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« Season 1   Settings    All Season (Printable Guide) Season 6 »
S-1 | S-2 | S-3 | S-4 | S-5 | S-6 | All

Season 1
1 :01x01 - A Hard Day's Night (Mar/27/2005)
On the morning of her first day as a surgical intern at Seattle Grace Hospital, Meredith Grey is running late as she recovers from a one-night stand and prepares for her first day. Meredith quickly befriends George O'Malley, who's quirky, yet lovable, Cristina Yang, a highly competitive woman, and Izzie Stevens, a model turned surgical intern. Each of the new interns get assigned to Dr. Miranda Bailey, who past interns have dubbed "the Nazi".

Meredith's first patient, a young beauty pageant contestant, recently began having severe, life-threatening seizures and Meredith uncovers that she'll need brain surgery to save her life. However, things take a turn when the neurosurgeon, Dr. Derek Shepard, happens to be Meredith's one-night stand. He wants their brief relationship to progress into something more, but Meredith is firm on her stance - their relationship should remain strictly professional.
Guest Stars: Randall Arney as Mr. Bryce, Martin Ighani as Rectal Exam Patient, Skyler Shaye as Katie Bryce, | Co-Guest Stars: Robbie Troy as Ms. Bryce, David Vegh as Tony Savitch, Laura Carson as Gloria Savitch, Moe Irvin as Tyler Christian, Sendhil Ramamurthy as Intern #2, Lynne Marie Stewart as Nurse, Sean Palmer as Intern #3, Richard Gilbert-Hill (2) as Small Town Doc, Grinnell Morris as Intern #4, Kathleen M. Darcy as Anesthesiologist, Brad Pennington as Radiologist, Noelle McCutchen as Nurse #2, Josh Bywater as Intern #1, Gregory Erff as Mr. Jones, Billy Wood as Senior Resident
Director: Peter Horton
Writer: Shonda Rhimes
Songs: O.A.O.T.S. -- Dance, Thirteen Senses -- Into The Fire, Butterfly Boucher -- Life Is Short, Rilo Kiley -- Portions For Foxes, Vaughan Penn -- Ready to Rise, BANG Sugar BANG -- Super Cool, -- They
 
2 :01x02 - The First Cut Is the Deepest (Apr/03/2005)
The surgical staff tries to stay positive when a young woman, despite brain surgery, is clinging to life after a brutal attempted rape. Meanwhile, Meredith risks her spot in the intern program when she crosses the line in order to save a newborn suffering from a undiagnosed heart condition. The other interns learn that in order to be a good surgeon and doctor, much more than medial knowledge is needed.
Guest Stars: Kate Burton as Ellis Grey, | Co-Guest Stars: Alice Lo as Qing Lu, Robin Pearson Rose as Patricia, Kristy Munden as Trauma Nurse, Scott Michael Morgan (1) as Patient #2, Sonia Jackson as Patient #1, Kerri Higuchi as Pediatrics Intern, Walter Wong as Tech, Scarlett Lam as Ahn, Kerry Carney as Intern #1, Dennis Gubbins as Paul, Stacey Hinnen as Mr. Johnson, Elise Robertson as Ms. Johnson, Alex Thayer as Allison, Jeff Marlow as Drunk Man, Kylie Dragna as Ellen Parkins, Shannon Burwell as Crying Patient, Gary Kraus (1) as Louis Cardon, Stephen Blackehart as Vic, Cindy Drummond as Louis' Wife, Helen McCardle (1) as ER Doc (as Helene McCardle), Chip Keyes as Big Man, Andre Panossian as Code Team Leader, Patricia Harris-Smith as Patient's Wife, Debra Holt as Big Man's Wife, Nate Reese as Father of Patient #1, Joan McCrea as Louis' Wife's Mother, Linda Nile as Louis' Wife's Sister
Director: Peter Horton
Writer: Shonda Rhimes
Songs: The Cardigans -- Live and Learn, The Ditty Bops -- Sister Kate, Keane -- Somewhere Only We Know, Get Set Go -- Wait, Tegan & Sara -- You Wouldn't Like Me
 
3 :01x03 - Winning a Battle, Losing the War (Apr/10/2005)
On the day of a bike race, injured individuals flood into the hospital, including a pedestrian who is left brain dead. Seeing that he has no chance of ever waking up, Cristina and Izzie wish to use his organs for organ donation, but find that the process is an emotional one. George gets assigned to Mack, a good friend of Chief Webber, and constantly flirts with George. Meanwhile, Meredith continues to try to distance herself from Derek and is forced to deal with Alex's big ego, but through the day, Meredith begins to realize the key to winning the battle.
Guest Stars: Callum Blue as Viper, Keith David as Lloyd Mackie, | Co-Guest Stars: Kristy Munden as Trauma Nurse (Kristy L. Munden), Kathleen M. Darcy as Anesthesiologist, Dinah Lee as Grungy Chick, Kelsy Kemper as Shelley's Daughter, Rudolph McCollum as Vipor's Male Friend, Claire Lautier as Shelly, Steven W. Bailey (1) as Jeremy, Zina Zaflow as Nurse
Director: Tony Goldwyn
Writer: Shonda Rhimes
Songs: Lisa Loeb -- Fools Like Me, Tegan & Sara -- I Won't Be Left, The Ditty Bops -- There Is A Girl, The Ditty Bops -- Wishful Thinking, Reindeer Section -- You Are My Joy
 
4 :01x04 - No Man's Land (Apr/17/2005)
While George begins to feel that he's loosing his masculinity due to Izzie and Meredith treating him like a sister, Izzie's newest patient may loose his masculinity to prostate cancer. Cristina assigns herself to a sick woman, who she believes will need surgery, but ends up learning more from the woman then standing in on a surgery would ever give her. Meredith faces the reality of her mother's Alzheimer's when Derek treats a patient with nails in his brain. Meanwhile, Alex tapes up pictures of Izzie's racy spread all over the locker room.
Guest Stars: Anna Maria Horsford as Nurse Liz Fallon, F. J. Rio as Jorge Cruz, Valerie Cruz as Zona Cruz, Kate Burton as Ellis Grey, Taylor Nichols as Rick Humphrey, | Co-Guest Stars: Tom Choi as Flouroscope Tech, Chris Hendrie as Dr. Harry Victor, Helen McCardle (1) as ER Doc, Jack Merrill as Radiology Tech #2, John O'Brien (1) as Radiology Tech #1, Moe Irvin as Tyler, | Uncredited: Linda Klein as Medical Technician
Director: Adam Davidson
Writer: James D. Parriott
Songs: Get Set Go -- Break Your Heart, The Eames Era -- Could Be Anything, Rosie Thomas -- Let Myself Fall, Sia -- Sunday, Vaughan Penn -- Truth, Tegan & Sara -- Where Does The Good Go
 
5 :01x05 - Shake Your Groove Thing (Apr/24/2005)
Meredith realizes the responsibility of adulthood when her mother has to sign all of her assets over to her. Izzie decides to throw a party for her boyfriend, Hank, and the scale of the party, which Meredith is unaware of, increases throughout the day. After popping a glove during a heart surgery, Meredith fears that she damaged the patient's heart and has to face a meeting with the chief and lawyers who will determine her future as a doctor. Meanwhile, sparks start to fly between Cristina and Burke, and Meredith and Derek's relationship is exposed when Bailey catches them together at the party.
Guest Stars: Brent Sexton as Jerry Frost, Kathryn Joosten as Mrs. Drake, Barry Shabaka Henley as Mr. Patterson, Kate Burton as Ellis Grey, Jonathan Scarfe as Hank, | Co-Guest Stars: Moe Irvin as Tyler, Kate Forster as Jane Richie, Vladimir Rajcic as Resident Doctor, Jeff Doucette as Warren Sterman, Steven W. Bailey (1) as Anesthesiologist Jeremy, Jane Morris as Ms. Goff, Andre Panossian as Perfusionist
Director: John David Coles
Writer: Ann Lewis Hamilton
Songs: Ivy -- Edge Of The Ocean, Interpol -- Evil, Dee -- Monkey Girl, Buffseeds -- Sparkle Me, Psapp -- Tiger, My Friend, The Ditty Bops -- Wake Up
 
6 :01x06 - If Tomorrow Never Comes (May/01/2005)
The interns are speechless when a woman comes in with a large, record-breaking tumor, but unfortunately for the woman, her outlook isn't good. Derek and Meredith's jobs are at risk now that Bailey knows about their relationship, and Dr. Bailey makes it clear that Derek better not give Meredith special treatment. Meanwhile, Izzie urges George to ask Meredith out, and Cristina and Burke's relationship continues to progress.
Guest Stars: Bruce Weitz as Mr. Levangie, Jane Galloway Heitz (1) as Annie's Mother, Alex Alexander (1) as Annie Connors (as Alex S. Alexander), Lara Phillips as Mary Levangie, | Co-Guest Stars: Linda Klein as Nurse, Brad Pennington as Radiologist, Moe Irvin as Tyler Christian, Steven W. Bailey (1) as Anesthesiologist, Sean Palmer as Intern, Patricia Bethune as Older Nurse, Yvonne Farrow as Heart Patient's Wife, John O'Brien (1) as CT Tech, Yolanda Snowball as Physical Therapist, Walter Wong as Echo Tech, Noelle McCutchen as Cardiac Nurse, Sharmila Devar as Female Intern
Director: Scott Brazil
Writer: Krista Vernoff
Songs: Psapp -- Chapter, Butterfly Boucher -- Never Leave Your Heart Alone, -- Save Me, The Ditty Bops -- Walk Or Ride
 
7 :01x07 - The Self Destruct Button (May/08/2005)
Derek and Meredith try to spend a night together at Meredith's, but their appearance the next morning does more harm than they expected and leads Bailey to tell Meredith to end it. Alex treats a self-mutilation patient, while Izzie's patient literally won't let go of his girlfriend. Meanwhile, George is suspicious that an anesthesiologist is drinking on the job and Cristina fills ill with flu-like symptoms.
Guest Stars: Russell Hornsby as Digby Owens, Ever Carradine (1) as Athena, Kim Morgan Greene as Mrs. Rice, Amanda MacDonald as Claire Rice, | Co-Guest Stars: Shenita Moore (1) as Surgical Nurse, Sarah Utterback as Nurse Olivia, Rebecca Rogers as Jamie Hayes, Vanessa Rogers as Jamie Hayes, Joseph Kell as Mr. Rice, Regan Forman as Gwen Hayes, Bill Birch as J.P., Larry Cahn as Dr. Taylor, Doug Sinclair as Brett Hayes, Steve Monroe (1) as Orderly
Director: Darnell Martin (1)
Writer: Kip Koenig
Songs: Tegan & Sara -- Downtown, Wilco -- Hummingbird, Joe Purdy -- Suitcase, -- Wish I
 
8 :01x08 - Save Me (May/15/2005)
The interns treat a patient who, after a series of seizures, thinks he's gained psychic abilities. Meredith becomes dissatisfied with her relationship with Derek when she realizes that she knows nothing about his personal life. Alex treats a patient whose religion interferes with her recovery; Izzie debates whether or not to reconnect with her mother; and Cristina's patient disagrees with her medical advice.
Guest Stars: Joan McMurtrey as Zoey Glass, Kevin Rahm as Mr. Duff - Psychic Guy, Sarah Hagan as Devo Friedman, Josh Stamberg as Tommy Walker, | Co-Guest Stars: Steven W. Bailey (1) as Anesthesiologist Jeremy, Anjul Nigam as Psych Intern, Sarah Utterback as Nurse Olivia, Ping Wu as Seymour Glass, Charles Walker as Dr. Chesney, Chad Einbinder as Sam Friedman, Lisa Kaminir as Doris Friedman, Kathleen Bailey (1) as Reproductive Counselor, Darlene Kegan as Ruby Walker
Director: Sarah Pia Anderson (1)
Writer: Mimi Schmir
Songs: Nellie McKay -- David, Masha Qrella -- Feels Like, Tegan & Sara -- Fix You Up, Masha Qrella -- I Love The Rain The Most, 78 Saab -- No Illusions, Laura Veirs -- Rapture
 
9 :01x09 - Who's Zoomin' Who? (May/22/2005)
When an STD breaks out, affecting several members of the staff, Webber calls a staff meeting. Later, the chief confides in Derek about his own medical concerns. Izzie and Cristina become stressed when a patient's wife and daughter can't decide on his care. Burke treats an old college friend, Bill, but his diagnosis creates questions about his wife. As Meredith and Derek continue to get closer, their relationship crashes down around them when a person from Derek's past shows up in his life.
Guest Stars: Wendy Davis as Holly Adams, Lauren Bowles as Alice Franklin, Kate Walsh as Addison Montgomery-Shepherd, Wayne Wilderson as Bill Adams, | Co-Guest Stars: Patricia McCormack (1) as Rebecca Franklin (as Patty McCormack), Catherine Dao as Dr. Knox, Sarah Utterback as Nurse Olivia, Joyce Guy as Ms. Henry, Jack Merrill as Lab Tech, Robin Pearson Rose as Patricia, Jack Shearer as Jordan Franklin
Director: Wendey Stanzler
Writer: Harry Werksman, Gabrielle Stanton
Songs: A.M. Sixty -- Big As the Sky, Medeski, Martin & Wood -- End of the World Party, Iron and Wine -- Naked As We Came, Nellie McKay -- The Dog Song, The Radio -- Whatever Gets You Through Today
 

Season 2
Recap Special: Straight to the Heart (Jan/08/2006)
See how it all began ...

Straight to the Heart re-examines the lives of the five interns and their past relationships, both personal and professional.
Guest Stars: Steven W. Bailey (1) as Narrator
 
10 :02x01 - Raindrops Keep Falling On My Head (Sep/25/2005)
While off from work, Meredith and Cristina discuss their mutual man problems and are interrupted when Joe, the bartender, collapses. While Webber recovers from his surgery, he appoints one of the surgeons as interim chief, but has George report to him all the happenings at the hospital. While Meredith learns more about Derek and Addison's past relationship, Cristina tries to decide what to do in her relationship with Burke.
Special Guest Stars: Kate Walsh as Addison Montgomery-Shepherd, | Guest Stars: Steven W. Bailey (1) as Joe, Wendy Gazelle as Julie Phillips, | Co-Guest Stars: Jeremy Rabb as Resident, Linda Klein as Scrub Nurse, Noelle McCutchen as Nurse Vivian, Robin Pearson Rose as Patricia, | Uncredited: Tracey Evans (1) as Donor Woman
Director: Peter Horton
Writer: Stacy McKee
Songs: Firstcom -- All I Need, Esthero Feat. Sean Lennon -- Everyday is a Holiday, Ivy -- Feel So Free, Bow Wow Wow -- I Want Candy, Mike Doughty -- Looking At the World From the Bottom of a Well, Blue Eyed Son -- Step Away From the Cliff, Joe Purdy -- The City
 
11 :02x02 - Enough Is Enough (No More Tears) (Oct/02/2005)

View Trailer
A family arrives at Seattle Grace after a car accident. While treating the members of the family, Alex discovers that their problems are deeper than their injuries. Meanwhile, Mrs. Webber admits her marital worries to Richard as he recovers.
Special Guest Stars: Kate Walsh as Addison Montgomery-Shepherd, | Guest Stars: Sarah Utterback as Nurse Olivia, Loretta Devine as Mrs. Webber, Scott Michael Campbell (1) as Mr. Hubble, Lukas Behnken as Scott Seibert, Romy Rosemont as Lea Seibert, | Co-Guest Stars: Linda Klein as Nurse, Jeremy Rabb as ER Resident, Seth Adams as Radiologist, Jim Gleason (3) as Dr. Domner, Yvette Cruise as Scrub Nurse, Johanna McKay as Grieving Widow, Robin Pearson Rose as Patricia, John Cappon as Paramedic #1, David Haley as Paramedic #2, Peter Birkenhead as Dr. Orsen
Director: Peter Horton
Writer: James D. Parriott
Songs: Goldfrapp -- Beautiful, Joy Zipper -- Go Tell The World, -- Just A Ride, K.T. Tunstall -- Suddenly I See, Brandi Carlile -- What Can I Say
 
12 :02x03 - Make Me Lose Control (Oct/09/2005)

View Trailer
Meredith's secrets about the state of her mother, Ellis Grey, are revealed to the staff when Ellis is brought in for surgery. Meanwhile, secrets about Cristina's health are also revealed.
Special Guest Stars: Kate Walsh as Addison Montgomery-Shepherd, | Guest Stars: Kate Burton as Ellis Grey, Angela Goethals as Kelly, | Co-Guest Stars: Jeremy Rabb as Resident #1, Linda Klein as Scrub Nurse, Noelle McCutchen as Nurse Vivian, Stephen Breithaupt as Mr. Geston, John O'Brien (1) as Lab Technician
Director: Adam Davidson
Writer: Krista Vernoff
Songs: Sylvie Lewis -- By Heart, Inara George -- Fools In Love, Roisin Murphy -- Ruby Blue, Maria Taylor -- Song Beneath The Song, K.T. Tunstall -- Suddenly I See
 
