisin Murphy -- Movie Star, Soulsavers -- Revival, The Cake Sale -- Some Surprise, Missy Higgins -- Where I Stood
 
71 :04x10 - Crash Into Me (Part 2) (Dec/06/2007)

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In the conclusion to the two-part episode arc, Meredith races to save the life of a paramedic, who is trapped inside an ambulance. Meanwhile, the life of a patient is in Lexie's hands and Derek and a nurse work together to save the life of a patient.
Guest Stars: Lauren Stamile as Rose, Cress Williams as Tucker, Seth Green as Nick, Elizabeth Reaser as Ava, Gale Harold as Shane, | Co-Guest Stars: Theo Rossi as Stan, Ray Ford as Ray the Paramedic, Moe Irvin as Nurse Tyler
Director: Jessica Yu (1)
Writer: Shonda Rhimes, Krista Vernoff
Songs: Natalie Walker -- Circles, Santogold -- Creator, Sara Melson -- Feel It Coming
 
72 :04x11 - Lay Your Hands On Me (Jan/10/2008)

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Bailey's family faces a medical trauma, just as her marriage is falling apart, a surprise visit from George's mother comes as a shock to both Izzie and Callie, a faith healer challenges Erica and Alex's beliefs in traditional medicine, and Derek must deal with the aftermath of his kiss with Rose.
Guest Stars: Carol Locatell as Mai, Lauren Stamile as Rose, Cress Williams as Tucker, Debra Monk as Louise O'Malley, Glenne Headly as Elizabeth
Director: John Terlesky
Writer: Allan Heinberg
Songs: Caedmon's Call -- 10,000 Angels, Lifehouse -- Broken, Joe Henry -- God Only Knows, Katie Herzig -- Sweeter Than This, Patty Griffin -- Up To The Mountain
 
73 :04x12 - Where The Wild Things Are (Apr/24/2008)

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Six weeks following Derek and Meredith's break-up, Derek continues to date Rose while Meredith, Alex, Izzie and Cristina compete in a surgical contest. Meanwhile, George and Lexie adjust to their new apartment and Callie finds a new friend in Erica Hahn.
Guest Stars: Jason O'Mara as Phillip, Steven Flynn (1) as Scott, Clea DuVall as Jennifer, Cheech Marin as Otis, Amy Madigan as Dr. Wyatt, Lauren Stamile as Rose, | Co-Guest Stars: Troy Westbrook as Paramedic
Director: Rob Corn
Writer: Zoanne Clack
Songs: Lykke Li -- I'm Good, I'm Gone, Goldfrapp -- Some People, Greg Laswell -- What A Day
 
74 :04x13 - Piece of My Heart (May/01/2008)

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Addison makes her return to Seattle Grace in order to perform an operation. As she does so, she is preoccupied by all of the changes in her former co-workers' lives. Meanwhile, Meredith and Derek's clinical trial has its first patient, and Rebecca returns to deliver Alex some shocking news.
Special Guest Stars: Kate Walsh as Addison Montgomery, | Guest Stars: Jason O'Mara as Phillip, Ken Barnett as Freddie, Kathleen Rose Perkins as Sarah, Lauren Stamile as Rose, Clea DuVall as Jennifer, Elizabeth Reaser as Rebecca, Amy Madigan as Dr. Wyatt, | Co-Guest Stars: Richard Keith as Intern Mitch, Molly Kidder as Intern Megan, Joy Osmanski as Intern Lucy, Winston Story as Intern Leo, Tymberlee Chanel as Intern Claire, Gloria Garayua as Intern Graciella, John O'Brien (1) as Lab Tech, Meg Cionni as Nikki, Sam Daly as Will
Director: Mark Tinker
Writer: Stacy McKee
Songs: Republic Tigers -- Buildings and Mountains, Neverending White Lights -- Distance, Meaghan Smith -- Five More Minutes, Jamie Lidell -- Little Bit Of Feel Good, Greenskeepers -- Money, Katalyst -- See What You Feel
 
75 :04x14 - The Becoming (May/08/2008)

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The nurses' outcry over McSteamy's frequent trysts leads the hospital to enact a new "date and tell" policy. Meanwhile, news about Burke's career force Cristina to cope with her feelings about the past; Meredith and Derek take in a veteran soldier to participate in their clinical trial; and Callie finds comfort in Sloane when she needs it the most.
Guest Stars: Amy Madigan as Dr. Wyatt, Loretta Devine as Adele, Dave Giuntoli as Todd, Zilah Mendoza as Kyra, Benny Ciaramello as Darren, John M. Jackson (1) as Kevin, Lauren Stamile as Rose
Director: Julie Ann Robinson
Writer: Tony Phelan, Joan Rater
Songs: The Submarines -- Brightest Hour, Beth Orton -- Carmella (Four Tet Remix), Frightened Rabbit -- Good Arms vs. Bad Arms, Jay Clifford -- Know When To Walk Away, Vampire Weekend -- Mansard Roof, Taken By Trees -- Only Yesterday
 
76 :04x15 - Losing My Mind (May/15/2008)

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As Dr. Wyatt refuses to let Meredith give up on her therapy sessons, Alex learns the truth about Rebecca's condition. Chief Webber has Dr. Hahn perform a high-risk surgery on his mentor. Meanwhile, after hearing about Burke, Cristina continues to act unusually, going as far as to clean her ever-messy apartment.
Guest Stars: Amy Madigan as Dr. Wyatt, Lauren Stamile as Rose, Elizabeth Reaser as Rebecca, Regina Taylor as Greta
Director: James Frawley
Writer: Debora Cahn (1)
Songs: Electrocute -- Uh Oh, The Puppini Sisters -- Walk Like An Egyptian, Alaska In Winter -- Your Red Dress (Wedding Song At Cemetery)
 
77 :04x16 - Freedom (1) (May/22/2008)
In the two-part season finale, Meredith and Derek take another shot at the clinical trial while the others race to free a boy from a hardening block of cement. Meanwhile, Izzie helps Alex care for Rebecca and Lexie learns a secret about George's intern status.
Guest Stars: John Cothran, Jr. as Ken, Jurnee Smollett as Beth, Lauren Stamile as Rose, Amy Madigan as Dr. Wyatt, Elizabeth Reaser as Rebecca, | Co-Guest Stars: Jana Kramer as Lola
Director: Rob Corn
Writer: Shonda Rhimes
Songs: Coldplay -- Death And All His Friends, Priscilla Ahn -- Dream, The Rosewood Thieves -- Heavy Eyes, Duffy -- Mercy
 
78 :04x17 - Freedom (2) (May/22/2008)

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In the two-part season finale, Meredith and Derek take another shot at the clinical trial while the others race to free a boy from a hardening block of cement. Meanwhile, Izzie helps Alex care for Rebecca and Lexie learns a secret about George's intern status.
Guest Stars: Amy Madigan as Dr. Wyatt, Elizabeth Reaser as Rebecca, Lauren Stamile as Rose, Loretta Devine as Adele, Jurnee Smollett as Beth, John Cothran, Jr. as Ken
Director: Rob Corn
Writer: Shonda Rhimes
Songs: Ingrid Michaelson -- Giving Up, Adele -- Hometown Glory, Ida Maria -- Keep Me Warm, Bryn Christopher -- Quest, Jon Foreman -- The Cure For Pain
 
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