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Episode number: 6x21 Airdate: Thursday May 06th, 2010 Alternate Airdates:
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| Artist | Song Title | Played When |
| Andrew Belle | Make It Without You | Patient Accepts the Idea of Change, Closing Scenes |
| Angus & Julia Stone | The Devil's Tears | Derek Exits, Seattle, Avery Compliments Cristina |
| The Deer Tracks | Bless the Waves | Opening Scenes, Bailey Leads Sensitivity Training |
| Jack Savoretti | Wonder | Patient's Wife Scolds Alex, Alex Talks to Patient |
| Luluc | One Day Soon | Derek Exits, Meredith Follows Owen, Cristina Sad |
| The Weepies | Be My Thrill | Lexie Amused, Hospital, Alex Takes Bets on Patient |
| • Creator | Shonda Rhimes |
| • Executive Producer | Betsy Beers  | Allan Heinberg  | Mark Wilding  | Rob Corn  | Mark Gordon (4)  | Shonda Rhimes  | Krista Vernoff |
| • Co-Executive Producer | Jenna Bans  | Tony Phelan  | Joan Rater |
| • Supervising Producer | Stacy McKee  | Zoanne Clack |
| • Producer | Linda Klein  | Tammy Ann Casper  | Jeff Rafner |
| • Consulting Producer | Debora Cahn (1) |
| • Production Designer | Donald Lee Harris (1) |
| • Editor | David Greenspan (1) |
| • Director of Photography | Herbert Davis (1) |