13 :02x04 - Deny, Deny, Deny (Oct/16/2005)
While trying to recover, Cristina proves to be a difficult patient, and matters are made worse when her mother visits. Ellis Grey, Meredith's mother also proves to be a difficult patient when she has the staff running in circles to please her. Derek and Meredith's relationship remains in limbo when Addison's departure is postponed when she becomes involved with the treatment of a cystic fibrosis patient.
Special Guest Stars: Kate Walsh as Addison Montgomery-Shepherd, | Guest Stars: Kate Burton as Ellis Grey, Steven W. Bailey (1) as Joe, Tsai Chin as Helen, Lee Garlington as Farah Linden, Don McManus (1) as Samuel Linden, Katherine La Nasa as Kalpana Vera, Thomas Ian Nicholas as Jeremiah Tate, | Co-Guest Stars: Kathleen M. Darcy as Anesthesiologist, Moe Irvin as Nurse Tyler, Don Wilson (1) as Radiology Tech, Linda Eve Miller (1) as ER Nurse, Noelle McCutchen as Nurse Vivian
Director: Wendey Stanzler
Writer: Zoanne Clack
Songs: Ben Lee (1) -- Catch My Disease, The Delgados -- I Fought The Angels, Merrick -- Infiinity, Roisin Murphy -- Ramalama
 
14 :02x05 - Bring The Pain (Oct/23/2005)

View Trailer
Meredith and Derek have to use more than their medical knowledge when a woman's strictly religious father forbids her from having an operation that would save her life. Meanwhile, George and Alex are forced to perform a surgery in scarce conditions, and Derek is forced to decide between Addison and Meredith.
Special Guest Stars: Kate Walsh as Addison Montgomery-Shepherd, | Guest Stars: Steven W. Bailey (1) as Joe, Mimi Kennedy as Verna Bradley, François Chao as Mr. Chue, Brent Briscoe as Henry Lamott, Michelle Krusiec as Anna Chue, Daniel Bess as Pete Willoughby, Kate Burton as Ellis Grey, | Co-Guest Stars: Jeremy Rabb as ER Resident, Bashir Salahuddin as Bailey's Husband, Sally Ann Brooks as Marie Lamott, Sean Moran as Lou Bradley
Director: Mark Tinker
Writer: Shonda Rhimes
Songs: Way Out West -- Don't Forget Me, Mike Doughty -- I Hear The Bells, Tegan & Sara -- Not Tonight, Roisin Murphy -- Prelude to Love In The Making, Blue Eyed Son -- When I Come Home, Cowboy Racer -- Yellow Horse
 
15 :02x06 - Into You Like A Train (Oct/30/2005)

View Trailer
Meredith temporarily forgets her worries about Derek's decision when a train crash results in dozens of injuries. Later, Addison sees potential in Izzie, but Izzie is forced to choose between her friendship with Meredith or her career.
Special Guest Stars: Kate Walsh as Addison Montgomery-Shepherd, | Guest Stars: Steven W. Bailey (1) as Joe, Cynthia Ettinger as Jana, Juliette Jeffers as Mary, Michelle Arthur as Brooke, Monica Keena as Bonnie, Bruce A. Young (1) as Tom, Kim Whitley as Yvonne (as Kym Whitley), | Co-Guest Stars: Linda Klein as Nurse, Chad Fisk as Med Tech #2, Brooke Blanchard as Jill the Paramedic, Michael Barreta as Danny, Derick Alexander as Lab Tech, Rigo Sanchez as Stan the Paramedic, Marty Lodge as Anesthesiologist, Ariel Felix as Intern #1, Ray Ford as Paramedic, Karen Lew (1) as Dr. Hoffman, Yvette Cruise as Scrub Nurse, Kerry Carney as Intern #2, Patricia Bethune as Nurse Ginger, Moe Irvin as Nurse Tyler, Robin Pearson Rose as Patricia
Director: Jeff Melman
Writer: Krista Vernoff
Songs: The Here After -- Back Where I Was, B.C. Camplight -- Blood & Peanut Butter, The Umbrellas -- The City Lights, Emiliana Torrini -- Today Has Been Okay
 
16 :02x07 - Something to Talk About (Nov/06/2005)

View Trailer
The entire staff is in awe when a patient, Shane, comes in with a hysterical pregnancy while Cristina, Izzie and Meredith aggressively work on his unique case. Meanwhile, Alex is encouraged to show his feelings for Izzie after treating a young, sheltered young patient.
Guest Stars: Steven W. Bailey (1) as Joe, Francis Guinan as Mr. Verma, Elaine Kagan as Mrs. Griswold, Tyrees Allen as Dr. Saltzman, Patti Yasutake as Mrs. Verma, Michelle Ongkingco as Nicole Verma, Joseph Sikora as Shane, Reni Santoni as Mr. Griswold, | Co-Guest Stars: Gianin Loffler as Psych Patient #2, Keeshan Giles as Intern #3, Peyton Hinson as Intern #2, Larry Weissman as Psych Patient #1, Maile Flanagan as Tech, Kerry Carney as Intern #1, Cathy Lind Hayes (3) as Debbie, Moe Irvin as Nurse Tyler, Alison Ward as Tina Herman
Director: Adam Davidson
Writer: Stacy McKee
Songs: The Faders -- Better Off Dead, Annie -- Chewing Gum, Mark Joseph -- Get Through, K.T. Tunstall -- Other Side Of The World, Rosie Thomas -- Since You've Been Around
 
17 :02x08 - Let It Be (Nov/13/2005)

View Trailer
Friends of Derek and Addison come to Seattle Grace for preemptive surgery to avoid breast and ovarian cancer. But the arrival of their friends tests Derek and Addison's professional relationship. Meanwhile, George treats a patient who fell five stories and is dissatisfied with his outcome and Cristina and Burke attempt a "normal" date.
Guest Stars: Arija Bareikis as Savannah, Janet Rotblatt as Esme, Joseph Lyle Taylor as Weiss, Geoffrey Rivas as Stu, Brittany Ishibashi as Talia, Shelley Berman as Jed, | Co-Guest Stars: Linda Klein as Nurse, Kate Blumberg as Daisy, Brian Reid as Waiter, Ray Ford as Paramedic, Kathleen M. Darcy as Anesthesiologist, Kai Lennox as Speed
Director: Lesli Linka Glatter
Writer: Mimi Schmir
Songs: Gabin -- Bang Bang to the Rock N Roll, Joe Purdy -- Far Away Blues, Nouvelle Vague -- I Melt With You, Anya Marina -- Miss Halfway, The Faders -- No Sleep Tonight, The Chalets -- Sexy Mistake
 
18 :02x09 - Thanks for the Memories (Nov/20/2005)

View Trailer
Thanksgiving proves to be a difficult holiday for both the interns and residents. Izzie plans a big dinner, but it doesn't look like all the invited guests will show up. Meanwhile, George participates in the O'Malley turkey hunting tradition, which abruptly ends after a shooting accident and Meredith treats a comatose patient whose condition might be better than it appears.
Special Guest Stars: Brian Kerwin as Holden McKee, | Guest Stars: Greg Pitts (1) as Jerry O'Malley, Tim Griffin as Ronny O'Malley, Sarah Utterback as Nurse Olivia, Steven W. Bailey (1) as Joe, | Co-Guest Stars: Michael Matthys (1) as Dr. Kent, Gregor Manns (1) as Levi Johnson, Mike Faiola as Guy, Andrew James Allen as Coby McKee, Dee Nelson as Cheryl Leonard, Peter Howard (1) as Hal Leonard, Jack Yang (1) as Walter, | Uncredited: George Dzundza as Harold O'Malley
Director: Michael Dinner
Writer: Shonda Rhimes
Songs: O.A.O.T.S. -- Dance, Dressy Bessy -- New Song (From Me to You), Keren Ann -- Not Going Anywhere, Fannypack -- Nu Nu (Yeah Yeah), Josh Rouse -- Sad Eyes, Emiliana Torrini -- Serenade, Mark McAdam -- Too Hard
 
19 :02x10 - Much Too Much (Nov/27/2005)

View Trailer
Meredith is horrified when her one-night stand needs treatment after suffering from priapism. Meanwhile, Alex begins to frustrate Izzie and a pregnant woman carrying quintuplets stresses over her high-risk pregnancy.
Guest Stars: Sunkrish Bala as Steve Murphy, Curtis Armstrong as Mr. Martin, Margaret Welsh as Dorie Russell, Sarah Utterback as Nurse Olivia, Robin Pearson Rose as Patricia, Pat Healy (1) as Tom Russell, | Co-Guest Stars: Jon Hershfield as Doyle
Director: Wendy Stanzler
Writer: Harry Werksman, Gabrielle Stanton
Songs: Get Set Go -- Crying Shame, James Blunt -- High, Greens Keepers -- Lotion, Roisin Murphy -- Night of the Dancing Flame, Lifehouse -- You and Me
 
20 :02x11 - Owner of a Lonely Heart (Dec/04/2005)

View Trailer
Cristina finds little sympathy for an inmate who purposely endangers her health to get out of serving her term in solitary confinement. Meanwhile, the interns are put in charge of watching the newborn quintuplets, each with varying health concerns; Izzie's frustrations with Alex's shortcomings hit their end; and Derek teaches Izzie an important, yet painful lesson.
Guest Stars: Rosanna Arquette as Constance Ferguson, Timothy Bottoms as Mr. Murphy, Curtis Armstrong as Mr. Martin, Pat Healy (1) as Tom Russell, Margaret Welsh as Dorie Russell, Sarah Utterback as Nurse Olivia, | Co-Guest Stars: Patricia Bethune as Nurse Ginger, Monica Garcia as Peds Nurse, Elaine Kao as NICU Nurse, Brooke Blanchard as Jill the Paramedic, Amie Donegan as NICU Nurse #2
Director: Dan Minahan (1)
Writer: Mark Wilding
Songs: Jim Noir -- I Me You, Emiliana Torrini -- Sunny Road, James Blunt -- Tears and Rain, Gemma Hayes -- Two Step, Moonbabies -- War On Sound
 
21 :02x12 - Grandma Got Run Over By a Reindeer (Dec/11/2005)

View Trailer
Burke and Cristina's differences are shown when a young boy needs a transplant but he refuses to get it. Meanwhile, the interns help Alex prepare for his exams when it's revealed that he failed them. Meredith has to re-instill the Christmas spirit in Izzie and Derek refuses to feel festive.
Guest Stars: Rik Deskin as Pedestrian #1, Helen Slater as Mrs. Shelton, Richard Jenik as Jimmy Shelton, Steven W. Bailey (1) as Joe, Robin Pearson Rose as Patricia, Kathe Mazur as Mrs. Hasting (as Kathe Mazur), Jenny O'Hara as Mrs. Shelton's Mother, Michael Hyatt (1) as Mariann, Andrew Bilgore as Tim Hasting, C. J. Sanders as Justin, | Co-Guest Stars: Sarah McDermott as Leah, Troy Curvey, Jr. as Priest, Alan Fudge as Ernie, Kathleen M. Darcy as Anesthesiologist, Alex Stamm as Josh, Linda Klein as Scrub Nurse, Savannah McDermott as Jesse, John Cappon as John the Paramedic, Sean McDermott as Jake
Director: Peter Horton
Writer: Krista Vernoff
Songs: Jet -- Back Door Santa, Maria Taylor -- Christmas After All, Sixpence None The Richer -- It Came Upon a Midnight Clear, The LeeVees -- Latke Clan, Catie Curtis -- Lo, How A Rose E'er Blooming, Lou Rawls -- Santa Claus Is Comin' to Town, Nat 'King' Cole -- The Christmas Song (Merry Christmas to You), Mascott & Dave Derby -- This Christmastime
 
22 :02x13 - Begin the Begin (Jan/15/2006)

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As the new year unfolds, Izzie vows to let Alex's affair go, and it comes easier when she hits it off with Denny Duquette, a heart transplant patient. George treats Bex, a teen hermaphrodite, with a tumor and Alex treats a man who ate his novel after not being pleased with the results. Meanwhile, Derek talks with Meredith's mom, Addison expresses her disgust with Derek's living arrangements, and the residents, especially Cristina, have a hard time dealing with the new work limit.
Guest Stars: Jeffrey Dean Morgan as Denny Duquette, Becca Gardner as Bex, Kate Burton as Ellis Grey, Stephen Spinella as Author, Lauren Tom as Wife, John Prosky as Bex's Father, Shannon Cochran as Bex's Mother, | Co-Guest Stars: Joyce Guy as Administrator, Rob Narita as Anesthesiologist, Linda Klein as Nurse Linda
Director: Jessica Yu (1)
Writer: Kip Koenig
Songs: Slow Runner -- Break Your Momma's Back, The 88 -- Hide Another Mistake, Kraak And Smaak -- One of These Days, Cary Brothers -- Ride
 
23 :02x14 - Tell Me Sweet Little Lies (Jan/22/2006)

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Cristina and Meredith hide the truth about their relationships from each other. George is assigned to discharge an elderly patient who refuses to leave; and Alex learns the fate of his career when the results from his medical exams come in.
Guest Stars: Carole Cook as Mrs. Sophie Larson, Donovan Leitch as Rick Freeark, Nancy Linari as Sophie's Daughter, Robin Pearson Rose as Patricia, | Co-Guest Stars: Cathy Lind Hayes (3) as Nurse Debbie, Jill Holden (1) as Naomi Cline, Christopher Boyer (2) as Tom Cline, John O'Brien (1) as Jeffrey, Ricardo Molina (1) as ID Resident Amir, Rigo Sanchez as Paramedic, Natalie N. Okamoto as Yumi, Kate Anthony as GI Nurse, Yutaka Takeuchi as Kamaji, Tyshawn Bryant as Friend #1
Director: Adam Davidson
Writer: Tony Phelan, Joan Rater
Songs: St. Etienne -- A Good Thing, Carey Ott -- Am I Just One, Adrienne Pierce -- Fool's Gold, Sam Winch -- I Got Some Moves, Metric -- Monster Hospital, Mike Tarantino -- Wienermobile Girl
 
24 :02x15 - Break on Through (Jan/29/2006)

View Trailer
When the nurses at Seattle Grace go on strike, the doctors are forced to work without them. While most of the doctors cross the picket line, George refuses to cross due to his union roots. With Bailey on maternity leave, the interns meet their temporary resident, Dr. Sydney Heron, who is the exact opposite of Dr. Bailey, which Cristina has a hard time adjusting to. Meanwhile, secrets from Izzie's past are revealed as she treats a young, pregnant teen; and Meredith makes a mistake in treating an elderly patient.
Guest Stars: Leisha Hailey as Claire Solomon, Kenneth Mitchell as Wade Solomon, Sarah Utterback as Nurse Olivia, Betty Garrett as Eleanor, Rae Allen (1) as Ruth, Monica Calhoun (1) as Shyan's Mother, June Lockhart as Agnes, Kali Rocha as Sydney Heron, Steven W. Bailey (1) as Joe, Regine Nehy as Shyan, Robin Pearson Rose as Patricia, Kate Burton as Ellis Grey, | Co-Guest Stars: Cathy Lind Hayes (3) as Nurse Debbie, Jeremy Rabb as ER Resident, Zibby Allen as Temp Nurse, Kate Anthony as GI Nurse, Donna Hardy as Grace Bickham, Moe Irvin as Nurse Tyler, Amy Cale Peterson as Nurse Home Staffer, Pamela Roylance as Alice Bickham, Teddi Siddall as Anne
Director: David Paymer
Writer: Zoanne Clack
Songs: Leeroy Stagger -- Just In Case, Landon Pigg -- Sailed On, Kendall Payne -- Scratch, Kate Earl -- Someone To Love, Aqueduct -- The Suggestion Box, Vassy -- Wanna Fly
 
25 :02x16 - It's the End of the World (1) (Feb/05/2006)

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All morning, Meredith felt like she was in for a bad day. Her fears are realized when a medical case threatens the lives of everyone at Seattle Grace, causing officials to put the hospital on a "code black".
Special Guest Stars: Christina Ricci as Hannah Davies, | Guest Stars: Kyle Chandler as Dylan Young, Sarah Utterback as Nurse Olivia, Larry Clarke (1) as Paul, Jillian Armenante as Mrs. Carlson, Cress Williams as Tucker, | Co-Guest Stars: Marty Lodge as Dr. Milton, Moe Irvin as Nurse Tyler, Cathy Lind Hayes (3) as Nurse Debbie, Kathleen M. Darcy as Anesthesiologist, John Bishop (1) as James Carlson, O. Austen Rey as Bomb Squad #1, Jamal Thomas as Larry the Paramedic
Director: Peter Horton
Writer: Shonda Rhimes
Songs: Monotypes -- Dead Streets, Chris Martin (1) -- In The Sun (feat. Michael Stripe), Ursula 1000 -- Kaboom!, K.T. Tunstall -- Miniature Disasters
 
