Guest Stars

James Tupper As Andrew Perkins Recurring	Art Chudabala As Jerry Adams
Caterina Scorsone As Dr. Amelia Shepherd	Dana Davis (1) As Gretchen
Jolene Kim As Tess Adams	Omar Gooding As Danny

Co-Guest Stars

Arlene Santana As Nurse Recurring	Sean Carrigan As Todd

Main Cast

Ellen Pompeo As Meredith Grey	Sandra Oh As Cristina Yang
Justin Chambers As Alex Karev	Chandra Wilson As Miranda Bailey
James Pickens, Jr. As Richard Webber	Sara Ramirez As Callie Torres
Eric Dane As Mark Sloan	Chyler Leigh As Lexie Grey
Kevin McKidd As Owen Hunt	Jessica Capshaw As Arizona Robbins
Kim Raver As Teddy Altman	Sarah Drew As April Kepner
Jesse Williams (2) As Jackson Avery	Patrick Dempsey As Derek Shepherd

Recap

The show opened with Amelia (Amy), Derek's estranged sister, appearing to Derek at the hospital. Derek was not happy to see her and asked her what she was doing there. She jokingly asked him was he not glad to see her? He angrily said he was not and asked her what she wanted. She said that she was a neurosurgeon now and was seeking work at the hospital. He told her to leave and she said she wanted to stay. When she was five, their mother and father had been confronted by a burglar who ended up shooting the mother to death over some jewelry, but Amy did not have much memory of the event. Amy asked Derek why he never seemed to want to talk about it and he changed the subject. Amy said that they would have to talk about it sometime and it might as well be now; he adamantly refused and left...

Read the full recap

• Creator	Shonda Rhimes
• Executive Producer	Betsy Beers  |  Joan Rater  |  Tony Phelan  |  Mark Gordon (1)  |  Rob Corn  |  Mark Wilding  |  Shonda Rhimes  |  Krista Vernoff
• Co-Executive Producer	Zoanne Clack  |  Stacy McKee
• Producer	Tammy Ann Casper  |  Jeff Rafner  |  Linda Klein
• Consulting Producer	Debora Cahn (1)
• Production Designer	Donald Lee Harris (1)
• Editor	David Greenspan (1)
• Director of Photography	Herbert Davis (1)