Guest Stars

James Tupper As Andrew Perkins Recurring	Art Chudabala As Jerry Adams
Caterina Scorsone As Dr. Amelia Shepherd	Dana Davis (1) As Gretchen
Jolene Kim As Tess Adams	Omar Gooding As Danny

Co-Guest Stars

Arlene Santana As Nurse Recurring	Sean Carrigan As Todd

Main Cast

Ellen Pompeo As Dr. Meredith Grey	Sandra Oh As Dr. Cristina Yang
Patrick Dempsey As Dr. Derek Shepherd	Justin Chambers As Dr. Alex Karev
Chandra Wilson As Dr. Miranda Bailey	James Pickens, Jr. As Dr. Richard Webber
Sara Ramirez As Dr. Calliope "Callie" Torres	Kevin McKidd As Dr. Owen Hunt
Jessica Capshaw As Dr. Arizona Robbins	Jesse Williams (2) As Dr. Jackson Avery
Eric Dane As Dr. Mark Sloan	Chyler Leigh As Dr. Lexie Grey
Kim Raver As Dr. Teddy Altman	Sarah Drew As Dr. April Kepner

Recap

The show opened with Amelia (Amy), Derek's estranged sister, appearing to Derek at the hospital. Derek was not happy to see her and asked her what she was doing there. She jokingly asked him was he not glad to see her? He angrily said he was not and asked her what she wanted. She said that she was a neurosurgeon now and was seeking work at the hospital. He told her to leave and she said she wanted to stay. When she was five, their mother and father had been confronted by a burglar who ended up shooting the mother to death over some jewelry, but Amy did not have much memory of the event. Amy asked Derek why he never seemed to want to talk about it and he changed the subject. Amy said that they would have to talk about it sometime and it might as well be now; he adamantly refused and left...

Read the full recap

• Creator	Shonda Rhimes
• Executive Producer	Betsy Beers  |  Mark Wilding  |  Rob Corn  |  Tony Phelan  |  Joan Rater  |  Mark Gordon (4)  |  Shonda Rhimes  |  Krista Vernoff
• Co-Executive Producer	Stacy McKee  |  Zoanne Clack
• Producer	Linda Klein  |  Tammy Ann Casper  |  Jeff Rafner
• Consulting Producer	Debora Cahn (1)
• Production Designer	Donald Lee Harris (1)
• Editor	David Greenspan (1)
• Director of Photography	Herbert Davis (1)