26 :02x17 - (As We Know It) (2) (Feb/12/2006)

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Despite the staff doing all they can, the potentially disastrous situation continues to escalate. Meredith begins to panic about her situation, as does Derek when he's told about her circumstances. Meanwhile, while the hospital is in chaos, Bailey and Webber have to deal with their own health issues.
Special Guest Stars: Christina Ricci as Hannah Davies, | Guest Stars: Kyle Chandler as Dylan Young, Loretta Devine as Adele Webber, Jillian Armenante as Mrs. Carlson, Cress Williams as Tucker, | Co-Guest Stars: Cathy Lind Hayes (3) as Nurse Debbie, Kathleen M. Darcy as Anesthesiologist, John Bishop (1) as James Carlson, Scott Lusby as Med Tech
Director: Peter Horton
Writer: Shonda Rhimes
Songs: Greens Keepers -- Back In The Wild, Anna Nalick -- Breathe (2 AM), Foy Vance -- Homebird, Correatown -- I Tell Myself, Ambulance, Ltd. -- Stay Where You Are, Kate Havnevik -- Unlike Me, The Weepies -- World Spins Madly On
 
27 :02x18 - Yesterday (Feb/19/2006)

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When a person from Derek and Addison's past arrives at Seattle Grace, their now stable relationship is shaken up. Meanwhile, after visiting with her mother, Burke is told Cristina's secret; and after a visit with her mother, Meredith digs to find the family's secrets.
Guest Stars: Kate Burton as Ellis Grey, Eric Dane as Dr. Mark Sloan, Jeff Perry as Thatcher Grey, Steven W. Bailey (1) as Joe, Julio Oscar Mechoso as Chucky Eaton, Arlene Tur as Pamela, Jesse Plemons as Jake Burton, | Co-Guest Stars: Carlos Cervantes as Mr. Calva, Deborah Geffner as Mrs. Burton, David Grant Wright (1) as Mr. Burton, Brooke Blanchard as Jill the Paramedic, Ariel Felix as CT Tech, Chad Fisk as The Anesthesiologist
Director: Rob Corn
Writer: Mimi Schmir, Krista Vernoff
Songs: Joshua Radin -- Closer, Diplo -- Diplo Rhythm, Headlights -- Everybody Needs A Fence To Lean On, Rosie Thomas -- It Don't Matter To The Sun, Devics -- Just One Breath, Corinne Bailey Rae -- Like A Star, The Chalets -- Night Rocker
 
28 :02x19 - What Have I Done To Deserve This? (Feb/26/2006)

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Meredith and George fight over who gets to treat a patient. Bailey, despite being on maternity leave, treats Addison for a specific feminine problem. Izzie starts spending time with Denny, and Alex becomes jealous. Meanwhile, Burke treats a man who had a heart attack, and the man's fiancée leaves him when she learns about the risky surgery he's decided to have.
Guest Stars: Jeffrey Dean Morgan as Denny Duquette, Sarah Utterback as Nurse Olivia, Cress Williams as Tucker, Sara Ramirez as Dr. Callie Torres, Mark Harelik as Keith Polus, Ann Cusack as Amy, Jonathan Slavin as Rick, Matt Roth as Michael, Noah Gray-Cabey as Shawn Beglighter, | Co-Guest Stars: Cathy Lind Hayes (3) as Nurse Debbie, Jeremy Rabb as ER Resident, Ray Ford as Ray the Paramedic
Director: Wendey Stanzler
Writer: Stacy McKee
Songs: Boy Least Likely To -- Be Gentle With Me, Madeleine Peyroux -- Careless Love, Get Set Go -- I Hate Everyone, New Moscow -- Slow Down, Brandi Carlile -- Throw It All Away
 
29 :02x20 - Band Aid Covers the Bullet Hole (Mar/12/2006)

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Cristina has a hard day on the job when Bailey has her take care of her baby after she gets involved in a case, despite being on maternity leave. Meredith continues to deal with the fact that she slept with George, who begins to bond with Burke much to Cristina's disgust. Addison and Derek have a deep talk about their relationship and Denny continues to get in the way of Alex being closer to Izzie. Meanwhile, the interns must deal with a hockey player who wants an unnecessary amputation and a woman with a fork stuck in her neck.
Guest Stars: Jeffrey Dean Morgan as Denny Duquette, Teddy Dunn as Heath, Stephen Lee (2) as Mr. Gibson, Sara Ramirez as Dr. Callie Torres, Tim Edward Rhoze as Kyle Booker, Natalie Cole as Sylvia Booker, | Co-Guest Stars: Kelley Hazen as Mrs. Mercer, Anne Moore as Penny Gibson, Ray Ford as Ray the Paramedic, Helen McCardle (1) as ER Doctor (as Helene McCardle)
Director: Julie Ann Robinson
Writer: Gabrielle Stanton, Harry Werksman
Songs: Sing Sing -- Come Sing Me A Song, -- Flying High, The Last Town Chorus -- Modern Love, Tina Dico -- One, The Urbs -- So Weit
 
30 :02x21 - Superstition (Mar/19/2006)

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The doctors' superstitious sides are brought out after several deaths and strange events take place at Seattle Grace. Derek and Addison talk about a more permanent living situation, Izzie worries about Denny's surgery, and Richard gets reacquainted with an old friend.
Guest Stars: Mary Kay Place as Ollie, Michaela Watkins as Nikki, Anjul Nigam as Raj, Jeffrey Dean Morgan as Denny Duquette, Sara Ramirez as Dr. Callie Torres, Omar Metwally as Jesse, the OCD Patient, | Co-Guest Stars: Annie Morgan as Gretchen, Linda Klein as Scrub Nurse, Chad Fisk as Richard's Anesthesiologist, Pamela Zane as AA Member #1, Alex Downs as AA Member #2, Domingo Vara as AA Member #3, Tola Thompson as AA Member #4, Kathleen M. Darcy as Derek's Anesthesiologist, Brooke Blanchard as Jill the Paramedic, Wayne Lopez as Paramedic #2, Keeshan Giles as Intern #2, Kerry Carney as Intern #1, Rob Narita as Burke's Anesthesiologist, Kate Anthony as Nurse Kate, Shenita Moore (1) as ER Nurse
Director: Tricia Brock
Writer: James D. Parriott
Songs: Anna Nalick -- Catalyst - Acoustic, Luke Doucet -- Free, Foy Vance -- Gabriel And The Vagabond, The Fray -- How To Save A Life, Jamie Lidell -- Multiply, Greens Keepers -- You Don't Know Me
 
31 :02x22 - Name of the Game (Apr/02/2006)

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Derek performs brain surgery on Andrew, a young spelling bee champion who suffered a serious head injury. George, who begins to overstay is welcome at Burke's, has trouble not speaking up when one of his patients constantly lies about her health to her daughter. Bailey begins to worry that the interns will no longer see her as "the Nazi" now that she has a child. Meanwhile, Addison treats a patient with pregnancy issues; Alex gets a lesson in manners; and secrets are revealed about Meredith's father.
Special Guest Stars: Chris O'Donnell as Finn Dandridge, | Guest Stars: Mare Winningham as Susan Grey, Laurie Metcalf as Beatrice, Jeffrey Dean Morgan as Denny Duquette, Sara Ramirez as Dr. Callie Torres, Jeff Perry as Thatcher Grey, Mandy Siegfried as Molly Thompson, Steven W. Bailey (1) as Joe, Jusak Yang Bernhard as Seminar Teacher, Harrison Knight as Andrew, Emilee Wallace as Amelia Carver, | Co-Guest Stars: Obie Sims as Neuro Fellow, Soledad St. Hilaire as Lola
Director: Seith Mann
Writer: Blythe Robe
Songs: Sunshine -- C'mon Yeah, Gnarls Barkley -- Crazy, Dressy Bessy -- Girl, You Shout!, Joshua Radin -- The Fear You Won't Fall, Anna Nalick -- Wreck Of The Day (acoustic)
 
32 :02x23 - Blues for Sister Someone (Apr/30/2006)

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A strict Catholic mother of seven children comes to the hospital to ask Addison for medical help because her equally religious husband refuses to use condoms. Addison is able to come up with a solution to her problem, but Alex's interference causes problems for both Addison and the mother. Derek rethinks his marriage after treating a divorce attorney for seizures. Izzie hounds George for information about his private life and pressures him to move back into the house. Meanwhile, Meredith agrees to go out with Doc's vet and Burke is faced with considerable pressure when he has to operate on his musical hero.
Special Guest Stars: Chris O'Donnell as Finn Dandridge, | Guest Stars: Sara Ramirez as Dr. Callie Torres, Jeffrey Dean Morgan as Denny Duquette, Albert Hall as Eugene Foote, Jayne Brook as Gwen Graber, Jean Louisa Kelly (1) as Rose Ward, Andrew Borba as Mr. Ward, | Co-Guest Stars: Noelle McCutchen as Nurse, Bryce Robinson as Timothy Ward, Kathleen M. Darcy as Burke's Anesthesiologist
Director: Jeff Melman
Writer: Elizabeth Klaviter
Songs: James Morrison (2) -- Better Man, Hotel Lights -- Follow Through, Sunshine -- Love, Metric -- Police And The Private
 
33 :02x24 - Damage Case (May/07/2006)

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The interns attend to Marshall, an intern from another hospital with short-term memory loss. Marshall was also the cause of a bad accident involving a family, which leads Derek to let his emotions get in the way of his work. Meanwhile, a woman from the past comes to visit one of the female interns, and Burke and Izzie have an idea relating to Denny's condition.
Special Guest Stars: Chris O'Donnell as Finn Dandridge, | Guest Stars: Sara Ramirez as Dr. Callie Torres, Jeffrey Dean Morgan as Denny Duquette, Frances Fisher as Betty Johnson, John Cho as Marshall, Gabriel Tigerman as Noah Reynolds, Sarah Lafleur as Melanie Reynolds, Graham Beckel as Jim Johnson (as Graham S. Beckel), | Co-Guest Stars: Maile Flanagan as CT Tech #1, Ray Ford as Ray the Paramedic, Wayne Lopez as Paramedic #2, Maria Elena Maglaris as Nurse, P. D. Mani (1) as Anesthesiologist, John O'Brien (1) as CT Tech #2, | Uncredited: Sean Lake as X-Ray Tech
Director: Tony Goldwyn
Writer: Mimi Schmir
Songs: Kate Havnevik -- Nowhere Warm, Inara George -- Oh My Love, Regina Spektor -- On The Radio, The Legends -- Something Good, Brandi Carlile -- Tragedy
 
34 :02x25 - 17 Seconds (May/14/2006)

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Finn continues to work with Doc and is able to give his owners, Meredith and Derek, and update on his condition. George is assigned to work with Derek, while Meredith is assigned to work with Callie. Denny still is without a heart donor, leaving Izzie and Burke to continue the hunt for a potential donor. Meanwhile, a 12-week pregnant woman dies in the O.R., and her parents' decision to try to keep the baby alive creates a rift between Addison and Derek.
Special Guest Stars: Chris O'Donnell as Finn Dandridge, | Guest Stars: Sara Ramirez as Dr. Callie Torres, Jeffrey Dean Morgan as Denny Duquette, Ken Marino as Brad, Jesse Head as Will, Sydney Tamiia Poitier as Deborah, Michael Arden as Neal, Michael Milhoan as Doug Thomas, Brooke Smith (1) as Dr. Erica Hahn, Steven W. Bailey (1) as Joe, Robin Pearson Rose as Patricia, | Co-Guest Stars: Kathleen M. Darcy as Derek's Anesthesiologist, Toby Meuli as Chaz, Kate Mines as Burke's Nurse, Carmen Mormino as Monnie, David Paluck as Surgeon #2, Jeremy Rabb as ER Resident, Keith Sellon-Wright as Surgeon #1, Patti Tippo as Cindy Thomas, | Uncredited: Jennifer Nyholm as Kendra
Director: Dan Minahan (1)
Writer: Mark Wilding
Songs: Yeah Yeah Yeahs -- Gold Lion, Snow Patrol -- Somewhere A Clock Is Ticking
 
35 :02x26 - Deterioration of the Fight or Flight Response (May/15/2006)

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George and Izzie race to find Denny a heart as his heart gets weaker and weaker by the minute. Derek is faced with the pressure of performing surgery on one of his friends, while Cristina is faced with the pressure of running the O.R. after she is left in charge. Meanwhile, the interns are supervised by Erica, a new attending, who tries her hardest to act like Bailey, but has a tough time doing so.
Special Guest Stars: Chris O'Donnell as Finn Dandridge, | Guest Stars: Sara Ramirez as Dr. Callie Torres, Jeffrey Dean Morgan as Denny Duquette, Loretta Devine as Adele Webber, Hallee Hirsh as Claire, Tessa Thompson as Camille, Tiffany Hines as Natalie, Brooke Smith (1) as Dr. Erica Hahn, Sarah Utterback as Nurse Olivia, | Co-Guest Stars: Charles Duckworth as Brian, Ariel Felix as Anesthesiologist, Linda Klein as Nurse Linda, David Paluck as Surgeon #2, Jeremy Rabb as ER Resident, Keith Sellon-Wright as Surgeon #1
Director: Rob Corn
Writer: Tony Phelan, Joan Rater
Songs: Gomez -- How We Operate, The Coral Sea -- Look At Her Face, Au Revoir Simone -- Through The Backyards, K.T. Tunstall -- Universe And U
 
36 :02x27 - Losing My Religion (May/15/2006)
After Richard learns who Derek is operating on, he tries to pump Addison for information. Callie and George have a talk about their relationship and George's true feelings. Meanwhile, Meredith and Derek get together to talk about Doc, and later realize that their feelings for each other may not entirely be gone despite Finn being in Meredith's life and Addison being in Derek's.
Guest Stars: Chris O'Donnell as Finn Dandridge, Sara Ramirez as Dr. Callie Torres, Jeffrey Dean Morgan as Denny Duquette, Loretta Devine as Adele Webber, Hallee Hirsh as Claire, Tessa Thompson as Camille, Tiffany Hines as Natalie, Brooke Smith (1) as Dr. Erica Hahn, Charles Duckworth as Brian, Sarah Utterback as Nurse Olivia, | Co-Guest Stars: Linda Klein as Nurse Linda, Ariel Felix as Anesthesiologist
Director: Mark Tinker
Writer: Shonda Rhimes
Songs: Snow Patrol -- Chasing Cars, Amos Lee -- Colors, Masha Qrella -- Destination Vertical, Kate Havnevik -- Grace, Dressy Bessy -- Side 2, Peter Droge -- Under The Waves
 
Under Pressure (Apr/23/2006)
A one-hour special recaping the lives of the interns at Seattle Grace Hospital. Starting with their first day, the intern's lives, both personal and professional, are recapped, along with the struggles of their first year of being surgical interns.
Guest Stars: Steven W. Bailey (1) as Narrator
 

Season 3
Complications of the Heart (Sep/21/2006)
In a clip-show, "Complications of the Heart" recaps the highlights of the previous season from the arrival of Addison to Meredith's cliff-hanging season finale scene. The episode will also feature the music video for The Fray’s single, “How to Save a Life" which features clips from season 2 as well as clips from the season 3 premiere.
Guest Stars: Steven W. Bailey (1) as Narrator
 
Every Moment Counts (Apr/12/2007)
"Every Moment Counts" recaps the events of the third season. Hosted by recurring guest star Jeffrey Dean Morgan (Denny Duquette), a montage of memorable scenes from the third season are shown as well as the premiere of an exclusive Grey's Anatomy music video set to Brandi Carlile's, "The Story."
Guest Stars: Jeffrey Dean Morgan as Denny Duquette (Host)
Songs: Carey Ott -- Am I Just One, Get Set Go -- Break Your Heart, The Sunshine -- C'mon Yeah, Snow Patrol -- Chasing Cars, 78 Saab -- No Illusions, Anya Marina -- Sociopath, The Jealous Girlfriends -- Something In The Water, Citizen Radio -- The Hop, Brandi Carlisle -- The Story, The Chalets -- Theme From The Chalets, The Radio -- Whatever Gets You Through Today, Mike Tarantino -- Wienermobile Girl
 
37 :03x01 - Time Has Come Today (Sep/21/2006)

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In the fallout of Izzie's decision to quit the program, the interns try to help Izzie come to terms with the death of her fiancé, Denny. Meredith is forced to decide who will be the man in her future after her fling with Derek during the prom. Meanwhile, Dr. Webber is confronted by his wife after spending the night at the hospital; George asks an unlikely person for relationship advice; and Addison must find out which one of a group of teenaged girls is the mother of a baby found in a trashcan.
Guest Stars: Chris O'Donnell as Finn Dandridge, Steven W. Bailey (1) as Joe, Kate Burton as Ellis Grey, Loretta Devine as Adele Webber, Jessica Tuck as Shannon's Mom, Sarah Utterback as Nurse Olivia, Joanie Fox (1) as Sara's Mom, Mis Qesley as Karen's Mom, Pepper Sweeney as Lisa's Dad, Robin Pearson Rose as Patricia, | Co-Guest Stars: Jeremy Rabb as ER Doctor, Haley Ramm as Shannon, Kelli King (1) as Sara, Wayne Lopez as Paramedic, Frank Merino as Funeral Home Guy, Damon Standifer as Hazmat Guy, Matt Crabtree as IDC Dude, Elizabeth Goldstein (1) as Giselle, Alexandra Brandl as Karen, Paulina Olszynski as Lisa, Nicolette Collier as Young Meredith, | Uncredited: Steve Harris (1) as Omar
Director: Dan Minahan (1)
Writer: Shonda Rhimes
Songs: Mat Kearney -- All I Need, Gnarls Barkley -- Gone Daddy Gone, The Dixie Chicks -- Lullaby, Emiliana Torrini -- Nothing Brings Me Down, Sleeping At Last -- Quicksand, Tegan & Sara -- Take Me Anywhere, Grant-Lee Phillips -- Under The Milky Way
 
38 :03x02 - I Am a Tree (Sep/28/2006)

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While Burke continues to recuperate in the hospital, his parents arrive at Seattle Grace to visit and end up meeting Cristina in embarrassing circumstances. The interns, as well as Bailey, lobby for Izzie to be re-admitted to the intern program. Meanwhile, Addison opts to take a day off from the hospital and spends the day at Joe's where she runs into both Izzie and a surprise visitor from her and Derek's past. Elsewhere at the hospital, a patient lives what she believes to be her last day to the fullest.
Guest Stars: Chris O'Donnell as Finn Dandridge, Diahann Carroll as Jane Burke, Richard Roundtree as Donald Burke, Roxanne Hart as Dana Seabury, Steven W. Bailey (1) as Joe, Elizabeth Sampson as Ruth O'Leary, Javier Grajeda as Jeffrey Hernandez, Peter Paige as Benjamin O'Leary, | Co-Guest Stars: Moe Irvin as Nurse Tyler, Brandon Melgar as Harley, Zibby Allen as Cute Nurse, Brooke Blanchard as Jill the Paramedic
Director: Jeff Melman
Writer: Krista Vernoff
Songs: Mat Kearney -- Crashing Down, Snow Patrol -- Open Your Eyes, Jesus Jackson -- Running On Sunshine, Bittersweet -- The Mating Game, Moloko -- The Time Is Now, The Chalets -- Theme From Chalets
 
39 :03x03 - Sometimes A Fantasy (Oct/05/2006)

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Finn and Derek continue to try to outdo one another in order to win Meredith's heart. Derek woos Meredith with once in a lifetime surgeries while Finn tries his hand at a romantic hospital date, all making it more difficult for Meredith to make a decision. With Burke's hand continuing to tremor, Cristina does her best to help him deal with his injury. As George and Callie's relationship continues to grow, Izzie attempts to visit the hospital for the first time since Denny's death. Meanwhile, Alex tends to a patient with numerous injuries.
Guest Stars: Abigail Breslin as Megan Culver, Eric Dane as Dr. Mark Sloan, Chris O'Donnell as Finn Dandridge, Jack Conley (1) as Jasper Hovey, Gabriel Casseus as Taylor Tressel, | Co-Guest Stars: Stephanie Erb as Megan's Mother, Lanai Chapman as Lianne Tressel, Kevin Will as Len Gantry, Linda Eve Miller (1) as ER Nurse, Daniel Tatar as Hotel Clerk #1, Julie Granata as Hotel Clerk #2
Director: Adam Arkin
Writer: Debra Cahn (1)
Songs: The Poems -- Ballad of a Bitter End, Joe Purdy -- Can't Get It Right Today, The Pipettes -- Dirty Mind, Outkast -- Idlewild Blues, The Bamboos -- Step it Up, Lilly Allen -- Take What You Take
 
40 :03x04 - What I Am (Oct/12/2006)

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As Addison works with Rebecca, a pregnant woman who needs to have a C-section but wants to give birth naturally, she begins to doubt her abilities as a doctor. The interns work with Shawn Sullivan, a car salesman who wants to return to his normal routine after he has surgery. However, when Shawn lights a cigarette that catches his face on fire, Derek and Mark argue over how they should procede with his burn treatment. Meanwhile, Burke continues to rehab his injured hands with the help of Cristina, gradually progressing from operating on chickens to operating on a corpse. Meredith goes into surgery after her appendix bursts and after surgery, she finally makes a decision between Derek and Finn. Elsewhere, Callie and George continue to discuss their relationship and Izzie meets a man who gives her the surprise of her life.
Guest Stars: Chris O'Donnell as Finn Dandridge, Fred Ward as Denny Duquette, Sr., Steven W. Bailey (1) as Joe, Stephanie Faracy as Mrs. Sullivan, Tina Holmes as Rebecca Bloom, Alan Blumenfeld as Shawn Sullivan, Jeff Rubino as Jeff Bloom, | Co-Guest Stars: Paula Weston Solano as OR Nurse, | Uncredited: Jeffrey Dean Morgan as Denny Duquette
Director: Dan Lerner
Writer: Allan Heinberg
Songs: Au Revoire Simone -- Back In Time, Mindy Smith -- Fall For Nothing, Camera Obscura -- If Looks Could Kill, TV On The Radio -- Province, Kate Havnevik -- So - Lo, The Gossip -- Standing In The Way Of Control
 
41 :03x05 - Oh, The Guilt (Oct/19/2006)

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Bailey treats a young woman suffering from breast cancer while Derek begins to learn more about Addison and Mark's rekindled relationship. Meanwhile, the interns team up to defend a resident at a staff meeting, and Meredith and Addison stumble into an awkward situation with one another.
Guest Stars: Justina Machado as Mrs. Nyles, Faith Prince as Eve, Chris Conner (1) as Mr. Nyles, Margo Harshman as Jennifer, Todd Babcock as Dr. Matthew Savoy, Arye Gross as Adam, | Co-Guest Stars: Rosemary Garris as Hospital Administrator, Moe Irvin as Nurse Tyler, Kate Anthony as Nurse Kate, Karl T. Wright as Mediator, Libby Barnes as Dr. #1, Tom Ormeny as Dr. #2, Dennis Depew as Intern
Director: Jeff Melman
Writer: Zoanne Clack, Tony Phelan, Joan Ratner
Songs: Fionn Regan -- Be Good Or Be Gone, Nellie McKay -- Clonie, Keisha White -- Don't Mistake Me, Kate Havnevik -- Kaleidoscope, The Second Band -- Wild Is The Wind
 
42 :03x06 - Let the Angels Commit (Nov/02/2006)

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Cristina gets the once in a lifetime opportunity to scrub in on a rare humpty-dumpty procedure, much to the envy of the other interns. Meanwhile, Alex begins to question his choice of surgical specialty and George and Addison work together to help Noelle, a woman pregnant with twins that are developing at different rates.
Guest Stars: Embeth Davidtz as Nancy, Edwin Hodge as Greg, Liza Lapira as Noel, Jillian Bach as Gretchen, Francesca P. Roberts as Mrs. Bird, | Co-Guest Stars: Patricia Bethune as Nurse Ginger, Moe Irvin as Nurse Tyler, Jeremy Rabb as Resident, Martin Yu as Resident
Director: Jessica Yu (1)
Writer: Stacy McKee
Songs: Teddy Bears feat. Mad Cobra -- Cobrastyle, Vega 4 -- Life is Beautiful, Jim Noir -- My Patch, Gomez -- Notice, The Album Leaf -- Writings On The Wall, Peter Bjorn And John -- Young Folks
 
43 :03x07 - Where the Boys Are (Nov/09/2006)

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The Seattle Grace men pack up and head out to the Seattle wilderness for a camping trip. Back at the hospital, Callie and Addison work together on a pregnant patient who slipped and broke her arm in the shower and Meredith helps Dr. Sloan with a unique sex reassignment surgery. Meanwhile, Bailey becomes increasingly suspicious of Cristina and Burke and decides to confront Cristina. Elsewhere, the interns treat a 9 year-old who swallowed Monopoly game pieces.
Guest Stars: Steven W. Bailey (1) as Joe, George Dzundza as Harold O'Malley, Kali Rocha as Sydney Heron, Clare Carey (1) as Vicky, Alexandra Billings as Donna, Alexandra Holden as Jamie, Jim Parrack as Ted, Jack Yang (1) as Walter
Director: Dan Minahan (1)
Writer: Mark Wilding
Songs: Bedouin Soundclash -- 12:59 Lullaby, Bill Ricchini -- A Cold Wind Will Blow Through Your Door, Inara George -- Greedy, Big Sandy & His Fly Rite Boys -- It's Time, Luke Temple -- Make Right With You, The Jealous Girlfriends -- Something In The Water, Jim Noir -- Tell Me What To Do, Brett Dennen -- There Is So Much More, Beck -- Think I'm In Love
 
44 :03x08 - Staring at the Sun (Nov/16/2006)

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George's family comes to Seattle Grace when George's father hurts his clavicle, throwing George into a frenzy. However, George's worst fears about his father's hospital visit are realized when the test results come back abnormal. As Meredith strives to have a more positive outlook on life, Derek and Addison work on finding away to have a civil relationship once again. Meanwhile, Richard attempts to work things out between him and Adele.
Guest Stars: George Dzundza as Harold O'Malley, Myndy Crist as Diane Hanson, Greg Pitts (1) as Jerry O'Malley, Tim Griffin as Ronny O'Malley, Matt Winston as Frank Jeffries, Paul Cassell (1) as John Hanson, Annie Campbell as Anna, Steven W. Bailey (1) as Joe, Kate Burton as Ellis Grey, | Co-Guest Stars: Ray Ford as Ray the Paramedic, Brooke Bryan as Mia, Martin Yu as Resident, Brad Sachs as Tech
Director: Jeff Melman
Writer: Harry Werksman, Gabrielle Stanton
Songs: Ingrid Michaelson -- Breakable, Get Set Go -- Everybody Get Movin', Lily Allen -- Not Big, The Watson Twins -- Time Of My Life, Mat Kearney -- Where We Gonna Go From Here
 
45 :03x09 - From A Whisper To A Scream (Nov/23/2006)

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The ER is taken over by a horrific car accident and the trauma caused by the accident pushes and challenges the interns. Elsewhere, Cristina begins to wonder if she's doing the right thing by helping Burke lie about his hand condition and Izzie pushes the boundaries of her probation.
Guest Stars: George Dzundza as Harold O'Malley, Brooke Smith (1) as Dr. Erica Hahn, Debra Monk as Louise O'Malley, Lois Smith as Mrs. Dickinson, Emy Coligado as Ms. Suko, | Co-Guest Stars: Kate Anthony as Nurse Kate, Linda Klein as Nurse Linda
Director: Julie Ann Robinson
Writer: Kip Koenig
Songs: Damian Rice -- 9 Crimes, Kate Havnevik -- New Day, The Dears -- You And I Are A Gang of Losers
 
46 :03x10 - Don't Stand So Close to Me (Nov/30/2006)

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Burke and Cristina's relationship continues to be strained in the aftermath of Cristina revealing Burke's limitations due to the shooting. Meredith's half-sister, Molly Thompson, is admitted to Seattle Grace forcing Meredith to once again confront her emotions towards her father and sister. Meanwhile, Derek and Mark are forced to work together when two conjoined brothers come to the hospital to be separated.
Guest Stars: Brooke Smith (1) as Dr. Erica Hahn, Mandy Siegfried as Molly Thompson, George Dzundza as Harold O'Malley, Tim Griffin as Ronny O'Malley, Greg Pitts (1) as Jerry O'Malley, Debra Monk as Louise O'Malley, Kate Burton as Ellis Grey, Mare Winningham as Susan Grey, Jason Sklar as Jake, Randy Sklar as Pete, Jennifer Aspen as Elaina, | Co-Guest Stars: Linda Klein as Nurse Linda, Jack Axelrod (1) as Really Old Man
Director: Seith Mann
Writer: Carolina Paiz
Songs: John Legend -- Show Me, Anya Marina -- Sociopath, Son Volt -- World Waits For You
 
47 :03x11 - Six Days (1) (Jan/11/2007)

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After George's father's heart operation, Mr. O'Malley heads back to the O.R. for another surgery for his cancer. As George continues to worry about his father, Meredith's father visits Seattle Grace in order to see his newborn granddaughter. Meanwhile, Meredith discovers that Derek is having trouble sleeping, which is no fault but her own. Elsewhere, the interns treat an angry 17 year-old girl with severe scoliosis who has a poor attitude towards the doctors due to the several surgeries she has endured during her life.
Guest Stars: George Dzundza as Harold O'Malley, Jeff Perry as Thatcher Grey, Debra Monk as Louise O'Malley, Greg Pitts (1) as Jerry O'Malley, Tim Griffin as Ronny O'Malley, Mae Whitman as Heather Douglas, Judith Hoag as Rhada Douglas, Steven W. Bailey (1) as Joe, | Co-Guest Stars: Sarah Utterback as Nurse Olivia, Moe Irvin as Nurse Tyler, Rhomeyn Johnson as Manager, Jake Mailey as Uncle Jim, Michael James Thompson as Cousin Joe
Director: Greg Yaitanes
Writer: Krista Vernoff
Songs: Emiliana Torrini -- Beggars Prayer, The Research -- Lonely Hearts Still Beat The Same, Travis -- Love Will Come Through, William Fitzsimmons -- Passion Play, Michelle Featherstone -- Rest Of My Life
 
48 :03x12 - Six Days (2) (Jan/18/2007)

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Mr. O'Malley heads back to surgery in order for the doctors to operate on his cancer. Meredith deals with her emotions while her father is at Seattle Grace to visit his new granddaughter. Meanwhile, a woman has a breakdown at the hospital after having to give up something important to her. Elsewhere, Meredith continues to worry about Derek when he is unable to sleep.
Guest Stars: George Dzundza as Harold O'Malley, Jeff Perry as Thatcher Grey, Debra Monk as Louise O'Malley, Greg Pitts (1) as Jerry O'Malley, Tim Griffin as Ronny O'Malley, Mae Whitman as Heather Douglas, Judith Hoag as Rhada Douglas, Steven W. Bailey (1) as Joe, | Co-Guest Stars: Moe Irvin as Nurse Tyler, Rhomeyn Johnson as Manager, Patricia Bethune as Nurse Ginger
Director: Greg Yaitanes
Writer: Krista Vernoff
Songs: Gary Jules -- Awake, Regina Spektor -- Fidelity, OK Go -- Here It Goes Again, The Slip -- Life in Disguise, Susanna & The Magical Orchestra -- Love Will Tear Us Apart, Ingrid Michaelson -- The Way That I Am
 
49 :03x13 - Great Expectations (Jan/25/2007)

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While rumors about the chief's retirement begin to fly among the hospital staff, Bailey pushes for the creation of a free clinic at Seattle Grace. George uses sex as a way to cope with the death of his father, which worries both Izzie and Callie. Meanwhile, The interns treat a woman diagnosed with stage 4 cancer who has a complex Puritan past and Callie and Cristina operate on a runner in order to save his legs. Later, one of the doctors receives a surprising proposal.
Guest Stars: Loretta Devine as Adele Webber, Rachel Boston as Rachel, Jessica Stroup as Jilly Miller, Joe Holt as Steve, | Co-Guest Stars: Kathleen Mary Carthy as Mrs. Miller, Michael P. Byrne (1) as Mr. Miller
Director: Michael Grossman
Writer: Eric Buchman
Songs: Lily Frost -- Enchantment, Skye -- Love Show, The Umbrellas -- Ships
 
50 :03x14 - Wishin' and Hopin' (Feb/01/2007)

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With Izzie's inheritance money, Bailey and Izzie open the Seattle Grace free clinic and eagerly wait for their first patient. The lives of the doctors are put at risk when a patient's blood is found to be toxic. Meredith, Cristina and Izzie volunteer to risk their lives to save the woman after Derek and Burke's air-tight suits run out of battery. Meanwhile, Ellis, Meredith's Alzheimer's-stricken mother, has a change in her condition; George and Callie return to the hospital with surprising news; and Cristina gives Burke an answer to his proposal.
Guest Stars: Kate Burton as Ellis Grey, Sarah Utterback as Nurse Olivia, | Co-Guest Stars: Matt McTighe as Vincent, Jasmine Di Angelo as Kailey Hanson, Ronobir Lahiri as Mr. Hanson, Joyce Guy as Ms. Henry, Kate Anthony as Nurse Kate, Maile Flanagan as Lab Tech, Tony Adelman as Hurts When He Pees, Liz Montgomery (1) as Coughing Lady, Amanda Collins as Marina, David J. Lee (1) as Sprained Ankle
Director: Julie Ann Robinson
Writer: Joan Rater, Tony Phelan
Songs: Miho Hatori -- Barracuda, Susanna and The Magical Orchestra -- Believer, Iain Archer -- Canal Song, Beck -- Elevator Music, The Whitest Boy Alive -- Fireworks, Psapp -- King of You, Sybarite -- Runaway
 
51 :03x15 - Walk On Water (1) (Feb/08/2007)

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A horrific ferry boat accident challenges the interns, as well as the rest of the hospital staff, both physically and mentally as they all near their breaking point. Chief Webber has to assemble and send out a team to the location of the accident to help save the few lives that were spared. On location, Alex tends to a woman who was crushed by a cement pylon. Meanwhile, Meredith looks out for a lost young girl and George searches frantically for a woman's young son.
Guest Stars: Elizabeth Reaser as Jane Doe, Kali Rocha as Sydney Heron, Kate Burton as Ellis Grey, Dean Norris as Rick's Friend, Kelly Wolf as Carly Height, Paul Perri as Rick's Friend, | Co-Guest Stars: Preston James Hillier as Cop, Terrance Christopher Jones (1) as Paramedic #7, Jeffrey Markle as Greg, Billy Mayo as Rick, Brian Chenoweth as Scared Guy, Danielle Kennedy as Angry Woman, Paul Norwood as Scared Guy #2, Madison Leisle as Lisa the Child, Yvans Jourdain as Businessman, Kim Delgado as Search & Rescue Guy #1, Terry Woodberry as Police Officer, John Cappon as Paramedic #2, Nicole Cummins-Rubio as Paramedic #4, Pete Flynn as Paramedic #1
Director: Rob Corn
Writer: Shonda Rhimes
Songs: 8MM -- Liar, Snow Patrol -- Make This Go On Forever, Union of Knives -- Opposite Direction, Radio Citizen -- The Hop
 
52 :03x16 - Drowning on Dry Land (2) (Feb/15/2007)

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As the chaos surrounding the ferry boat accident continues, Derek frantically searches for Meredith, and is devastated when he finds her barely clinging to life. Cristina is also devastated when she learns about Meredith's condition. Meanwhile, emotions run high at Seattle Grace as family of the accident victims demand to know the status of their loved ones. In the midst of the trauma, Alex has trouble dealing with the death surrounding him; George searches for a missing 7 year-old boy; and Izzie is forced to take desperate measures to save the life of the man stuck under a car.
Special Guest Stars: Kyle Chandler as Dylan Young, Jeffrey Dean Morgan as Denny Duquette, | Guest Stars: Elizabeth Reaser as Jane Doe, Kali Rocha as Sydney Heron, Dean Norris as Rick's Friend, Kelly Wolf as Carly Height, Paul Perri as Rick's Friend, Madison Leisle as Lisa the Child, | Co-Guest Stars: Billy Mayo as Rick, Danielle Kennedy as Angry Woman, Yvans Jourdain as Businessman, Jonah Bay as Hopeful Guy, Liza de Weerd as Woman, Mac Brandt as Paramedic #3, Tim Chiou as Paramedic #6, John Koyama as Search and Rescue #2, Marlon John as Search and Rescue #3, Akeem Smith as Young Man
Director: Rob Corn
Writer: Shonda Rhimes
Songs: Butterfly Boucher -- A Bitter Song, Patrick Watson -- The Great Escape, Kate Havnevik -- Timeless
 
53 :03x17 - Some Kind of Miracle (3) (Feb/22/2007)

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While Meredith's life hangs in the balance, the interns each have to grapple with the reality that she may not make it. Derek refuses to give up hope that Meredith will pull through, but as time passes, Derek begins to slowly break down. Cristina takes the possibility of her death the hardest, and refuses to accept that it could happen. As Bailey and Chief Webber work to save Meredith's life, Meredith is visited by figures from her past, including Denny and Dylan Young, both of whom try to convince her not to die. Elsewhere, Addison and Alex continue to work with their pregnant Jane Doe, who has no memory of the ferry boat accident or her life prior it.
Special Guest Stars: Kyle Chandler as Dylan Young, Jeffrey Dean Morgan as Denny Duquette, | Guest Stars: Elizabeth Reaser as Jane Doe, Anna Maria Horsford as Nurse Liz Fallon, Kate Burton as Ellis Grey, Monica Keena as Bonnie, Kali Rocha as Sydney Heron, Sarah Utterback as Nurse Olivia, Steven W. Bailey (1) as Joe, | Co-Guest Stars: Moe Irvin as Nurse Tyler, David Downs as Man, Yvette Cruise as ICU Nurse, Billy Wood as Perfusionist
Director: Adam Arkin
Writer: Marti Noxon, Shonda Rhimes
Songs: Damien Rice -- Sleep Don't Weep, Unkle Bob -- Swans, Aqualung -- The Lake, Kate Havnevik -- Timeless
 
54 :03x18 - Scars and Souvenirs (Mar/15/2007)

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The race for Chief of Surgery continues to heat up, especially when a new contender enters the race. Callie reveals a big secret to George, and when George ends up telling Meredith, Callie kicks him out, leaving George with no where to go except to Meredith's. Cristina and Burke's engagement suffers when a secret about one of Cristina's past relationships is revealed. Meanwhile, Derek treats an old friend; Alex and Jane Doe get closer; and Meredith has dinner with her father and step-mother.
Guest Stars: Shohreh Aghdashloo as Helen Crawford, Elizabeth Reaser as Jane Doe, Mare Winningham as Susan Grey, Jeff Perry as Thatcher Grey, James Gammon as Mr. Scofield, Roger Rees as Colin Marlowe, | Co-Guest Stars: Rob Narita as Anesthesiologist
Director: James Frawley
Writer: Debora Cahn (1)
Songs: Koop -- Come To Me, Gomez -- Girlshapedlovedrug, Psapp -- Hi, Wild Sweet Orange -- Land Of No Return, Anya Marina -- Move You
 
55 :03x19 - My Favorite Mistake (Mar/22/2007)

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George comes face-to-face with his father-in-law, but the circumstances of their meeting are less than perfect. Alex continues to tend to Jane Doe and helps her choose how the world will see her from here on. Meanwhile, the board interviews Chief of Surgery candidates, and everyone is stunned when Sloan emerges as a top candidate. Elsewhere, Izzie wrestles with the events of her drunken night with George.
Guest Stars: Hector Elizondo as Mr. Torres, Elizabeth Reaser as Jane Doe, Michael Boatman as Doug Kendry, Roger Rees as Colin Marlowe, Catherine Dent as Cathy Rogerson, Elisabeth Moss (1) as Nina Rogerson, | Co-Guest Stars: Judi Barton as Board Member
Director: Tamra Davis (1)
Writer: Chris Van Dusen
Songs: Let's Go Sailing -- All I Want From You Is Love, Alamo Race Track -- Black Cat John Brown, Mirah -- La Familia, Let's Go Sailing -- Sideways, Adam Merrin -- Still Alright
 
56 :03x20 - Time After Time (Apr/19/2007)

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When Izzie has to face her past, she turns to George for support and comfort. As Alex continues to work with Jane Doe, the two become more attached to each other. Meanwhile, Meredith and Derek begin to question their status while Cristina strives to repair her relationship with Burke despite her past history with Dr. Marlow that continues to damage their engagement.
Guest Stars: Elizabeth Reaser as Jane Doe, Roger Rees as Colin Marlowe, Brent Jennings (1) as Charles, Suzanne Cryer as Caroline Klein, Tim Hopper as Dustin Klein, Steven W. Bailey (1) as Joe, Mare Winningham as Susan Grey, Dee Wallace Stone as Joan Waring, | Co-Guest Stars: Melissa Fitzgerald as Social Worker, Marc Vann as Hematologist, Liv Hutchings as Hannah, Randy Thompson as Frank Waring, Kate Anthony as Nurse Kate, Zibby Allen as Nurse Zibby, Nichelle Hines as Young Woman, Craig Tsuyumine as TV Reporter
Director: Christopher Misiano
Writer: Stacy McKee
Songs: Maria Taylor -- A Good Start, The Whitest Boy Alive -- Burning, Maria Taylor -- Clean Getaway, Nouvelle Vague -- Dancing With Myself, Lullaby Baxter -- Fontana Fontaine, Amy Winehouse -- You Know I'm No Good
 
57 :03x21 - Desire (Apr/26/2007)

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As the interns study for and stress over their upcoming exam, the attendings suck up to the chairman of the board in order to become front runner for the Chief's position when he is admitted to the hospital as a patient. Meanwhile, Burke has a difficult time involving Cristina in the planning of their wedding, Addison and Alex get closer, and Derek begins to second guess his relationship with Meredith.
Guest Stars: Kali Rocha as Sydney Heron, Elizabeth Reaser as Jane Doe, Mitch Pileggi as Larry Jennings, Mary-Margaret Humes as Nancy Jennings, Rowena King (1) as Celeste Newman, Ramon De Ocampo as James Benton, | Co-Guest Stars: Stewart Skelton as Dr. Fischer
Director: Tom Verica
Writer: Mark Wilding
Songs: The Bird & The Bee -- Again & Again, Let's Go Sailing -- Better Off, Anna Waronker -- How Am I Doing, Beck -- Nausea, The Reddmen -- The Secrets of Amanda Prine
 
58 :03x22 - The Other Side of This Life (1) (May/03/2007)
Addison, on leave from Seattle Grace, heads to Los Angeles to reconnect with old friends from med school. Back in Seattle, Meredith continues to bond with Susan, her step-mother, and Cristina, with the help of both her mother and Burke's mother, begins planning her wedding. Meanwhile, Derek performs emergency surgery on Ava (Jane Doe) and Alex continues to stand by her.
Special Guest Stars: Taye Diggs as Jackson, Paul Adelstein as Cooper, Amy Brenneman as Violet, Timothy Daly as Pete (as Tim Daly), Merrin Dungey as Naomi, Chris Lowell (1) as Dell, | Guest Stars: Tsai Chin as Helen, Stephanie Niznik as Carol, Jeff Perry as Thatcher Grey, Mare Winningham as Susan Grey, Diahann Carroll as Jane Burke, Elizabeth Reaser as Jane Doe, D. W. Moffett (1) as Alan, Bellamy Young as Kathy, Raphael Sbarge as Paul, David Anders as Sam, Becky Wahlstrom as Lisa, Cameron Watson as Rick, Garrison Hershberger as Doug (as Gary Hershberger), Parisa Fitz-Henley as Tammie, Shavon Kirksey as Maya, | Co-Guest Stars: Mary Joy as Elevator Voice, Garon Grigsby as Keith, Jane Clark (1) as Nurse, Trista Delamere as SGH Clinic Nurse, William B. Jackson (3) as Old Man, Robin Hines as Cute Girl
Director: Michael Grossman
Writer: Shonda Rhimes
Songs: -- California Sun, The Broken West -- Down in the Valley, The Rosewood Thieves -- Los Angeles, The Mary Onettes -- Lost, The Switches -- Message From Yuz, Feist -- Sealion
 
59 :03x23 - The Other Side of This Life (2) (May/03/2007)

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In the conclusion to part 1, Addison visits Los Angeles and continues to reconnect with her old medical school friends. In Seattle, Meredith gets closer to her step mother. Cristina deals with the pressures of her pending marriage, and reluctantly plans the wedding with her mother and future mother-in-law. Meanwhile, Derek operates on Ava.
Special Guest Stars: Taye Diggs as Jackson, Paul Adelstein as Cooper, Amy Brenneman as Violet, Timothy Daly as Pete (as Tim Daly), Merrin Dungey as Naomi, Chris Lowell (1) as Dell, | Guest Stars: Tsai Chin as Helen, Mare Winningham as Susan Grey, Jeff Perry as Thatcher Grey, Stephanie Niznik as Carol, Bellamy Young as Kathy, Diahann Carroll as Jane Burke, Elizabeth Reaser as Jane Doe, Shavon Kirksey as Maya, Raphael Sbarge as Paul, David Anders as Sam, Becky Wahlstrom as Lisa, Cameron Watson as Rick, Garrison Hershberger as Doug (as Gary Hershberger), | Co-Guest Stars: Mary Joy as Elevator Voice, Garon Grigsby as Keith, Jane Clark (1) as Nurse, Trista Delamere as SGH Clinic Nurse, William B. Jackson (3) as Old Man, Robin Hines as Cute Girl
Director: Michael Grossman
Writer: Shonda Rhimes
Songs: Robert Randolph & The Family Band -- Ain't Nothing Wrong With That, A.B. O'Neill -- California, Mojo Love -- Lay Low, Psapp -- Leaving In Coffins, Tim Myers -- Momma's Boy, The Adored -- Not Having It, Bloc Party -- SRXT, Brandi Carlile -- Turpentine, Candi Staton -- You Don't Have Far To Go, Kate Walsh -- Your Song
 
60 :03x24 - Testing 1-2-3 (May/10/2007)

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The interns face one of their biggest challenges yet -- their first-year medical exams. Meanwhile, the interns must tend to three injured mountain climbers. Elsewhere, Callie becomes increasingly suspicious of George and Izzie and Cristina has trouble writing her vows.
Guest Stars: Loretta Devine as Adele Webber, Elizabeth Reaser as Jane Doe, Steven W. Bailey (1) as Joe, Jeff Perry as Thatcher Grey, Mandy Siegfried as Molly Thompson, Aasha Davis as Rina, Kevin Rankin as Jack, Brian Tee as Andy, Jack Yang (1) as Walter, Derek Phillips as Dale, Chyler Leigh as Lexie Grey, | Co-Guest Stars: Tim Chiou as Paramedic, Nicole Cummins-Rubio as Paramedic Nicole, Michelle N. Carter as Proctor
Director: Christopher Misiano
Writer: Allan Heinberg
Songs: Ingrid Michaelson -- Corner of My Heart, Paolo Nutini -- Million Faces, The Weather Machines -- Stains of Saints, 8MM -- Stunning, Let's Go Sailing -- This Rope is Long, Amy Winehouse -- Wake Up Alone
 
61 :03x25 - Didn't We Almost Have It All (May/17/2007)
A big day arrives for all -- Cristina and Burke's wedding and the interns receive their exam results. Meanwhile, Chief Webber's replacement is named and George and Callie make a decision about their relationship.
Guest Stars: Elizabeth Reaser as Jane Doe, Loretta Devine as Adele Webber, Diahann Carroll as Jane Burke, Chyler Leigh as Lexie Grey, Jason London as Jeff Pope, Steven W. Bailey (1) as Joe, Tsai Chin as Helen, Aasha Davis as Rina, Kevin Rankin as Jack, Brian Tee as Andy, Jack Yang (1) as Walter, Derek Phillips as Dale, Robin Pearson Rose as Patricia, | Co-Guest Stars: Ajay Vidure as Intern #1, Candice Afia as Intern #2, Artie O'Daly as Intern #3, Joseph Williamson as Intern #4, Traber Burns as Andy's Lawyer
Director: Rob Corn
Writer: Joan Rater, Tony Phelan
Songs: Coburn -- Closer, The Here After -- Eulogy, The Mary Onettes -- Explosions, Grace Potter -- Falling or Flying, Ray LaMontagne -- Hold You In My Arms, Ingrid Michaelson -- Keep Breathing, The Jealous Girlfriends -- Roboxula, Ray LaMontagne -- Within You
 

Season 4
Come Rain or Shine - From Grey's Anatomy to Private Practice (Sep/19/2007)
"Come Rain or Shine: From Grey's Anatomy to Private Practice" goes into the life of Dr. Addison Montgomery as she transitions from Seattle Grace to Oceanside in the new spin-off Private Practice. The episode also includes the premiere of the Grey's Anatomy music video featuring "Breath In Breath Out," a song by Mat Kearney. The video features clips from the previous three seasons and the episode will feature a glimpse at the new season of Grey's Anatomy.
 
62 :04x01 - A Change Is Gonna Come (Sep/27/2007)

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Meredith and Cristina return from Cristina's honeymoon to find that Burke is long gone. Izzie, Alex, Meredith and Cristina start their first day as residents, each with their own set of interns. Among the interns are George, who is repeating his internship after failing the exam, and Lexie, Meredith's half-sister. Meanwhile, Derek begins to look elsewhere after his relationship with Meredith hits an emotional impasse; Bailey grapples with the fact that her former interns now report to Callie, the new Chief Resident; and Richard returns to his position as Chief of Surgery.
Guest Stars: Tymberlee Chanel as Claire, Gloria Garayua as Graciella, Richard Keith as Mitch Greenberg, Mark Pellegrino as Chris, Sandra Thigpen as Clara, Stephanie Childers as Nancy, Steven M. Porter as Joey, Candice Afia as Intern Laura, Amrapali Ambegaokar as Intern Dani, Molly Kidder as Intern Megan, Joy Osmanski as Intern Lucy, Winston Story as Intern Leo, Joseph Williamson as Intern Pierce
Director: Rob Corn
Writer: Shonda Rhimes
Songs: Blonde Redhead -- 23, Lily Allen -- Knock 'Em Out, I'm From Barcelona -- Oversleeping, Meiko -- Reasons To Love You, Cinematic Orchestra -- To Build A Home
 
63 :04x02 - Love/Addiction (Oct/04/2007)

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The interns and residents treat victims of an apartment complex explosion as Alex looks into the cause of the devastating accident. Mama Burke arrives at Seattle Grace to pick up the rest of Burke's personal things while Cristina trades wedding gifts for surgeries. Meanwhile, Lexie tries to talk to Meredith, who is less than willing to do so; Callie deals with the stress of being Chief Resident; and Bailey tries to figure out what to do with her excess leadership skills.
Guest Stars: Diahann Carroll as Jane Burke, Ben Vereen as Archie, Brendan Elliott as Dave, Nicholas Gonzalez as Clark, | Co-Guest Stars: Amy Landers as Marla Krestler, Tanya Linette Smith as Jennifer, Moe Irvin as Nurse Tyler, Brooke Blanchard as Jill the Paramedic, Ray Ford as Ray the Paramedic, Candice Afia as Intern Laura, Amrapali Ambegaokar as Intern Dani, Mark Saul as Intern Steve, Joseph Williamson as Intern Pierce
Director: James Frawley
Writer: Debora Cahn (1)
Songs: Amy Obenski -- Carousel, Chris Garneau -- Castle Time, Laura Izibor -- From My Heart To Yours, The Rentals -- Little Bit of You in Everything, Gomez -- Moon and Sun, Trolle Siebenhaar -- The Yard
 
64 :04x03 - Let the Truth Sting (Oct/11/2007)

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The new interns are in awe of fellow intern George's skill level, and Lexie tries to keep his "repeater" status secret. Meredith comes to Lexie's aide when Lexie is faced with her first emergency situation. The Chief and Sloan have to use a radical surgery to save a woman's vocal ability. Meanwhile, George debates telling Callie about his affair with Izzie.
Guest Stars: Edward Herrmann as Norman, Caroline Aaron as Connie, Eve Gordon as Mary, Amy Hill as Joanne, Debra Christofferson as Elaine, Jack Axelrod (1) as Really Old Guy (Charlie), | Co-Guest Stars: Martin Spanjers as Hunter Chapman, Moe Irvin as Nurse Tyler, Ray Ford as Ray the Paramedic, Linda Eve Miller (1) as ER Nurse, Candice Afia as Intern Laura, Amrapali Ambegaokar as Intern Dani, Tymberlee Chanel as Intern Claire, Gloria Garayua as Intern Graciella, Richard Keith as Intern Mitch, Molly Kidder as Intern Megan, Joy Osmanski as Intern Lucy, Mark Saul as Intern Steve, Joseph Williamson as Intern Pierce, Winston Story as Intern Leo, Alison Crowley as Clinic Nurse, Peter Smith (5) as Clinic Nurse
Director: Dan Minahan (1)
Writer: Mark Wilding
Songs: The Perishers -- Best Friends, Feist -- My Moon My Man, The Bravery -- The Ocean
 
65 :04x04 - The Heart Of The Matter (Oct/18/2007)

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Izzie reveals her true feelings for George to one of her and George's friends, and the reaction she receives is not what she expected. Meanwhile, Adele Webber rushes her niece to Seattle Grace; Derek gives Cristina pointers on how to be a better teaching resident; and Norman, the world's oldest intern, misdiagnoses Meredith's patient.
Guest Stars: Edward Herrmann as Norman, Michael McGrady as Stanley, Matt Lanter as Adam, Maggie Siff as Ruthie, Miriam Flynn as Ms. Bitzer, Camille Winbush as Camille, Ron Melendez as Will, Loretta Devine as Adele Webber, | Co-Guest Stars: Shelley Robertson as Arlene, Jeremy Rabb as ER Doctor, Maile Flanagan as Lab Tech, Tymberlee Chanel as Intern Claire, Gloria Garayua as Intern Graciella, Richard Keith as Intern Mitch, Molly Kidder as Intern Megan, Joy Osmanski as Intern Lucy, Mark Saul as Intern Steve, Winston Story as Intern Leo, Cassandra Braden as Housekeeping Staffer, Nicole Cummins-Rubio as Paramedic
Director: Randall Zisk
Writer: Allan Heinberg
Songs: Northern State -- Better Already, Meiko -- Hawaii, Prince Fatty -- Milk And Honey, Yeah Yeah Yeahs -- Rockers To Swallow, John Legend -- Sun Comes Up, Kim Richey -- The Absence Of Your Company
 
66 :04x05 - Haunt You Every Day (Oct/25/2007)

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It's Halloween at Seattle Grace and the day is chock-full of surprises for the doctors. Alex has a surprise visit from a former patient; Meredith thinks her mother's ashes are haunting her; Cristina is snubbed by a top surgeon; and everyone is shocked when Callie reveals George and Izzie's relationship to the public.
Guest Stars: Edward Herrmann as Norman, Elizabeth Reaser as Ava, Rocky Carroll as James, Kali Rocha as Sydney Heron, David Clennon as Jack, Dylan Minnette as Ryan, Sarah Utterback as Nurse Olivia, Anjul Nigam as Raj, | Co-Guest Stars: Bhama Roget as Erin, Crystal Kwon as Nurse Jolene, Jeremiah Hu as Fingerless Guy, Ray Ford as Ray the Paramedic, Linda Eve Miller (1) as ER Nurse, Suzanne Quinn as Clinic Nurse
Director: Bethany Rooney
Writer: Krista Vernoff
Songs: The Perishers -- Come Out Of The Shade, Katie Herzig -- Fools Gold, The Perishers -- Get Well, Kendall Payne -- I Will Show You Love, The Gossip -- Listen Up!, The Bird & The Bee -- Polite Dance Song
 
67 :04x06 - Kung Fu Fighting (Nov/01/2007)

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With his marriage once again falling apart, Chief Webber invites the male surgeons out on a "gentleman's evening." Meanwhile, Cristina and Izzie compete for the same surgeries, mainly to impress the doctor performing them; Meredith treats the survivor of a skydiving accident; and two finalists competing in a promotional competition are treated by the doctors.
Guest Stars: David Denman as Rick, Cullen Douglas (2) as Mr. Arnold, Marina Black as Sally, Tommy Dewey as Mike, Amanda Loncar as Jackie, Steve Sandvoss as Jason, Chryssie Whitehead as Helena
Director: Tom Verica
Writer: Stacy McKee
Songs: New Buffalo -- Cheer Me Up Thank You, Miss Li -- Don't Try To Fool Me, Magic Numbers -- Let Somebody In, Kate Nash -- Merry Happy, Imani Coppola -- Raindrops From The Sun, Buddy -- Say A Lot
 
68 :04x07 - Physical Attraction... Chemical Reaction (Nov/08/2007)

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George and Izzie's relationship is tested, as is Derek and Meredith's when Derek wants more than a physical relationship with her. Meanwhile, Mark falls for a surgeon and Callie's position as Chief Resident is put on the line when she gives too many duties to Bailey.
Guest Stars: Jeff Perry as Thatcher Grey, Rockmond Dunbar as Sean, Stephanie March as Jane, Vicki Lewis (1) as Harriet, David Burke (1) as Don, Kurt Fuller as Jerry, Enuka Okuma as Teresa
Director: Jeff Melman
Writer: Tony Phelan, Joan Rater
Songs: Northern State -- iluvitwhenya, Derek Webb -- Name, Calahan -- Pouring On The Gasoline, Priscilla Ahn -- Rain, Joe Purdy -- San Jose
 
69 :04x08 - Forever Young (Nov/15/2007)

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The ER is thrown into a state of chaos following a school bus accident. Meanwhile, Bailey treats her high school crush; Derek goes on a date; and Thatcher comes to Seattle Grace in search of Meredith.
Guest Stars: Jeff Perry as Thatcher Grey, Kali Rocha as Sydney Heron, D. B. Woodside as Marcus, Lauren Stamile as Rose, Madeline Zima as Marissa, Brooke Nevin as Tricia, Stephen Sowan as Danny, Andrea Vercetti as Marissa
Director: Rob Corn
Writer: Mark Wilding
Songs: Chris Garneau -- Black & Blue, Rilo Kiley -- Breakin' Up, Tegan & Sara -- Call It Off, John Ralston -- Second Hand Lovers, Cary Brothers -- The Last One, Ben Lee (1) -- What Would Jay-Z Do?
 
70 :04x09 - Crash Into Me (Part 1) (Nov/22/2007)

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Meredith and the Chief rush to the scene of a devastating ambulance crash in which the lives of the paramedics are at stake. Bailey treats a difficult patient and Ava returns to find Alex with a new girlfriend.
Guest Stars: Seth Green as Nick, Elizabeth Reaser as Ava, Lauren Stamile as Rose, Cress Williams as Tucker, Gale Harold as Shane, John Billingsley as Jacob, Theo Rossi as Stan, Kimberly Huie as Mary Daltren, Alison La Placa as Jacob's Wife, | Co-Guest Stars: Ray Ford as Ray the Paramedic, Shanelle Gray as Sara, Mark Saul as Intern Steve, Joseph Williamson as Intern Pierce, Candice Afia as Intern Laura, Joy Osmanski as Intern Lucy, Crystal Kwon as Nurse Jolene, Roger Bridges as Firefighter, Nick Hoffa as Firefighter #2, Emma Prescott as Lucy, Suzi Holrichter as Sandra, Parker Goris as Garrett, Linda Klein as O.R. Nurse
Director: Michael Grossman
Writer: Krista Vernoff, Shonda Rhimes
Songs: Correatown -- All The World (I Tell Myself), Ben's Brother -- Let Me Out, Roisin Murphy -- Movie Star, Soulsavers -- Revival, The Cake Sale -- Some Surprise, Missy Higgins -- Where I Stood
 
71 :04x10 - Crash Into Me (Part 2) (Dec/06/2007)

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In the conclusion to the two-part episode arc, Meredith races to save the life of a paramedic, who is trapped inside an ambulance. Meanwhile, the life of a patient is in Lexie's hands and Derek and a nurse work together to save the life of a patient.
Guest Stars: Elizabeth Reaser as Ava, Seth Green as Nick, Cress Williams as Tucker, Lauren Stamile as Rose, Gale Harold as Shane, | Co-Guest Stars: Moe Irvin as Nurse Tyler, Ray Ford as Ray the Paramedic, Theo Rossi as Stan
Director: Jessica Yu (1)
Writer: Shonda Rhimes, Krista Vernoff
Songs: Natalie Walker -- Circles, Santogold -- Creator, Sara Melson -- Feel It Coming
 
72 :04x11 - Lay Your Hands On Me (Jan/10/2008)

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Bailey's family faces a medical trauma, just as her marriage is falling apart, a surprise visit from George's mother comes as a shock to both Izzie and Callie, a faith healer challenges Erica and Alex's beliefs in traditional medicine, and Derek must deal with the aftermath of his kiss with Rose.
Guest Stars: Glenne Headly as Elizabeth, Debra Monk as Louise O'Malley, Cress Williams as Tucker, Lauren Stamile as Rose, Carol Locatell as Mai
Director: John Terlesky
Writer: Allan Heinberg
Songs: Caedmon's Call -- 10,000 Angels, Lifehouse -- Broken, Joe Henry -- God Only Knows, Katie Herzig -- Sweeter Than This, Patty Griffin -- Up To The Mountain
 
73 :04x12 - Where The Wild Things Are (Apr/24/2008)

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Six weeks following Derek and Meredith's break-up, Derek continues to date Rose while Meredith, Alex, Izzie and Cristina compete in a surgical contest. Meanwhile, George and Lexie adjust to their new apartment and Callie finds a new friend in Erica Hahn.
Guest Stars: Lauren Stamile as Rose, Amy Madigan as Dr. Wyatt, Cheech Marin as Otis, Clea DuVall as Jennifer, Steven Flynn (1) as Scott, Jason O'Mara as Phillip, | Co-Guest Stars: Troy Westbrook as Paramedic
Director: Rob Corn
Writer: Zoanne Clack
Songs: Lykke Li -- I'm Good, I'm Gone, Goldfrapp -- Some People, Greg Laswell -- What A Day
 
74 :04x13 - Piece of My Heart (May/01/2008)

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Addison makes her return to Seattle Grace in order to perform an operation. As she does so, she is preoccupied by all of the changes in her former co-workers' lives. Meanwhile, Meredith and Derek's clinical trial has its first patient, and Rebecca returns to deliver Alex some shocking news.
Special Guest Stars: Kate Walsh as Addison Montgomery, | Guest Stars: Amy Madigan as Dr. Wyatt, Elizabeth Reaser as Rebecca, Clea DuVall as Jennifer, Lauren Stamile as Rose, Kathleen Rose Perkins as Sarah, Ken Barnett as Freddie, Jason O'Mara as Phillip, | Co-Guest Stars: Sam Daly as Will, Meg Cionni as Nikki, John O'Brien (1) as Lab Tech, Gloria Garayua as Intern Graciella, Tymberlee Chanel as Intern Claire, Winston Story as Intern Leo, Joy Osmanski as Intern Lucy, Molly Kidder as Intern Megan, Richard Keith as Intern Mitch
Director: Mark Tinker
Writer: Stacy McKee
Songs: Republic Tigers -- Buildings and Mountains, Neverending White Lights -- Distance, Meaghan Smith -- Five More Minutes, Jamie Lidell -- Little Bit Of Feel Good, Greenskeepers -- Money, Katalyst -- See What You Feel
 
75 :04x14 - The Becoming (May/08/2008)

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The nurses' outcry over McSteamy's frequent trysts leads the hospital to enact a new "date and tell" policy. Meanwhile, news about Burke's career force Cristina to cope with her feelings about the past; Meredith and Derek take in a veteran soldier to participate in their clinical trial; and Callie finds comfort in Sloane when she needs it the most.
Guest Stars: Lauren Stamile as Rose, John M. Jackson (1) as Kevin, Benny Ciaramello as Darren, Zilah Mendoza as Kyra, Dave Giuntoli as Todd, Loretta Devine as Adele, Amy Madigan as Dr. Wyatt
Director: Julie Ann Robinson
Writer: Tony Phelan, Joan Rater
Songs: The Submarines -- Brightest Hour, Beth Orton -- Carmella (Four Tet Remix), Frightened Rabbit -- Good Arms vs. Bad Arms, Jay Clifford -- Know When To Walk Away, Vampire Weekend -- Mansard Roof, Taken By Trees -- Only Yesterday
 
76 :04x15 - Losing My Mind (May/15/2008)

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As Dr. Wyatt refuses to let Meredith give up on her therapy sessons, Alex learns the truth about Rebecca's condition. Chief Webber has Dr. Hahn perform a high-risk surgery on his mentor. Meanwhile, after hearing about Burke, Cristina continues to act unusually, going as far as to clean her ever-messy apartment.
Guest Stars: Amy Madigan as Dr. Wyatt, Lauren Stamile as Rose, Elizabeth Reaser as Rebecca, Regina Taylor as Greta
Director: James Frawley
Writer: Debora Cahn (1)
Songs: Electrocute -- Uh Oh, The Puppini Sisters -- Walk Like An Egyptian, Alaska In Winter -- Your Red Dress (Wedding Song At Cemetery)
 
77 :04x16 - Freedom (1) (May/22/2008)
In the two-part season finale, Meredith and Derek take another shot at the clinical trial while the others race to free a boy from a hardening block of cement. Meanwhile, Izzie helps Alex care for Rebecca and Lexie learns a secret about George's intern status.
Guest Stars: Elizabeth Reaser as Rebecca, Amy Madigan as Dr. Wyatt, Lauren Stamile as Rose, Jurnee Smollett as Beth, John Cothran, Jr. as Ken, | Co-Guest Stars: Jana Kramer as Lola
Director: Rob Corn
Writer: Shonda Rhimes
Songs: Coldplay -- Death And All His Friends, Priscilla Ahn -- Dream, The Rosewood Thieves -- Heavy Eyes, Duffy -- Mercy
 
78 :04x17 - Freedom (2) (May/22/2008)

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In the two-part season finale, Meredith and Derek take another shot at the clinical trial while the others race to free a boy from a hardening block of cement. Meanwhile, Izzie helps Alex care for Rebecca and Lexie learns a secret about George's intern status.
Guest Stars: Amy Madigan as Dr. Wyatt, Elizabeth Reaser as Rebecca, Lauren Stamile as Rose, Loretta Devine as Adele, Jurnee Smollett as Beth, John Cothran, Jr. as Ken
Director: Rob Corn
Writer: Shonda Rhimes
Songs: Ingrid Michaelson -- Giving Up, Adele -- Hometown Glory, Ida Maria -- Keep Me Warm, Bryn Christopher -- Quest, Jon Foreman -- The Cure For Pain
 

Season 5
79 :05x01 - Dream a Little Dream of Me (1) (Sep/25/2008)

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As Meredith and Derek begin to find that their "happily ever after" is anything but easy, Cristina develops a crush on a military doctor who brings in a trauma patient. Meanwhile, the Chief and his staff cope with the news that Seattle Grace is no longer considered a top-tier teaching hospital.
Guest Stars: Lauren Stamile as Rose, Kevin McKidd as Owen Hunt, Mariette Hartley as Betty, Cliff DeYoung as Phil, Bernadette Peters as Sarabeth, Kathy Baker (1) as Anna, | Co-Guest Stars: John Getz as Michael
Director: Rob Corn
Writer: Shonda Rhimes
Songs: Other Lives -- Black Tables, Emiliana Torrini -- Jungle Drum, Steve Reynolds (2) -- Mistaken Identity, Jade McNelis -- Wins, Beck -- Youthless
 
80 :05x02 - Dream a Little Dream of Me (2) (Sep/25/2008)

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While Meredith and Derek continue in their new relationship, Cristina continues to get to know the military doctor as they treat his trauma patient.
Guest Stars: Kevin McKidd as Owen Hunt, Mariette Hartley as Betty, Lauren Stamile as Rose, Cliff DeYoung as Phil, Bernadette Peters as Sarabeth, Kathy Baker (1) as Anna, | Co-Guest Stars: John Getz as Michael
Director: Rob Corn
Writer: Shonda Rhimes
Songs: Greg Laswell -- And Then You, Jont -- Another Door Closes, The Rescues -- Crazy Ever After, The Perishers -- Never Bloom Again, Bon Iver -- Skinny Love, Taylor Swift -- White Horse, Jade McNelis -- Wins
 
81 :05x03 - Here Comes the Flood (Oct/09/2008)

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When the plumbing springs a leak, chaos breaks out at Seattle Grace as the Chief tries to put in place new teaching methods. Meanwhile, George takes his residency exam; and Derek attempts to get Meredith's roommates to move out, much to their surprise.
Guest Stars: Amy Madigan as Dr. Wyatt, Daniel J. Travanti as Barry, Jim Ortlieb as Jack, | Co-Guest Stars: Samantha Quan as Shelly, Suzy Nakamura as Jenn
Director: Michael Pressman
Writer: Krista Vernoff
Songs: Sia -- Cares At The Door, Emiliana Torrini -- Ha Ha, Little Jackie -- LOL, Erin McCarley -- Pitterpat, Santogold -- Say Aha
 
82 :05x04 - Brave New World (Oct/16/2008)

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Meredith is sent into a state of panic when Derek finds her mother's diary in the house. Meanwhile, Callie stresses while preparing for her first date with Erica. Later, Cristina stumbles across a part of the hospital no one has ever seen before.
Guest Stars: Amy Aquino as Marianne, Larry Brandenburg as Arnie, Bre Blair (1) as Lauren, John Sloan as David, Steven W. Bailey (1) as Joe, Kathleen Early as Dr. Daisy Pepman, Max Burkholder as Duncan
Director: Eric Stoltz
Writer: Debora Cahn (1)
Songs: Brett Dennen -- Ain't Gonna Lose You, Patrick & Eugene -- Altogether Now, Emiliana Torrini -- Big Jumps, The Whitest Boy Alive -- Done With You, Bernadette Moley -- Love to Me, The Rescues -- My Heart With You, The Bird & The Bee -- My Love, Josh Radin -- One Of Those Days
 
83 :05x05 - There's No 'I' in Team (Oct/23/2008)

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Bailey leads a team for a "domino procedure" in which each surgery is dependent on the one before it. Meanwhile, Derek receives sole credit for the study he and Meredith worked on; Lexie tries to get George to see her in a different light; and Sloan gives Callie relationship advice.
Guest Stars: Kevin McKidd as Owen Hunt, Carl Lumbly as Kurt, George Newbern as Stan, Colleen Flynn as Nancy, Saige Thompson as Lindsay, | Co-Guest Stars: Leslie Odom, Jr. as PJ, Steven W. Bailey (1) as Joe
Director: Randall Zisk
Writer: Jenna Bans
Songs: Greg Laswell -- Comes And Goes (In Waves), Brandi Carlile -- Hiding My Heart, Lenka -- Live Like You're Dying, Erin McCarley -- Love Save The Empty, Emilie Mover -- Ordinary Day, Shady Bard -- These Quiet Times
 
84 :05x06 - Life During Wartime (Oct/30/2008)

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The Chief gives Bailey new responsibility in order to help her to be one of the best surgeons at Seattle Grace. Meanwhile, Owen Hunt, the new head of trauma, clashes with the current staff's methods and abilities.
Guest Stars: Kevin McKidd as Owen Hunt, Scott Haven as Randy, | Co-Guest Stars: Lauri Johnson (1) as Grandma Ruth, Brandon Scott (2) as Intern Ryan, Adair Tishler as Tori Begler
Director: James Frawley
Writer: Mark Wilding
Songs: Greg Laswell -- Days Go On, El Perro Del Mar -- From The Valley To The Stars, Raining Jane -- Prelude, Vampire Weekend -- Walcott
 
85 :05x07 - Rise Up (Nov/06/2008)

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When the Chief makes an announcement that a solo surgery is up as an award, the residents are sent into a frenzy all trying to get an edge over one another. Meanwhile, Derek asks Bailey for advice after Cristina continues to interfere in his relationship with Meredith. Elsewhere, Erica uncovers a shocking connection between a resident and a patient.
Special Guest Stars: Jeffrey Dean Morgan as Denny Duquette, | Guest Stars: Kevin McKidd as Owen Hunt, Bonnie Bartlett as Rosie Bullard, | Co-Guest Stars: Avery Clyde as Elyse, Gloria Garayua as Intern Graciella, Mark Saul as Intern Steve, Fidel Gomez as Morgue Attendant, Shi Ne Nielson as Paramedic, Gordon James as Tech
Director: Joanna Kerns
Writer: William Harper
Songs: Brazilian Girls -- Good Times, Erin McCarley -- Gotta Figure This Out, Psapp -- I Want That, Shady Bard -- Torch Song
 
86 :05x08 - These Ties That Bind (Nov/13/2008)

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Sadie, one of Meredith's oldest friends, is brought on as an intern at Seattle Grace; however, Meredith's friends are less than welcoming to her. Meanwhile, Lexie leads the interns on a unique training session; and Virginia, a new surgeon, brings new rules to the O.R.
Special Guest Stars: Jeffrey Dean Morgan as Denny Duquette, | Guest Stars: Kevin McKidd as Owen Hunt, Melissa George as Sadie, Mary McDonnell (1) as Virginia Dixon, August Schellenberg as Clay Bedonie, Ed Lauter as Garbage Truck Homeless Guy
Director: Eric Stoltz
Writer: Stacy McKee
Songs: The Coral Sea -- Ah, Ah, Ah, Seabird -- Falling For You, Jets Overhead -- It's A Funny Thing, The Flying Tourbillon Orchestra -- The Uniform, Lenka -- Trouble Is A Friend
 
87 :05x09 - In the Midnight Hour (Nov/20/2008)

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Meredith, Cristina and Bailey must save Lexie and Sadie after a routine surgery goes terribly awry. Meanwhile, Owen and Derek treat a man injured while sleepwalking.
Special Guest Stars: Jeffrey Dean Morgan as Denny Duquette, | Guest Stars: Kevin McKidd as Owen Hunt, Melissa George as Sadie, Leslie Grossman as Lauren, Joshua Malina as Seth, John Allen Nelson as Arthur, Madeline Carroll (1) as Ivy, | Co-Guest Stars: Brandon Scott (2) as Intern Ryan, Joseph Williamson as Intern Pierce, Gloria Garayua as Intern Graciella, Mark Saul as Intern Steve, Molly Kidder as Intern Megan, Winston Story as Intern Leo, Jody Sclavos as ER Nurse, Nicole Cummins as EMT
Director: Tom Verica
Writer: Joan Rater, Tony Phelan
Songs: Meiko -- Boys With Girlfriends, Tina Dico -- No Time To Sleep, Lisa Hannigan -- Ocean And A Rock, Waz -- Ordinary Girl, Dido -- Quiet Times
 
88 :05x10 - All By Myself (Dec/04/2008)

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Cristina wins the first solo surgery among the residents, but is forced to give it up and choose who will perform the surgery in her place. Meanwhile, Mark heads up a procedure that will allow his patient to regain their ability to speak. Elsewhere, Callie tries to figure out if Sadie is being friendly to her or hitting on her.
Guest Stars: Kevin McKidd as Owen Hunt, Melissa George as Sadie, Mary McDonnell (1) as Virginia Dixon, | Co-Guest Stars: Larkin Campbell as Mr. Anderson, Perry Smith as Mrs. Anderson, Gloria Garayua as Intern Graciella, Mark Saul as Intern Steve, Zibby Allen as Nurse, Keeshan Giles as Paramedic #2
Director: Arlene Sanford
Writer: Peter Nowalk
Songs: Max Morgan -- Secret, Kanye West -- Street Lights, Sugarush Beat Company -- They Said I Said, Ray LaMontagne -- Winter Birds
 
89 :05x11 - Wish You Were Here (Jan/08/2009)

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Bailey pairs up with Dr. Arizona Robbins, Seattle Grace's new pediatric surgeon, to help save the life of a young patient. Derek is furious when a death row inmate is checked in to the hospital; Cristina and Meredith's friendship continues to erode; Callie and Sloan work through their attractions to Sadie and Lexie; and Izzie confesses to Alex that she has been seeing Denny.
Special Guest Stars: Jeffrey Dean Morgan as Denny, | Guest Stars: Kevin McKidd as Owen, Eric Stoltz as William, Jessica Capshaw as Dr. Arizona Robbins, Samantha Mathis as Melinda, Perrey Reeves as Margaret, Steven W. Bailey (1) as Joe, Robin Pearson Rose as Patricia, Melissa George as Sadie, | Co-Guest Stars: Aaron Refrem as Jackson, John Sloman as Dr. Kinley, Gloria Garayua as Intern Graciella, Molly Kidder as Intern Megan, Candice Afia as Intern Laura, Amrapali Ambegaokar as Intern Dani, Kevin Clarke (1) as Paramedic
Director: Rob Corn
Writer: Debora Cahn (1)
Songs: The Coral Sea -- Ah, Ah, Ah, Daniel Powter -- Am I Still the One (feat. Linda Perry), Tandy -- Home, Santogold -- Lights Out, Dido -- The Day Before the Day, Ben Folds -- You Don't Know Me (feat. Regina Spektor)
 
90 :05x12 - Sympathy for the Devil (Jan/15/2009)

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Derek's mother, Carolyn, makes a surprise visit and meets Meredith for the first time. Meanwhile, Mark tries to hide his relationship with Lexie; William, the death row inmate, asks to donate his organs to Bailey's patient; and Owen and Cristina go on their first date.
Special Guest Stars: Jeffrey Dean Morgan as Denny, Tyne Daly as Carolyn, | Guest Stars: Kevin McKidd as Owen, Melissa George as Sadie, Eric Stoltz as William, Jessica Capshaw as Dr. Arizona, Samantha Mathis as Melinda, Jason Kravits as Chuck, Ernie Grunwald as Gary, Brandon Scott (2) as Intern Ryan
Director: Jeannot Szwarc
Writer: Jenna Bans
Songs: Anya Marina -- All The Same To Me, Glass Pear -- Last Days Of Your Life, Winterpills -- Take Away The Words, Johnathan Rice -- The Acrobat, Right Away, Great Captain -- What A Pity
 
91 :05x13 - Stairway to Heaven (Jan/22/2009)

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Bailey becomes desperate as her patient's condition rapidly worsens, causing everyone to work to find the boy an organ donor before it's too late. Meanwhile, Mark finds himself in a compromising position and Crisitina avoids Owen.
Guest Stars: Jeffrey Dean Morgan as Denny, Kevin McKidd as Owen, Melissa George as Sadie, Eric Stoltz as William, Jessica Capshaw as Dr. Arizona Robbins, Samantha Mathis as Melinda, Jason Kravits as Chuck, Ernie Grunwald as Gary, Brandon Scott (2) as Intern Ryan
Director: Allison Liddi
Writer: Mark Wilding
Songs: Emiliana Torrini -- Birds, Bon Iver -- Blindsided, Powderfinger -- Drifting Further Away
 
92 :05x14 - Beat Your Heart Out (Feb/05/2009)

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With the engagement ring taken care of, Derek ponders the perfect way to pop the question to Meredith. Meanwhile, Lexie demands that Mark go public with their relationship; and Bailey, happy with her work with recent patients, considers a new career direction.
Guest Stars: Jessica Capshaw as Dr. Arizona, Jennifer Westfeldt as Jen, Ben Shenkman as Rob, Peter MacKenzie (1) as Warren, Laura Allen (1) as Beth, Brandon Scott (2) as Intern Ryan, Mary McDonnell (1) as Dr. Dixon, Melissa George as Sadie
Director: Julie Ann Robinson
Writer: William Harper
Songs: Kate Havnevik -- Halo, Dido -- Never Want To Say It's Love, Bon Iver -- Stacks, Nikka Costa -- Stuck to You, Trolle//Siebenhaar -- These Streets, Panda Transport -- Transmission
 
93 :05x15 - Before and After (Feb/12/2009)

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Addison, Naomi and Sam bring Archer to Seattle Grace in order to have Derek and Mark work to save his life. Meanwhile, Izzie works on a medical game to help the interns.
Special Guest Stars: Kate Walsh as Addison, Audra McDonald as Naomi, Taye Diggs as Sam, | Guest Stars: Grant Show as Archer, Jennifer Westfeldt as Jen, Ben Shenkman as Rob, Laura Allen (1) as Beth, Sam Anderson as Michael, Steven W. Bailey (1) as Joe, Brandon Scott (2) as Intern Ryan, Melissa George as Sadie
Director: Daniel Attias
Writer: Tony Phelan, Joan Rater
Songs: Keri Noble -- Emily, Liam Finn -- Gather to the Chapel, Slow Runner -- Happy Ending, Shontelle -- Roll It, Sara Bareilles -- Winter Song (feat. Ingrid Michaelson)
 
94 :05x16 - An Honest Mistake (Feb/19/2009)

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Derek's confidence is dashed as he squares off with Addison over a patient. Cristina begins to doubt the abilities of a surgeon after she messes up on a routine procedure. Meanwhile, Bailey, pursuing a fellowship in pediatrics, is appalled by the Chief's recommendation letter.
Special Guest Stars: Kate Walsh as Addison Montgomery, | Guest Stars: Faye Dunaway as Dr. Campbell, Brandon Scott (2) as Intern Ryan, Jessica Capshaw as Dr. Arizona Robbins, Gloria Garayua as Intern Graciella, Mark Saul as Intern Steve, Joy Osmanski as Intern Lucy, Winston Story as Intern Leo, Molly Kidder as Intern Megan, Jennifer Westfeldt as Jen, Ben Shenkman as Rob, Kathleen Early as Dr. Daisy Pepman, Louis Giambalvo as John, Susan Merson as Lorraine
Director: Randall Zisk
Writer: Peter Nowalk
Songs: Dash and Will -- Error, Error, Calahan -- Like A Ghost, Snow Patrol -- The Planets Bend Between Us, Matt Hires -- Turn The Page, Little Dragon -- Twice
 
95 :05x17 - I Will Follow You Into the Dark (Mar/12/2009)

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When Derek learns that more of his patients have died than survived, he decides to quit despite Meredith standing by him. Meanwhile, Bailey and the Chief continue to fail to see eye-to-eye on the fellowship until Adele steps in. Elsewhere, Izzie's interns discover dire news in regards to "patient x," unaware it's Izzie.
Guest Stars: Jessica Capshaw as Dr. Arizona Robbins, Michael Rady as Mike Shelley, Wendy Hoopes as Tricia, Erin Cahill as Meg, Susane Lee (1) as Beth, Brandon Scott (2) as Intern Ryan, Loretta Devine as Adele Webber, | Co-Guest Stars: Phil Abrams as Dr. John Nelson, B.K. Cannon as Girl Band Geek, Marcus McGee as Boy Band Geek, Mark Saul as Intern Steve, Gloria Garayua as Intern Graciella, Candice Afia as Intern Laura, Amrapali Ambegaokar as Intern Dani, Tymberlee Chanel as Intern Claire, Molly Kidder as Intern Megan, Joseph Williamson as Intern Pierce, Winston Story as Intern Leo
Director: Rob Corn
Writer: Jenna Bans
Songs: Piers Faccini -- A Storm Is Going To Come, Rachael Yamagata -- Duet, Metric -- Front Row, Shady Bard -- Treeology
 
96 :05x18 - Stand By Me (Mar/19/2009)

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As Izzie continues to hide her medical secret, the residents all try to convince Derek to come back to work but fail at doing so. Meanwhile, Mark attempts a radical face transplant surgery; and Cristina is awarded a solo surgery, but is preoccupied by Izzie's condition.
Guest Stars: Larry Sullivan as Dave, Emily Kuroda as Kendall, Brandon Scott (2) as Intern Ryan, | Co-Guest Stars: Candice Afia as Intern Laura, Darcy Martin as Sharon, Greta Sesheta as TBA, Michael Merton as Dexter, Mark Saul as Intern Steve, Candace Brown as Milo, Amrapali Ambegaokar as Intern Dani, Tymberlee Chanel as Intern Claire, Molly Kidder as Intern Megan, Joseph Williamson as Intern Pierce, Winston Story as Intern Leo, Martin Yu as Anesthesiologist
Director: Jessica Yu (1)
Writer: Zoanne Clack
Songs: Royal Wood -- A Mirror Without, Great Northern -- Driveway, Common -- Everywhere (feat. Martina Topley-Bird)
 
97 :05x19 - Elevator Love Letter (Mar/26/2009)

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Tensions are high as Derek returns to Seattle Grace to perform his first surgery following his breakdown. Meanwhile, everyone turns their attention to Izzie, who must undergo surgery for her condition; and Owen suffers from another PTSD episode that injures Cristina, putting their relationship at risk.
Guest Stars: Jessica Capshaw as Dr. Arizona Robbins, Kimberly Elise as Dr. Swender, Molly Hagan as Jackie, Todd Waring as Tobin, Brandon Scott (2) as Dr. Ryan Spalding
Director: Ed Ornelas
Writer: Stacy McKee
Songs: Gomez -- Little Pieces, Ben Lee (1) -- Rise Up, The Cinematic Orchestra -- That Home, Sanders Bohlke -- The Weight of Us, O+S -- We Do What We Want To, Peter Broderick -- With The Notes In My Ears
 
98 :05x20 - Sweet Surrender (Apr/23/2009)

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As she endures aggressive treatment for her cancer, Izzie throws herself into planning Derek and Meredith's wedding.
Guest Stars: Obba Babatundé as Gates, Jose Zuniga as Meloy, Elden Henson as Mr. Smithson, Kimberly Elise as Dr. Swender, Jessica Capshaw as Dr. Arizona Robbins, Hector Elizondo as Mr. Torres, Amy Madigan as Dr. Wyatt
Director: Tony Phelan
Writer: Sonay Washington
Songs: The Rescues -- Break me out
 
99 :05x21 - No Good at Saying Sorry (One More Chance) (Apr/30/2009)
As Meredith and Derek continue to prepare for their wedding day, Izzie receives a surprise visit from her mother, and a person from Meredith and Lexie's past arrives at Seattle Grace.
Guest Stars: Jeff Perry as Thatcher Grey, Kellie Martin as Julie, Megan Henning as Willow, Sharon Lawrence as Robbie, Jessica Capshaw as Dr. Arizona, Nina Siemaszko as Kate
Director: Tom Verica
Writer: Krista Vernoff
Songs: Emilie Mover -- Brand New, Brett Dennen -- So Far From Me, The Rescues -- Stay Over, All Thieves -- Turn and Turn Again, The Hard Lessons -- Wedding Ring
 
100 :05x22 - What a Difference a Day Makes (May/07/2009)
As Meredith, Derek and their friends and family gather for their wedding, a group of several college students are admitted to the E.R. following a car crash.
Special Guest Stars: Jeffrey Dean Morgan as Denny Duquette, | Guest Stars: Jessica Capshaw as Dr. Arizona Robbins
Director: Rob Corn
Writer: Shonda Rhimes
Songs: Au Revoir Simone -- Another Likely Story, Matthew Mayfield -- First In Line, Ingrid Michaelson -- Turn to Stone
 
101 :05x23 - Here's to the Future (1) (May/14/2009)
After spending time with a fellow cancer patient, Izzie begins to question whether or not to undergo a risky procedure. Meanwhile, Mark considers taking his relationship with Lexie to the next level; and after helping a patient, Owen begins to rethink his position at Seattle Grace.
Special Guest Stars: Jeffrey Dean Morgan as Denny Duquette, | Guest Stars: Debra Mooney as Mrs. Hunt, Zach Gilford as Charlie, Liza Weil as TBA, Jessica Capshaw as Dr. Arizona Robbins, Kimberly Elise as Dr. Swender
Director: Bill D'Elia
Writer: Allan Heinberg
 
102 :05x24 - Now or Never (2) (May/14/2009)
George gives Bailey news that shocks the entire hospital as everyone awaits for Izzie to recover from surgery. Meanwhile, Bailey is accepted into the pediatric fellowship program; and Seattle Grace comes together to help save a traffic accident victim.
Guest Stars: Shannon Lucio as Amanda, Jessica Capshaw as Dr. Arizona Robbins, Kimberly Elise as Dr. Swender
Director: Rob Corn
Writer: Debora Cahn (1)
 

Season 6
103 :06x01 - Good Mourning (1) (Sep/24/2009)
The Seattle Grace staff has to deal with the aftermath of George's tragic death. As the news hits the staff hard, they all must find a way to get through the stages of grief. Later, George's mother arrives at the hospital to decide what to do with his organs.
Guest Stars: Shannon Lucio as Amanda, Debra Monk as Louise O'Malley, Mitch Pileggi as Larry Jennings, Tymberlee Chanel as Intern Claire, Mark Saul as Intern Steve, Molly Kidder as Intern Megan, Joseph Williamson as Intern Pierce, Winston Story as Intern Leo, Gloria Garayua as Intern Graziella, Tony Casale as ND Surgeon #2, Alicia Hannah as Jasmine, Jim Metzler as Priest, Emily Roche as Jo, Payton Silver as Dr. Knox, Lori Yeghiayan as ND Surgeon #1, Ray Ford as Paramedic, | Co-Guest Stars: Martha Plimpton as Pam, Zoe Boyle as Clara, Zack Shada as Andy
Director: Ed Ornelas
Writer: Krista Vernoff
Songs: Joy Williams -- Speaking a Dead Language, O+S -- The Fox, James Yuill -- This Sweet Love, Sweet Honey In The Rock -- Wade In the Water
 
104 :06x02 - Goodbye (2) (Sep/24/2009)
Though time has passed since George's death, everyone continues to struggle with his passing by finding distractions to keep themselves occupied. Meredith and Derek cope by consummating their marriage anywhere and everywhere, while Dr. Wyatt suggests that Cristina and Owen abstain from sex.
Guest Stars: Amy Madigan as Dr. Wyatt, Martha Plimpton as Pam, Mitch Pileggi as Larry Jennings, Kate Anthony as Nurse Kate, T. J. Lowther (1) as Intern Hank, Miguel Nájera as Janitor, T'Shawn Barett, Jr. as Jon, | Co-Guest Stars: Shannon Lucio as Amanda, Zoe Boyle as Clara, Zack Shada as Andy, Adam Lazarre-White as Oncology Resident
Director: Ed Ornelas
Writer: Krista Vernoff
Songs: Fanfarlo -- Ghosts, Lucy Schwartz -- Gravity, Katie Herzig -- Hologram, Emiliana Torrini -- Today Has Been OK
 
105 :06x03 - I Always Feel Like Somebody's Watchin' Me (Oct/01/2009)
Several weeks after her near-death experience, a recovering Izzie returns to work. Meanwhile, nervous that there will be layoffs in the hospital in the wake of an announcement from the Chief, the Seattle Grace residents compete to survive the cuts, including Cristina, who attempts to work alongside Arizona in pediatrics. And Bailey and Alex's patient's already complex case is further complicated by her schizophrenic son.

Source: ABC
Guest Stars: Sarah Utterback as Nurse Olivia, Adrienne Barbeau as Jodie, James Frain as Tom, Mark Saul as Intern Steve, Gloria Garayua as Intern Graziella, Amrapali Ambegaokar as Intern Dani, Tymberlee Chanel as Intern Claire, Molly Kidder as Intern Megan, Winston Story as Intern Leo, Candice Afia as Intern Laura, Joseph Williamson as Intern Pierce, Kim Swennen as Kelly, Joyce Lee as Julia, Taylor Geare as Sage, Curtis Harris as Tyler, Shi Ne Nielson as Paramedic #1, Nicole Cummins-Rubio as Paramedic #2, Kerri Higuchi as Dr. Elizabeth Chen
Director: Michael Pressman
Writer: Joan Rater, Tony Phelan
Songs: Rachael Yamagata -- Brown Eyes, Until June -- In My Head, Gossip -- Pop Goes the World, Ingrid Michaelson -- The Chain
 
106 :06x04 - Tainted Obligation (Oct/08/2009)
When Meredith and Lexie's father, Thatcher, returns to the hospital with a failed liver, it's up to Meredith to save his life. Meanwhile, Izzie empathizes with a patient riddled with tumors, as Mark, annoyed with Cristina's competitive zeal, tricks her into assisting on an unusual surgery.

Source: ABC
Guest Stars: Jeff Perry as Thatcher Grey, Ralph Waite as Irving Waller, Tom Amandes as Charlie Waller, Isabella Hofmann as Irene Waller, Jocko Sims as Randy, Kristen Ariza as Angela, Phil Abrams as Dr. Nelson, Payton Silver as Dr. Knox, Ursula Whittaker as Angry Attending #1, | Co-Guest Stars: Mark Saul as Intern Steve
Director: Tom Verica
Writer: Jenna Bans
Songs: Dragonette -- Come On Be Good, Bachelorette -- Long Time Gone, Sebastien Schuller -- Morning Mist, The Voluntary Butler Scheme -- Trading Things In, Katie Herzig -- Wish You Well
 
107 :06x05 - Invasion (Oct/15/2009)
The residents of Seattle Grace and Mercy West vie for surgeries and their careers as day one of the hospital merger begins. Meanwhile, Arizona stands by an enraged Callie when her father, Mr. Torres, employs a priest to help convince her to date men, and Izzie experiences the brunt of her new surgical competition.

Source: ABC
Guest Stars: Alexie Gilmore as Sarah, Sarah Drew as April, David Bowe (1) as Don, Robert Baker (5) as Charles Denman, Jack Gwaltney as Frank, J. P. Pitoc as Billy, Brandon Scott (2) as Intern Ryan, Kathleen Wilhoite as Leslie, Jesse Williams as Jackson, Nora Zehetner as Reed Adamson, Bruce French as Father Kevin, Hector Elizondo as Mr. Torres, Mark Saul as Intern Steve, Gloria Garayua as Intern Graziella, Chelsea Ricketts as Jeanie, Ray Ford as Paramedic Ray, Frank Ertl as Michael, John O'Brien (1) as Lab Tech, | Co-Guest Stars: Freda Foh Shen (1) as Missy Grant
Director: Tony Phelan
Writer: Mark Wilding
Songs: The Myrmidons -- Clap, Traildriver -- I Want You Now, Greg Laswell -- Your Ghost
 
108 :06x06 - I Saw What I Saw (Oct/22/2009)
When a burn victim unexpectedly dies during a chaotic time in the emergency room, the Chief, with the help of board member Jennings, interview each of the residents in order to find who was to blame in the incident, leading each of the doctors to defend their actions of the day to save their jobs.
Guest Stars: Robert Baker (5) as Charles Percy, Sarah Drew as April Kepner, Bill Fagerbakke as Roy, Erinn Hayes as Cathy, Mitch Pileggi as Larry Jennings, Jesse Williams as Jackson Avery, Nora Zehetner as Reed Adamson, Moe Irvin as E.R. Nurse, Saundra McClain as Lawyer, Jakob Miller as Danny, Andrew Miller (1) as Danny, Mark Daugherty as Evan, Ron Roggé as Fire Captain, Arlene Santana as Nurse, John Bradford as Danny's Dad
Director: Allison Liddi
Writer: William Harper
Songs: Metric -- Blindness, Matt Hires -- Out of the Dark, Faded Paper Figures -- Polaroid Solution, Jack Savoretti -- Songs From Different Times, All Thieves -- We Will Be Dust
 
109 :06x07 - Give Peace a Chance (Oct/29/2009)
When Isaac, the hospital lab tech discovers he has an inoperable tumor wrapped around his spine, he seeks Derek for help. Meanwhile, Richard's authority is challenged by Derek.
Guest Stars: Jesse Williams as Jackson Avery, Nora Zehetner as Reed Adamson, Mark Saul as Intern Steve, Faran Tahir as Isaac
Director: Chandra Wilson
Writer: Peter Nowalk
Songs: Bat for Lashes -- Moon and Moon
 
110 :06x08 - Invest In Love (Nov/05/2009)
The parents of Arizona's 10-year-old patient offer the hospital a generous donation, but Arizona finds herself in a conflict of interest when the patient's condition worsens. Cristina tests her boundaries with Owen.

Source: abc.com
Guest Stars: Nora Zehetner as Dr. Reed Adamson, Jesse Williams as Dr. Jackson Avery, Robert Baker (5) as Dr. Charles Percy, Mitch Pileggi as Larry Jennings, Alanna Masterson as Hillary, Khamani Griffin as Wallace, Caroline Choi as Laura, Erica Gimpel (1) as Bethany Anderson, Angelo Tiffe as Trey Boyd, Derek Webster as Paul Anderson, Nealla Gordon (1) as Jill Boyd
Director: Jessica Yu (1)
Writer: Stacy McKee
Songs: Brandi Carlile -- Before it Breaks, The Cinematic Orchestra -- Breathe, Correatown -- Everything All at Once, Metric -- Gold Guns Girls, Bachelorette -- Her Rotating Head, Sébastien Schuller -- High Green Grass, Faded Paper Figures -- North by North
 
111 :06x09 - New History (Nov/12/2009)
Owen recruits a new cardiothoracic surgeon, Iraqi War vet Dr. Teddy Altman, but Cristina is quick to judge her abilities in the O.R. Meanwhile, Izzie returns to Seattle Grace with her former high school teacher who is suffering from dementia; and the Chief begins to feel the strain of his new responsibilities post-merger.
Guest Stars: Kim Raver as Dr. Teddy Altman, Joel Grey (1) as Dr. Singer, Loretta Devine as Adele Webber, Robert Baker (5) as Dr. Charles Percy, Jesse Williams as Dr. Jackson Avery, Nora Zehetner as Dr. Reed Adamson, Steven W. Bailey (1) as Joe, James DuMont as Sheldon Morris, Heather Corwin as Casey's Mom, Mason Cook as Casey
Director: Rob Corn
Writer: Allan Heinberg
Songs: Stars of Track and Field -- End of All Time, Greg Laswell -- In Spite of Me, The Civil Wars -- Poison & Wine, Joy Williams -- Sunny Day, Gossip -- Vertical Rhythm
 
112 :06x10 - Holidaze (Nov/19/2009)
As the holidays come and go, Miranda has a surprise visit from her father, William, who has a strong disapproval of her choices in life. Mark and Lexie must cope with a person who re-enters Mark's life, and Thatcher Grey questions the Chief's behavior, but Meredith is quick to come to the Chief's defense.
Guest Stars: Kim Raver as Dr. Teddy Altman, Jeff Perry as Thatcher Grey, Steven W. Bailey (1) as Joe, Jesse Williams as Dr. Jackson Avery, Frankie Faison as William Bailey, Leven Rambin as Sloan Riley, Danielle Panabaker as Chelsea, James Nardini as , Nathan West as , Hillary Tuck as Mrs. Jacobsen
Director: Robert Berlinger
Writer: Krista Vernoff
 
113 :06x11 - Blink (Jan/14/2010)
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